Lancet Global HealthPub Date : 2026-08-01Epub Date: 2026-05-22DOI: 10.1016/j.langlo.2026.104002
{"title":"Correction to Lancet Glob Health 2026; 14: e552-59.","authors":"","doi":"10.1016/j.langlo.2026.104002","DOIUrl":"10.1016/j.langlo.2026.104002","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":" ","pages":"104002"},"PeriodicalIF":22.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148007007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lancet Global HealthPub Date : 2026-08-01Epub Date: 2026-06-30DOI: 10.1016/j.langlo.2026.104000
Alehandrea Raiha Manuel
{"title":"Confronting an epidemiological paradox in Indigenous sensory health.","authors":"Alehandrea Raiha Manuel","doi":"10.1016/j.langlo.2026.104000","DOIUrl":"10.1016/j.langlo.2026.104000","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":" ","pages":"104000"},"PeriodicalIF":22.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lancet Global HealthPub Date : 2026-08-01Epub Date: 2026-06-30DOI: 10.1016/j.langlo.2026.103960
Richard Kha, Oonagh Macken, Alemka Davis, Gary Low, Yasemin Kapucu, Colina Waddell, Tim Fricke, Lauren Carr, Eleanor Yang, John Newall, Andrew White, Lisa Keay, Bamini Gopinath, Gerald Liew, Paul Mitchell
{"title":"Prevalence of vision and hearing impairment in Australia: a nationally representative survey of Indigenous and non-Indigenous Australians aged 50 years and older.","authors":"Richard Kha, Oonagh Macken, Alemka Davis, Gary Low, Yasemin Kapucu, Colina Waddell, Tim Fricke, Lauren Carr, Eleanor Yang, John Newall, Andrew White, Lisa Keay, Bamini Gopinath, Gerald Liew, Paul Mitchell","doi":"10.1016/j.langlo.2026.103960","DOIUrl":"10.1016/j.langlo.2026.103960","url":null,"abstract":"<p><strong>Background: </strong>Vision and hearing impairment are leading causes of disability, yet nationally representative data in Australia, particularly among Indigenous peoples, are scarce. The Australian Eye and Ear Health Survey aimed to estimate prevalence and risk factors of vision impairment and hearing impairment among Indigenous and non-Indigenous adults aged 50 years and older nationwide.</p><p><strong>Methods: </strong>This cross-sectional survey used stratified, multistage, random cluster sampling and was conducted across 30 sites in Australia. Stratification was done by geographical location and by Indigenous status to achieve national representativeness. Participants were systematically assessed for any vision impairment (presenting visual acuity <6/12 in the better eye), and any hearing impairment, and moderate or worse hearing impairment (pure tone average>25 decibels hearing level [dB HL], and >40 dB HL in the better ear), respectively. Door-to-door recruitment was the primary recruitment method. Crude and age-standardised prevalence estimates were calculated. Multivariable logistic regression models identified risk and protective factors.</p><p><strong>Findings: </strong>Between Aug 1, 2022, and March 31, 2025, a total of 4519 of 6128 eligible participants were recruited, of whom 617 (13·6%) participants were Indigenous (53·2% [328 participants] female vs 46·8% [289 participants] male; mean age 63·8 [SD 10·6] years) and 3902 (86·4%) participants were non-Indigenous (54·8% [2137 participants] female vs 45·2% [1765 participants] male; mean age 70·5 [9·8] years). The age-standardised prevalence of any vision impairment was 11·1% (95% CI 8·4-14·5) among Indigenous participants, 3·9% (3·3-4·6) among non-Indigenous participants, and 5·2% (4·5-6·0) overall. Any vision impairment was 2·9-times more prevalent among Indigenous than non-Indigenous Australians. The age-standardised prevalences of any hearing impairment, and moderate or worse hearing impairment were 42·8% (95% CI 36·8-49·5) and 14·3% (11·0-18·4) in Indigenous participants; 39·4% (37·3-41·8) and 13·2% (12·0-14·5) in non-Indigenous participants, and 41·7% (39·6-43·9) and 14·2% (13·1-15·5) overall, respectively. Among younger Indigenous participants, moderate or worse hearing impairment was almost three-fold higher than in similarly aged non-Indigenous participants (9·4% [95% CI 5·3-15·8] vs 3·2% [1·8-5·5] among individuals aged 50-59 years), and two-fold higher for Indigenous participants aged 60-69 years (14·3% [9·7-20·4] vs 6·9% [5·4-8·8]). Multivariable-adjusted risk factors in the whole sample were increasing age (both vision impairment and hearing impairment), having diabetes (both), current smoking (hearing impairment), and residence in remote locations (vision impairment). Protective factors were attainment of tertiary education (both), having private health insurance (both), attending an eye examination in the last 12 months (vision impairment), and female sex (hea","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":" ","pages":"103960"},"PeriodicalIF":22.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lancet Global HealthPub Date : 2026-08-01Epub Date: 2026-06-15DOI: 10.1016/j.langlo.2026.103997
Shannon E Majowicz, Josh M Colston, Martyn D Kirk, Sara M Pires, Yuki Minato, Luria L Founou, Brecht Devleesschauwer, Carlotta di Bari, Teresa Estrada-Garcia, Louise Vaes, Arie H Havelaar, Charlee Roberts, Tesfaye Gobena, Ashok Kumar, Fadi Al Natour, Robin J Lake, Gabriela F Nane, Lucy J Robertson, Kim Fernandez, Elaine Scallan Walter, Margaret Kosek
{"title":"WHO estimates of the global, regional, and national burden of 14 foodborne diarrhoeal enteric hazards, 2000-21: an updated data synthesis.","authors":"Shannon E Majowicz, Josh M Colston, Martyn D Kirk, Sara M Pires, Yuki Minato, Luria L Founou, Brecht Devleesschauwer, Carlotta di Bari, Teresa Estrada-Garcia, Louise Vaes, Arie H Havelaar, Charlee Roberts, Tesfaye Gobena, Ashok Kumar, Fadi Al Natour, Robin J Lake, Gabriela F Nane, Lucy J Robertson, Kim Fernandez, Elaine Scallan Walter, Margaret Kosek","doi":"10.1016/j.langlo.2026.103997","DOIUrl":"10.1016/j.langlo.2026.103997","url":null,"abstract":"<p><strong>Background: </strong>Foodborne diseases cause significant illness and death globally. We updated WHO estimates of the burden caused by diarrhoeal hazards commonly transmitted by food: Campylobacter jejuni, Campylobacter coli, and other thermotolerant Campylobacter species; Cryptosporidium spp; Cyclospora cayetanensis; Entamoeba histolytica; enteroaggregative Escherichia coli; enteropathogenic E coli; enterotoxigenic E coli; Giardia duodenalis; norovirus; rotavirus; non-typhoidal Salmonella enterica; Shiga toxin-producing E coli; Shigella spp; and Vibrio cholerae.</p><p><strong>Methods: </strong>We estimated illnesses, deaths, and disability-adjusted life-years (DALYs) for 194 countries for the period 2000-21 using data from systematic reviews; the Global Burden of Diseases, Injuries, and Risk Factors Study 2021; a structured expert judgement study; and country consultations. We used disease-specific computational models, and a hierarchical meta-regression model with geographical clustering, a global linear time trend, and uncertainty propagation.</p><p><strong>Findings: </strong>In 2021, the 14 diarrhoeal hazards caused 666 million (95% UI 483-884) illnesses, 265 000 deaths (196 000-351 000), and 15·2 million (11·6-19·1) DALYs from foodborne transmission. Shigella spp, Campylobacter, and rotavirus caused the most DALYs from foodborne transmission. The greatest burden was in the African region (773·5 DALYs [95% UI 559·7-1033·3] per 100 000 population due to foodborne transmission). Mortality rates were 7·1 times higher and DALY rates 18·9 times higher in children younger than 5 years than in people aged 5 years or older. While the overall foodborne burden decreased between 2000 (692·3 DALYs [517·9-938·1] per 100 000 population) and 2021 (193·6 [147·2-243·0] per 100 000), this trend was not consistent for all hazards.</p><p><strong>Interpretation: </strong>Diarrhoeal hazards continue to cause a substantial foodborne disease burden, despite decreases over time. Children in low-income countries bear the greatest burden. Prevention requires concerted efforts, including expanding global diarrhoeal disease prevention efforts beyond water, sanitation, and hygiene and vaccination to include improvements in the safety of the food supply.</p><p><strong>Funding: </strong>WHO.</p>","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":" ","pages":"103997"},"PeriodicalIF":22.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lancet Global HealthPub Date : 2026-08-01Epub Date: 2026-06-03DOI: 10.1016/j.langlo.2026.103994
Robin J Lake, Brecht Devleesschauwer, Shannon E Majowicz, Lucy J Robertson, Lea Sletting Jakobsen, Antonio Agudo, Sara M Pires, Martyn D Kirk, Elaine Scallan Walter, Karen H Keddy, Carlotta di Bari, Louise Vaes, Arie H Havelaar, Charlee Roberts, Tesfaye Gobena, Mirjam E Kretzschmar, Gabriela F Nane, Sandra Hoffmann, Lapo Mughini-Gras, Banchob Sripa, Kunihiro Kubota, Luria Leslie Founou, Li Bai, Mohammed Al Huthiel, Tety Rachmawati, Teresa Estrada-Garcia, Ashok Kumar, Fadi Al Natour, Steven Jaffee, Spencer Henson, Luc Ingenbleek, Richard Kumapley, Elaine Borghi, Yuki Minato
{"title":"WHO estimates of the global, regional, and national burden of 42 foodborne infectious and chemical hazards, 2000-21: an updated data synthesis.","authors":"Robin J Lake, Brecht Devleesschauwer, Shannon E Majowicz, Lucy J Robertson, Lea Sletting Jakobsen, Antonio Agudo, Sara M Pires, Martyn D Kirk, Elaine Scallan Walter, Karen H Keddy, Carlotta di Bari, Louise Vaes, Arie H Havelaar, Charlee Roberts, Tesfaye Gobena, Mirjam E Kretzschmar, Gabriela F Nane, Sandra Hoffmann, Lapo Mughini-Gras, Banchob Sripa, Kunihiro Kubota, Luria Leslie Founou, Li Bai, Mohammed Al Huthiel, Tety Rachmawati, Teresa Estrada-Garcia, Ashok Kumar, Fadi Al Natour, Steven Jaffee, Spencer Henson, Luc Ingenbleek, Richard Kumapley, Elaine Borghi, Yuki Minato","doi":"10.1016/j.langlo.2026.103994","DOIUrl":"10.1016/j.langlo.2026.103994","url":null,"abstract":"<p><strong>Background: </strong>Foodborne diseases are important causes of illness and death. The first estimates of their burden were published by WHO in 2015. We updated WHO estimates of the global, regional, subregional, and national foodborne disease burden caused by 42 infectious and chemical hazards in 2021, including time trends for 2000-21.</p><p><strong>Methods: </strong>We provide a high-level summary of foodborne disease burden, expressed as incidence, deaths, and disability-adjusted life-years (DALYs). Data for burden estimation were provided from a WHO-commissioned series of systematic reviews on the incidence, aetiology, sequelae, and case fatality or mortality of the hazards. Data were analysed using hierarchical meta-regression modelling with geographical clustering and a global linear time trend, disease-specific computational models, and uncertainty propagation through Monte Carlo simulations to calculate 95% uncertainty intervals. Attribution to foodborne transmission was principally based on a structured expert judgement process. Economic impact was measured as lost productivity.</p><p><strong>Findings: </strong>For 2021, foodborne transmission of the 42 hazards caused 866 million (95% uncertainty interval 680-1090) illnesses, 1·52 million (0·783-2·51) deaths, and 57·1 million (39·4-81·1) DALYs. Inorganic arsenic, lead, and non-typhoidal Salmonella enterica (diarrhoeal and invasive disease) resulted in the most DALYs. The greatest burden of foodborne disease was in the African and South-East Asia regions. The incidence in children younger than 5 years was 2·7 times higher than in people aged 5 years or older, resulting in 4·3 times the rate of DALYs. The total burden from all hazards decreased over time. In 2021, these 42 hazards resulted in productivity losses of US$310 billion in nominal terms, and US$647 billion after adjusting for purchasing power parity.</p><p><strong>Interpretation: </strong>Foodborne diseases causes a burden similar to that from tuberculosis, HIV and AIDS, or malaria. The high burden of both communicable and non-communicable foodborne diseases requires countries to prioritise developing strategies to improve the safety of the food supply.</p><p><strong>Funding: </strong>WHO.</p>","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":" ","pages":"103994"},"PeriodicalIF":22.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13433341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lancet Global HealthPub Date : 2026-08-01Epub Date: 2026-06-18DOI: 10.1016/j.langlo.2026.104010
Jessica O'Logbon, Alexandra Ridout, Kate Bramham, Kypros Nicolaides, Eugene Oteng-Ntim
{"title":"Low-dose aspirin in pregnant women with sickle cell disease: timing, translation, and access.","authors":"Jessica O'Logbon, Alexandra Ridout, Kate Bramham, Kypros Nicolaides, Eugene Oteng-Ntim","doi":"10.1016/j.langlo.2026.104010","DOIUrl":"10.1016/j.langlo.2026.104010","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":" ","pages":"104010"},"PeriodicalIF":22.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148279345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew Medina-Marino, Sharon Olifant, Maria Pieruccini, Kuhle Fiphaza, Nondumiso Ngcelwane, Morten Ruhwald, Adam Penn-Nicholson, Bernard Fourie
{"title":"In-home tongue swab testing for tuberculosis screening among household contacts in South Africa: a prospective cohort study.","authors":"Andrew Medina-Marino, Sharon Olifant, Maria Pieruccini, Kuhle Fiphaza, Nondumiso Ngcelwane, Morten Ruhwald, Adam Penn-Nicholson, Bernard Fourie","doi":"10.1016/j.langlo.2026.103988","DOIUrl":"10.1016/j.langlo.2026.103988","url":null,"abstract":"<p><strong>Background: </strong>Household contact investigation for tuberculosis is limited by reliance on clinic-based testing and sputum-dependent diagnostics. To inform household-level screening strategies, we estimated the diagnostic accuracy of in-home molecular testing using tongue swabs compared with sputum, and quantified linkage to care among household contacts with confirmed tuberculosis.</p><p><strong>Methods: </strong>We conducted a prospective cohort study at 26 government health clinics in South Africa. We recruited index patients with drug-sensitive pulmonary tuberculosis and their household contacts. Participants aged 18 years or older and not on tuberculosis treatment within the past 6 months were eligible. Household contacts provided tongue swabs and, where possible, sputum specimens during household visits. Xpert MTB/RIF Ultra on GeneXpert Omni or Edge devices were used. Tongue swabs were tested individually or in pools of up to three participants, whereas sputa were tested individually. The primary outcome was the estimated diagnostic accuracy (ie, sensitivity and specificity) of tongue swab testing compared with sputum using paired results, irrespective of pooling strategy. Secondary outcomes included performance of pooled tongue swab testing as a household-level screening strategy (defined by conditional detection of tuberculosis by pool size and the residual probability of underlying tuberculosis following a negative pooled result) and linkage to care (defined as the proportion of individuals with a positive sputum result presenting for clinic-based tuberculosis services and their time-to-clinic presentation).</p><p><strong>Findings: </strong>Between June 15, 2021, and Oct 29, 2024, 438 households and 909 household contacts were enrolled. The median age of household contacts was 39 years (IQR 28-55), 570 (62·7%) of 909 were female and 338 (37·2%) were male, 377 (41·5%) were symptomatic, 132 (14·5%) reported living with HIV, and 207 (22·8%) had a previous history of tuberculosis. Tongue swabs were obtained from 901 (99·1%) of 909 household contacts, whereas 292 (32·1%) produced sputum. Among 203 paired tongue swab-sputum results, sensitivity of tongue swab testing was 61·9% (95% CI 38·4-81·9) and specificity was 100% (98·9-100). Among individually tested tongue swabs paired with sputum results (58 paired tests), sensitivity was 100% (95% CI 47·8-100) and specificity was 100% (93·3-100). Among pooled tests in which at least one contributing participant was sputum-positive, five (55·6%) of nine for two-swab pools and three (42·9%) of seven for three-swab pools tested positive. Among pooled tests with a negative result, the residual probability of an underlying sputum-positive case was four (4·4%) of 91 for two-swab pools and four (9·5%) of 42 for three-swab pools. Sputum testing identified 29 (3·2%) of 909 household contacts with tuberculosis (all previously undiagnosed). Following referral, 25 (86·2%) of 29 presented for clin","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":" ","pages":"103988"},"PeriodicalIF":22.5,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148609076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jie Wang, Yikai Feng, Yihong Liu, Minmin Wang, Teck Chuan Voo, Tran Diep Tuan, Emmanuel S Baja, Sok King Ong, Victor Chee Wai Hoe, Sarawut Thepanondh, Chhea Chhorvann, Andreasta Meliala, Hla Hla Win, Mayfong Mayxay, Minghui Ren, Yinzi Jin
{"title":"From fragmentation to integration: regional health governance in southeast Asia.","authors":"Jie Wang, Yikai Feng, Yihong Liu, Minmin Wang, Teck Chuan Voo, Tran Diep Tuan, Emmanuel S Baja, Sok King Ong, Victor Chee Wai Hoe, Sarawut Thepanondh, Chhea Chhorvann, Andreasta Meliala, Hla Hla Win, Mayfong Mayxay, Minghui Ren, Yinzi Jin","doi":"10.1016/j.langlo.2026.104014","DOIUrl":"https://doi.org/10.1016/j.langlo.2026.104014","url":null,"abstract":"<p><p>Southeast Asia's regional health governance has evolved into a dense but weakly integrated system of overlapping institutions. This Health Policy paper maps the regional health governance of the Association of Southeast Asian Nations (ASEAN) as an evolving health regime complex, tracing the historical origins of regional health governance to the early 20th century and examining developments from 1980 to 2024. The study also identifies two structural features: functional specialisation along with persistent fragmentation and structural asymmetry, in which external actors dominate technical and agenda-setting roles while ASEAN retains coordination authority. Although recent reforms under the ASEAN Post-2015 Health Development Agenda have improved institutional alignment, system-wide coherence remains poor. Strengthening regional health governance will require institutional rationalisation to reduce duplication and strengthen underdeveloped functions, alongside a rebalancing of external engagement to restore regional ownership of policy priorities. The analytical approach developed in this Health Policy paper offers a transferable framework for other regions facing institutional proliferation. Policy efforts should shift from expanding arrangements towards managing complexity through coordination, functional differentiation, and clearer authority structures.</p>","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":" ","pages":"104014"},"PeriodicalIF":22.5,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global, regional, and national prevalence of peripheral arterial disease in 2023: an updated systematic review and modelling study.","authors":"Jiali Zhou,Xinyu Liu,Shiyi Shan,Tiantian He,Xuan Zhu,Longzhu Zhu,Aziz Sheikh,Kazem Rahimi,Peige Song,Igor Rudan","doi":"10.1016/j.langlo.2026.103983","DOIUrl":"https://doi.org/10.1016/j.langlo.2026.103983","url":null,"abstract":"BACKGROUNDPeripheral arterial disease is a growing public health concern. We aimed to provide updated estimates of peripheral arterial disease prevalence and case numbers at the global, regional, and national levels in 2023, and synthesise evidence on factors associated with peripheral arterial disease.METHODSIn this systematic review and modelling analysis, we searched PubMed, Embase, MEDLINE, CINAHL, Global Health, AMED, and ProQuest Dissertations and Theses Global for articles and grey literature published between April 30, 2019, and Dec 9, 2024, reporting peripheral arterial disease prevalence in the general population. This search was supplemented by eligible studies identified through relevant systematic reviews and manual reference screening. Studies were eligible if peripheral arterial disease was defined as an ankle-brachial index (ABI) lower than or equal to 0·90. Studies using hospital-based or clinical samples and studies conducted exclusively in populations with specific characteristics (eg, diabetes) were excluded. Two reviewers independently screened records for eligibility, extracted study-level data, and assessed the study quality using the Joanna Briggs Institute Critical Appraisal Checklist for Prevalence Studies. An age-sex splitting procedure was applied to disaggregate prevalence data. A multilevel multivariable mixed-effects meta-regression approach was used to examine the associations between age and peripheral arterial disease prevalence, stratified by sex and income level (high-income countries [HICs] and low-income and middle-income countries [LMICs]). Pooled odds ratios (ORs) for factors associated with peripheral arterial disease were estimated through a random-effects meta-analysis. Peripheral arterial disease prevalence at regional and national levels was derived using an associated factor-based distribution model. The study protocol was registered in PROSPERO (CRD420261290434).FINDINGSOf 12 733 records identified, 157 articles from 37 countries met the inclusion criteria, encompassing more than 9·7 million participants. In 2023, the global prevalence of peripheral arterial disease among individuals aged 25 years and older was 6·58% (95% CI 4·83-9·02), equivalent to 316·54 million (232·34-433·78) affected individuals. Peripheral arterial disease prevalence increased consistently with age, ranging from 4·31% (2·82-6·81) among those aged 25-29 years to 22·09% (15·50-30·26) among those aged 90-99 years, with a similar pattern in both sexes. Prevalence was slightly higher in women (6·79% [5·14-9·05]) than in men (6·37% [4·52-9·00]), and was higher in HICs (7·52% [5·57-10·45]) than in LMICs (6·33% [4·63-8·63]). Despite the lower prevalence in LMICs, these countries accounted for over three-quarters of the global peripheral arterial disease cases (239·35 million [175·11-326·50]). Four associated factors were incorporated into the distribution model, namely current smoking (OR 2·85 [95% CI 2·13-3·80]), diabetes (1·81 [1·63","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"32 1","pages":"103983"},"PeriodicalIF":34.3,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148539119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nelson Aghogho Evaborhene,Afifah Rahman-Shepherd,Luchuo Engelbert Bain,Shashika Bandara,Arush Lal
{"title":"PABS deferred: the rise of bilateralism and future of pandemic governance.","authors":"Nelson Aghogho Evaborhene,Afifah Rahman-Shepherd,Luchuo Engelbert Bain,Shashika Bandara,Arush Lal","doi":"10.1016/j.langlo.2026.104021","DOIUrl":"https://doi.org/10.1016/j.langlo.2026.104021","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"53 1","pages":"104021"},"PeriodicalIF":34.3,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148462662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}