发布求助
文献互助 智能选刊 最新文献

Annual Review of Vision Science最新文献

筛选
英文 中文
Microglia in the Retina: Roles in Development, Maturity, and Disease. 视网膜中的小胶质细胞:在发育、成熟和疾病中的作用。
IF 6 2区 医学
Annual Review of Vision Science Pub Date : 2018-09-15 Epub Date: 2018-05-31 DOI: 10.1146/annurev-vision-091517-034425
Sean M Silverman, Wai T Wong
{"title":"Microglia in the Retina: Roles in Development, Maturity, and Disease.","authors":"Sean M Silverman,&nbsp;Wai T Wong","doi":"10.1146/annurev-vision-091517-034425","DOIUrl":"https://doi.org/10.1146/annurev-vision-091517-034425","url":null,"abstract":"<p><p>Microglia, the primary resident immune cell type, constitute a key population of glia in the retina. Recent evidence indicates that microglia play significant functional roles in the retina at different life stages. During development, retinal microglia regulate neuronal survival by exerting trophic influences and influencing programmed cell death. During adulthood, ramified microglia in the plexiform layers interact closely with synapses to maintain synaptic structure and function that underlie the retina's electrophysiological response to light. Under pathological conditions, retinal microglia participate in potentiating neurodegeneration in diseases such as glaucoma, retinitis pigmentosa, and age-related neurodegeneration by producing proinflammatory neurotoxic cytokines and removing living neurons via phagocytosis. Modulation of pathogenic microglial activation states and effector mechanisms has been linked to neuroprotection in animal models of retinal diseases. These findings have led to the design of early proof-of-concept clinical trials with microglial modulation as a therapeutic strategy.</p>","PeriodicalId":48658,"journal":{"name":"Annual Review of Vision Science","volume":"4 ","pages":"45-77"},"PeriodicalIF":6.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-vision-091517-034425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36180783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 170
Linking V1 Activity to Behavior. 将V1活动与行为联系起来。
IF 6 2区 医学
Annual Review of Vision Science Pub Date : 2018-09-15 Epub Date: 2018-07-05 DOI: 10.1146/annurev-vision-102016-061324
Eyal Seidemann, Wilson S Geisler
{"title":"Linking V1 Activity to Behavior.","authors":"Eyal Seidemann, Wilson S Geisler","doi":"10.1146/annurev-vision-102016-061324","DOIUrl":"10.1146/annurev-vision-102016-061324","url":null,"abstract":"<p><p>A long-term goal of visual neuroscience is to develop and test quantitative models that account for the moment-by-moment relationship between neural responses in early visual cortex and human performance in natural visual tasks. This review focuses on efforts to address this goal by measuring and perturbing the activity of primary visual cortex (V1) neurons while nonhuman primates perform demanding, well-controlled visual tasks. We start by describing a conceptual approach-the decoder linking model (DLM) framework-in which candidate decoding models take neural responses as input and generate predicted behavior as output. The ultimate goal in this framework is to find the actual decoder-the model that best predicts behavior from neural responses. We discuss key relevant properties of primate V1 and review current literature from the DLM perspective. We conclude by discussing major technological and theoretical advances that are likely to accelerate our understanding of the link between V1 activity and behavior.</p>","PeriodicalId":48658,"journal":{"name":"Annual Review of Vision Science","volume":"4 ","pages":"287-310"},"PeriodicalIF":6.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141357/pdf/nihms-981770.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36286380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Motion Perception: From Detection to Interpretation. 运动感知:从检测到解释。
IF 6 2区 医学
Annual Review of Vision Science Pub Date : 2018-09-15 Epub Date: 2018-07-27 DOI: 10.1146/annurev-vision-091517-034328
Shin'ya Nishida, Takahiro Kawabe, Masataka Sawayama, Taiki Fukiage
{"title":"Motion Perception: From Detection to Interpretation.","authors":"Shin'ya Nishida,&nbsp;Takahiro Kawabe,&nbsp;Masataka Sawayama,&nbsp;Taiki Fukiage","doi":"10.1146/annurev-vision-091517-034328","DOIUrl":"https://doi.org/10.1146/annurev-vision-091517-034328","url":null,"abstract":"<p><p>Visual motion processing can be conceptually divided into two levels. In the lower level, local motion signals are detected by spatiotemporal-frequency-selective sensors and then integrated into a motion vector flow. Although the model based on V1-MT physiology provides a good computational framework for this level of processing, it needs to be updated to fully explain psychophysical findings about motion perception, including complex motion signal interactions in the spatiotemporal-frequency and space domains. In the higher level, the velocity map is interpreted. Although there are many motion interpretation processes, we highlight the recent progress in research on the perception of material (e.g., specular reflection, liquid viscosity) and on animacy perception. We then consider possible linking mechanisms of the two levels and propose intrinsic flow decomposition as the key problem. To provide insights into computational mechanisms of motion perception, in addition to psychophysics and neurosciences, we review machine vision studies seeking to solve similar problems.</p>","PeriodicalId":48658,"journal":{"name":"Annual Review of Vision Science","volume":"4 ","pages":"501-523"},"PeriodicalIF":6.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-vision-091517-034328","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36350399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Retinal Vasculature in Development and Diseases. 视网膜脉管系统的发育和疾病。
IF 6 2区 医学
Annual Review of Vision Science Pub Date : 2018-09-15 DOI: 10.1146/annurev-vision-091517-034018
Ye Sun, Lois E H Smith
{"title":"Retinal Vasculature in Development and Diseases.","authors":"Ye Sun,&nbsp;Lois E H Smith","doi":"10.1146/annurev-vision-091517-034018","DOIUrl":"https://doi.org/10.1146/annurev-vision-091517-034018","url":null,"abstract":"<p><p>The retina is one of the most metabolically active tissues in the body, consuming high levels of oxygen and nutrients. A well-organized ocular vascular system adapts to meet the metabolic requirements of the retina to ensure visual function. Pathological conditions affect growth of the blood vessels in the eye. Understanding the neuronal biological processes that govern retinal vascular development is of interest for translational researchers and clinicians to develop preventive and interventional therapeutics for vascular eye diseases that address early drivers of abnormal vascular growth. This review summarizes the current knowledge of the cellular and molecular processes governing both physiological and pathological retinal vascular development, which is dependent on the interaction among retinal cell populations, including neurons, glia, immune cells, and vascular endothelial cells. We also review animal models currently used for studying retinal vascular development.</p>","PeriodicalId":48658,"journal":{"name":"Annual Review of Vision Science","volume":"4 ","pages":"101-122"},"PeriodicalIF":6.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36497181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 87
Elementary Motion Detection in Drosophila: Algorithms and Mechanisms. 果蝇的基本运动检测:算法和机制。
IF 6 2区 医学
Annual Review of Vision Science Pub Date : 2018-09-15 Epub Date: 2018-06-27 DOI: 10.1146/annurev-vision-091517-034153
Helen H Yang, Thomas R Clandinin
{"title":"Elementary Motion Detection in Drosophila: Algorithms and Mechanisms.","authors":"Helen H Yang,&nbsp;Thomas R Clandinin","doi":"10.1146/annurev-vision-091517-034153","DOIUrl":"https://doi.org/10.1146/annurev-vision-091517-034153","url":null,"abstract":"<p><p>Motion in the visual world provides critical information to guide the behavior of sighted animals. Furthermore, as visual motion estimation requires comparisons of signals across inputs and over time, it represents a paradigmatic and generalizable neural computation. Focusing on the Drosophila visual system, where an explosion of technological advances has recently accelerated experimental progress, we review our understanding of how, algorithmically and mechanistically, motion signals are first computed.</p>","PeriodicalId":48658,"journal":{"name":"Annual Review of Vision Science","volume":"4 ","pages":"143-163"},"PeriodicalIF":6.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-vision-091517-034153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36263267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 40
The Organization and Operation of Inferior Temporal Cortex. 颞下皮层的组织与运作。
IF 6 2区 医学
Annual Review of Vision Science Pub Date : 2018-09-15 Epub Date: 2018-07-30 DOI: 10.1146/annurev-vision-091517-034202
Bevil R Conway
{"title":"The Organization and Operation of Inferior Temporal Cortex.","authors":"Bevil R Conway","doi":"10.1146/annurev-vision-091517-034202","DOIUrl":"https://doi.org/10.1146/annurev-vision-091517-034202","url":null,"abstract":"<p><p>Inferior temporal cortex (IT) is a key part of the ventral visual pathway implicated in object, face, and scene perception. But how does IT work? Here, I describe an organizational scheme that marries form and function and provides a framework for future research. The scheme consists of a series of stages arranged along the posterior-anterior axis of IT, defined by anatomical connections and functional responses. Each stage comprises a complement of subregions that have a systematic spatial relationship. The organization of each stage is governed by an eccentricity template, and corresponding eccentricity representations across stages are interconnected. Foveal representations take on a role in high-acuity object vision (including face recognition); intermediate representations compute other aspects of object vision such as behavioral valence (using color and surface cues); and peripheral representations encode information about scenes. This multistage, parallel-processing model invokes an innately determined organization refined by visual experience that is consistent with principles of cortical development. The model is also consistent with principles of evolution, which suggest that visual cortex expanded through replication of retinotopic areas. Finally, the model predicts that the most extensively studied network within IT-the face patches-is not unique but rather one manifestation of a canonical set of operations that reveal general principles of how IT works.</p>","PeriodicalId":48658,"journal":{"name":"Annual Review of Vision Science","volume":"4 ","pages":"381-402"},"PeriodicalIF":6.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-vision-091517-034202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36357094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 137
Neural Mechanisms of Motion Processing in the Mammalian Retina. 哺乳动物视网膜运动加工的神经机制。
IF 6 2区 医学
Annual Review of Vision Science Pub Date : 2018-09-15 Epub Date: 2018-08-10 DOI: 10.1146/annurev-vision-091517-034048
Wei Wei
{"title":"Neural Mechanisms of Motion Processing in the Mammalian Retina.","authors":"Wei Wei","doi":"10.1146/annurev-vision-091517-034048","DOIUrl":"https://doi.org/10.1146/annurev-vision-091517-034048","url":null,"abstract":"<p><p>Visual motion on the retina activates a cohort of retinal ganglion cells (RGCs). This population activity encodes multiple streams of information extracted by parallel retinal circuits. Motion processing in the retina is best studied in the direction-selective circuit. The main focus of this review is the neural basis of direction selectivity, which has been investigated in unprecedented detail using state-of-the-art functional, connectomic, and modeling methods. Mechanisms underlying the encoding of other motion features by broader RGC populations are also discussed. Recent discoveries at both single-cell and population levels highlight the dynamic and stimulus-dependent engagement of multiple mechanisms that collectively implement robust motion detection under diverse visual conditions.</p>","PeriodicalId":48658,"journal":{"name":"Annual Review of Vision Science","volume":"4 ","pages":"165-192"},"PeriodicalIF":6.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-vision-091517-034048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36386612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 69
How Visual Cortical Organization Is Altered by Ophthalmologic and Neurologic Disorders. 视觉皮层组织如何被眼科和神经疾病改变。
IF 6 2区 医学
Annual Review of Vision Science Pub Date : 2018-09-15 Epub Date: 2018-06-11 DOI: 10.1146/annurev-vision-091517-033948
Serge O Dumoulin, Tomas Knapen
{"title":"How Visual Cortical Organization Is Altered by Ophthalmologic and Neurologic Disorders.","authors":"Serge O Dumoulin,&nbsp;Tomas Knapen","doi":"10.1146/annurev-vision-091517-033948","DOIUrl":"https://doi.org/10.1146/annurev-vision-091517-033948","url":null,"abstract":"<p><p>Receptive fields are a core property of cortical organization. Modern neuroimaging allows routine access to visual population receptive fields (pRFs), enabling investigations of clinical disorders. Yet how the underlying neural circuitry operates is controversial. The controversy surrounds observations that measurements of pRFs can change in healthy adults as well as in patients with a range of ophthalmological and neurological disorders. The debate relates to the balance between plasticity and stability of the underlying neural circuitry. We propose that to move the debate forward, the field needs to define the implied mechanism. First, we review the pRF changes in both healthy subjects and those with clinical disorders. Then, we propose a computational model that describes how pRFs can change in healthy humans. We assert that we can correctly interpret the pRF changes in clinical disorders only if we establish the capabilities and limitations of pRF dynamics in healthy humans with mechanistic models that provide quantitative predictions.</p>","PeriodicalId":48658,"journal":{"name":"Annual Review of Vision Science","volume":"4 ","pages":"357-379"},"PeriodicalIF":6.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-vision-091517-033948","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Shape from Contour: Computation and Representation. 轮廓的形状:计算和表示。
IF 6 2区 医学
Annual Review of Vision Science Pub Date : 2018-09-15 DOI: 10.1146/annurev-vision-091517-034110
James H Elder
{"title":"Shape from Contour: Computation and Representation.","authors":"James H Elder","doi":"10.1146/annurev-vision-091517-034110","DOIUrl":"https://doi.org/10.1146/annurev-vision-091517-034110","url":null,"abstract":"<p><p>The human visual system reliably extracts shape information from complex natural scenes in spite of noise and fragmentation caused by clutter and occlusions. A fast, feedforward sweep through ventral stream involving mechanisms tuned for orientation, curvature, and local Gestalt principles produces partial shape representations sufficient for simpler discriminative tasks. More complete shape representations may involve recurrent processes that integrate local and global cues. While feedforward discriminative deep neural network models currently produce the best predictions of object selectivity in higher areas of the object pathway, a generative model may be required to account for all aspects of shape perception. Research suggests that a successful model will account for our acute sensitivity to four key perceptual dimensions of shape: topology, symmetry, composition, and deformation.</p>","PeriodicalId":48658,"journal":{"name":"Annual Review of Vision Science","volume":"4 ","pages":"423-450"},"PeriodicalIF":6.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-vision-091517-034110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36497176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
A Life in Vision. 想象中的生活。
IF 6 2区 医学
Annual Review of Vision Science Pub Date : 2018-09-15 DOI: 10.1146/annurev-vision-091517-034222
John E Dowling
{"title":"A Life in Vision.","authors":"John E Dowling","doi":"10.1146/annurev-vision-091517-034222","DOIUrl":"https://doi.org/10.1146/annurev-vision-091517-034222","url":null,"abstract":"<p><p>I was drawn into research in George Wald's laboratory at Harvard, where as an undergraduate and graduate student, I studied vitamin A deficiency and dark adaptation. A chance observation while an assistant professor at Harvard led to the major research of my career-to understand the functional organization of vertebrate retinas. I started with a retinal circuit analysis of the primate retina with Brian Boycott and intracellular retinal cell recordings in mudpuppies with Frank Werblin. Subsequent pharmacology studies with Berndt Ehinger primarily with fish focused on dopamine and neuromodulation. Using zebrafish, we studied retinal development, neuronal connectivity, and the effects of genetic mutations on retinal structure and function. Now semi-retired, I have returned to primate retinal circuitry, undertaking a connectomic analysis of the human fovea in Jeffrey Lichtman's laboratory.</p>","PeriodicalId":48658,"journal":{"name":"Annual Review of Vision Science","volume":"4 ","pages":"1-23"},"PeriodicalIF":6.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-vision-091517-034222","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36497177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信