{"title":"AI Clinical Decision Tools in Multidisciplinary Team Discussions for Colorectal Cancer.","authors":"Nir Horesh, Anjelli Wignakumar, Sameh Hany Emile","doi":"10.1055/a-2769-1363","DOIUrl":"10.1055/a-2769-1363","url":null,"abstract":"<p><p>Multidisciplinary team (MDT) discussions have become a cornerstone of colorectal cancer (CRC) management, integrating the expertise of surgeons, oncologists, radiologists, pathologists, and allied health professionals to facilitate personalized, evidence-based care. However, increasing complexity in treatment options, particularly with the rise of neoadjuvant strategies and immunotherapies, has rendered decision-making more challenging. Traditional tools-including clinical guidelines, risk calculators, and nomograms-offer structured decision support but lack flexibility and personalization. Artificial intelligence (AI), particularly through machine learning (ML), radiomics, and large language models (LLMs), is emerging as a transformative adjunct to clinical decision-making in CRC. Machine learning models have demonstrated strong predictive performance for treatment response, recurrence risk, and surgical complications, while radiomics and deep learning have improved diagnostic accuracy and treatment response prediction using imaging and endoscopy. LLMs such as ChatGPT have shown promising concordance with MDT recommendations in early studies, especially for standard clinical scenarios. However, limitations remain in handling complex, nuanced cases. Despite their growing capabilities, AI and LLMs are not yet integrated into routine MDT workflows due to concerns about interpretability, regulatory oversight, and ethical challenges. Future directions include developing real-time, multimodal AI-MDT platforms, improving explainability, ensuring equitable data representation, and integrating AI training into medical education. This review outlines current evidence on AI integration within CRC MDTs, highlighting both its clinical potential and the barriers that must be addressed to ensure safe, effective, and equitable implementation. Ultimately, AI is poised to augment-not replace-human expertise, enhancing the consistency, efficiency, and personalization of multidisciplinary CRC care.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"39 3","pages":"227-234"},"PeriodicalIF":1.6,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Carrie Y. Peterson, MD, MS, FACS, FASCRS.","authors":"Scott R Steele","doi":"10.1055/a-2768-9935","DOIUrl":"10.1055/a-2768-9935","url":null,"abstract":"","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"39 3","pages":"165-166"},"PeriodicalIF":1.6,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Artificial Intelligence for the Treatment and Management of Colorectal Liver Metastases.","authors":"Kaitlyn M Weyman, Anai N Kothari","doi":"10.1055/a-2769-1413","DOIUrl":"10.1055/a-2769-1413","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is the third most commonly diagnosed malignancy worldwide. Prognosis is significantly worsened in patients with colorectal liver metastases (CRLM), whose management requires a multidisciplinary approach encompassing diagnosis, systemic therapy, surgery, and surveillance. Artificial intelligence (AI) offers the potential to improve treatment processes and outcomes across all aspects of CRLM care. This review summarizes current and future applications of AI throughout the CRLM treatment continuum. In diagnostics, radiomics-based AI models have demonstrated improved sensitivity in detecting small or ambiguous liver lesions, supporting radiologist interpretation, and improving efficiency. Similarly, AI models are increasingly employed to predict systemic treatment response, using deep learning (DL) to extract imaging-derived features that correlate with genomic and histopathologic profiles relevant to therapy selection. In surgical planning, AI tools can assist in preoperative preparation and optimization by measuring tumor volume and transection planes. Intraoperatively, computer vision and augmented reality are emerging to support tumor localization, margin assessment, and real-time anatomical navigation. Postoperatively, advanced AI models can integrate clinical, radiologic, and molecular data to stratify recurrence risk and inform individualized follow-up strategies. Despite its promise, clinical translation of AI in CRLM remains limited by the retrospective nature of many studies, challenges with external validation, and limitations in the interpretability of model decisions. Still, AI has the potential to be a transformative tool in the treatment of CRLM by supporting precision, standardization, and personalization across the treatment spectrum.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"39 3","pages":"235-241"},"PeriodicalIF":1.6,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving Acute Care Surgery with Artificial Intelligence: A Practical Review.","authors":"William M Rice, Rachel S Morris, Krista L Haines","doi":"10.1055/a-2769-0955","DOIUrl":"10.1055/a-2769-0955","url":null,"abstract":"<p><p>Artificial intelligence (AI) and machine learning are poised to transform trauma care across the entire continuum, from prehospital triage to postoperative critical care. Trauma systems are uniquely suited for AI integration due to the time-sensitive, high-volume, and data-rich nature of care delivery. In this narrative review, we describe current and emerging AI applications across the trauma care spectrum, including triage, acute resuscitation, operative decision-making, intensive care, and detection of complications. We also examine AI's potential in nontraditional care environments, including prehospital, rural, and military settings, where resource constraints and variability in provider expertise pose significant challenges. Across multiple domains, AI models outperform conventional approaches in predicting injury severity, identifying patients in need of intervention, and detecting complications. Specific tools include AI-powered triage support, resuscitation sequencing systems, real-time imaging interpretation, and outcome prediction applications. Despite this promise, many AI applications remain investigational, and widespread adoption will require validation, transparency, and alignment with ethical and regulatory standards. Thoughtful implementation of AI in trauma care has the potential to enhance decision-making, improve patient outcomes, and address disparities in access to high-quality trauma care.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"39 3","pages":"178-184"},"PeriodicalIF":1.6,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unique Challenges of Shared Decision-Making in Colorectal Surgery for the Elderly Patient.","authors":"Madhuri V Nishtala, Julia R Berian","doi":"10.1055/a-2760-7343","DOIUrl":"10.1055/a-2760-7343","url":null,"abstract":"<p><p>Older adults require disproportionately more operations and suffer more complications than their younger counterparts, making a thoughtful approach to shared decision-making imperative. This article reviews key considerations in the decision to pursue operative intervention for older adults. First, we explore the \"Fix It\" model and the importance of acknowledging trade-offs, with a specific focus on quality of life. This is followed by a discussion of how surgical recovery affects physical function, bowel function, and cognition. We describe strategies for shared decision-making in the older population, specifically eliciting patient preferences for overall health goals, establishing the goals of surgery, discussing advanced directives, and engaging caregivers. We anticipate these key content areas will provide surgeons with important insights with which to approach surgical decision-making for this vulnerable patient group.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12900247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Successful APP-Managed Anal Dysplasia Clinic.","authors":"Kathryn Drogan, Meghan Leusch","doi":"10.1055/s-0045-1809894","DOIUrl":"10.1055/s-0045-1809894","url":null,"abstract":"<p><p>Anal cancer, while rare, is increasing in incidence. Recent studies and trials indicate that effective screening with treatment of precancerous anal dysplastic lesions can decrease the risk of anal cancer in high-risk patient populations. Therefore, it is important that anal cancer screening is made accessible. To this end, as has been done in other specialties, advanced practice practitioners (APPs) can help fill this need. This paper will discuss how a well-established APP managed anal dysplasia clinic, has been successful and remained viable for many years. We will discuss clinic functions, key points, and tips that can help an APP clinic run efficiently and successfully, as well as measures that have helped us with patient satisfaction and continuity.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"39 2","pages":"158-161"},"PeriodicalIF":1.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment Options for Anal Neoplasia: Going from Anal Dysplasia to Anal Cancer.","authors":"Trista J Stankowski","doi":"10.1055/s-0045-1809890","DOIUrl":"10.1055/s-0045-1809890","url":null,"abstract":"<p><p>While overall uncommon, the incidence of anal cancer in the United States is on the rise. The majority of these cases are squamous cell in origin and attributed to infection with human papillomavirus (HPV) and the associated evolution of anal squamous intraepithelial lesions. Immunosuppressed patients such as those with human immunodeficiency virus (HIV) or solid organ transplants and those with high-grade dysplasia or carcinoma of the cervix or vulva are at highest risk for evolution to anal cancer. The recently published anal cancer HSIL outcomes research (ANCHOR) trial demonstrated benefit to treating anal high-grade squamous intraepithelial lesions (HSILs) to reduce the progression to anal cancer. This article reviews screening and treatment of anal HSIL including ablative, topical, and surgical options as well as the diagnosis and treatment of anal cancer.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"39 2","pages":"131-137"},"PeriodicalIF":1.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew C Esposito, Andres Doval Rojas, Ira L Leeds
{"title":"No Time for That: Health Care Economics and Population Health Limitations of Anal Cancer Screening.","authors":"Andrew C Esposito, Andres Doval Rojas, Ira L Leeds","doi":"10.1055/s-0045-1809892","DOIUrl":"10.1055/s-0045-1809892","url":null,"abstract":"<p><p>High-resolution anoscopy has become an integral component of recommended anal cancer screening in broad populations. While high-resolution anoscopy has been shown to decrease the rate of anal cancer in high-risk populations with known high-grade squamous intraepithelial lesions, it may have low utility as a broader population screening tool. Its applicability and implementation are limited by the current number of trained providers, high monetary costs, and high opportunity costs to patients and providers. Efforts to enhance its attractiveness should focus on decreasing the ratio of the number of procedures per available provider, better illustrating costs, and clear and precise national guidelines.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"39 2","pages":"144-150"},"PeriodicalIF":1.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luiz Felipe de Campos-Lobato, Arielle E Kanters, Paulo Gonçalves de Oliveira, Leonardo de Castro Durães
{"title":"Evidence for Anal Dysplasia Treatment.","authors":"Luiz Felipe de Campos-Lobato, Arielle E Kanters, Paulo Gonçalves de Oliveira, Leonardo de Castro Durães","doi":"10.1055/s-0045-1809891","DOIUrl":"10.1055/s-0045-1809891","url":null,"abstract":"<p><p>Anal dysplasia, primarily caused by high-risk human papillomavirus (HPV) infection, presents as a precursor to anal cancer (AC), especially among high-risk populations such as human immunodeficiency virus (HIV)-positive individuals. This review evaluates evidence for the treatment of anal intraepithelial neoplasia, focusing on recent advancements in the context of the Anal Cancer/HSIL Outcomes Research Study (ANCHOR) trial which demonstrates that active treatment of high-grade squamous intraepithelial lesions markedly reduced progression to AC. This affirms the value of proactive treatment strategies over passive monitoring. Furthermore, we will discuss various treatment modalities, including topical agents, electrocautery, and HPV vaccination, and their efficacy and limitations. This review underscores the necessity of integrating screening and targeted interventions, particularly for high-risk groups, to reduce AC incidence. Future research should aim to validate these findings across broader demographic groups, refining public health policies and clinical guidelines to include effective screening and treatment protocols.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"39 2","pages":"138-143"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Updates in Anal Neoplasia Screening and Treatment.","authors":"Zhaomin Xu","doi":"10.1055/s-0045-1809873","DOIUrl":"10.1055/s-0045-1809873","url":null,"abstract":"","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"39 2","pages":"115-116"},"PeriodicalIF":1.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}