Bio-Design and Manufacturing最新文献_第9页

Microcapillary cell extrusion deposition with picolitre dispensing resolution. 微毛细管挤压沉积与皮升点胶分辨率。

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2023-01-01 DOI: 10.1007/s42242-022-00205-3

Saeed Fathi, Iek Man Lei, Yang Cao, Yan Yan Shery Huang

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引用次数: 0

Organoids revealed: morphological analysis of the profound next generation in-vitro model with artificial intelligence. 揭示的类器官:具有人工智能的深层下一代体外模型的形态学分析。

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2023-01-01 DOI: 10.1007/s42242-022-00226-y

Xuan Du, Zaozao Chen, Qiwei Li, Sheng Yang, Lincao Jiang, Yi Yang, Yanhui Li, Zhongze Gu

{"title":"Organoids revealed: morphological analysis of the profound next generation in-vitro model with artificial intelligence.","authors":"Xuan Du, Zaozao Chen, Qiwei Li, Sheng Yang, Lincao Jiang, Yi Yang, Yanhui Li, Zhongze Gu","doi":"10.1007/s42242-022-00226-y","DOIUrl":"https://doi.org/10.1007/s42242-022-00226-y","url":null,"abstract":"In modern terminology, \"organoids\" refer to cells that grow in a specific three-dimensional (3D) environment in vitro, sharing similar structures with their source organs or tissues. Observing the morphology or growth characteristics of organoids through a microscope is a commonly used method of organoid analysis. However, it is difficult, time-consuming, and inaccurate to screen and analyze organoids only manually, a problem which cannot be easily solved with traditional technology. Artificial intelligence (AI) technology has proven to be effective in many biological and medical research fields, especially in the analysis of single-cell or hematoxylin/eosin stained tissue slices. When used to analyze organoids, AI should also provide more efficient, quantitative, accurate, and fast solutions. In this review, we will first briefly outline the application areas of organoids and then discuss the shortcomings of traditional organoid measurement and analysis methods. Secondly, we will summarize the development from machine learning to deep learning and the advantages of the latter, and then describe how to utilize a convolutional neural network to solve the challenges in organoid observation and analysis. Finally, we will discuss the limitations of current AI used in organoid research, as well as opportunities and future research directions.Graphic abstract: ","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":"6 3","pages":"319-339"},"PeriodicalIF":7.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9374483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Multidrug dissolvable microneedle patch for the treatment of recurrent oral ulcer 多药溶性微针贴片治疗复发性口腔溃疡

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2022-12-28 DOI: 10.1007/s42242-022-00221-3

Yuqiong Wang, An’an Sheng, Xinran Jiang, Shanshan Yang, Long Lin, Mingzhu Yang, Fengshuo Zhu, Yongyan Hu, Jian Li, Lingqian Chang

引用次数: 5

Direct ink writing to fabricate porous acetabular cups from titanium alloy 用钛合金直接墨水书写制备多孔髋臼杯

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2022-12-28 DOI: 10.1007/s42242-022-00222-2

Naima Valentin, W. Hua, A. Kasar, Lily Raymond, P. Menezes, Yifei Jin

引用次数: 2

Bioinspired flexible piezoresistive sensor for high-sensitivity detection of broad pressure range 仿生柔性压阻传感器用于宽压力范围的高灵敏度检测

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2022-12-28 DOI: 10.1007/s42242-022-00220-4

Meng Wang, Hao Zhang, Hang Wu, Suqian Ma, L. Ren, Yunhong Liang, Chongxing Liu, Zhiwu Han

引用次数: 6

Functionalized alginate-based bioinks for microscale electrohydrodynamic bioprinting of living tissue constructs with improved cellular spreading and alignment 功能化海藻酸盐基生物墨水用于微尺度电流体动力生物打印的活组织结构，改善细胞扩散和排列

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2022-12-24 DOI: 10.1007/s42242-022-00225-z

Zhennan Qiu, Huilin Zhu, Yutao Wang, Ayiguli Kasimu, Dichen Li, Jiankang He

引用次数: 4

Designs and methodologies to recreate in vitro human gut microbiota models 体外重建人类肠道微生物群模型的设计和方法

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2022-12-17 DOI: 10.1007/s42242-022-00210-6

Francesco Biagini, C. Daddi, Marco Calvigioni, C. De Maria, Y. S. Zhang, E. Ghelardi, G. Vozzi

引用次数: 3

Development of a portable reflectance confocal microscope and its application in the noninvasive in vivo evaluation of mesenchymal stem cell-promoted cutaneous wound healing 便携式反射共聚焦显微镜的研制及其在无创体内评价间充质干细胞促进皮肤创面愈合中的应用

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2022-12-12 DOI: 10.1007/s42242-022-00223-1

Lixing Zhang, Xin Miao, Meijia Wang, Aihua Shi, Jingwen Wang, Zhonglin Ma, Yunhai Zhang, Jingzhong Zhang, Shuang Yu

引用次数: 0

Three-dimensional kagome structures in a PCL/HA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration 以PCL/ ha为基础的水凝胶支架中的三维鹿茸结构，可导致BMP-2缓慢释放，从而实现有效的骨再生

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2022-12-03 DOI: 10.1007/s42242-022-00219-x

Se-Hwan Lee, Kang-Gon Lee, Jaeyeon Lee, Y. Cho, Min-Soo Ghim, Soojin Kim, S. Heo, Yongdoo Park, Young-Sam Cho, B. Lee

引用次数: 2

Junction matters in hydraulic circuit bio-design of microfluidics 微流体液压回路生物设计中的连接问题

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2022-11-11 DOI: 10.1007/s42242-022-00215-1

Yao Lin, Dongliang He, Zerui Wu, Y. Yao, Zhanhao Zhang, Yuheng Qiu, Shangyu Wei, G. Shang, Xingyue Lei, Ping Wu, Weiping Ding, Liqun He

引用次数: 0