The Lancet Diabetes & Endocrinology最新文献

{"title":"Enrichment of strontium and magnesium improves the physical, mechanical and biological properties of bioactive glasses undergoing thermal treatments: new cues for biomedical applications","authors":"Devis Bellucci, Alessia Mazzilli, Andrea Martelli, Francesco Gerardo Mecca, Susanna Bonacorsi, Francesco Demetrio Lofaro, Federica Boraldi, Daniela Quaglino, Valeria Cannillo","doi":"10.1016/j.ceramint.2024.10.135","DOIUrl":"https://doi.org/10.1016/j.ceramint.2024.10.135","url":null,"abstract":"Bioactive glasses (BGs) have emerged as invaluable resources for bone tissue engineering due to their remarkable properties such as bioactivity, resorbability, cell compatibility, and osteoconductivity. However, these materials exhibit certain limitations when subjected to high temperatures, for their tendency to crystallize, thus leading to diminished bioactivity, reduced mechanical strength, and altered dissolution kinetics. One promising approach to counteract this problem is to reduce the alkaline element content in BGs while simultaneously adding strontium and magnesium. Building on previous studies of Bio_MS, a recently developed experimental formulation, we investigated the contributions of strontium and magnesium to the thermal, mechanical, and biological properties of various bioactive glasses, including commercially available options. Differential thermal analysis, heating microscopy, X-ray diffractometry, environmental scanning electron microscopy, measurement of the Young’s modulus, simulated body fluid testing, cytotoxicity tests, cell viability, growth, adhesion and morphology were assessed through an integrated approach and compared for a complete evaluation of BGs, and of doped BGs, also undergoing thermal treatments. The results demonstrated improved thermal, mechanical and biological behaviors of the magnesium-strontium-doped BGs, thus paving the way for the development of BGs with enhanced biomedical perspectives.","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"33 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MOFs-Derived Copper Selenides Nanoparticles Implanted in Carbon Matrix for Broadband Electromagnetic Wave Absorption","authors":"Shengtao Gao, Chuanlei Zhu, Yuanchun Zhang","doi":"10.1016/j.ceramint.2024.10.129","DOIUrl":"https://doi.org/10.1016/j.ceramint.2024.10.129","url":null,"abstract":"Selenide-based functional composites materials demonstrated tunable dielectric properties and heterogeneous interface design, which has been widely studied in electromagnetic (EM) wave absorption field. Herein, Metal-organic frameworks (MOFs) derived carbon coating copper selenide (Cu_2-XSe@C) composites were successfully fabricated by using the Cu-MOFs as precursor. After reacting with the gaseous Se in the selenization annealing process, the metal host was converted into the Cu_2-XSe nanoparticles, where embodied in the carbon matrix transformed from the organic linker. Based on the tunning dielectric property and building heterogeneous interface, MOFs-derived Cu_2-XSe@C composites displayed outstanding EM wave absorption performance. Though the conduction loss, interfacial and dipole polarization behaviors, the minimum reflection loss (<em>RL</em>_min) value of Cu_2-XSe@C-600 composites reached to -74.3 dB at 11.7 GHz when the thickness is 2.0 mm. The efficient absorption bandwidth (EAB) can be regulated via controlling the applied thickness. When the thickness is 2.3 mm, above-mentioned Cu_2-XSe@C-600 got the broadest absorption performance with the EAB of 5.5 GHz from the 7.7 to 13.2 GHz, covering the whole X-band. Therefore, MOFs-derived selenide-based composites shed a new design strategy for constructing broadband EM wave absorption, especially in radar stealth applications.","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"58 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem-cell therapy for diabetes: the hope continues","authors":"","doi":"10.1016/s2213-8587(24)00314-0","DOIUrl":"https://doi.org/10.1016/s2213-8587(24)00314-0","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"39 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Abrasive Slurry Assisted Rotating Ultrasonic Machining for Enhanced Micro-Channel Fabrication on Ceramic Silicon Wafer (111)","authors":"Mohit Vishnoi, Siddharth Srivastava, Mamatha Theetha Gangadhar, Vikrant Singh, Vansh Malik, Anuj Bansal","doi":"10.1016/j.ceramint.2024.10.083","DOIUrl":"https://doi.org/10.1016/j.ceramint.2024.10.083","url":null,"abstract":"This study examined the impact of abrasive slurry assisted Rotating Ultrasonic Machining (RUM) using Boron Carbide (B₄C) powder of three mesh sizes: 400 Mesh, 600 Mesh, and 800 Mesh. The effects of abrasive size, feed rate, and tool rotation on Material Removal Rate (MRR) and Surface Roughness (SR) were investigated. The highest MRR of 3.454 mm³/min was achieved with 400 mesh, 30 mm/min feed rate, and 1250 rpm due to larger abrasive size, medium feed rate, and medium tool rotation velocity, while the lowest MRR of 0.284 mm³/min was noted with 600 mesh, 30 mm/min feed rate, and 1500 rpm, attributed to intermediate abrasive size and high tool rotation. The lowest SR of 1.16 μm was observed at 800 mesh, 15 mm/min feed rate, and 1500 rpm, resulting from smaller abrasive size and higher tool rotation facilitating polishing action and vibrational dampening. The highest SR of 3.71 μm occurred at 400 mesh, 45 mm/min feed rate, and 1500 rpm, due to larger abrasive size, higher feed rate, and tool rotation, increasing surface corrosion. ANOVA and regression analyses highlighted mesh size as the most significant parameter for both MRR and SR, with strong model-experimental value correlations. The findings demonstrate the suitability of abrasive slurry assisted RUM for fabricating micro-channels in X-Ray, optoelectronic, and semiconductor applications.","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"88 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multispectral emissive and elongated red emission decay in Sm(DBM)3phen complex modified by SrAl2O4:Eu2+, Dy3+ composite","authors":"Kiran Pooja, Y. Dwivedi","doi":"10.1016/j.ceramint.2024.10.125","DOIUrl":"https://doi.org/10.1016/j.ceramint.2024.10.125","url":null,"abstract":"In the present study, we report elongated red emission decay in Sm(DBM)₃phen (SDp) complex stimulated via radiative transfer from a persistent luminescent phosphor SrAl₂O₄:Eu²⁺,Dy³⁺ (SrAl) in the Polyvinyl alcohol (PVA) matrix. The detailed spectroscopic investigations carried out on 405 nm laser excitation reveal the predominating broad emission, centered at 520 nm with a prolonged decay time, while the SDp complex in PVA yields characteristic yellow-red emissions with a decay time of ∼535 μs. The PVA composite yields an amalgam of emissions with modified intensities and change in peak shape due to the lattice effect. We report spectroscopic analysis of the emission spectrum with varying concentrations, layer stacking, lattice effect, etc. The lattice leads the emission peak broadening, facilitating improved interaction between the SDp complex and SrAl phosphor. The radiative decay analysis of red emission for transition ⁴G_5/2→⁶H_9/2 (Sm³⁺ ion) reveals that in PVA, it decays slower (∼535μs) than the pure complex (∼260μs). Further, red emission was present even after cessation of excitation due to the elongated radiative decay (∼3.5ms) in the presence of SrAl phosphor in PVA, indicating efficient radiative transfer (transfer rate of ∼1580 s^-1) from the phosphor to Sm(DBM)₃phen complex. Detailed photophysics and CIE coordinate calculations were presented.","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"229 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sintering activation energy and low-temperature sinterable process of Boron-lanthanide glass/Li2Zn3Ti4O12 ceramic composite systems for LTCC technology","authors":"Yanbin Xiong, Junjie Chen, Kaixin Song, Tianyi Xie, Guoqing Xia, Xiaolong Ma, Runhong Tang, Fancheng Meng, Zhongqing Tian, Haishen Ren, Huixing Lin","doi":"10.1016/j.ceramint.2024.10.133","DOIUrl":"https://doi.org/10.1016/j.ceramint.2024.10.133","url":null,"abstract":"This work investigates the characteristics of wettability, activation energy for sintering, evolution of phase structure, and behavior during the low-temperature sintering process of B₂O₃-La₂O₃-MgO-TiO₂ (BLMT) glass/Li₂Zn₃Ti₄O₁₂ ceramic composites for low temperature co-fried ceramics technology (LTCC). As the BLMT glass content increases from 0 to 10 wt%, the average sintering activation energy (<em>Ea</em>) of the composite decreases from 450 ± 8 to 356 ± 37 kJ/mol. There are two phases the primary Li₂Zn₃Ti₄O₁₂ phase and the secondary LaBO₃ phase, the latter precipitates from the BLMT glass after sintering at 700 °C. This indicates that BLMT glass promotes the sintering of Li₂Zn₃Ti₄O₁₂ ceramic below 900 °C. In composites containing 20 wt% or more glass, sintering is governed by both liquid-phase sintering and reactive viscous sintering. As the BLMT glass content increases, the impact of viscous flow on the densification process becomes more pronounced. Simultaneously, when the glass content is greater than 20 wt%, the glass precipitates LaBO₃, TiO₂, and MgLaB₅O₁₀ phases between 700 and 750 °C. After 850 °C, the glass melts and reacts with Li₂Zn₃Ti₄O₁₂ phase to produce a new TiO₂ phase. Accordingly, the activation energy (<em>Ea</em>) of sintering the composite material increases from 393 ± 17 to 667 ± 1 kJ/mol.","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"77 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heat treatment effects on the shear performance and microstructure evolution of W-core SiC fibers","authors":"Lei Pan, Zhigang Sun, Xuming Niu, Jiaoling Shi, Yingdong Song","doi":"10.1016/j.ceramint.2024.10.053","DOIUrl":"https://doi.org/10.1016/j.ceramint.2024.10.053","url":null,"abstract":"SiC fiber reinforced titanium alloy matrix composites employed in elevated temperature aeroengine components are subjected to complex loading conditions. Investigating the shear performance of SiC fibers after heat treatment can help ensure the load-carrying capability of composites at service temperatures. This study presents a novel double shear testing method for W-core SiC fibers. The shear strength and stiffness of the SiC fibers in as-received and heat-treated conditions were measured. The morphologies of SiC fibers’ shear fracture surfaces and C coatings were thoroughly analyzed. The evolution of the internal microstructure and the composition of reaction layers after heat treatments were investigated. The shear strength of W-core SiC fibers at 95% survival probability reached 588.64 MPa after 200 h of heat treatment at 600 °Celsius, representing a 55% improvement over both the as-received and 1100 °Celsius heat-treated conditions. After heat treatment at 1100 °Celsius, the reaction layer between the W core and the SiC sheath thickened exponentially due to extensive elemental diffusion, resulting in the formation of numerous Kirkendall voids. The voids facilitated crack initiation and propagation, leading to a deterioration in fiber shear performance. The insights gained in this study regarding the shear properties of SiC fibers can provide support for predicting the mechanical performance of composites under complex loading conditions.","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"9 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Critical Conditions for Ductile-brittle Transition in Ultrasonic-assisted Grinding of SiC Particle-reinforced Al-MMCs","authors":"Xiaoxing Gao, Wenzhao An, Liyu Wang, Bochuan Chen, Weiwei Xu, Qiaosheng Feng, Qilin Li, Songmei Yuan","doi":"10.1016/j.ceramint.2024.10.128","DOIUrl":"https://doi.org/10.1016/j.ceramint.2024.10.128","url":null,"abstract":"High volume fraction (45 %) silicon carbide particle-reinforced aluminum matrix composites (SiC_p/Al-MMCs) play a significant role in various engineering fields due to their outstanding performance. However, damages characterized by SiC particle fracture during machining lead to poor surface integrity, which severely affects the fatigue performance of SiC_p/Al composite structural components. Ultrasonic-assisted grinding (UAG) is acknowledged as beneficial for promoting ductile grinding in hard and brittle materials. This study focuses on the critical conditions for ductile-brittle transition in ultrasonic-assisted grinding of SiC_p/Al composites and develops a mechanism and data driven model of critical undeformed chip thickness (UCT) for ductile grinding to accurately predict the material removal mode. The model thoroughly integrates considerations of chip morphology, removal mode transition mechanism, and grinding surface damage characteristics. Response surface methodology (RSM) and genetic algorithms (GA) were utilized to correct the impact of processing parameters on the removal regime. Experiments on ultrasonic-assisted side and end grinding were conducted to thoroughly discuss the effects of different undeformed chip thicknesses, grinding speeds and ultrasonic vibration amplitude on surface damage and the critical conditions for the ductile-brittle transition. The findings corroborate the experimental data with the predicted values. Ultrasonic vibration can effectively reduce the brittle fracture of SiC particles in SiC_p/Al composites. Appropriately increasing the grinding speed and reducing the chip thickness can enhance the critical chip thickness for ductile grinding and decrease the proportion of brittle surfaces, thereby achieving a balance between surface integrity and grinding efficiency. This research provides guidance for high-performance machining of SiC_p/Al composites.","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"9 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fe2O3-Co3O4 nanocomposite gas sensor for ethanol sensing studies","authors":"Seyed Mohammad Hossein Bagherzadeh Enferadi, Ali Mirzaei","doi":"10.1016/j.ceramint.2024.10.138","DOIUrl":"https://doi.org/10.1016/j.ceramint.2024.10.138","url":null,"abstract":"This study focused on pristine Fe₂O₃, pristine Co₃O₄, and Fe₂O₃-Co₃O₄ composite using the Pechini sol-gel method for ethanol gas sensing applications. Advanced characterization techniques were used to analyze the phase, morphology, and composition of the synthesized materials. Gas sensors were then fabricated and used for ethanol gas sensing at different temperatures. The results indicated that Fe₂O₃-Co₃O₄ composite gas sensor crystallized at 600°C, had higher response compared to both pristine Fe₂O₃ and pristine Co₃O₄ gas sensors. The composite sensor manifested a high response of 26.2 to 100 ppm ethanol at 250°C, while maximum responses of pristine Co₃O₄ gas sensor was only 4.4 at 200°C and that of pristine Fe₂O₃ sensor was 11.4 at 300°C. The boosted sensing performance of the composite sensor was related to the formation of p-n heterojunctions between Co₃O₄ and Fe₂O₃ in composite sensor, the formation of dangling bonds at interfaces, and high intrinsic ethanol sensing properties of Fe₂O₃.","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"38 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Synthesis and Forensic Application of CoPr(x)Cr(2-x)O4 Nanoparticles for Latent Fingerprint Detection","authors":"Sachin Haigar, Vaishnavi Khanapur, B.R.Radha Krushna, H. Nagabhushana, V. Ganesh, I.S. Yahia, H. Algarni, Nipa Roy, Sang Woo Joo, Jagadeesha Angadi V","doi":"10.1016/j.ceramint.2024.10.096","DOIUrl":"https://doi.org/10.1016/j.ceramint.2024.10.096","url":null,"abstract":"The production, characterisation, and use of CoPr_(x)Cr_(2-x)O₄ (x=0.00, 0.01, 0.03, and 0.05) nanoparticles for improved latent fingerprint (LFP) detection are investigated in this study. CoCr₂O₄ containing different amounts of Praseodymium(Pr³⁺) were prepared by solution combustion process using 1:1 molar ratio of oxidiser and fuel. X-ray diffraction (XRD) was used to examine the structural characteristics of these nanoparticles, and the results showed that the crystallite sizes and lattice parameters varied while the spinel structure remained constant. The effective synthesis of the intended nanoparticles was indicated by the confirmation of CoCr₂O₄ presence in the spinel structure by Fourier Transform Infrared Spectroscopy, or FTIR. In particular, the study showed how these nanoparticles can be used in forensic science to identify LFP on a variety of surfaces, including steel, paper, and OHP sheets. In daylight, the CoPr_0.03Cr_1.97O₄ (CoPr-3)variation with x=0.05 performed better, allowing for a clear viewing of Level I–III fingerprint features. 3D interactive plots and high-resolution images demonstrated that the nanoparticles stuck to fingerprint remnants, improving visibility and detail. The study also looked at how stable these nanoparticles were under UV irradiation and aging, and it discovered that CoPr-3 phosphor was remarkably resistant to UV degradation and retained its efficacy for 60 days. These results demonstrate the potential of CoPr_(x)Cr_(2-x)O₄ nanoparticles as a reliable and effective material for forensic fingerprint analysis, providing notable enhancements in LFP detection sensitivity and resolution.","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"9 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}