The Lancet Diabetes & Endocrinology最新文献

{"title":"Diabetes prevention: current promise and future directions","authors":"Mary Beth Weber","doi":"10.1016/s2213-8587(25)00055-5","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00055-5","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"8 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effects and effect heterogeneity of lifestyle and metformin interventions on type 2 diabetes incidence over 21 years in the US Diabetes Prevention Program randomised clinical trial","authors":"William C Knowler, Lindsay Doherty, Sharon L Edelstein, Peter H Bennett, Dana Dabelea, Mary Hoskin, Steven E Kahn, Rita R Kalyani, Catherine Kim, F Xavier Pi-Sunyer, Sridharan Raghavan, Vallabh O Shah, Marinella Temprosa, Elizabeth M Venditti, David M Nathan","doi":"10.1016/s2213-8587(25)00022-1","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00022-1","url":null,"abstract":"<h3>Background</h3>In the US Diabetes Prevention Program (DPP), a 3-year randomised clinical trial in 3234 adults with prediabetes, type 2 diabetes incidence was reduced by 58% with intensive lifestyle intervention (ILS) and by 31% with metformin, compared with placebo. We sought to assess the long-term effects and potential heterogeneity of treatment effects over approximately 21 years of follow-up.<h3>Methods</h3>The DPP trial was continued with protocol modifications as the DPP Outcomes Study (DPPOS). In the DPPOS, placebo was discontinued, metformin (850 mg twice a day as tolerated) was continued after unmasking, and group-based booster intervention classes were offered to the ILS group twice a year; additionally, all participants were offered group-based lifestyle intervention four times a year. The prespecified primary outcome during DPP and DPPOS was diabetes incidence defined by American Diabetes Association criteria. The DPPOS protocol specified continued diabetes incidence as an outcome; Feb 23, 2020, was chosen as the closing date for the present analysis, as a date prior to the COVID-19 pandemic, which caused major disruptions in clinic visits and complicated longitudinal data analyses. We assessed long-term persistence of intervention effects on diabetes incidence, and heterogeneity of effects in subgroups defined by baseline diabetes risk factors. Follow-up is reported for the combined study from July 31, 1996, to Feb 23, 2020, and analysis was by intention to treat. The trial is registered with <span><span>ClinicalTrials.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>, <span><span>NCT00004992</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> (DPP) and <span><span>NCT00038727</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> (DPPOS); follow-up is ongoing but the trial is closed to enrolment except for previous DPP participants.<h3>Findings</h3>3195 participants originally enrolled in the DPP were included in the present analyses. This population comprised 2171 (67·9%) female participants and 1024 (32·1%) male participants, with a mean baseline age of 50·6 years (SD 10·7). Individual follow-up times ranged from 0·2 to 23·2 years (median 8·0 years [IQR 3·0 to 18·0]); remaining numbers at risk decreased sharply after 21 years because of administrative censoring and thus follow-up was considered to represent a 21-year period. During follow-up, compared with placebo, diabetes incidence rate was reduced in the original ILS group (hazard ratio [HR] 0·76 [95","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"69 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosing arginine vasopressin deficiency and primary polydipsia","authors":"Kay Weng Choy, Cherie Chiang","doi":"10.1016/s2213-8587(25)00067-1","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00067-1","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"252 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel diagnostic score for diagnosing arginine vasopressin deficiency (central diabetes insipidus) or primary polydipsia with basal laboratory parameters and a novel diagnostic score: results from two international multicentre prospective diagnostic studies","authors":"Cihan Atila, Irina Chifu, Juliana B Drummond, Deborah R Vogt, Uri Nahum, Martin Fassnacht, Bettina Winzeler, Julie Refardt, Mirjam Christ-Crain","doi":"10.1016/s2213-8587(25)00053-1","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00053-1","url":null,"abstract":"<h3>Background</h3>Distinguishing arginine vasopressin deficiency (central diabetes insipidus) from primary polydipsia is challenging. There is no validated initial laboratory assessment or diagnostic score to rule-in or rule-out arginine vasopressin deficiency during the first consultation. Therefore, this study aimed to evaluate the diagnostic potential of basal laboratory parameters and to develop a practical diagnostic score.<h3>Methods</h3>Data from two international multicentre studies of patients with arginine vasopressin deficiency and primary polydipsia undergoing the hypertonic saline test were used to evaluate the diagnostic potential of basal laboratory tests and to develop a score incorporating laboratory results, symptoms, and medical history. CODDI was a non-randomised, controlled, diagnostic, international, multicentre non-inferiority study in 11 tertiary medical centres in Switzerland, Germany, and Brazil. CARGOx was a randomised, controlled, cross-over, diagnostic, international, multicentre non-inferiority study across seven tertiary medical centres in Switzerland, Germany, the Netherlands, Italy, the UK, and Brazil. Participants were adult patients with polydipsia (>3 L per day) and hypotonic polyuria (>50 mL/kg bodyweight in 24 h and urine osmolality <800 mOsm/kg) and adult patients with a previous diagnosis of arginine vasopressin deficiency. Data were derived from the initial consultation and a basal laboratory test. For each laboratory parameter, the cutoffs resulting in the highest specificity at 100% sensitivity and the highest sensitivity at 100% specificity were identified. For the diagnostic score, the overall best cutoff, high-sensitivity cutoff (≥95% sensitivity), and high-specificity cutoff (≥95% specificity) were identified. Each cutoff was derived from the first study (development), and their performance was determined in the second study (validation). The final score included the sum of: basal plasma sodium multiplied by plasma osmolality, divided by 100; –50 points for plasma copeptin more than 4·9 pmol/L; +30 points for nycturia (≥3 times per night) or +20 points for nycturia (2 times per night); +20 points for sudden polyuria or polydipsia onset; +30 points for drinking more than 1 L per night; +50 points for anterior pituitary dysfunction and +50 points for pituitary surgery history. The diagnostic performance in predicting arginine vasopressin deficiency was examined by the receiver operating characteristic (ROC) area under the curve (AUC) and by sensitivity and specificity. The studies were registered with <span><span>ClinicalTrials.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> (<span><span>NCT01940614</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"16 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disproportionate increase in BMI of ≥60 kg/m2 in the USA","authors":"Michael Kachmar, Vance L Albaugh, Shengping Yang, Florina Corpodean, Steven B Heymsfield, Peter T Katzmarzyk, David S Freedman, Philip R Schauer","doi":"10.1016/s2213-8587(25)00069-5","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00069-5","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"8 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes and frailty in an ageing world","authors":"","doi":"10.1016/s2213-8587(25)00094-4","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00094-4","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"2 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A call for increased involvement of people with obesity and neurodiversity in policy, research, and practice","authors":"Stuart W Flint, Joe Naglowski, Kim Murray, Juliana Simonetti","doi":"10.1016/s2213-8587(25)00088-9","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00088-9","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"108 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compassionate care in obesity management: reclaiming humanity in health care","authors":"Sean Wharton, Brunna Boaventura, Ximena Ramos Salas, Sarah Le Brocq, Shane Sinclair, Fatima Cody Stanford","doi":"10.1016/s2213-8587(25)00089-0","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00089-0","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"19 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-onset type 2 diabetes and frailty","authors":"Giuseppe Maltese, Janaka Karalliedde, Shivani Misra, Peter Hanlon","doi":"10.1016/s2213-8587(25)00086-5","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00086-5","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"26 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 diabetes and accelerated ageing in skeletal muscle","authors":"Joseph Henson, Luke A Baker, Emma Watson, Thomas Yates, Melanie J Davies","doi":"10.1016/s2213-8587(25)00061-0","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00061-0","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"26 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}