U. Carbonara, Jennifer Lee, F. Crocerossa, A. Veccia, L. Hampton, D. Eun, R. Autorino
{"title":"Single overnight stay after robot-assisted partial nephrectomy: a bi-center experience.","authors":"U. Carbonara, Jennifer Lee, F. Crocerossa, A. Veccia, L. Hampton, D. Eun, R. Autorino","doi":"10.23736/S0393-2249.20.04054-0","DOIUrl":"https://doi.org/10.23736/S0393-2249.20.04054-0","url":null,"abstract":"BACKGROUND\u0000Despite hospital length of stay (LOS) being shorter for robot-assisted partial nephrectomy (RAPN) compared to its open counterpart, several series in the literature report on average a LOS of 2-3 days or more. We aimed to assess factors predicting a prolonged length of stay (beyond a single overnight stay) in patients undergoing RAPN.\u0000\u0000\u0000METHODS\u0000Patients who underwent RAPN between 2010 and 2019 at two U.S. Centers were included and divided into two groups according to LOS: the study group included all patients who were discharged on POD1, whereas the control group included patients with LOS≥2 days. Demographics, surgical and perioperative outcomes were compared between the groups. Multivariable logistic regression analyses were used to identify independent predictors of LOS≥2.\u0000\u0000\u0000RESULTS\u0000Overall, 173 (60.5%) patients discharged on POD1, and 113 (39.5%) discharged on POD≥2. Patients in the study group presented a lower mean BMI (29 vs. 32, p=0.02). Retroperitoneal approach was performed in 13.3% patients with shorter LOS (p<0.001). There was a statistically significant difference in median OT (144 vs. 168min, p=0.005) and WIT (19 vs. 23min, p=0.001). We observed six postoperative complications (3.6%) in patients discharged on POD1 and 35 (30.5%) in control group (p<0.001). Major complications (Clavien-Dindo grade≥III) were observed in 3 of POD1 patients (1.8 vs. 6.1%, p<0.001). There was no difference in hospital readmission rate. On logistic regression analysis, independent predictors of prolonged LOS were OT (OR 1.01, 95%C.I.: 1.0-1.2, p=0.001), and occurrence of a postoperative complication (OR 2.2, 95%C.I. 2.0-2.5, p<0.001).\u0000\u0000\u0000CONCLUSIONS\u0000Our findings confirm that a single overnight stay after RAPN is feasible and safe. In our experience, and within the limitations of the present analysis, prolonged operative time and occurrence of immediate postoperative complications translate into higher risk of prolonged hospital stay. Besides adopting a minimally invasive approach, surgeons should also implement perioperative care pathways facilitating early discharge without increasing the risk of readmission.","PeriodicalId":49015,"journal":{"name":"Minerva Urologica E Nefrologica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89813057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Nini, F. Muttin, F. Cianflone, C. Carenzi, R. Lucianò, M. Catena, A. Larcher, M. Salvioni, W. Cazzaniga, F. Pederzoli, R. Matloob, R. Colombo, M. Paganelli, A. Salonia, A. Briganti, C. Doglioni, A. Zangrillo, F. de Cobelli, P. Rigatti, M. Freschi, G. Cornero, R. Nicoletti, L. Aldrighetti, F. Montorsi, U. Capitanio, R. Bertini
{"title":"Perioperative and oncologic outcomes of open radical nephrectomy and inferior vena cava thrombectomy with liver mobilization and Pringle maneuver for Mayo III level tumor thrombus: single institution experience.","authors":"A. Nini, F. Muttin, F. Cianflone, C. Carenzi, R. Lucianò, M. Catena, A. Larcher, M. Salvioni, W. Cazzaniga, F. Pederzoli, R. Matloob, R. Colombo, M. Paganelli, A. Salonia, A. Briganti, C. Doglioni, A. Zangrillo, F. de Cobelli, P. Rigatti, M. Freschi, G. Cornero, R. Nicoletti, L. Aldrighetti, F. Montorsi, U. Capitanio, R. Bertini","doi":"10.23736/S0393-2249.20.03844-8","DOIUrl":"https://doi.org/10.23736/S0393-2249.20.03844-8","url":null,"abstract":"BACKGROUND\u0000Scarce data are available regarding the technique and outcomes for patients with RCC and Mayo III caval thrombi. To report surgical and oncological outcomes of RCC patients with Mayo III thrombi treated with radical nephrectomy and thrombectomy after liver mobilization (LM) and Pringle Manoeuvre (PM).\u0000\u0000\u0000METHODS\u0000Retrospective analysis of surgical technique, outcomes and cancer control in 19 patients undergoing LM and PM in a single tertiary care institution.\u0000\u0000\u0000RESULTS\u0000Overall, 78% of the patients had performance status ECOG 1 and 58% had a comorbidity index >2. Median surgical time was 305 minutes (IQR 264-440). Intraoperative complications were reported for 39% of patients and postoperative ones for 58% (only Grade 1 and 2). Intensive Care Unit support was necessary in 16% of the cases. Median length of hospital stay was 9 days (IQR 7-11). Thirty- and 90-day mortality were 5% and 15%. Twoyear overall survival and cancer-specific survival were 60% and 62%, respectively.\u0000\u0000\u0000CONCLUSIONS\u0000We reported surgical techniques, intra and perioperative complications and follow-up in the largest cohort of RCC patients requiring LM and PM.","PeriodicalId":49015,"journal":{"name":"Minerva Urologica E Nefrologica","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78614687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Gacci, I. Greco, W. Artibani, P. Bassi, F. Bertoni, S. Bracarda, A. Briganti, G. Carmignani, L. Carmignani, G. Conti, R. Corvò, C. de Nunzio, F. Fusco, P. Graziotti, S. Maggi, S. Magrini, V. Mirone, R. Montironi, G. Muto, M. Noale, S. Pecoraro, A. Porreca, U. Ricardi, E. Russi, A. Salonia, A. Simonato, S. Serni, A. Tubaro, V. Zagonel, G. Crepaldi
{"title":"The waiting time for prostate cancer treatment in Italy: analysis from the Pros-IT CNR study.","authors":"M. Gacci, I. Greco, W. Artibani, P. Bassi, F. Bertoni, S. Bracarda, A. Briganti, G. Carmignani, L. Carmignani, G. Conti, R. Corvò, C. de Nunzio, F. Fusco, P. Graziotti, S. Maggi, S. Magrini, V. Mirone, R. Montironi, G. Muto, M. Noale, S. Pecoraro, A. Porreca, U. Ricardi, E. Russi, A. Salonia, A. Simonato, S. Serni, A. Tubaro, V. Zagonel, G. Crepaldi","doi":"10.23736/S0393-2249.20.03925-9","DOIUrl":"https://doi.org/10.23736/S0393-2249.20.03925-9","url":null,"abstract":"BACKGROUND\u0000Prostate cancer (PCa) is the second most common neoplasm in male patients. To date, there's no certain indication about the maximum waiting time (WT) acceptable for treatment beginning and the impact on oncological and functional outcomes has not been well established.\u0000\u0000\u0000METHODS\u0000Data from the National Research Council PCa monitoring multicenter project in Italy (Pros-IT CNR) were prospectively collected and analyzed. WT was defined as the time from the bioptical diagnosis of PCa to the first treatment received. Patients were divided in two groups, using a time frame of 90 days. Quality of life was measured through the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and of the Short-Form Health Survey (SF-12). The occurrence of upgrading, upstaging, presence of lymph node metastasis and positive surgical margins at the final histopathological diagnosis, and PSA at 12 months follow-up were evaluated.\u0000\u0000\u0000RESULTS\u0000The overall median WT was 93 days. The logistic multivariable model confirmed that age, being resident in Southern regions of Italy and T staging at diagnosis were significantly associated with a WT >90 days. At 6 months from diagnosis the mean SF-12 score for the emotionalpsychological component was significantly lower in WT ≥ 90 days group (p=0.0428). Among patients treated with surgical approach, no significant differences in oncological outcomes were found in the two groups.\u0000\u0000\u0000CONCLUSIONS\u0000In our study age, clinical T stage and provenance from Southern regions of Italy are associated with a WT > 90 days. WT might have no impact on functional and oncological outcome.","PeriodicalId":49015,"journal":{"name":"Minerva Urologica E Nefrologica","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89229330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ercolino, M. Droghetti, R. Schiavina, L. Bianchi, F. Chessa, F. Mineo Bianchi, U. Barbaresi, A. Angiolini, C. Casablanca, A. Mottaran, E. Molinaroli, C. Pultrone, H. Dababneh, A. Bertaccini, E. Brunocilla
{"title":"Postoperative outcomes of Fast Track enhanced recovery protocol in open radical cystectomy: comparison with standard management in a high-volume center and Trifecta proposal.","authors":"A. Ercolino, M. Droghetti, R. Schiavina, L. Bianchi, F. Chessa, F. Mineo Bianchi, U. Barbaresi, A. Angiolini, C. Casablanca, A. Mottaran, E. Molinaroli, C. Pultrone, H. Dababneh, A. Bertaccini, E. Brunocilla","doi":"10.23736/S0393-2249.20.03843-6","DOIUrl":"https://doi.org/10.23736/S0393-2249.20.03843-6","url":null,"abstract":"BACKGROUND\u0000We aimed at comparing perioperative outcomes in patients submitted to radical cystectomy followed by Fast Track (FT) protocol or standard management, and propose a definition of Trifecta, to improve standardized quality assessment for RC.\u0000\u0000\u0000METHODS\u0000We considered 191 patients submitted to RC between January 2017 and January 2019. Patients followed FT or standard management according to surgeon's preference. Preoperative and intraoperative characteristics, alongside with postoperative outcomes were compared between the two groups. Trifecta was defined as follows: inhospital stay (HS) ≤ 10 days, time to defecation (TtD) below the overall mean and no major (≥ Clavien-Dindo grade III) complications. Finally, Trifecta achievement rates were assessed in both groups.\u0000\u0000\u0000RESULTS\u000075 patients (39%) followed the FT protocol and 116 (61%) standard management. The two groups were homogeneous for preoperative, intraoperative and pathological characteristics. Patients in the FT group had shorter TtD (5 vs. 6 days p=0.006), HS (12 vs. 14 days p=0.008) and lower readmission rate (8% vs. 19% p=0.04). Early complication rates and grades were similar, while less late complications were found in FT group (6.7% vs. 21.6% p=0,006). Trifecta achievement rate was higher for FT group (31% vs. 8% p<0.001). Single-item failure percentages for HS, TtD and major grade complications were respectively 90%, 60% and 19%, with no difference between the two groups.\u0000\u0000\u0000CONCLUSIONS\u0000FT protocol can safely consent faster bowel recovery and earlier discharge after RC, plus reducing readmission rates. Using a Trifecta incorporating essential perioperative outcomes, could improve standardized quality assessment for RC.","PeriodicalId":49015,"journal":{"name":"Minerva Urologica E Nefrologica","volume":"366 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84911272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Şahan, Erdinç Dinçer, O. Özkaptan, A. Çubuk, K. Ertaş, B. Eryıldırım, O. Akça
{"title":"The impact of anterior calyceal stones on the outcomes of percutaneous nephrolithotomy for complex kidney stones: a comparative study.","authors":"A. Şahan, Erdinç Dinçer, O. Özkaptan, A. Çubuk, K. Ertaş, B. Eryıldırım, O. Akça","doi":"10.23736/S0393-2249.20.04002-3","DOIUrl":"https://doi.org/10.23736/S0393-2249.20.04002-3","url":null,"abstract":"BACKGROUND\u0000This study aimed to evaluate the possible effect of anterior calyceal stones on the surgical outcomes of percutaneous nephrolithotomy.\u0000\u0000\u0000METHODS\u0000Consecutive patients with complex kidney stones from 2012 to 2020 were evaluated retrospectively. In total, 219 patients were divided into 2 groups based on the presence of anterior calyceal stones (group 1; n=89) or not (group 2; n=130). The groups were compared in terms of surgical outcomes (i.e., stonefree rate [SFR], operation time, and hemoglobin drop) and complications.\u0000\u0000\u0000RESULTS\u0000The patient demographics and stone characteristics were similar between the groups. Multiple access was more frequently done in group 1 than it was in group 2 (47.2% vs. 30.8%; p = 0.014), and the SFR was lower in group 1 (51.7%) than it was in group 2 (67.7%; p = 0.017). Of the anterior calyceal stones in group 1, 42.6% could not be cleaned. However, when excluding patients who have only anterior residual stones from the statistical analysis, the groups had similar SFRs (68.5% vs. 67.7% for group 1 and group 2, respectively).\u0000\u0000\u0000CONCLUSIONS\u0000The presence of complex kidney stones with anterior calyceal extension are associated with higher residual stones rates in the anterior calyx. Also, it increases multiple access, the operation time, and level of hemoglobin drop.","PeriodicalId":49015,"journal":{"name":"Minerva Urologica E Nefrologica","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88497719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Sebastianelli, S. Morselli, P. Spatafora, A. Liaci, L. Gemma, C. Zaccaro, L. Vignozzi, M. Maggi, K. McVary, S. Kaplan, C. Chapple, S. Gravas, S. Serni, M. Gacci
{"title":"Outcomes of combination therapy with daily Tadalafil 5mg plus Tamsulosin 0.4mg to treat lower urinary tract symptoms and erectile dysfunction in men with or without metabolic syndrome.","authors":"A. Sebastianelli, S. Morselli, P. Spatafora, A. Liaci, L. Gemma, C. Zaccaro, L. Vignozzi, M. Maggi, K. McVary, S. Kaplan, C. Chapple, S. Gravas, S. Serni, M. Gacci","doi":"10.23736/S0393-2249.20.04099-0","DOIUrl":"https://doi.org/10.23736/S0393-2249.20.04099-0","url":null,"abstract":"BACKGROUND\u0000To assess the impact of Tadalafil 5mg/die plus Tamsulosin 0.4mg/die combination therapy on LUTS and ED, according to presence vs. absence of Mets.\u0000\u0000\u0000METHODS\u000075 consecutive men presenting with ED and LUTS were enrolled. Patients were divided into two groups according to MetS presence. All subjects were treated with combination therapy for 12 weeks. Patients were re-evaluated after treatment with Uroflowmetry and PVR, IPSS, IPSS QoL, OAB-q and IIEF-5.\u0000\u0000\u0000RESULTS\u0000After enrollment, 50 patients were included: 31(62.0%) with MetS and 19(38.0%) without MetS. At baseline, patients without MetS showed a significantly better IPSS, IIEF and OAB-q, as compared to those with MetS. After 12 weeks of combination therapy LUTS, ED and flowmetry significantly improved in both groups(p<0.001). The improvement after 12 weeks was similar between groups in all parameters(p>0.05), except for ΔOAB-q that was significantly better for patients with MetS(p=0.028). Nevertheless, total IPSS, all IPSS subscores and OAB-q were significantly better at 12 weeks in men without MetS(p<0.05). Despite IIEF-5 was significantly different at baseline, after 12 weeks of combination therapy, erectile function was similar in men with or without METS:16.3±3.8 vs 7.7±4.7(p=0.238). No serious AE was reported and complications were comparable between groups(p>0.05).\u0000\u0000\u0000CONCLUSIONS\u0000Patients with MetS have worse LUTS and ED profiles. However, tadalafil plus tamsulosin combination treatment provided them a similar ED profile and a greater relief of OAB symptoms at the end of the trial. Combination therapy had the same safety profile in men besides MetS. Further randomized controlled trials are needed.","PeriodicalId":49015,"journal":{"name":"Minerva Urologica E Nefrologica","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77189351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Porpiglia, D. Amparore, E. Checcucci, C. Fiori, W. Artibani, R. Scarpa
{"title":"The revolution of congress meetings and scientific events: how to navigate among their heterogeneous modalities?","authors":"F. Porpiglia, D. Amparore, E. Checcucci, C. Fiori, W. Artibani, R. Scarpa","doi":"10.23736/S0393-2249.20.04177-6","DOIUrl":"https://doi.org/10.23736/S0393-2249.20.04177-6","url":null,"abstract":"","PeriodicalId":49015,"journal":{"name":"Minerva Urologica E Nefrologica","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75947082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The train has already left the station: analyzing the rise of PSMA PET/CT as new standard for staging high risk prostate cancer.","authors":"S. Albisinni, R. Diamand, C. de Nunzio","doi":"10.23736/S0393-2249.20.04051-5","DOIUrl":"https://doi.org/10.23736/S0393-2249.20.04051-5","url":null,"abstract":"","PeriodicalId":49015,"journal":{"name":"Minerva Urologica E Nefrologica","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80566854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Peng, Wei Wang, Xiao-shuai Gao, Xing-peng Di, D. Luo
{"title":"Fluoroless versus conventional ureteroscopy for urinary stones: a systematic review and meta-analysis.","authors":"L. Peng, Wei Wang, Xiao-shuai Gao, Xing-peng Di, D. Luo","doi":"10.23736/S0393-2249.20.04042-4","DOIUrl":"https://doi.org/10.23736/S0393-2249.20.04042-4","url":null,"abstract":"INTRODUCTION\u0000To comprehensively assess the effectiveness and safety of fluoroless ureteroscopy (URS) vs conventional URS for urinary stones.\u0000\u0000\u0000EVIDENCE ACQUISITION\u0000An exhaustive search of PubMed, EMBASE, Web of Science and Cochrane Library were performed to find eligible researches before May 2020. Result parameters including stone-free rate (SFR), operation time, repeat procedure rate and complication rate were assessed using RevMan 5.3.\u0000\u0000\u0000EVIDENCE SYNTHESIS\u00007 studies (5 retrospective studies and 2 prospective randomized controlled trials) involving 1404 individuals were included. Pooled results demonstrated that the operation time in fluoroless URS group was slightly longer than conventional URS group (weighted mean difference [MD]=2.79, p=0.0001), but no statistically significant differences regarding SFR (odds ratio [OR]=1.18, p=0.57), repeat procedure rate (OR=1.32, p=0.52), and total complication rate (OR=0.75, p=0.16) were observed between two techniques.\u0000\u0000\u0000CONCLUSIONS\u0000Fluoroless URS is equally safe and effective to conventional URS procedure with zero radiation exposure. However, it needs to be cautiously conducted in selected patients and fluoroscopy equipment should always be available intraoperatively.","PeriodicalId":49015,"journal":{"name":"Minerva Urologica E Nefrologica","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88424535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. X. Keller, V. de Coninck, S. Proietti, M. Talso, E. Emiliani, A. Ploumidis, G. Mantica, B. Somani, O. Traxer, R. Scarpa, F. Esperto
{"title":"Prone versus supine PNL: a systematic review and metaanalysis of current literature.","authors":"E. X. Keller, V. de Coninck, S. Proietti, M. Talso, E. Emiliani, A. Ploumidis, G. Mantica, B. Somani, O. Traxer, R. Scarpa, F. Esperto","doi":"10.23736/S0393-2249.20.03960-0","DOIUrl":"https://doi.org/10.23736/S0393-2249.20.03960-0","url":null,"abstract":"INTRODUCTION\u0000Percutaneous nephrolithotomy (PNL) can be performed either in prone or supine position. This study aimed at gathering together randomized controlled trials (RCTs) comparing efficacy and safety between prone and supine PNL.\u0000\u0000\u0000EVIDENCE ACQUISITION\u0000Systematic review of literature was conducted using the Scopus, Medline and Web of Science databases. Study selection, data extraction and quality assessment were independently assessed by two authors. Meta-analysis was performed with Review Manager 5.3. Sensitivity analyses were performed to exclude studies with high risk of bias.\u0000\u0000\u0000EVIDENCE SYNTHESIS\u0000Pooled data from 12 studies including 1290 patients were available for analysis. Only one study was found to have overall low risk of bias. Significantly shorter operative time was found in favor of supine PNL (mean difference 13 minutes, 95% confidence interval (CI) 3.4 - 22.7; p < 0.01). Stone-free rate (SFR) ≥ 14 days after surgery was significantly higher in prone PNL (odds ratio (OR) 2.15, 95% CI 1.07 - 4.34; p = 0.03). Significantly higher fever rate was found in prone PNL (OR 1.60, 95% CI 1.03 - 2.47; p = 0.04). Overall SFR, hospital stay length, complications rate, transfusions rate and blood loss, as well as non-lower calyx puncture rate, puncture attempts and tubeless intervention rate did not differ between prone and supine PNL (p > 0.05).\u0000\u0000\u0000CONCLUSIONS\u0000Efficacy of PNL seems balanced between prone and supine position, with comparable overall SFR and shorter operative time in favor of supine PNL. Safety of PNL appears in favor of supine PNL, with lower fever rate. Because of study heterogeneity and possible risks of outcome bias, results from this study should be interpreted with caution. Altogether, both prone and supine PNL account for appropriate therapy options.","PeriodicalId":49015,"journal":{"name":"Minerva Urologica E Nefrologica","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83817991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}