Bone & Joint JournalPub Date : 2024-12-01DOI: 10.1302/0301-620X.106B12.BJJ-2024-1060
Fares S Haddad
{"title":"Thank you for an excellent 2024.","authors":"Fares S Haddad","doi":"10.1302/0301-620X.106B12.BJJ-2024-1060","DOIUrl":"https://doi.org/10.1302/0301-620X.106B12.BJJ-2024-1060","url":null,"abstract":"","PeriodicalId":48944,"journal":{"name":"Bone & Joint Journal","volume":"106-B 12","pages":"1361-1362"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bone & Joint JournalPub Date : 2024-12-01DOI: 10.1302/0301-620X.106B12.BJJ-2023-1089.R2
Richard M Terek, Richard McGough, Nicola Fabbri, Felix Cheung, Brian Brigman, James Wittig, Cynthia Emory, Albert Aboulafia, Raffi Avedian, Joel Mayerson, Robert Henshaw, Nickolas Reimer, William Eward, Kurt Weiss, John Healey, David Mohler, Brock Adams
{"title":"IlluminOss photodynamic bone stabilization system improves pain and function in the treatment of humeral metastatic disease.","authors":"Richard M Terek, Richard McGough, Nicola Fabbri, Felix Cheung, Brian Brigman, James Wittig, Cynthia Emory, Albert Aboulafia, Raffi Avedian, Joel Mayerson, Robert Henshaw, Nickolas Reimer, William Eward, Kurt Weiss, John Healey, David Mohler, Brock Adams","doi":"10.1302/0301-620X.106B12.BJJ-2023-1089.R2","DOIUrl":"10.1302/0301-620X.106B12.BJJ-2023-1089.R2","url":null,"abstract":"<p><strong>Aims: </strong>The aim of the LightFix Trial was to evaluate the clinical outcomes for one year after the treatment of impending and completed pathological fractures of the humerus using the IlluminOss System (IS), and to analyze the performance of this device.</p><p><strong>Methods: </strong>A total of 81 patients with an impending or completed pathological fracture were enrolled in a multicentre, open label single cohort study and treated with IS. Inclusion criteria were visual analogue scale (VAS) Pain Scores > 60 mm/100 mm and Mirels' Score ≥ 8. VAS pain, Musculoskeletal Tumor Society (MSTS) Upper Limb Function, and The European Organization for Research and Treatment of Cancer QoL Group Bone Metastases Module (QLQ-BM22) scores were all normalized to 100, and radiographs were obtained at baseline and at 14, 30, 90, 180, and 360 days postoperatively.</p><p><strong>Results: </strong>The mean VAS pain score decreased significantly from 84 (SD 15) to 50 (SD 29), 38 (SD 30), 31 (SD 29), 31 (SD 29), and 21 (SD 23) between the baseline and follow-up times (p < 0.001). The mean MSTS function scores significantly increased from 27 (SD 19) to 52 (SD 22), 60 (23), 67 (SD 23), 72 (SD 26), and 83 (SD 14) (p < 0.001). The pain and functional subscales of the QLQ-BM22 also significantly improved at most times. A total of 12 devices broke, giving an unadjusted device fracture rate of 15%.</p><p><strong>Conclusion: </strong>Stabilization with the IS decreased pain and improved function with consistent results during the first postoperative year. IS is a new, minimally invasive type of internal fixation. The use of the IS alone may be better for impending rather than completed pathological fractures, and may be better in completed fractures if an added plate or more than the usual number of locking screws is required. Caution is warranted regarding its use alone in patients with a completed pathological fracture due to the rate of breakage of the device.</p>","PeriodicalId":48944,"journal":{"name":"Bone & Joint Journal","volume":"106-B 12","pages":"1485-1492"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bone & Joint JournalPub Date : 2024-12-01DOI: 10.1302/0301-620X.106B12.BJJ-2024-0321.R1
Yuqing Wang, Liusong Shen, Dongxing Xie, Huizhong Long, Hu Chen, Jie Wei, Chao Zeng, Guanghua Lei
{"title":"Comparing surgical readmission, in-hospital complications, and charges between total hip arthroplasty and hemiarthroplasty for geriatric femoral neck fractures.","authors":"Yuqing Wang, Liusong Shen, Dongxing Xie, Huizhong Long, Hu Chen, Jie Wei, Chao Zeng, Guanghua Lei","doi":"10.1302/0301-620X.106B12.BJJ-2024-0321.R1","DOIUrl":"https://doi.org/10.1302/0301-620X.106B12.BJJ-2024-0321.R1","url":null,"abstract":"<p><strong>Aims: </strong>For displaced femoral neck fractures (FNFs) in geriatric patients, there remains uncertainty regarding the effect of total hip arthroplasty (THA) compared with hemiarthroplasty (HA) in the guidelines. We aimed to compare 90-day surgical readmission, in-hospital complications, and charges between THA and HA in these patients.</p><p><strong>Methods: </strong>The Hospital Quality Monitoring System was queried from 1 January 2013 to 31 December 2019 for displaced FNFs in geriatric patients treated with THA or HA. After propensity score matching, which identified 33,849 paired patients, outcomes were compared between THA and HA using logistic and linear regression models.</p><p><strong>Results: </strong>The HA group had a lower incidence of 90-day surgical readmission than the THA group (odds ratio (OR) 0.75 (95% CI 0.68 to 0.83)). Meanwhile, the HA group had lower incidence of dislocation (OR 0.42 (95% CI 0.33 to 0.52)), aseptic loosening (OR 0.50 (95% CI 0.38 to 0.66)), and joint pain (OR 0.63 (95% CI 0.40 to 0.98)), but a higher incidence of periprosthetic fracture (OR 1.41 (95% CI 1.07 to 1.87)) for readmission, compared to the THA group. The incidence of in-hospital complications did not differ significantly between the two groups. Moreover, the HA group had lower mean charges than the THA group (47,578.29 Chinese Yuan (CNY) (SD 20,069.71) vs 57,641.00 CNY (SD 21,524.07)).</p><p><strong>Conclusion: </strong>When considering 90-day surgical readmission rate, in-hospital complications, and mortality, HA resulted in a significantly lower surgical readmission rate within 90 days compared to THA, despite the patients being older and having a higher Charlson Comorbidity Index.</p>","PeriodicalId":48944,"journal":{"name":"Bone & Joint Journal","volume":"106-B 12","pages":"1477-1484"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bone & Joint JournalPub Date : 2024-12-01DOI: 10.1302/0301-620X.106B12.BJJ-2024-0282.R1
Andreas Fontalis, Adam T Yasen, Dia E Giebaly, Tianyi D Luo, Ahmed Magan, Fares S Haddad
{"title":"Optimizing debridement and implant retention in acute periprosthetic joint infections.","authors":"Andreas Fontalis, Adam T Yasen, Dia E Giebaly, Tianyi D Luo, Ahmed Magan, Fares S Haddad","doi":"10.1302/0301-620X.106B12.BJJ-2024-0282.R1","DOIUrl":"https://doi.org/10.1302/0301-620X.106B12.BJJ-2024-0282.R1","url":null,"abstract":"<p><p>Periprosthetic joint infection (PJI) represents a complex challenge in orthopaedic surgery associated with substantial morbidity and healthcare expenditures. The debridement, antibiotics, and implant retention (DAIR) protocol is a viable treatment, offering several advantages over exchange arthroplasty. With the evolution of treatment strategies, considerable efforts have been directed towards enhancing the efficacy of DAIR, including the development of a phased debridement protocol for acute PJI management. This article provides an in-depth analysis of DAIR, presenting the outcomes of single-stage, two-stage, and repeated DAIR procedures. It delves into the challenges faced, including patient heterogeneity, pathogen identification, variability in surgical techniques, and antibiotics selection. Moreover, critical factors that influence the decision-making process between single- and two-stage DAIR protocols are addressed, including team composition, timing of the intervention, antibiotic regimens, and both anatomical and implant-related considerations. By providing a comprehensive overview of DAIR protocols and their clinical implications, this annotation aims to elucidate the advancements, challenges, and potential future directions in the application of DAIR for PJI management. It is intended to equip clinicians with the insights required to effectively navigate the complexities of implementing DAIR strategies, thereby facilitating informed decision-making for optimizing patient outcomes.</p>","PeriodicalId":48944,"journal":{"name":"Bone & Joint Journal","volume":"106-B 12","pages":"1377-1384"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bone & Joint JournalPub Date : 2024-12-01DOI: 10.1302/0301-620X.106B12.BJJ-2024-0652
Irewin Tabu, Rebecca Ivers, Matt L Costa
{"title":"Looking after patients with hip fracture in low- and middle-income countries.","authors":"Irewin Tabu, Rebecca Ivers, Matt L Costa","doi":"10.1302/0301-620X.106B12.BJJ-2024-0652","DOIUrl":"10.1302/0301-620X.106B12.BJJ-2024-0652","url":null,"abstract":"<p><p>In the UK, multidisciplinary teamwork for patients with hip fracture has been shown to reduce mortality and improves health-related quality of life for patients, while also reducing hospital bed days and associated healthcare costs. However, despite rapidly increasing numbers of fragility fractures, multidisciplinary shared care is rare in low- and middle-income countries around the world. The HIPCARE trial will test the introduction of multidisciplinary care pathways in five low- and middle-income countries in South and Southeast Asia, with the aim to improve patients' quality of life and reduce healthcare costs.</p>","PeriodicalId":48944,"journal":{"name":"Bone & Joint Journal","volume":"106-B 12","pages":"1369-1371"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bone & Joint JournalPub Date : 2024-12-01DOI: 10.1302/0301-620X.106B12.BJJ-2023-1269.R1
Darren B Chen, Jil A Wood, William Griffiths-Jones, Johan Bellemans, Fares S Haddad, Samuel J MacDessi
{"title":"Considerations of morphometry and phenotypes in modern knee arthroplasty.","authors":"Darren B Chen, Jil A Wood, William Griffiths-Jones, Johan Bellemans, Fares S Haddad, Samuel J MacDessi","doi":"10.1302/0301-620X.106B12.BJJ-2023-1269.R1","DOIUrl":"10.1302/0301-620X.106B12.BJJ-2023-1269.R1","url":null,"abstract":"<p><p>As advancements in total knee arthroplasty progress at an exciting pace, two areas are of special interest, as they directly impact implant design and surgical decision making. Knee morphometry considers the three-dimensional shape of the articulating surfaces within the knee joint, and knee phenotyping provides the ability to categorize alignment into practical groupings that can be used in both clinical and research settings. This annotation discusses the details of these concepts, and the ways in which they are helping us better understand the individual subtleties of each patient's knee.</p>","PeriodicalId":48944,"journal":{"name":"Bone & Joint Journal","volume":"106-B 12","pages":"1363-1368"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bone & Joint JournalPub Date : 2024-12-01DOI: 10.1302/0301-620X.106B12.BJJ-2024-0553.R1
Lenka Stroobant, Ewoud Jacobs, Nele Arnout, Stefaan Van Onsem, Thomas Tampere, Arne Burssens, Erik Witvrouw, Jan Victor
{"title":"Can blood flow restriction therapy improve quality of life and function in dissatisfied knee arthroplasty patients?","authors":"Lenka Stroobant, Ewoud Jacobs, Nele Arnout, Stefaan Van Onsem, Thomas Tampere, Arne Burssens, Erik Witvrouw, Jan Victor","doi":"10.1302/0301-620X.106B12.BJJ-2024-0553.R1","DOIUrl":"https://doi.org/10.1302/0301-620X.106B12.BJJ-2024-0553.R1","url":null,"abstract":"<p><strong>Aims: </strong>Approximately 10% to 20% of knee arthroplasty patients are not satisfied with the result, while a clear indication for revision surgery might not be present. Therapeutic options for these patients, who often lack adequate quadriceps strength, are limited. Therefore, the primary aim of this study was to evaluate the clinical effect of a novel rehabilitation protocol that combines low-load resistance training (LL-RT) with blood flow restriction (BFR).</p><p><strong>Methods: </strong>Between May 2022 and March 2024, we enrolled 45 dissatisfied knee arthroplasty patients who lacked any clear indication for revision to this prospective cohort study. All patients were at least six months post-surgery and had undergone conventional physiotherapy previously. The patients participated in a supervised LL-RT combined with BFR in 18 sessions. Primary assessments included the following patient-reported outcome measures (PROMs): Knee injury and Osteoarthritis Outcome Score (KOOS); Knee Society Score: satisfaction (KSSs); the EuroQol five-dimension five-level questionnaire (EQ-5D-5L); and the pain catastrophizing scale (PCS). Functionality was assessed using the six-minute walk Test (6MWT) and the 30-second chair stand test (30CST). Follow-up timepoints were at baseline, six weeks, three months, and six months after the start.</p><p><strong>Results: </strong>Six weeks of BFR with LL-RT improved all the PROMs except the sports subscale of the KOOS compared to baseline. Highest improvements after six weeks were found for quality of life (QoL) (mean 28.2 (SD 17.2) vs 19 (SD 14.7); p = 0.002), activities of daily living (mean 54.7 (SD 18.7) vs 42.9 (SD 17.3); p < 0.001), and KSSs (mean 17.1 (SD 8.8) vs 12.8 (SD 6.7); p < 0.001). PROMs improvements continued to be present at three-month and six-month follow-up compared to baseline. However, no significant differences were observed in the paired comparisons of the six-week, three-month, and six-month follow-up. The same trends are observed for the 6MWT and 30CST.</p><p><strong>Conclusion: </strong>The reported regime demonstrates improved QoL and function of dissatisfied knee arthroplasty patients. In light of this, the pathway described may provide a valuable and safe treatment option for dissatisfied knee arthroplasty patients for whom therapeutic options are limited.</p>","PeriodicalId":48944,"journal":{"name":"Bone & Joint Journal","volume":"106-B 12","pages":"1416-1425"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bone & Joint JournalPub Date : 2024-12-01DOI: 10.1302/0301-620X.106B12.BJJ-2023-1266.R2
Laura Wall, Samantha Bunzli, Elizabeth Nelson, Lyndon J Hawke, Mesfin Genie, Madeleine Hinwood, Danielle Lang, Michelle M Dowsey, Phillip Clarke, Peter F Choong, Zsolt J Balogh, L S Lohmander, Francesco Paolucci
{"title":"Willingness to participate in placebo-controlled surgical trials of the knee.","authors":"Laura Wall, Samantha Bunzli, Elizabeth Nelson, Lyndon J Hawke, Mesfin Genie, Madeleine Hinwood, Danielle Lang, Michelle M Dowsey, Phillip Clarke, Peter F Choong, Zsolt J Balogh, L S Lohmander, Francesco Paolucci","doi":"10.1302/0301-620X.106B12.BJJ-2023-1266.R2","DOIUrl":"https://doi.org/10.1302/0301-620X.106B12.BJJ-2023-1266.R2","url":null,"abstract":"<p><strong>Aims: </strong>Surgeon and patient reluctance to participate are potential significant barriers to conducting placebo-controlled trials of orthopaedic surgery. Understanding the preferences of orthopaedic surgeons and patients regarding the design of randomized placebo-controlled trials (RCT-Ps) of knee procedures can help to identify what RCT-P features will lead to the greatest participation. This information could inform future trial designs and feasibility assessments.</p><p><strong>Methods: </strong>This study used two discrete choice experiments (DCEs) to determine which features of RCT-Ps of knee procedures influence surgeon and patient participation. A mixed-methods approach informed the DCE development. The DCEs were analyzed with a baseline category multinomial logit model.</p><p><strong>Results: </strong>The proportion of respondents (surgeons n = 103; patients n = 140) who would not participate in any of the DCE choice sets (surgeons = 31%; patients = 40%), and the proportion who would participate in all (surgeons = 18%; patients = 30%), indicated strong views regarding the conduct of RCT-Ps. There were three main findings: for both surgeons and patients, studies which involved an arthroscopic procedure were more likely to result in participation than those with a total knee arthroplasty; as the age (for patients) and years of experience (for surgeons) increased, the overall likelihood of participation decreased; and, for surgeons, offering authorship and input into the RCT-P design was preferred for less experienced surgeons, while only completing the procedure was preferred by more experienced surgeons.</p><p><strong>Conclusion: </strong>Patients and surgeons have strong views regarding participation in RCT-Ps. However, understanding their preferences can inform future trial designs and feasibility assessments with regard to recruitment rates.</p>","PeriodicalId":48944,"journal":{"name":"Bone & Joint Journal","volume":"106-B 12","pages":"1408-1415"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bone & Joint JournalPub Date : 2024-12-01DOI: 10.1302/0301-620X.106B12.BJJ-2023-1459.R1
Krishna Mandalia, Stephen Le Breton, Christopher Roche, Sarav S Shah
{"title":"Clinical outcomes validate the RAND/UCLA appropriateness criteria algorithm for anatomical total shoulder arthroplasty for streamlining the clinical decision-making process.","authors":"Krishna Mandalia, Stephen Le Breton, Christopher Roche, Sarav S Shah","doi":"10.1302/0301-620X.106B12.BJJ-2023-1459.R1","DOIUrl":"10.1302/0301-620X.106B12.BJJ-2023-1459.R1","url":null,"abstract":"<p><strong>Aims: </strong>A recent study used the RAND Corporation at University of California, Los Angeles (RAND/UCLA) method to develop anatomical total shoulder arthroplasty (aTSA) appropriateness criteria. The purpose of our study was to determine how patient-reported outcome measures (PROMs) vary based on appropriateness.</p><p><strong>Methods: </strong>Clinical data from a multicentre database identified patients who underwent primary aTSA from November 2004 to January 2023. A total of 390 patients (mean follow-up 48.1 months (SD 42.0)) were included: 97 (24.9%) were classified as appropriate, 218 (55.9%) inconclusive, and 75 (19.2%) inappropriate. Patients were classified as \"appropriate\", \"inconclusive\", or \"inappropriate\", using a modified version of an appropriateness algorithm, which accounted for age, rotator cuff status, mobility, symptomatology, and Walch classification. Multiple pre- and postoperative scores were analyzed using Pearson's chi-squared test and one-way analysis of variance (ANOVA). Postoperative complications were also analyzed.</p><p><strong>Results: </strong>All groups achieved significant improvement in mean PROM scores postoperatively. \"Appropriate\" patients experienced significantly greater improvement in visual analogue scale (VAS) and American Shoulder and Elbow Surgeons (ASES) score compared to \"inconclusive\" and \"inappropriate\". The appropriate group had a significantly greater proportion of patients who achieved minimal clinically important difference (MCID) (95.8%; n = 93) and substantial clinical benefit (SCB) (92.6%; n = 89). Overall, 13 patients had postoperative complications. No significant differences in postoperative complications among classifications were found.</p><p><strong>Conclusion: </strong>Our data clinically validate the RAND/UCLA aTSA appropriateness criteria algorithm, allowing for more rapid and reliable determination of aTSA candidacy. \"Appropriate\" patients were more likely to achieve MCID and SCB for ASES scores compared to \"inappropriate\" patients. Among \"appropriate\" patients who did not achieve SCB, 50% (n = 4) had a postoperative complication. There was a significantly higher proportion of postoperative complications among those who did not achieve SCB across all three groups. Only 7.1% (n = 1) of patients who did not achieve SCB in the inappropriate group had a postoperative complication. Thus, it can be inferred that the failure to reach SCB in the appropriate group was likely to be due to a postoperative complication, whereas for patients deemed \"inappropriate\", failure to reach SCB may be secondary to factors accounted for within our algorithm.</p>","PeriodicalId":48944,"journal":{"name":"Bone & Joint Journal","volume":"106-B 12","pages":"1451-1460"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}