Systemic Therapy for Metastatic Colon Cancer: New Frontiers

IF 1.2 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY

Clinics in Colon and Rectal Surgery Pub Date : 2024-06-25 DOI:10.1055/s-0044-1787826

Yoanna S. Pumpalova

引用次数: 0

Abstract

We have made steady gains in improving overall survival in patients with metastatic, unresectable, colon cancer in the last 5 to 10 years. The backbone of systemic treatment for most patients remains combination chemotherapy, but the field is becoming increasingly biomarker driven, with exciting new targeted therapies on the horizon. This review is organized in sections corresponding to currently relevant biomarkers in colon cancer and will summarize first-, second-, and third-line standard of care for metastatic, unresectable, colon cancer. The last section is intended to introduce the reader to promising agents and novel therapeutic strategies currently under investigation.

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转移性结肠癌的系统疗法：新领域

过去 5 到 10 年间，我们在提高转移性、不可切除结肠癌患者的总生存率方面取得了稳步进展。对大多数患者来说，全身治疗的支柱仍然是联合化疗，但这一领域正日益受到生物标志物的驱动，令人兴奋的新靶向疗法即将问世。本综述按照结肠癌目前相关的生物标记物分为几个部分，并将总结治疗转移性、不可切除结肠癌的一线、二线和三线标准疗法。最后一部分旨在向读者介绍目前正在研究的有前景的药物和新型治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics in Colon and Rectal Surgery GASTROENTEROLOGY & HEPATOLOGYSURGERY-SURGERY

CiteScore

2.60

自引率

7.10%

发文量

期刊介绍： Clinics in Colon and Rectal Surgery is a review journal that publishes topic-specific issues on diseases of the small bowel, colon, rectum, and anus. Designed for clinicians, researchers, and educators involved with diseases of the intestinal tract, the journal covers a broad spectrum of basic information, controversial clinical issues, and established and innovative diagnostic techniques. Issue topics comprehensively cover the entire specialty over a 3-4 year period, allowing the articles to serve as study material for educational programs and certifying examinations. The inclusion of research and clinical material also allows physicians to remain knowledgeable of current advances in the specialty.