Korean Journal of Internal Medicine最新文献_第9页

Current status of modifiable risk factors for cardiovascular disease in Korean women. 韩国妇女心血管疾病可改变风险因素的现状。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-01-01 Epub Date: 2024-10-22 DOI: 10.3904/kjim.2024.077

In-Jeong Cho, Mi-Seung Shin

引用次数: 0

Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample Cohort. 抑酸药物与牛皮癣风险的关系：韩国国民健康保险服务国家样本队列的回顾性研究

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-01-01 DOI: 10.3904/kjim.2024.096

Ji Hyun Kim, Joon-Hong Min, Young Woo Jo, Jae Woo Kwon, Young Her

{"title":"Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample Cohort.","authors":"Ji Hyun Kim, Joon-Hong Min, Young Woo Jo, Jae Woo Kwon, Young Her","doi":"10.3904/kjim.2024.096","DOIUrl":"10.3904/kjim.2024.096","url":null,"abstract":"Background/aims: Psoriasis is a common inflammatory skin disorder following non-specific triggers. Involvement of immune system is widely accepted for pathogenesis studies have demonstrated importance of gut microbiota in pathogenesis of inflammatory skin diseases. Proton pump inhibitor (PPI) and histamine-2 receptor antagonist (H2RA) are acid-suppressive drugs widely used for acid related gastrointestinal diseases, and prolonged use has been associated with altered gut microbiota. This study aimed to investigate association between psoriasis and acid suppressing drugs in Korean population.Methods: This study was conducted with 3,662 patients diagnosed with psoriasis between 2002 and 2013 in NHIS-NSC. A total of 14,648 controls were matched at 1:4 based on sex, age, and gastrointestinal disease. ORs were estimated to determine the association between acid suppressing drug use and psoriasis.Results: Our study found a statistically significant association between the prolonged use of acid-suppressive drugs and the development of psoriasis in the Korean population. Specifically, patients with gastrointestinal diseases who used histamine-2 receptor antagonists (H2RA) or proton pump inhibitors (PPI) for extended periods exhibited a higher risk of developing psoriasis. The adjusted odds ratio for psoriasis was 1.89 (95% CI, 1.66-2.17) with long-term use, indicating a clear dose-response relationship.Conclusion: Results from our study indicate that prolonged use of H2RA or PPI is associated with the risk of psoriasis among patients with gastrointestinal diseases in Korean population. The risk was increased in dose-response trend after adjusting for confounding variables. Clinicians should be aware of risks associated with prolonged use of acid suppressing drugs.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 1","pages":"57-64"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening and diagnosis of atrial fibrillation using wearable devices. 使用可穿戴设备筛查和诊断心房颤动。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-01-01 Epub Date: 2024-05-03 DOI: 10.3904/kjim.2023.521

Yoon Jung Park, Myung Hwan Bae

引用次数: 0

Incidence and risk factors of immune checkpoint inhibitor-induced colitis in Korean patients with cancer. 韩国癌症患者免疫检查点抑制剂诱导结肠炎的发病率及危险因素

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-01-01 DOI: 10.3904/kjim.2024.135

Tae Kyun Kim, Hyun Seok Lee, Eun Soo Kim

{"title":"Incidence and risk factors of immune checkpoint inhibitor-induced colitis in Korean patients with cancer.","authors":"Tae Kyun Kim, Hyun Seok Lee, Eun Soo Kim","doi":"10.3904/kjim.2024.135","DOIUrl":"10.3904/kjim.2024.135","url":null,"abstract":"Background/aims: Immune checkpoint inhibitors (ICIs) are effective in treating cancer. However, various immune-related adverse events (irAEs) have become prevalent, with ICI-induced colitis being the most common gastrointestinal irAE. Thus, we aimed to investigate the incidence and risk factors of ICI-induced colitis in Korean patients with cancer.Methods: This retrospective study included patients treated with ICIs between October 2015 and June 2022 in two tertiary referral centers in Daegu, Korea. The incidence of ICI-induced colitis was determined using electronic medical records. Risk factors for ICI-induced colitis were identified using univariate and multivariate logistic regression analyses.Results: We included 1,478 patients with ICI-treated cancer. The incidence of ICI-induced colitis was 3.5% (n = 52/1,478). Multivariate logistic regression analysis showed that the combination of nivolumab and ipilimumab was a risk factor for ICI-induced colitis (p = 0.006; odds ratio, 9.768; 95% confidence interval, 1.93-49.30).Conclusion: ICI-induced colitis had an incidence rate of 3.5% and was associated with the combination of nivolumab and ipilimumab. Most patients with ICI-induced colitis developed mild symptoms that improved with supportive care alone, making ICI therapy resumption possible.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 1","pages":"49-56"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reclassification of the overlap syndrome of Behçet's disease and antineutrophil cytoplasmic antibody-associated vasculitis in patients with Behçet's disease. behet病患者重叠综合征与抗中性粒细胞细胞质抗体相关性血管炎的再分类

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-01-01 DOI: 10.3904/kjim.2024.011

Tae Geom Lee, Jang Woo Ha, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee

{"title":"Reclassification of the overlap syndrome of Behçet's disease and antineutrophil cytoplasmic antibody-associated vasculitis in patients with Behçet's disease.","authors":"Tae Geom Lee, Jang Woo Ha, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee","doi":"10.3904/kjim.2024.011","DOIUrl":"10.3904/kjim.2024.011","url":null,"abstract":"Background/aims: This study applied the 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) criteria for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) to patients with Behçet's disease (BD) to investigate the proportion and clinical implications of the reclassification to the overlap syndrome of BD and AAV (OS-BD-AAV).Methods: We included 280 BD patients presenting with ANCA positivity but without medical conditions mimicking AAV at diagnosis. Demographic data, items from the 2014 revised International Criteria for BD and 2022 American College of Rheumatology and European Alliance of Associations for Rheumatology criteria for AAV, ANCA positivity, and laboratory results were recorded as clinical data at diagnosis. A total score ≥ 5 indicated microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA), whereas a total score ≥ 6 indicated a diagnosis of eosinophilic GPA (EGPA).Results: The overall reclassification rate of OS-BD-AAV was 8.6%. Of the 280 patients, 16 (5.7%) and 8 (2.9%) were reclassified as having OS-BD-MPA and OS-BD-GPA, respectively; none were classified as having OS-BD-EGPA. ANCA, myeloperoxidase-ANCA (P-ANCA), proteinase 3-ANCA (C-ANCA) positivity, hearing loss, and interstitial lung disease (ILD) at diagnosis were more common in patients with OS-BD-AAV than in those without. ANCA positivity and ILD at BD diagnosis contributed to the reclassification of OS-BD-AAV. However, hearing loss was not considered a major contributor to BD due to its possibility of developing as a manifestation of BD.Conclusion: To our knowledge, this is the first study to demonstrate the reclassification rate (8.6%) of patients with BD and ANCA results at diagnosis as OS-BD-AAV.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 1","pages":"135-147"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcome of interstitial lung disease in patients with primary Sjögren's syndrome: a retrospective observational study. 原发性斯约格伦综合征患者间质性肺病的长期预后：一项回顾性观察研究。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI: 10.3904/kjim.2023.402

Jung Hee Koh, Youngjae Park, Jennifer Lee, Howook Jeon, Su-Jin Moon, Yong Hyun Kim, Jun-Ki Min, Sung-Hwan Park, Seung-Ki Kwok

{"title":"Long-term outcome of interstitial lung disease in patients with primary Sjögren's syndrome: a retrospective observational study.","authors":"Jung Hee Koh, Youngjae Park, Jennifer Lee, Howook Jeon, Su-Jin Moon, Yong Hyun Kim, Jun-Ki Min, Sung-Hwan Park, Seung-Ki Kwok","doi":"10.3904/kjim.2023.402","DOIUrl":"10.3904/kjim.2023.402","url":null,"abstract":"Background/aims: Interstitial lung disease (ILD) is a potentially serious but underdiagnosed manifestation of primary Sjögren's syndrome (pSS). This observational study investigated the prevalence and clinical course of ILD in pSS, together with prognostic factors.Methods: A multicenter, retrospective longitudinal study was performed using findings from baseline and follow-up pulmonary function tests and chest computed tomography. Predisposing factors for the development of ILD and acute exacerbation (AE) were identified using a logistic regression model. The risk factors for a significant decline of pulmonary function were determined by the Cox proportional hazard model.Results: A total of 1,306 patients with pSS were included in this study (female, 98%; mean age, 54 years). Among them, 79 patients with pSS were comorbid with ILD. ILD was more frequently found in male, older patients. Nonspecific interstitial pneumonia was the most prevalent imaging pattern in pSS-ILD (51%), followed by usual interstitial pneumonia (22%). At diagnosis with pSS-ILD, 54% of patients had restrictive pulmonary function, and 41% of patients initiated pharmacological treatment. During the median 4-year follow-up period, AE, a significant decline in pulmonary function, and death occurred in 19%, 29%, and 9% of patients with pSS-ILD, respectively. The neutrophil-to-lymphocyte ratio (NLR) increased 3 months prior to AE, and it was associated with AE. Older age at pSS-ILD diagnosis was a prognostic factor for a significant decline in pulmonary function.Conclusion: ILD accounted for 6% of the comorbidity of pSS. AE was associated with a significant decline in pulmonary function, and the NLR may predict AE.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"148-159"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The characteristics of Korean elderly multiple myeloma patients aged 80 years or over. 80岁及以上韩国老年多发性骨髓瘤患者的特点。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-01-01 DOI: 10.3904/kjim.2024.041

Sang Hwan Lee, Hee-Jeong Cho, Joon Ho Moon, Ji Yoon Jung, Min Kyoung Kim, Mi Hwa Heo, Young Rok Do, Yunhwi Hwang, Sung Hwa Bae

{"title":"The characteristics of Korean elderly multiple myeloma patients aged 80 years or over.","authors":"Sang Hwan Lee, Hee-Jeong Cho, Joon Ho Moon, Ji Yoon Jung, Min Kyoung Kim, Mi Hwa Heo, Young Rok Do, Yunhwi Hwang, Sung Hwa Bae","doi":"10.3904/kjim.2024.041","DOIUrl":"10.3904/kjim.2024.041","url":null,"abstract":"Background/aims: Multiple myeloma (MM) predominantly affects elderly individuals, but studies on older patients with MM are limited. The clinical characteristics and survival outcomes of patients with MM aged 80 years or over were retrospectively analyzed.Methods: This retrospective multicenter study was conducted to investigate the clinical characteristics, treatment patterns, and survival outcomes of patients aged 80 years or over who were newly diagnosed with MM at five academic hospitals in Daegu, Korea, between 2010 and 2019.Results: A total of 127 patients with a median age of 83 years (range, 80-93 yr) were enrolled: 52 (40.9%) with Eastern Cooperative Oncology Group Performance Status (ECOG PS) > 2, 84 (66.1%) with International Staging System (ISS) stage III disease, and 93 (73.2%) with a Charlson comorbidity index (CCI) > 4. Chemotherapy was administered to 86 patients (67.7%). The median overall survival was 9.3 months. Overall survival was significantly associated with ECOG PS > 2 (HR 2.26, 95% CI 1.43-3.59), ISS stage III (HR 1.99, 95% CI 1.18-3.34), and chemotherapy (HR 0.34, 95% CI 0.21-0.55). There was no statistically significant difference in event-free survival according to the type of anti-myeloma chemotherapy administered. The early mortality (EM) rate was 28.3%.Conclusion: Even in patients with MM aged 80 years or over, chemotherapy can result in better survival outcomes than supportive care. Patients aged ≥ 80 years should not be excluded from chemotherapy based on age alone. However, reducing EM in elderly patients with newly diagnosed MM remains challenging.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 1","pages":"115-123"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep appreciation to our reviewers in the past year. 衷心感谢过去一年的评审人员。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-01-01 DOI: 10.3904/kjim.2024.411

引用次数: 0

KJIM update 2025.

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-01-01 DOI: 10.3904/kjim.2024.405

Hyoung-Chul Oh

引用次数: 0

Stability, variability, and treatment implications of the blood eosinophil count in Korean patients with chronic obstructive pulmonary disease. 韩国慢性阻塞性肺疾病患者嗜酸性粒细胞计数的稳定性、变异性和治疗意义

IF 2.2 4区医学