Revista Brasileira De Reumatologia最新文献

{"title":"Febre reumática: atualização dos critérios de Jones à luz da revisão da American Heart Association – 2015","authors":"Breno Álvares de Faria Pereira ,&nbsp;Alinne Rodrigues Belo ,&nbsp;Nilzio Antônio da Silva","doi":"10.1016/j.rbr.2016.12.005","DOIUrl":"https://doi.org/10.1016/j.rbr.2016.12.005","url":null,"abstract":"<div><p>Rheumatic fever is still currently a prevalent disease, especially in developing countries. Triggered by a Group A β‐hemolytic <em>Streptococcus</em> infection, the disease may affect genetically predisposed patients. Rheumatic carditis is the most important of its clinical manifestations, which can generate incapacitating sequelae of great impact for the individual and for society. Currently, its diagnosis is made based on the Jones Criteria, established in 1992 by the American Heart Association (AHA). In 2015, the AHA carried out a significant review of these criteria, with new diagnostic parameters and recommendations. In the present study, the authors perform a critical analysis of this new review, emphasizing the most relevant points for clinical practice.</p></div>","PeriodicalId":48991,"journal":{"name":"Revista Brasileira De Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbr.2016.12.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72245028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artrite reumatoide e qualidade do sono","authors":"Ana Claudia Janiszewski Goes,&nbsp;Larissa Aparecida Busatto Reis,&nbsp;Marilia Barreto G. Silva,&nbsp;Barbara Stadler Kahlow,&nbsp;Thelma L. Skare","doi":"10.1016/j.rbr.2016.06.002","DOIUrl":"https://doi.org/10.1016/j.rbr.2016.06.002","url":null,"abstract":"<div><h3>Background</h3><p>Sleep disturbances are common in rheumatoid arthritis (RA) patients and contribute to loss of life quality.</p></div><div><h3>Objective</h3><p>To study associations of sleep quality with pain, depression and disease activity in RA.</p></div><div><h3>Methods</h3><p>This is a transversal observational study of 112 RA patients submitted to measurement of DAS‐28, Epworth scale for daily sleepiness, index of sleep quality by Pittsburg index, risk of sleep apnea by the Berlin questionnaire and degree of depression by the CES‐D (Center for Epidemiologic Studies Depression scale) questionnaire. We also collected epidemiological, clinical, serological and treatment data.</p></div><div><h3>Results</h3><p>Only 18.5% of RA patients had sleep of good quality. In univariate analysis a bad sleep measured by Pittsburg index was associated with daily doses of prednisone (p<!--> <!-->=<!--> <!-->0.03), DAS‐28 (p<!--> <!-->=<!--> <!-->0.01), CES‐D (p<!--> <!-->=<!--> <!-->0.0005) and showed a tendency to be associated with Berlin sleep apnea questionnaire (p<!--> <!-->=<!--> <!-->0.06). In multivariate analysis only depression (p<!--> <!-->=<!--> <!-->0.008) and Berlin sleep apnea questionnaire (p<!--> <!-->=<!--> <!-->0.004) kept this association.</p></div><div><h3>Conclusions</h3><p>Most of RA patients do not have a good sleep quality. Depression and risk of sleep apnea are independently associated with sleep impairment.</p></div>","PeriodicalId":48991,"journal":{"name":"Revista Brasileira De Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbr.2016.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72285820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid arthritis and sleep quality.","authors":"Ana Claudia Janiszewski Goes, Larissa Aparecida Busatto Reis, M. B. Silva, B. Kahlow, T. Skare","doi":"10.1016/j.rbr.2016.06.002","DOIUrl":"https://doi.org/10.1016/j.rbr.2016.06.002","url":null,"abstract":"","PeriodicalId":48991,"journal":{"name":"Revista Brasileira De Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbr.2016.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41462150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of fibromyalgia: literature review update.","authors":"A. Marques, A. S. Santo, A. A. Berssaneti, L. A. Matsutani, S. Yuan","doi":"10.1016/j.rbr.2016.10.004","DOIUrl":"https://doi.org/10.1016/j.rbr.2016.10.004","url":null,"abstract":"","PeriodicalId":48991,"journal":{"name":"Revista Brasileira De Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbr.2016.10.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43075649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A obesidade é um determinante da resistência à insulina mais importante do que os níveis circulantes de citocinas pró‐inflamatórias em pacientes com artrite reumatoide","authors":"Jesus Castillo‐Hernandez ,&nbsp;Martha Imelda Maldonado‐Cervantes ,&nbsp;Juan Pablo Reyes ,&nbsp;Nuria Patiño‐Marin ,&nbsp;Enrique Maldonado‐Cervantes ,&nbsp;Claudia Solorzano‐Rodriguez ,&nbsp;Esperanza de la Cruz Mendoza ,&nbsp;Brenda Alvarado‐Sanchez","doi":"10.1016/j.rbr.2016.10.005","DOIUrl":"10.1016/j.rbr.2016.10.005","url":null,"abstract":"<div><h3>Background</h3><p>Systemic blockade of TNF‐α in Rheumatoid arthritis (RA) with insulin resistance (IR) seems to produce more improvement in insulin sensitivity in normal weight patients with RA than in obese patients with RA, suggesting that systemic‐inflammation and obesity are independent risk factors for IR in RA patients.</p></div><div><h3>Objectives</h3><p>To evaluate the insulin resistance in: normal weight patients with RA (RA NW), overweight patients with RA (RA OW), obese RA patients (RA OB), and matched control subjects with normal weight (NW) and obesity (OB); and its association with major cytokines involved in the pathogenesis of the disease.</p></div><div><h3>Methods</h3><p>Assessments included: body mass index (BMI), insulin resistance by HOMA‐IR, ELISA method, and enzymatic colorimetric assay.</p></div><div><h3>Results</h3><p>Outstanding results from these studies include: (1) In RA patients, IR was well correlated with Body Mass Index (the higher the BMI, the higher IR), but not with levels of serum cytokines. In fact, levels of cytokines were similar in all RA patients, regardless of being obese, overweight or normal weight (2) IR was significantly higher in RA NW than in NW (3) No significant difference was observed between IRs of RA OB and OB (4) As expected, levels of circulating cytokines were significantly higher in RA patients than in OB.</p></div><div><h3>Conclusions</h3><p>Obesity appears to be a dominant condition above inflammation to produce IR in RA patients. The dissociation of the inflammation and obesity components to produce IR suggests the need of an independent therapeutic strategy in obese patients with RA.</p></div>","PeriodicalId":48991,"journal":{"name":"Revista Brasileira De Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbr.2016.10.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41776391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Análise de quatro marcadores sorológicos na artrite reumatoide: associação com manifestações extra‐articulares no paciente e artralgia em familiares","authors":"Flávia R. Nass ,&nbsp;Thelma L. Skare ,&nbsp;Isabela Goeldner ,&nbsp;Renato Nisihara ,&nbsp;Iara T. Messias‐Reason ,&nbsp;Shirley R.R. Utiyama","doi":"10.1016/j.rbr.2015.11.002","DOIUrl":"10.1016/j.rbr.2015.11.002","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate the frequency of four serum biomarkers in RA patients and their relatives and identify possible associations with clinical findings of the disease.</p></div><div><h3>Methods</h3><p>This was a transversal analytical study. Anti‐cyclic citrullinated peptide (anti‐CCP), anti‐mutated citrullinated vimentin (anti‐MCV) and IgA‐rheumatoid factor (RF) were determined by ELISA and IgM‐RF by latex agglutination in 210 RA patients, 198 relatives and 92 healthy controls from Southern Brazil. Clinical and demographic data were obtained through charts review and questionnaires.</p></div><div><h3>Results</h3><p>A higher positivity for all antibodies was observed in RA patients when compared to relatives and controls (p<!--> <!-->&lt;<!--> <!-->0.0001). IgA‐RF was more frequent in relatives compared to controls (14.6% vs. 5.4%, p<!--> <!-->=<!--> <!-->0.03, OR<!--> <!-->=<!--> <!-->2.98; 95%<span>CI</span> <!-->=<!--> <!-->1.11‐7.98) whereas anti‐CCP was the most common biomarker among RA patients (75.6%). Concomitant positivity for the four biomarkers was more common in patients (46.2%, p<!--> <!-->&lt;<!--> <!-->0.0001). Relatives and controls were mostly positive for just one biomarker (20.2%, p<!--> <!-->&lt;<!--> <!-->0.0001 and 15.2%, p<!--> <!-->=<!--> <!-->0.016, respectively). No association was observed between the number of positive biomarkers and age of disease onset, functional class or tobacco exposure. In seronegative patients predominate absence of extra articular manifestations (EAMs) (p<!--> <!-->=<!--> <!-->0.01; OR<!--> <!-->=<!--> <!-->3.25; CI<!--> <!-->=<!--> <!-->1.16‐10.66). Arthralgia was present in positive relatives, regardless the type of biomarker.</p></div><div><h3>Conclusions</h3><p>A higher number of biomarkers was present in RA patients with EAMs. Positivity of biomarkers was related to arthralgia in relatives. These findings reinforce the link between distinct biomarkers and the pathophysiologic mechanisms of AR.</p></div>","PeriodicalId":48991,"journal":{"name":"Revista Brasileira De Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbr.2015.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43152949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisão crítica do tratamento medicamentoso da gota no Brasil","authors":"Valderilio Feijó Azevedo ,&nbsp;Maicon Piana Lopes ,&nbsp;Nathan Marostica Catholino ,&nbsp;Eduardo dos Santos Paiva ,&nbsp;Vitor Andrei Araújo ,&nbsp;Geraldo da Rocha Castelar Pinheiro","doi":"10.1016/j.rbr.2016.06.009","DOIUrl":"10.1016/j.rbr.2016.06.009","url":null,"abstract":"<div><p>Gout is considered the most common form of inflammatory arthritis in men over 40 years. The authors present a brief review of the current treatment of gout and discuss the existing pharmacological limitations in Brazil for the treatment of this disease. Although allopurinol is still the main drug administered for decreasing serum levels of uric acid in gout patients in this country, the authors also present data that show a great opportunity for the Brazilian drug market for the treatment of hyperuricemia and gout and especially for patients using private and public (SUS) health care systems.</p></div>","PeriodicalId":48991,"journal":{"name":"Revista Brasileira De Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbr.2016.06.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48259861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O maior índice de massa corporal e a presença de anticorpos antifármacos predizem a interrupção no uso de agentes anti‐TNF em pacientes sul‐coreanos com espondiloartrite axial","authors":"Jiwon Hwang ,&nbsp;Hye‐Mi Kim ,&nbsp;Hyemin Jeong ,&nbsp;Jaejoon Lee ,&nbsp;Joong Kyong Ahn ,&nbsp;Eun‐Mi Koh ,&nbsp;Eun‐Suk Kang ,&nbsp;Hoon‐Suk Cha","doi":"10.1016/j.rbr.2016.10.001","DOIUrl":"10.1016/j.rbr.2016.10.001","url":null,"abstract":"<div><h3>Objective</h3><p>The development of anti‐drug antibodies (ADAbs) against tumor necrosis factor (TNF) inhibitors is a likely explanation for the failure of TNF‐inhibitors in patients with spondyloarthritis (SpA). Our study determined the existence and clinical implications of ADAbs in axial SpA patients.</p></div><div><h3>Methods</h3><p>According to the Assessment of SpondyloArthritis International Society classification criteria for axial SpA, patients treated with adalimumab or infliximab were recruited consecutively. Serum samples were collected at enrollment to measure ADAb and drug levels.</p></div><div><h3>Results</h3><p>Of 100 patients, the mean duration of current TNF inhibitor use was 22.3<!--> <!-->±<!--> <!-->17.9 months. ADAbs were detected in 5 of 72 adalimumab users compared to 5 of 28 infliximab users (6.9% vs. 17.9%). ADAb‐positive patients had a significantly higher body mass index than ADAb‐negative patients among both adalimumab (28.4<!--> <!-->±<!--> <!-->5.9<!--> <!-->kg/m² vs. 24.3<!--> <!-->±<!--> <!-->2.9<!--> <!-->kg/m², respectively, p<!--> <!-->=<!--> <!-->0.01) and infliximab users (25.9<!--> <!-->±<!--> <!-->2.8<!--> <!-->kg/m² vs. 22.6<!--> <!-->±<!--> <!-->2.8<!--> <!-->kg/m², respectively, p<!--> <!-->=<!--> <!-->0.02). During the median 15‐month follow‐up period, drug discontinuation occurred more frequently in the ADAb‐positive group than the ADAb‐negative group (30.0% vs. 6.5%, respectively, p<!--> <!-->=<!--> <!-->0.04). In logistic regression, ADAb positivity (OR<!--> <!-->=<!--> <!-->5.85, 95% CI 1.19–28.61, p<!--> <!-->=<!--> <!-->0.029) and BMI (OR<!--> <!-->=<!--> <!-->4.35, 95% CI 1.01–18.69, p<!--> <!-->=<!--> <!-->0.048) were associated with a greater risk of stopping TNF inhibitor treatment.</p></div><div><h3>Conclusions</h3><p>Our result suggests that the presence of ADAbs against adalimumab and infliximab as well as a higher BMI can predict subsequent drug discontinuation in axial SpA patients.</p></div>","PeriodicalId":48991,"journal":{"name":"Revista Brasileira De Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbr.2016.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55036348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crenças de medo e evitação aumentam a percepção de dor e incapacidade em mexicanos com lombalgia crônica","authors":"Tania Inés Nava‐Bringas,&nbsp;Salvador Israel Macías‐Hernández,&nbsp;Jorge Rodrigo Vásquez‐Ríos,&nbsp;Roberto Coronado‐Zarco,&nbsp;Antonio Miranda‐Duarte,&nbsp;Eva Cruz‐Medina,&nbsp;Aurelia Arellano‐Hernández","doi":"10.1016/j.rbr.2016.09.004","DOIUrl":"10.1016/j.rbr.2016.09.004","url":null,"abstract":"<div><h3>Background</h3><p>Fear‐avoidance beliefs are related to the prognosis of chronicity in low back pain in subacute stages, however in chronic pain, is no clear the influence of these factors; it has been suggested that the study population can determine the magnitude of influence on disability and pain of those suffering from back pain. Currently, information does not exist in the Mexican population.</p></div><div><h3>Objective</h3><p>To analyze the relationship between fear‐avoidance beliefs with pain and disability in Mexicans with chronic low back pain; analyze potentials differences between subgroups according to the time of evolution.</p></div><div><h3>Methods</h3><p>Cross‐sectional study in Mexicans with chronic LBP aged between 18 and 45. Data were collected on general socio demographic characteristics, time of evolution, body mass index, pain, disability and fear‐avoidance beliefs.</p></div><div><h3>Results</h3><p>33 men and 47 women, with an average age of 34.19<!--> <!-->±<!--> <!-->7.65 years. Higher scores of fear‐avoidance beliefs were obtained in women (47.2<!--> <!-->±<!--> <!-->20.99 <em>versus</em> 38.5<!--> <!-->±<!--> <!-->9.7; p<!--> <!-->=<!--> <!-->0.05) and single participants (p<!--> <!-->=<!--> <!-->0.04). A positive correlation was found between disability (r<!--> <!-->=<!--> <!-->0.603, p<!--> <!-->&lt;<!--> <!-->0.001) and pain (r<!--> <!-->=<!--> <!-->0.234, p<!--> <!-->=<!--> <!-->0.03) with high scores of fear‐avoidance beliefs. Through generalized linear models for disability, total score of the fear avoidance beliefs questionnaire showed a standardized beta coefficient of 0.603, p<!--> <!-->&lt;<!--> <!-->0.001 (R² of 0.656); for pain showed a standardized beta coefficient of 0.29, p<!--> <!-->=<!--> <!-->0.01 (R² of 0.721)</p></div><div><h3>Conclusion</h3><p>The present study suggests that there is a strong relationship between pain severity, FABQ scores, and functional disability in Mexicans with chronic LBP.</p></div>","PeriodicalId":48991,"journal":{"name":"Revista Brasileira De Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbr.2016.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41277710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Policondrite recidivante: prevalência de doenças cardiovasculares e seus fatores de risco e características gerais da doença de acordo com o gênero","authors":"Pablo Arturo Olivo Pallo ,&nbsp;Maurício Levy‐Neto ,&nbsp;Rosa Maria Rodrigues Pereira ,&nbsp;Samuel Katsuyuki Shinjo","doi":"10.1016/j.rbr.2017.01.002","DOIUrl":"https://doi.org/10.1016/j.rbr.2017.01.002","url":null,"abstract":"<div><p>The comorbidities in relapsing polychondritis (RP) have been scarcely described in the literature. Moreover, apart from a few RP epidemiological studies, no studies specifically addressing RP distribution according to gender are available. Therefore, the objetives of the present study were: (a) to analyse the prevalence of cardiovascular diseases and its risk factors in a series of patients with RP; (b) to determine the influence of gender on RP. A cross‐sectional tertiary single center study evaluating 30 RP cases from 1990 to 2016 was carried out. To compare comorbidities, 60 healthy individuals matched for age‐, gender‐, ethnicity‐ and body mass index were recruted. The mean age of RP patientes was 49.0<!--> <!-->±<!--> <!-->12.4 years, the median disease duration 6.0 years, and 70% were women. A higher frequency of arterial hypertension (53.3% <em>vs</em>. 23.3%; p<!--> <!-->=<!--> <!-->0.008) and diabetes mellitus (16.7% <em>vs</em>. 3.3%; p<!--> <!-->=<!--> <!-->0.039) was found in the RP group, compared to the control group. As an additional analysis, patients were compared according to gender distribution (9 men <em>vs</em>. 21 women). The clinical disease onset features were comparable in both genders. However, over the follow‐up period, male patients had a greater prevalence of hearing loss, vestibular disorder and uveitis events, and also received more cyclophosphamide therapy (p<!--> <!-->&lt;<!--> <!-->0.05). There was a high prevalence of arterial hypertension and diabetes mellitus, and the male patients seemed to have worse prognosis than the female patients in the follow up.</p></div>","PeriodicalId":48991,"journal":{"name":"Revista Brasileira De Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbr.2017.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72244986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}