Revista Portuguesa De Cardiologia最新文献_第6页

Giant pleuropericardial cyst: An unexpected finding 巨大胸膜囊肿：意外发现

IF 1.6 4区医学

Revista Portuguesa De Cardiologia Pub Date : 2024-09-01 DOI: 10.1016/j.repc.2024.02.010

引用次数: 0

The balance between thrombosis and bleeding after mitral valve surgery: The need for robust evidence 二尖瓣手术后血栓形成与出血之间的平衡：需要强有力的证据。

IF 1.6 4区医学

Revista Portuguesa De Cardiologia Pub Date : 2024-09-01 DOI: 10.1016/j.repc.2024.07.004

Rui Azevedo Guerreiro

引用次数: 0

Exploring the evidence gap: Loop diuretic withdrawal in chronic heart failure 探索证据差距：慢性心力衰竭患者停用环利尿剂。

IF 1.6 4区医学

Revista Portuguesa De Cardiologia Pub Date : 2024-09-01 DOI: 10.1016/j.repc.2024.07.005

Aurora Andrade

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Loop diuretic discontinuation in chronic heart failure patients: A retrospective study 慢性心力衰竭患者停用环利尿剂：回顾性研究

IF 1.6 4区医学

Revista Portuguesa De Cardiologia Pub Date : 2024-09-01 DOI: 10.1016/j.repc.2024.02.012

{"title":"Loop diuretic discontinuation in chronic heart failure patients: A retrospective study","authors":"","doi":"10.1016/j.repc.2024.02.012","DOIUrl":"10.1016/j.repc.2024.02.012","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><p>The use of loop diuretics is central in managing congestion in heart failure (HF), but their impact on prognosis remains unclear. In euvolemic patients, dose reduction is recommended, but there is no recommendation on their discontinuation. This study aims to assess the impact of loop diuretic discontinuation on the prognosis of outpatients with HF with reduced ejection fraction.</p></div><div><h3>Methods</h3><p>This retrospective cohort study collected data from medical records of patients followed in an outpatient HF clinic at a university hospital center. Patients were included if they had been on loop diuretics and these were discontinued. Demographic, clinical and laboratory data were collected, and number and type of congestive events during the one-year period after discontinuation were recorded.</p></div><div><h3>Results</h3><p>Among 265 patients on loop diuretics, almost half (129) discontinued them at some point. Patients had optimized medical therapy, low median age, low New York Heart Association class, low B-type natriuretic peptide values, normal blood pressure, controlled heart rate and kidney function within normal limits. Among 122 patients with one year of follow-up, 18 (14.8%) had a congestive event. Fifteen events (83.3%) were low-dose diuretic reinitiation at a scheduled visit. There were only three worsening heart failure events (2.5%) during the one-year period. A significant improvement in kidney function from discontinuation to the one-year follow-up appointment was also observed.</p></div><div><h3>Conclusions</h3><p>In our cohort, loop diuretic discontinuation was possible and safe in a large proportion of patients. The results should be interpreted with caution and cannot be extrapolated to a broader population of HF patients.</p></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"43 9","pages":"Pages 513-522"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0870255124001847/pdfft?md5=cc45c1d91bcd328d608e6d1ff4cc54e9&pid=1-s2.0-S0870255124001847-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left atrial appendage thrombus in severe mitral stenosis: Can chamber morphology and thrombus location influence therapeutic choice? 严重二尖瓣狭窄的左心房附壁血栓：心腔形态和血栓位置会影响治疗选择吗？

IF 1.6 4区医学

Revista Portuguesa De Cardiologia Pub Date : 2024-09-01 DOI: 10.1016/j.repc.2024.07.001

引用次数: 0

Cardiac rehabilitation training in cardiology residency: A missing block in the training program 心脏科住院医生的心脏康复训练：培训计划中缺失的一环。

IF 1.6 4区医学

Revista Portuguesa De Cardiologia Pub Date : 2024-09-01 DOI: 10.1016/j.repc.2024.07.003

Miguel Mendes

引用次数: 0

Left atrial appendage thrombus with severe mitral stenosis: Responders and non-responders to anticoagulation 左心房阑尾血栓伴严重二尖瓣狭窄：抗凝反应者和非反应者。

IF 1.6 4区医学

Revista Portuguesa De Cardiologia Pub Date : 2024-09-01 DOI: 10.1016/j.repc.2023.12.007

{"title":"Left atrial appendage thrombus with severe mitral stenosis: Responders and non-responders to anticoagulation","authors":"","doi":"10.1016/j.repc.2023.12.007","DOIUrl":"10.1016/j.repc.2023.12.007","url":null,"abstract":"<div><h3>Introduction and Objective</h3><p>Mitral stenosis (MS) is one of the most frequently observed valvular heart lesions in developing countries and is due to different etiologies. The effects of anticoagulation in different types of left atrial appendage (LAA) are unknown. The current study aimed to determine the resolution of LAA thrombus on transesophageal echocardiography (TEE) after three months of optimal anticoagulation in patients with different types of LAA at baseline cardiac computed tomography of patients with severe MS.</p></div><div><h3>Methods</h3><p>This prospective cohort study observed the frequency of LAA thrombus resolution after three months of anticoagulation therapy in patients with severe MS. The response rate in different morphologies of LAA and locations was also assessed. Thrombus resolution after three months of warfarin therapy was assessed on repeat TEE.</p></div><div><h3>Results</h3><p>A total of 88 patients were included, mean age 37.95±11.87 years. Repeat TEE showed thrombus resolution in only 27.3% of patients. The rate of thrombus resolution was 8/12 (66.7%), 4/28 (14.3%), 8/36 (22.2%), and 4/12 (33.3%) for patients with cactus, cauliflower, chicken wing, and windsock LAA type, respectively. The resolution rate was 0/12 (0%), 4/44 (9.1%), and 20/32 (62.5%) for patients with thrombus in the base, body, and tip of the LAA, respectively.</p></div><div><h3>Conclusion</h3><p>The cactus type of LAA morphology and thrombus at the LAA tip responded well to three months of anticoagulation, however, patients with thrombus in the LAA base and body and cauliflower and chicken wing morphology were non-responders and could benefit from early referral for surgical management.</p></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"43 9","pages":"Pages 477-484"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0870255124000702/pdfft?md5=b809f2cb9d9492ba54cc0664a182ba35&pid=1-s2.0-S0870255124000702-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiopulmonary exercise testing in clinical practice: Principles, applications, and basic interpretation 临床实践中的心肺运动测试：原理、应用和基本解释。

IF 1.6 4区医学

Revista Portuguesa De Cardiologia Pub Date : 2024-09-01 DOI: 10.1016/j.repc.2024.01.005

引用次数: 0

Non-vitamin K versus vitamin K antagonist oral anticoagulants in surgical mitral valve repair or bioprosthetic valve replacement in the first three months after surgery 手术二尖瓣修复或生物人工瓣膜置换术后头三个月内使用非维生素 K 与维生素 K 拮抗剂口服抗凝剂的比较。

IF 1.6 4区医学

Revista Portuguesa De Cardiologia Pub Date : 2024-09-01 DOI: 10.1016/j.repc.2024.02.013

{"title":"Non-vitamin K versus vitamin K antagonist oral anticoagulants in surgical mitral valve repair or bioprosthetic valve replacement in the first three months after surgery","authors":"","doi":"10.1016/j.repc.2024.02.013","DOIUrl":"10.1016/j.repc.2024.02.013","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><p>Oral anticoagulation (OAC) with non-vitamin K antagonist oral anticoagulants (NOACs) after surgical mitral valve repair (MVR) or bioprosthetic valve replacement (BVR) in mitral position remains a controversial topic among the cardiovascular community, in particular in the early postoperative period. This study aimed to evaluate the efficacy and safety of NOACs in the first three months after MVR or mitral BVR compared to vitamin K antagonists (VKAs).</p></div><div><h3>Methods</h3><p>This was a single-center retrospective study with prospectively collected peri-intervention outcomes between 2020 and 2021. Records were retrieved and all participants were contacted by telephone. Patients were divided into groups according to OAC strategy. The primary outcome was a composite of death, rehospitalization, myocardial infarction, stroke or transient ischemic attack, systemic embolism, mitral thrombosis, or bleeding during the first three months after surgery.</p></div><div><h3>Results</h3><p>A total of 148 patients were enrolled, with a mean age of 65.5±12.2 years, 56.8% male. On discharge, 98 (66.2%) patients were on VKAs and 50 (33.8%) were on DOACs for at least three months. The primary outcome occurred in 22 (22.4%) patients in the VKA group and in three (6%) in the NOAC group (p=0.012), mainly driven by more bleeding events in the former. Independent predictors of the primary outcome were smoking (p=0.028) and OAC with VKAs at discharge, the latter predicting three times more events (p=0.046, OR 3.72, 95% CI 1.02–13.5).</p></div><div><h3>Conclusions</h3><p>NOACs were associated with fewer events, supporting their efficacy and safety during the first three months after surgical MVR or mitral BVR.</p></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"43 9","pages":"Pages 501-509"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0870255124001884/pdfft?md5=2df89b7cd1922df7cf020c0b35a35554&pid=1-s2.0-S0870255124001884-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardioprotective effect of chelidonic acid against doxorubicin-induced cardiac toxicity in rats. 诃子酮酸对大鼠多柔比星所致心脏毒性的保护作用

IF 1.6 4区医学

Revista Portuguesa De Cardiologia Pub Date : 2024-08-30 DOI: 10.1016/j.repc.2024.06.003

Shraddha I Khairnar, Yogesh A Kulkarni, Kavita Singh

{"title":"Cardioprotective effect of chelidonic acid against doxorubicin-induced cardiac toxicity in rats.","authors":"Shraddha I Khairnar, Yogesh A Kulkarni, Kavita Singh","doi":"10.1016/j.repc.2024.06.003","DOIUrl":"10.1016/j.repc.2024.06.003","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>The current study evaluates the effect of chelidonic acid on doxorubicin-induced cardiac toxicity. Chelidonic acid (CA) is a natural pyran-skeleton heterocyclic compound found in rhizomes of the perennial plant, celandine (Chelidonium majus).</p><p><strong>Methods: </strong>Wistar rats were given an intraperitoneal injection of doxorubicin (1.25 mg/kg, cumulative dose of 20 mg/kg) four times per week for a duration of four weeks to induce cardiotoxicity. CA treatment (10, 20, and 40 mg/kg orally for four weeks) was started together with doxorubicin.</p><p><strong>Results: </strong>CA treatment reduced myocardial damage and improved cardiac dysfunction in doxorubicin-treated rats. It improved blood pressure, restored ST wave height and normalized the QTc interval compared to the rats treated only with doxorubicin. Administration of CA for four weeks reduced left ventricular end-diastolic pressure. Moreover, CA treatment decreased the level of cardiac markers such as creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and cardiac troponin-T. Masson's trichrome, hematoxylin, and eosin staining of heart tissue revealed that CA attenuated the deleterious effects of doxorubicin and prevented further damage and fibrosis in rats.</p><p><strong>Conclusion: </strong>The study findings confirm that CA treatment can protect the myocardium against doxorubicin-induced cardiotoxicity.</p>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0