Canadian Journal of Gastroenterology and Hepatology最新文献

{"title":"A2ML1 Inhibits Esophageal Squamous Cell Carcinoma Progression and Serves as a Novel Prognostic Biomarker.","authors":"Xiaoyun Zhang, Chaogui Tang, Jianchun Lian, Yuzhang Jiang","doi":"10.1155/2023/5557546","DOIUrl":"10.1155/2023/5557546","url":null,"abstract":"<p><p>Studies have established a correlation between <i>α</i>2-macroglobulin-like 1 (A2ML1) and the prognosis of lung, pancreatic, and breast cancers; however, research on its involvement in the pathogenesis of esophageal carcinoma remains limited. Therefore, in this study, we aimed to investigate the role of A2ML1 in the progression of esophageal squamous cell carcinoma (ESCC). Immunohistochemical staining was employed to assess the expression level of A2ML1 protein in both tumor and adjacent normal tissues of patients with ESCC. The Kaplan-Meier method, along with univariate and multivariate Cox risk ratio analyses, was used to determine survival rates and prognostic factors. Furthermore, two human ESCC cell lines, KYSE30 and KYSE150, were used to assess the effect of A2ML1 overexpression on cell proliferation and apoptosis. A human apoptosis antibody kit was also used to analyze the downstream action proteins of A2ML1, and a nude mouse xenotransplantation model was used to evaluate the effect of A2ML1 on ESCC tumorigenesis <i>in vivo</i>. The protein level of A2ML1 in ESCC tissues was significantly lower than that in normal esophageal tissues, and higher A2ML1 protein levels were associated with smaller ESCC tumor sizes and improved tumor-specific survival rates. Multivariate analysis established A2ML1 as a novel independent prognostic factor for ESCC. Moreover, A2ML1 overexpression significantly inhibited ESCC cell proliferation and promoted apoptosis. A2ML1 consistently inhibited tumor growth in mouse models. Furthermore, the human apoptotic antibody kit results showed increased expression of the proliferation-inhibiting protein p21 downstream of KYSE150 cells overexpressing A2ML1. Our findings demonstrate that a correlation exists between A2ML1 and ESCC prognosis and that A2ML1 plays an antitumor role in ESCC progression. This study underscores the potential of A2ML1 as a novel biomarker for predicting the prognosis of ESCC.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":"2023 ","pages":"5557546"},"PeriodicalIF":2.7,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>miR-325-3p</i> Reduces Proliferation and Promotes Apoptosis of Gastric Cancer Cells by Inhibiting Human Antigen R.","authors":"Zhengwei Huang,&nbsp;Yacan Luo,&nbsp;Congcong Chen,&nbsp;Chaoyang Zhou,&nbsp;Zhengkang Su,&nbsp;Chang Cai,&nbsp;Xi Li,&nbsp;Wenzhi Wu","doi":"10.1155/2023/6882851","DOIUrl":"https://doi.org/10.1155/2023/6882851","url":null,"abstract":"<p><p>Human antigen R (HuR), also known as ELAVL1, is a widely expressed RNA-binding protein (RBP) that has a significant impact on the development and advancement of tumors. Our previous study found that 5-fluorouracil (5-FU) may impede the proliferation and increase apoptosis in gastric cancer cells by reducing the nucleocytoplasmic shuttling of HuR. However, how posttranscriptional regulation influences HuR functions in gastric cancer remains to be elucidated. Here, we demonstrated that <i>miR-325-3p</i> has the potential to regulate the expression level of HuR by directly binding to its 3'UTR, which in turn led to a significant reduction in proliferation and an increase in apoptosis in gastric cancer cells. In addition, xenograft experiment showed that knockdown of HuR or overexpression of <i>miR-325-3p</i> group exhibited smaller tumor sizes after transplant of gastric cancer cells into zebrafish larvae. Thus, our findings offer new insights into the pathogenesis of gastric cancer and may potentially assist in identifying novel targets for drug therapy.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":"2023 ","pages":"6882851"},"PeriodicalIF":2.7,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential Dual Role of H2.0-like Homeobox in the Tumorgenesis and Development of Colorectal Cancer and Its Prognostic Value.","authors":"Shuo Chen,&nbsp;Lin Zhang,&nbsp;Kai Wang,&nbsp;Jizhen Huo,&nbsp;Siqi Zhang,&nbsp;Xipeng Zhang","doi":"10.1155/2023/5521544","DOIUrl":"10.1155/2023/5521544","url":null,"abstract":"<p><strong>Background: </strong><i>H2.0-like homeobox</i> (<i>HLX</i>) is highly expressed in several hematopoietic malignancies. However, the role of <i>HLX</i> in the carcinogenesis and progression of colorectal cancer (CRC) patients has rarely been reported.</p><p><strong>Methods: </strong>In this study, the data were collected from The Cancer Genome Atlas and Gene Expression Omnibus databases. The diagnostic value of <i>HLX</i> was analyzed by the R package \"pROC.\" The overall survival was estimated using the \"survival\" and \"survminer\" packages. A nomogram was established to predict 1-, 3-, and 5-year overall survival of CRC patients. The CIBERSORT software was employed to calculate the relative proportions of 22 immune cells.</p><p><strong>Results: </strong><i>HLX</i> expression was downregulated in CRC patients. Remarkably, <i>HLX</i> expression was increased with stage (stage I-stage III) of CRC, and the CRC patients with high <i>HLX</i> expression exhibited a poor prognosis. The promoter methylation level of <i>HLX</i> was prominently increased in CRC samples compared to paracancerous samples. We also found that the six miRNAs target <i>HLX</i> genes, leading to its downregulation, and <i>HLX</i> expression had a negative correlation with its downstream target gene <i>BRI3BP</i> in both CRC and normal samples. Finally, we found that the 12 immune infiltrating cells were observably different between high and low <i>HLX</i> expression groups. The <i>HLX</i> had a significant positive correlation with 8 immune checkpoints (PD-1 (PDCD1), CTLA4, PDL-1 (CD274), PDL-2 (PDCD1LG2), CD80, CD86, LAG3, and TIGIT) expressions.</p><p><strong>Conclusion: </strong><i>HLX</i> probably played a carcinostasis role in the early stages of CRC but exhibited a cancer-promoting effect in the advanced stages. Meanwhile, <i>HLX</i> could serve as a reliable prognostic indicator for CRC.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":"2023 ","pages":"5521544"},"PeriodicalIF":2.7,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Management Using Novel Haemostatic Agents for Immediate Bleeding during Endoscopic Retrograde Cholangio-Pancreatography.","authors":"Cosmas Rinaldi Adithya Lesmana, Sharon Sandra, Maria Satya Paramitha, Rino Alvani Gani, Laurentius A Lesmana","doi":"10.1155/2023/5212580","DOIUrl":"10.1155/2023/5212580","url":null,"abstract":"<p><p>Bleeding after endoscopic sphincterotomy (ES) remains as a major challenge during ERCP procedure. Standard endoscopic haemostatic procedures have demonstrated good performance for bleeding control. Novel endoscopic haemostatic agents have also been widely used in gastrointestinal bleeding management. Regardless, there is still a paucity of high-quality evidence evaluating the practicality of these agents in ERCP. This case series study was performed on the patients who underwent ERCP procedure in a tertiary referral private hospital within 2 years period. Post-ES immediate bleeding is defined as the onset of bleeding at the time of sphincterotomy. Treatment groups for post-ES bleeding are divided into (1) standard haemostatic methods and (2) novel haemostatic agents. There were 40 patients who received standard haemostatic treatment and 60 patients who received novel haemostatic agents. Initial haemostasis was achieved in all patients. Two patients who received standard haemostatic treatment had rebleeding. Meanwhile, no patients in novel haemostatic treatment group had rebleeding. In conclusion, novel haemostatic agent can be considered as an easy and practical method in daily practice, especially when an ERCP procedure is performed. Further studies with larger sample size which, if possible, can also include a cost-effectiveness analysis are still required to implement these agents as a standard procedure in clinical practice. (This abstract has been presented at the American College of Gastroenterology meeting October 2021).</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":"2023 ","pages":"5212580"},"PeriodicalIF":2.7,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9441672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and Analysis of Hepatocellular Carcinoma Prognostic Model Based on Random Forest.","authors":"Yikai Wang, Le Ma, Pengjun Xue, Bianni Qin, Ting Wang, Bo Li, Lina Wu, Liyan Zhao, Xiongtao Liu","doi":"10.1155/2023/6707698","DOIUrl":"10.1155/2023/6707698","url":null,"abstract":"<p><strong>Methods: </strong>Transcriptome data and clinical data of HCC were downloaded from the TCGA database. Screen important genes based on the random forest method, combined with differential expression genes (DEGs) to screen out important DEGs. The Kaplan‒Meier curve was used to evaluate its prognostic significance. Cox regression analysis was used to construct a survival prognosis prediction model, and the ROC curve was used to verify it. Finally, the mechanism of action was explored through GO and KEGG pathway enrichment and GeneMANIA coexpression analyses.</p><p><strong>Results: </strong>Seven important DEGs were identified, three were highly expressed and four were lowly expressed. Among them, GPRIN1, MYBL2, and GSTM5 were closely related to prognosis (<i>P</i> < 0.05). After the survival prognosis prediction model was established, the survival analysis showed that the survival time of the high-risk group was significantly shortened (<i>P</i> < 0.001), but the ROC analysis indicated that the model was not superior to staging. Twenty coexpressed genes were screened, and enrichment analysis indicated that glutathione metabolism was an important mechanism for these genes to regulate HCC progression.</p><p><strong>Conclusion: </strong>This study revealed the important DEGs affecting HCC progression and provided references for clinical assessment of patient prognosis and exploration of HCC progression mechanisms through the construction of predictive models and gene enrichment analysis.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":"2023 ","pages":"6707698"},"PeriodicalIF":2.7,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10805872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma S100A8 and S100A9 Are Strong Prognostic Factors for Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.","authors":"Yao Zhang,&nbsp;Xueyun Zhang,&nbsp;Jiajia Han,&nbsp;Yifei Guo,&nbsp;Jingjing He,&nbsp;Feifei Yang,&nbsp;Richeng Mao,&nbsp;Yuxian Huang,&nbsp;Jiming Zhang","doi":"10.1155/2023/6164611","DOIUrl":"https://doi.org/10.1155/2023/6164611","url":null,"abstract":"<p><strong>Objectives: </strong>The rapidly evolving organ failure and high short-run mortality of acute-on-chronic liver failure (ACLF) are inseparable from the role of systemic inflammatory response. S100A8 and S100A9 are associated with the excessive cytokine storm and play a decisive part within the process of inflammation. We aimed to clarify the role of them in predicting prognosis of hepatitis B virus-related ACLF (HBV-ACLF).</p><p><strong>Methods: </strong>S100A8 and S100A9 levels were analyzed in plasma of 187 transplant-free HBV-ACLF patients, 28 healthy controls and 40 chronic hepatitis B (CHB) patients. S100A8 and S100A9 mRNAs were checked in liver samples from 32 HBV-ACLF patients with liver transplantation, 19 patients undergoing surgery for hepatic hemangioma and 10 CHB patients with needle biopsy.</p><p><strong>Results: </strong>The plasma levels of the S100A8 and S100A9 were higher in HBV-ACLF patients than in CHB patients (S100A8 : <i>P</i> < 0.001 and S100A9 : <i>P</i> < 0.001) and healthy controls (S100A8 : <i>P</i> < 0.001 and S100A9 : <i>P</i> < 0.001), and similar results were obtained for mRNA expression. Moreover, both proteins were related to ACLF grade, different types of organ failure, and infection, and they correlated with other prognostic scoring systems. S100A8 and S100A9 can dependently predict 28/90-day mortality (28-day: S100A8: hazard ratio (HR): 1.027; 95% confidence interval (CI): 1.007-1.048; <i>P</i>=0.026, S100A9 : HR: 1.009; 95% CI: 1.001-1.017; <i>P</i>=0.007, 90-day: S100A8 : HR: 1.023; 95% CI: 1.011-1.035; <i>P</i>=0.004, S100A9 : HR: 1.008; 95% CI: 1.004-1.012; and <i>P</i> < 0.001). Among all of the scoring systems, the combined scoring model (S100A8 and S100A9 jointly with the Chronic Liver Failure-Consortium Organ Failure score (CLIF-C OFs)) displayed the highest area under the receiver operating curve (0.923 (95% CI, 0.887-0.961)) in the prediction of 90-day mortality.</p><p><strong>Conclusions: </strong>S100A8 and S100A9 are promising biomarkers for the analysis of risk stratification and prognosis in ACLF patients. In addition, combining them with the CLIF-C OFs may better predict the prognosis of ACLF.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":"2023 ","pages":"6164611"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9852658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of <i>Helicobacter pylori</i> Infection with Nonalcoholic Fatty Liver Disease: A Meta-Analysis.","authors":"Guangqin Xu,&nbsp;Shaoze Ma,&nbsp;Liyan Dong,&nbsp;Nahum Mendez-Sanchez,&nbsp;Hongyu Li,&nbsp;Xingshun Qi","doi":"10.1155/2023/5521239","DOIUrl":"https://doi.org/10.1155/2023/5521239","url":null,"abstract":"<p><strong>Background and aims: </strong><i>Helicobacter pylori</i> (<i>H. pylori</i>) and nonalcoholic fatty liver disease (NAFLD) have become increasingly recognized, both of which affect human health globally. The association of <i>H. pylori</i> infection with NAFLD remains unclear.</p><p><strong>Methods: </strong>PubMed, EMBASE, and Cochrane Library databases were searched. Only a random-effects model was used. Odds ratios (ORs) and risk ratios (RRs) with 95% confidence intervals (CIs) were calculated for the combined estimates of raw data. Adjusted ORs (aORs) and hazard ratios (aHRs) with 95% CIs were calculated for the combined estimates of data adjusted for confounders.</p><p><strong>Results: </strong>Thirty-four studies with 218573 participants were included. Based on unadjusted data from 26 cross-sectional studies and 3 case-control studies, <i>H. pylori</i> infection was significantly associated with the presence of NAFLD (OR = 1.26, 95% CI = 1.17-1.36, <i>P</i> < 0.001). Based on adjusted data from 15 cross-sectional studies and 1 case-control study, <i>H. pylori</i> infection was significantly associated with the presence of NAFLD (aOR = 1.25, 95% CI = 1.08-1.44, <i>P</i> < 0.001). Compared with control subjects without NAFLD, patients with moderate (OR = 1.67, 95% CI = 1.17-2.39, <i>P</i> = 0.005) and severe (OR = 1.71, 95% CI = 1.30-2.24, <i>P</i> < 0.001) NAFLD, but not those with mild NAFLD (OR = 1.14, 95% CI = 0.9-1.45, <i>P</i> = 0.286), had significantly higher proportions of <i>H. pylori</i> infection. The association of <i>H. pylori</i> infection with the occurrence of NAFLD was statistically significant based on adjusted data from 3 cohort studies (aHR = 1.18, 95% CI = 1.05-1.34, <i>P</i> = 0.007), but not based on unadjusted data from 3 cohort studies (RR = 1.41, 95% CI = 0.80-2.48, <i>P</i> = 0.237).</p><p><strong>Conclusion: </strong><i>H. pylori</i> infection is associated with NAFLD, especially moderate and severe NAFLD. The impact of <i>H. pylori</i> eradication on the prevention of NAFLD should be further explored.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":"2023 ","pages":"5521239"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gambogic Acid Inhibits Gastric Cancer Cell Proliferation through Necroptosis.","authors":"Shujun Wang,&nbsp;Yiping Wang,&nbsp;Hui Zhu,&nbsp;Miaohui Chen,&nbsp;Liang Zhang","doi":"10.1155/2023/7532367","DOIUrl":"https://doi.org/10.1155/2023/7532367","url":null,"abstract":"<p><p>Gambogic acid (GA) is a natural xanthonoid secreted by <i>Garcinia hanburyi</i> tree. It possesses anti-cancer activity in various types of cancers. In gastric cancer, it inhibits cell proliferation through increasing apoptosis. However, whether necroptosis is involved in the GA-induced proliferation inhibited in gastric cancer is unknown. In the present study, we found that RIPK1 specific inhibitor necrostatin-1 (Nec-1) attenuated GA-induced proliferation inhibition. GA treatment increased the phosphorylation of necroptosis-related proteins, RIPK1, RIPK3, and MLKL, and their interactions to form the necrosome complex. The effector protein Drp-1 was dephosphorylated by GA treatment. Inhibition of necroptosis by different inhibitors and PGAM5 knockdown attenuated GA-induced cell death in gastric cancer cell lines, thereby attenuating GA-caused cell proliferation inhibition. All the data supported the conclusion that GA could inhibit gastric cancer cell proliferation by inducing necroptosis.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":"2023 ","pages":"7532367"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10426365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Serum Parameters Associated with Kidney Function on the Short-Term Outcomes and Prognosis of Colorectal Cancer Patients Undergoing Radical Surgery.","authors":"Bin Zhang,&nbsp;Xu-Rui Liu,&nbsp;Xiao-Yu Liu,&nbsp;Bing Kang,&nbsp;Chao Yuan,&nbsp;Fei Liu,&nbsp;Zi-Wei Li,&nbsp;Zheng-Qiang Wei,&nbsp;Dong Peng","doi":"10.1155/2023/2017171","DOIUrl":"https://doi.org/10.1155/2023/2017171","url":null,"abstract":"<p><strong>Purpose: </strong>The current study was designed to investigate the impact of blood urea nitrogen (BUN), serum uric acid (UA), and cystatin (CysC) on the short-term outcomes and prognosis of colorectal cancer (CRC) patients undergoing radical surgery.</p><p><strong>Methods: </strong>CRC patients who underwent radical resection were included from Jan 2011 to Jan 2020 in a single clinical centre. The short-term outcomes, overall survival (OS), and disease-free survival (DFS) were compared in different groups. A Cox regression analysis was conducted to identify independent risk factors for OS and DFS.</p><p><strong>Results: </strong>A total of 2047 CRC patients who underwent radical resection were included in the current study. Patients in the abnormal BUN group had a longer hospital stay (<i>p</i>=0.002) and more overall complications (<i>p</i>=0.001) than that of the normal BUN group. The abnormal CysC group had longer hospital stay (<i>p</i> < 0.01), more overall complications (<i>p</i>=<i>p</i> < 0.01), and more major complications (<i>p</i>=0.001) than the normal CysC group. Abnormal CysC was associated with worse OS and DFS for CRC patients in tumor stage I (<i>p</i> < 0.01). In Cox regression analysis, age (<i>p</i> < 0.01, HR = 1.041, 95% CI = 1.029-1.053), tumor stage (<i>p</i> < 0.01, HR = 2.134, 95% CI = 1.828-2.491), and overall complications (<i>p</i>=0.002, HR = 1.499, 95% CI = 1.166-1.928) were independent risk factors for OS. Similarly, age (<i>p</i> < 0.01, HR = 1.026, 95% CI = 1.016-1.037), tumor stage (<i>p</i> < 0.01, HR = 2.053, 95% CI = 1.788-2.357), and overall complications (<i>p</i>=0.002, HR = 1.440, 95% CI = 1.144-1.814) were independent risk factors for DFS.</p><p><strong>Conclusion: </strong>In conclusion, abnormal CysC was significantly associated with worse OS and DFS at TNM stage I, and abnormal CysC and BUN were related to more postoperative complications. However, preoperative BUN and UA in the serum might not affect OS and DFS for CRC patients who underwent radical resection.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":"2023 ","pages":"2017171"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9089965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Drug-Eluting Bead TACE in the Treatment of Primary or Secondary Liver Cancer.","authors":"Jiabing Wang,&nbsp;Haoqian Xu,&nbsp;Ying Wang,&nbsp;Long Feng,&nbsp;Fengming Yi","doi":"10.1155/2023/5492931","DOIUrl":"https://doi.org/10.1155/2023/5492931","url":null,"abstract":"<p><strong>Background: </strong>The drug-eluting beads transarterial chemoembolization (DEB-TACE) has already been used in hepatic malignancies. We aim to evaluate the efficacy and safety of DEB-TACE in treating primary or secondary liver cancer.</p><p><strong>Methods: </strong>We retrospectively evaluated 59 patients with hepatic malignancies, including 41 patients with primary liver cancer and 18 patients with secondary liver cancer, between September 2016 and February 2019. All patients were treated with DEB-TACE. Objective response rate (ORR) and disease control rate (DCR) were evaluated by mRECIST. The pain was assessed using a numerical rating scale (NRS) where 0 represented no pain, and a score of ten was unbearable. Adverse reactions were assessed according to Common Terminology Criteria for Adverse Events 4.0 (CTCAE4.0).</p><p><strong>Results: </strong>In the subgroup of primary liver cancer, 3 patients (7.32%) got complete response, 13 patients (31.71%) got partial response, 21 patients (51.22%) experienced stable disease, and 4 patients (9.76%) suffered progressive disease; ORR was 39.02% and DCR was 90.24%. In the subgroup of secondary liver cancer, 0 patients (0%) got complete response, 6 patients (33.33%) got partial response, 11 patients (61.11%) experienced stable disease, and 1 patient (5.56%) suffered progressive disease; ORR was 33.33% and DCR was 94.44%. We did not find any difference when comparing the efficacy between primary and secondary liver cancer (<i>P</i>=0.612). The one-year survival rate was 70.73% for primary liver cancer and 61.11% for secondary liver cancer. There was no significant difference between the two groups (<i>P</i>=0.52). For the patients with CR or PR, no factor could predict the efficacy of DEB-TACE. The most common treatment-related adverse reactions were short-term liver function disorders. The symptoms included fever (20.34%), abdomen pain (16.95%), and vomiting (5.08%), all patients with adverse reactions got remission after treatment.</p><p><strong>Conclusions: </strong>DEB-TACE has a promising effect in the treatment of primary or secondary liver cancer. The treatment-related adverse reactions are tolerable.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":"2023 ","pages":"5492931"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9442397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}