{"title":"Introduction to Contemporary Pediatric Interventional Radiology.","authors":"C Matthew Hawkins","doi":"10.1055/s-0045-1811198","DOIUrl":"https://doi.org/10.1055/s-0045-1811198","url":null,"abstract":"","PeriodicalId":48689,"journal":{"name":"Seminars in Interventional Radiology","volume":"42 3","pages":"251-252"},"PeriodicalIF":1.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of IR in Pediatric Liver Cancer.","authors":"Michael R Acord, Allison Aguado, Anne E Gill","doi":"10.1055/s-0045-1811256","DOIUrl":"10.1055/s-0045-1811256","url":null,"abstract":"<p><p>Despite the well-defined role of interventional radiology (IR) in the management of adult patients with hepatocellular carcinoma (HCC), the role of IR for pediatric liver tumors is still being established. This is, in part, due to the rarity and heterogeneity of pediatric liver tumors as well as the limited literature supporting liver-directed therapies for children. In addition, hepatoblastoma, the most common primary pediatric liver tumor, carries a good prognosis with current surgical and systemic treatment options directed by well-established clinical trials. Still, a subset of patients will not be amenable to operative treatment, and other pediatric liver tumors, such as HCC, portend a dismal prognosis. These settings offer opportunities for growth of pediatric IR and to provide services that improve the lives of children. The purpose of this article is to review the role of IR in pediatric liver cancer, including biopsy recommendations set forth by current clinical trials, transarterial chemoembolization and radioembolization, and percutaneous ablation.</p>","PeriodicalId":48689,"journal":{"name":"Seminars in Interventional Radiology","volume":"42 3","pages":"328-335"},"PeriodicalIF":1.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vaz Zavaletta, Beth B Warren, Danielle Katz, Grace Eliason, Michael Collard, Aparna Annam
{"title":"Endovascular Management of Pediatric Deep Venous Thrombosis.","authors":"Vaz Zavaletta, Beth B Warren, Danielle Katz, Grace Eliason, Michael Collard, Aparna Annam","doi":"10.1055/s-0045-1811718","DOIUrl":"10.1055/s-0045-1811718","url":null,"abstract":"<p><p>This study aims to review current practices in thrombolysis and thrombectomy for managing deep venous thrombosis (DVT) and associated complications in the pediatric population. Pediatric thrombosis care has a rich history of evolution, from the early days of anticoagulation to the current era of endovascular therapies. This evolution has been driven by the need for a nuanced, multidisciplinary approach that includes interventional radiology (IR) and hematology. While anticoagulation remains the standard of care, endovascular therapies are increasingly utilized in cases of extensive, occlusive, or limb-threatening DVT, particularly to prevent pulmonary embolism and postthrombotic syndrome (PTS) and to preserve venous patency. This review outlines the indications, contraindications, and procedural techniques for catheter-directed thrombolysis, pharmaco-mechanical thrombectomy (PMT), mechanical thrombectomy, and venous stenting in children. It emphasizes the crucial role of a multidisciplinary team, including pediatric hematologists, interventional radiologists, and other medical professionals, in managing pediatric DVT. This collaboration is essential for considering pediatric-specific factors such as patient size, sedation requirements, radiation, contrast dosing, and anticoagulation. Also highlighted are postprocedural care, anticoagulation strategies, and imaging follow-up. Multidisciplinary collaboration is critical to improving outcomes for children with thrombotic disease.</p>","PeriodicalId":48689,"journal":{"name":"Seminars in Interventional Radiology","volume":"42 3","pages":"313-323"},"PeriodicalIF":1.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Percutaneous Lung Biopsy: Evidence-Based Techniques to Reduce Complications.","authors":"Kylie Zane, Qian Yu, Steven M Zangan","doi":"10.1055/s-0045-1811697","DOIUrl":"https://doi.org/10.1055/s-0045-1811697","url":null,"abstract":"","PeriodicalId":48689,"journal":{"name":"Seminars in Interventional Radiology","volume":"42 3","pages":"374-382"},"PeriodicalIF":1.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pediatric Renovascular Hypertension: Diagnosis and Management.","authors":"Kishore Minhas, Anne Marie Cahill, Premal A Patel","doi":"10.1055/s-0045-1811577","DOIUrl":"10.1055/s-0045-1811577","url":null,"abstract":"<p><p>Pediatric renovascular hypertension (RVH) is a significant cause of secondary hypertension in children, often resulting from renal artery stenosis (RAS) due to nonatherosclerotic etiologies such as fibromuscular dysplasia (FMD), mid aortic syndrome (MAS), and syndromic conditions like neurofibromatosis type 1 (NF-1). Early diagnosis is critical to prevent long-term complications, including renal dysfunction and cardiovascular disease. Diagnostic evaluation begins with ultrasound, which, despite its limitations, remains the first-line modality. Advanced imaging techniques such as CT angiography (CTA), MR angiography (MRA), and digital subtraction angiography (DSA) provide detailed vascular assessment, with DSA considered the gold standard. Adjunctive tools like intravascular pressure measurements, intravascular imaging, and renal vein renin sampling supplement DSA. Management should have multidisciplinary consensus and is tailored to the individual patient. Pharmacological therapy is seldom sufficient and percutaneous transluminal angioplasty is effective in many cases. Stent placement and surgical interventions are reserved for refractory or complex cases. Chemical ablation in select cases and emerging therapies such as renal denervation offer additional options. This review outlines the current diagnostic and therapeutic approaches to pediatric RVH, emphasizing the importance of personalized care and the role of specialist pediatric centers, with experience in managing RVH, in optimizing outcomes.</p>","PeriodicalId":48689,"journal":{"name":"Seminars in Interventional Radiology","volume":"42 3","pages":"269-278"},"PeriodicalIF":1.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Core Tenets of Central Venous Access in Children.","authors":"Madeline E Leo, Anne E Gill","doi":"10.1055/s-0045-1811255","DOIUrl":"10.1055/s-0045-1811255","url":null,"abstract":"<p><p>Central venous access device (CVAD) placement is a common procedure for outpatient and inpatient pediatric interventional radiology practices. The principles of CVAD placement in pediatrics are similar to those in adults; however, certain clinical parameters must be considered when choosing the optimal type of line, size of catheter, and location for pediatric patients. The vessel lumen to catheter ratio is of utmost importance, and unique techniques may be necessary to facilitate bedside procedures. As in adults, all CVAD placements confer some level of risk. This review article discusses vascular anatomy, CVAD procedural techniques, and complications specifically concerning venous access in children.</p>","PeriodicalId":48689,"journal":{"name":"Seminars in Interventional Radiology","volume":"42 3","pages":"253-261"},"PeriodicalIF":1.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Systemic Venous Recanalization: Iliocaval and Superior Vena Cava Reconstruction in Children.","authors":"Frederic J Bertino","doi":"10.1055/s-0045-1810419","DOIUrl":"https://doi.org/10.1055/s-0045-1810419","url":null,"abstract":"<p><p>Restoring venous patency and flow is crucial for pediatric patients with superior vena cava (SVC), IVC, and iliac vein occlusion, and advancements in venous recanalization and stent reconstruction have proven safe and efficacious in the adult population, with techniques from adult patients adapted to manage these conditions in younger individuals. Endovascular therapy has advanced significantly, improving device and stent technologies, imaging modalities, and procedural techniques. This study reviews indications, technical considerations, and outcomes for venous stenting in pediatric patients, focusing on SVC syndrome, IVC atresia, and iliac vein compression. This guide is a reference for interventional radiologists to optimize outcomes through precise stent selection and procedure execution.</p>","PeriodicalId":48689,"journal":{"name":"Seminars in Interventional Radiology","volume":"42 3","pages":"303-312"},"PeriodicalIF":1.3,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
William Mitchell, Michael H White, Prashant Raghavendran, Gary Woods, Karen L Zimowski
{"title":"Pediatric Venous Thromboembolism: Considerations for the Interventional Radiologist.","authors":"William Mitchell, Michael H White, Prashant Raghavendran, Gary Woods, Karen L Zimowski","doi":"10.1055/s-0045-1810081","DOIUrl":"10.1055/s-0045-1810081","url":null,"abstract":"<p><p>Pediatric venous thromboembolism (VTE) has seen a significant rise in prevalence coinciding with the increasing availability of complex and invasive treatments in children. While anticoagulation remains the cornerstone of VTE treatment, increasing evidence supports interventional approaches for select cases, particularly in life- or limb-threatening scenarios. Treatment strategies must be individualized, considering age-related differences in hemostasis and the higher bleeding risk associated with interventions. This remains challenging due to a dearth of pediatric-specific studies. This manuscript explores pathophysiology, risk factors, and management strategies for pediatric VTE, emphasizing both pharmacologic and interventional treatments and providing updated recommendations regarding available anticoagulant agents and VTE management paradigms in children. It highlights the potential of interventional techniques in special conditions, namely Paget-Schroetter syndrome, superior vena cava syndrome, inferior vena cava atresia, pulmonary emboli, and May-Thurner syndrome. In the absence of rigorous clinical trial data, continued multidisciplinary collaboration and standardized approaches will remain imperative for ensuring careful use of interventional procedures to achieve optimal outcomes in these young patients.</p>","PeriodicalId":48689,"journal":{"name":"Seminars in Interventional Radiology","volume":"42 3","pages":"289-302"},"PeriodicalIF":1.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fundamentals of Pediatric Cancer: How Pediatric Pathology and Infrastructure of Clinical Trials Impact Contemporary Interventional Oncology in Children.","authors":"Sarah G Mitchell, Kathryn S Sutton, Thomas Cash","doi":"10.1055/s-0045-1810054","DOIUrl":"10.1055/s-0045-1810054","url":null,"abstract":"<p><p>Pediatric cancer, though rare compared with adult malignancy, remains a significant cause of morbidity and mortality, with approximately 15,000 new diagnoses and over 1,500 deaths annually in the United States. Advances in multimodal therapy and cooperative group clinical trials have improved overall survival rates to over 80% in developed nations. Pediatric interventional oncology, a subset of pediatric interventional radiology (IR), has expanded beyond its role in biopsy and vascular access to include tumor-targeted and supportive care interventions. However, challenges in the field remain, including less pediatric-specific data and limited access to pediatric-trained interventional radiologists. Multidisciplinary collaboration is important for the integration of pediatric interventional oncology as a key component of pediatric cancer treatment.</p>","PeriodicalId":48689,"journal":{"name":"Seminars in Interventional Radiology","volume":"42 3","pages":"324-327"},"PeriodicalIF":1.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sheena Pimpalwar, Tarique Hussain, Surendranath R Veeram Reddy
{"title":"MR Lymphangiography in Pediatrics: Indications, Technique, Findings, and Management.","authors":"Sheena Pimpalwar, Tarique Hussain, Surendranath R Veeram Reddy","doi":"10.1055/s-0045-1810064","DOIUrl":"https://doi.org/10.1055/s-0045-1810064","url":null,"abstract":"<p><p>Over the past two decades, magnetic resonance imaging (MRI) has become the mainstay for lymphatic imaging in pediatric patients suffering from lymphatic disorders caused by congenital or acquired causes. Pediatric patients, especially those born with complex congenital heart disease, status post single ventricle palliation increasingly constitute the largest group of patients presenting with lymphatic dysfunction. Heavily T2-weighted and 3D-balanced steady-state free precession are complementary MRI sequences used for noninvasive assessment of the central lymphatic anatomy as well as distribution of lymphatic fluid in body cavities, lymphatic cysts, and lymphatic malformations. These sequences are, however, limited in their ability to visualize smaller lymphatics, to differentiate lymphatics from other fluid-filled structures, or to provide sequential flow information. This limitation is overcome by administering a gadolinium-based contrast agent into a lymph node, lymphatic vessel, or interstitial tissue with simultaneous image acquisition, a technique called dynamic contrast-enhanced magnetic resonance lymphangiography. This imaging is invasive but critical for evaluating lymphatic flow and identifying potential targets for lymphatic intervention. Medical therapy, along with traditional transcatheter or surgical approaches to address the underlying cause of the lymphatic disorder, remains the first-line approach, while lymphatic interventions are reserved for patients who have failed these therapies.</p>","PeriodicalId":48689,"journal":{"name":"Seminars in Interventional Radiology","volume":"42 3","pages":"356-373"},"PeriodicalIF":1.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}