{"title":"New drug approved for hyperphagia in Prader–Willi syndrome","authors":"Merlin G Butler","doi":"10.1016/s2213-8587(25)00161-5","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00161-5","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"64 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144177296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sofia Amylidi-Mohr, Giulia Zennaro, Sophie Schneider, Luigi Raio, Beatrice Mosimann, Daniel Surbek
{"title":"Continuous glucose monitoring in the management of gestational diabetes in Switzerland (DipGluMo): an open-label, single-centre, randomised, controlled trial","authors":"Sofia Amylidi-Mohr, Giulia Zennaro, Sophie Schneider, Luigi Raio, Beatrice Mosimann, Daniel Surbek","doi":"10.1016/s2213-8587(25)00063-4","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00063-4","url":null,"abstract":"<h3>Background</h3>In gestational diabetes, one of the key factors affecting perinatal outcomes is glycaemic control. We aimed to investigate the effect of real-time continuous glucose monitoring (rtCGM) on perinatal outcomes versus self-monitoring of blood glucose (SMBG).<h3>Methods</h3>In this open-label, randomised, controlled trial, we recruited pregnant individuals aged 18–45 years with gestational diabetes, according to the International Association of Diabetes and Pregnancy Study Groups criteria, from a university hospital in Bern, Switzerland. Participants were randomly assigned (1:1) to the rtCGM intervention group or the SMBG control group. Randomisation was done centrally on the basis of pre-pregnancy BMI, previous gestational diabetes, family history of type 2 diabetes, and ethnicity. The primary endpoint was a composite of perinatal outcomes: large for gestational age, macrosomia, polyhydramnios, neonatal hypoglycaemia, and stillbirth. Key secondary outcomes were patient preference and maternal glycaemic control. Analyses were conducted on an intention-to-treat basis. This trial is registered with <span><span>ClinicalTrials.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>, <span><span>NCT05037526</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>.<h3>Findings</h3>Between Sept 29, 2021, and June 11, 2024, 302 pregnant women with gestational diabetes were included in the study and randomly assigned to one of the groups. 156 participants were assigned to the rtCGM intervention group and 143 were assigned to the SMBG control group completed the study. Primary outcome data were available for 297 (99%) of 299 participants. The composite outcome did not differ significantly between the two groups (odds ratio 1·02 [95% CI 0·63–1·66]). The only adverse events were skin changes, occurring in six (4%) participants in the rtCGM intervention group and in one (<1%) participant in the SMBG control group (blinded device).<h3>Interpretation</h3>Our results show that the outcome in individuals with gestational diabetes is not improved by the use of rtCGM. However, individuals expressed a higher preference for the rtCGM device. This finding suggests that rtCGM could be offered to simplify the management of gestational diabetes. A cost-effectiveness study could address what method requires fewer resources. To our knowledge, this is the first randomised trial powered to evaluate the efficacy of rtCGM regarding pregnancy outcomes.<h3>Funding</h3>The University of Bern and the Swiss Diabetes Foundation.<h3>Translation</h3>For the German translation of the abstract see Supplementary Materials section.","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"57 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Copenhagen Declaration: a transformative vision for global diabetes","authors":"K M Venkat Narayan","doi":"10.1016/s2213-8587(25)00137-8","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00137-8","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"21 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefan R Bornstein, Amit Kumar Dey, Charlotte Steenblock, Viswanathan Mohan, Ranjit Mohan Anjana, Peter E H Schwarz
{"title":"Artificial intelligence and diabetes: time for action and caution","authors":"Stefan R Bornstein, Amit Kumar Dey, Charlotte Steenblock, Viswanathan Mohan, Ranjit Mohan Anjana, Peter E H Schwarz","doi":"10.1016/s2213-8587(25)00142-1","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00142-1","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"31 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The obesity drug craze in Brazil","authors":"Heather Van Epps","doi":"10.1016/s2213-8587(25)00124-x","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00124-x","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"19 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to Lancet Diabetes Endocrinol 2025; 13: 307–20","authors":"","doi":"10.1016/s2213-8587(25)00158-5","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00158-5","url":null,"abstract":"<em>Jolliffe DA, Camargo CA Jr, Sluyter JD, et al. Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of stratified aggregate data. Lancet Diabetes Endocrinol 2025;</em> 13: <em>307–20</em>—In this Article, the affiliation for Prof Rachel E Neale has been corrected. This correction has been made to the online version as of May 16, 2025.","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"127 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}