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The Gene Editing Juggernaut is Picking Up Speed. 基因编辑巨轮正在加速前进。
IF 0.6 4区 医学
IEEE Pulse Pub Date : 2023-09-01 DOI: 10.1109/MPULS.2023.3344054
Jim Banks
{"title":"The Gene Editing Juggernaut is Picking Up Speed.","authors":"Jim Banks","doi":"10.1109/MPULS.2023.3344054","DOIUrl":"10.1109/MPULS.2023.3344054","url":null,"abstract":"<p><p>CRISPR-Cas9, the tool for editing genes by precisely cutting DNA and letting the body's natural DNA repair processes take over, deservedly led to Nobel prizes in 2020 for its pioneers, Emmanuelle Charpentier and Jennifer Doudna. Since their breakthroughs in 2012, the technology has moved forward in leaps and bounds, and techniques to manipulate genes that were once the realm of science fiction are becoming very much science \"fact.\"</p>","PeriodicalId":49065,"journal":{"name":"IEEE Pulse","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NASA Takes on Climate Change: Focusing Tech From Space to Earth. 美国国家航空航天局应对气候变化：将技术从太空聚焦到地球。
IF 0.6 4区 医学
IEEE Pulse Pub Date : 2023-09-01 DOI: 10.1109/MPULS.2023.3344080
Leslie Mertz
{"title":"NASA Takes on Climate Change: Focusing Tech From Space to Earth.","authors":"Leslie Mertz","doi":"10.1109/MPULS.2023.3344080","DOIUrl":"10.1109/MPULS.2023.3344080","url":null,"abstract":"<p><p>When the Voyager 1 spacecraft was hurtling past Neptune to points beyond, its camera swung back to snap an image of Earth, a tiny spot of light in the vast, dark expanse. That 1990 image offered a stark reminder of just how vulnerable our planet is. The U.S. National Aeronautics and Space Administration (NASA) remains focused on space exploration today, but is also providing an Earth-side role, notably in understanding climate change and how it affects human health, and in inspiring new research and products to help people cope with varying weather patterns and the threats they bring.</p>","PeriodicalId":49065,"journal":{"name":"IEEE Pulse","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Brain Cells That Make Us Uniquely Human. 让我们成为独特人类的脑细胞
IF 0.6 4区 医学
IEEE Pulse Pub Date : 2023-09-01 DOI: 10.1109/MPULS.2023.3344068
Zara Abrams
{"title":"The Brain Cells That Make Us Uniquely Human.","authors":"Zara Abrams","doi":"10.1109/MPULS.2023.3344068","DOIUrl":"10.1109/MPULS.2023.3344068","url":null,"abstract":"<p><p>For over a century, scientists have known that the brain contains multiple cell types, dating back to Santiago Ramón y Cajal's earliest observations of brain tissue under a microscope. But until recently, we lacked the tools to study those cells with enough resolution to truly understand their roles.</p>","PeriodicalId":49065,"journal":{"name":"IEEE Pulse","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treating the Brain With Focused Ultrasound. 用聚焦超声波治疗大脑
IF 0.6 4区 医学
IEEE Pulse Pub Date : 2023-09-01 DOI: 10.1109/MPULS.2023.3344082
Mary Bates
{"title":"Treating the Brain With Focused Ultrasound.","authors":"Mary Bates","doi":"10.1109/MPULS.2023.3344082","DOIUrl":"10.1109/MPULS.2023.3344082","url":null,"abstract":"<p><p>Focused ultrasound is an early stage, noninvasive therapy with the potential to treat a range of medical conditions. Like diagnostic ultrasound, it uses sound waves above the range of human hearing. But its purpose is to interact with tissues in the body, rather than just produce images of them. In focused ultrasound, multiple, intersecting beams of high frequency sound are aimed to converge on specific targets deep within the body. There, the ultrasound energy can act in multiple ways to either modify or destroy tissue.</p>","PeriodicalId":49065,"journal":{"name":"IEEE Pulse","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA Testing for Preventative Health: Do Outcomes Justify Continued Investment? DNA检测用于预防健康:结果证明继续投资是合理的吗?
IF 0.6 4区 医学
IEEE Pulse Pub Date : 2023-07-01 DOI: 10.1109/MPULS.2023.3324240
Jim Banks
{"title":"DNA Testing for Preventative Health: Do Outcomes Justify Continued Investment?","authors":"Jim Banks","doi":"10.1109/MPULS.2023.3324240","DOIUrl":"10.1109/MPULS.2023.3324240","url":null,"abstract":"<p><p>In The U.K., a heated debate is raging in the genetics community about a not-so-new technology and its role in public health. Cheap genetic tests to discover our ancestry have become familiar consumer products, and our genes can tell us a lot about our ancestry, so it is an appealing idea that they can tell us about our susceptibility to serious diseases. Polygenic risk scores (PRS)-generated by sequencing multiple parts of a person's DNA-are said by some to hold the key to helping people avoid everything from type 1 diabetes to cardiovascular disease and cancer. This could herald a new era of preventive medicine, and the U.K. is investing heavily, but ultimately, whether or not this a good investment is still being determined.</p>","PeriodicalId":49065,"journal":{"name":"IEEE Pulse","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Considering Sex in Biomedical Research. 在生物医学研究中考虑性别。
IF 0.6 4区 医学
IEEE Pulse Pub Date : 2023-07-01 DOI: 10.1109/MPULS.2023.3324238
Mary Bates
{"title":"Considering Sex in Biomedical Research.","authors":"Mary Bates","doi":"10.1109/MPULS.2023.3324238","DOIUrl":"10.1109/MPULS.2023.3324238","url":null,"abstract":"<p><p>Until relatively recently, basic biomedical research was almost exclusively conducted with male human, animal, and cell models. It was widely assumed that the research findings and medical treatments developed from these studies could be generalized to the whole population. However, there are sex differences in key biological pathways and processes that can influence a person's disease risk, experience of symptoms, and response to treatment. The lack of female representation in preclinical biomedical research has resulted in gaps in our medical knowledge, with important consequences for women's health. In the past decade, efforts to remedy this historic exclusion have increased, but opportunities remain to make basic biomedical research more equitable, reproducible, and applicable to all people.</p>","PeriodicalId":49065,"journal":{"name":"IEEE Pulse","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence Aided Ethics in Frontier Research. 人工智能辅助伦理前沿研究。
IF 0.6 4区 医学
IEEE Pulse Pub Date : 2023-07-01 Epub Date: 2023-11-20 DOI: 10.1109/MPULS.2023.3324241
Andres Diaz Lantada, Mette Ebbesen
{"title":"Artificial Intelligence Aided Ethics in Frontier Research.","authors":"Andres Diaz Lantada, Mette Ebbesen","doi":"10.1109/MPULS.2023.3324241","DOIUrl":"10.1109/MPULS.2023.3324241","url":null,"abstract":"<p><p>Emergent technologies are frequently demonized due to the fear of the unknown. The doubts and alarms are more often than not sparked by their own developers, in a secret wish to become the masters of such fears, and thereby increase their control and influence upon laymen. The story is as old as the use of fire by the sorcerers guiding most ancient rituals. Now it seems to be the turn of artificial intelligence (AI), which is being continuously tainted with quasi-apocalyptic shadows, despite its remarkable potentials for supporting highly desirable societal transformations.</p>","PeriodicalId":49065,"journal":{"name":"IEEE Pulse","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cover 2 封二
IF 0.6 4区 医学
IEEE Pulse Pub Date : 2023-07-01 DOI: 10.1109/mpuls.2023.3328726
{"title":"Cover 2","authors":"","doi":"10.1109/mpuls.2023.3328726","DOIUrl":"https://doi.org/10.1109/mpuls.2023.3328726","url":null,"abstract":"","PeriodicalId":49065,"journal":{"name":"IEEE Pulse","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139365799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Fitness for Air travel in Patients with Pulmonary Diseases 肺部疾病患者适合乘飞机旅行的评估
IF 0.6 4区 医学
IEEE Pulse Pub Date : 2023-06-14 DOI: 10.3329/pulse.v14i1-3.66892
S. Mamun, Ziaul Haque, R. Jahan, Sharif Md, Qazi Tariqul Islam
{"title":"Assessment of Fitness for Air travel in Patients with Pulmonary Diseases","authors":"S. Mamun, Ziaul Haque, R. Jahan, Sharif Md, Qazi Tariqul Islam","doi":"10.3329/pulse.v14i1-3.66892","DOIUrl":"https://doi.org/10.3329/pulse.v14i1-3.66892","url":null,"abstract":"During air travel, increasing hypoxia with altitude ascent is a potentially serious problem for patients with hypoxemic chronic airway obstruction (CAO). Travel by air is the most popular way of transport nowadays & estimated that each year worldwide, more than 3 billion passengers travel by air & 736 million in the United States alone. For most passengers, even those with respiratory disease, air travel is safe and comfortable. Some patients with COPD &other Chronic Lung diseases may be at risk but, with screening, these patients can be identified and most of them can travel safely with supplemental oxygen. Some patients with chronic lung disease may have mild hypoxemia at sea level but during air travel in a hypobaric hypoxic environment, compensatory pulmonary mechanisms may be inadequate despite normal sea-level oxygen requirements. In addition, compensatory cardiovascular mechanisms may be less effective in some patients who are unable to increase cardiac output. Air travel also presents an increased risk of venous thromboembolism. It's estimated that, almost 1 medical emergency for every 600 flights. Respiratory symptoms accounted for 12% of all these in-air emergencies. \u0000Pulse Volume 12-14 2020-2022 p.16-21","PeriodicalId":49065,"journal":{"name":"IEEE Pulse","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78785143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dominance of human Influenza H1N1pdm09 in flu like patients during early two months of 2020 2020年前两个月流感样患者中人类流感H1N1pdm09的优势
IF 0.6 4区 医学
IEEE Pulse Pub Date : 2023-06-14 DOI: 10.3329/pulse.v14i1-3.66831
R. Rahim, A. Hasan, Nazmul Hasan, N. Ara, S. Biswas, Mizanur Rahman
{"title":"Dominance of human Influenza H1N1pdm09 in flu like patients during early two months of 2020","authors":"R. Rahim, A. Hasan, Nazmul Hasan, N. Ara, S. Biswas, Mizanur Rahman","doi":"10.3329/pulse.v14i1-3.66831","DOIUrl":"https://doi.org/10.3329/pulse.v14i1-3.66831","url":null,"abstract":"Introduction:Influenza is a worldwide respiratory infectious disease which affect all age groups and associated with significant number of morbidity and mortality each year. The circulating subtypes varies countrywide yearly, and it helps policy maker to get preparedness for early effective management of influenza epidemics. \u0000Materials and methods Nasal swabs were collected from 463 patients in January and February 2020 presenting flu-like symptoms and Rapid Influenza Diagnostics Tests (RIDTs) were performed for influenza A & B screening as a routine test. Then influenza A subtyping was done by RT-PCR followed by gel electrophoresis of 27 influenza positive samples. \u0000Result Among 463 cases, 106 (22.9%) were Influenza positive with huge (99.06%) dominance of Influenza A. Subtyping of randomly selected outpatient derived 27 Influenza A positive cases showed flourishing presence of seasonal Influenza A/H1N1pdm09 (21; 77.8%). \u0000Conclusion This small study warrants further elaborate investigation to know circulating influenza A subtyping in the country which may assist health care providers in making treatment decisions and hence, appropriate patient management. \u0000Pulse Volume 12-14 2020-2022 p.4-9","PeriodicalId":49065,"journal":{"name":"IEEE Pulse","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87477726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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