{"title":"Microbial Dynamics and Quality Monitoring in Biopharmaceutical Production","authors":"Rosha Pashang, Kimberley A. Gilbride, Jannis Wenk","doi":"10.1002/cben.202400022","DOIUrl":"https://doi.org/10.1002/cben.202400022","url":null,"abstract":"<p>Prokaryotic cells are pivotal in meeting the global demand for biopharmaceuticals. However, challenges such as the absence of advanced technology for real-time monitoring, standardized testing methodologies, and quality risk assessment of microbial activity have led to increased production costs, delays, and shortages of biopharmaceutical products. A thorough understanding of how biomolecule production interacts with microbial population structure and function is vital for improving continuous manufacturing and process automation. In this review, we discuss the current microbiological techniques that meet good manufacturing practice requirements in industrial settings, explore the advantages of monitoring and measuring biomass growth efficiency and turnover rates beyond regulatory criteria for product release, and provide a critical assessment of the current state of knowledge on bioassays and engineering tools for biomolecule yield measurement and monitoring. Furthermore, we identify areas for future development, potential applications, and the need for interdisciplinary innovation to drive future research, including advancing bioassays for biopharmaceutical wastewater risk.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"11 6","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cben.202400022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142860242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cover Picture: ChemBioEng Reviews 5/2024","authors":"","doi":"10.1002/cben.202470501","DOIUrl":"https://doi.org/10.1002/cben.202470501","url":null,"abstract":"<p>Effective biobased thermally insulating materials are crucial to addressing the escalating concerns surrounding climate change and plastic waste. Numerous experimental biobased foams have demonstrated properties that are either equal to or superior to those of traditional foams employed in the construction sector. The comprehensive review titled “Recent Advances in Biobased Foams and Foam Composites for Construction Applications” by DSouza et al. (DOI: https://doi.org/10.1002/cben.202300014) specifically focuses on the fabrication methods, advancements, and future prospects of biobased polyurethanes (BPU), biobased phenol formaldehyde (BPF), and cellulose nanofibers (CNF) foams for application in residential construction. To be a suitable material for construction, a biobased foam must be an excellent thermal insulator (possessing low thermal conductivity), a fire retardant (with high limiting oxygen index) and possess remarkable mechanical properties. The cover image thus depicts forest waste-based foams that meet the design criteria for construction applications. [Credits: Riddhi Gadre for the initial design and InMyWork Studio team for the final design]</p><p>Biobased Foams for Construction Applications. Copyright: Glen Cletus DSouza, Harrison Ng, Paul Charpentier, Chunbao Charles Xu\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"11 5","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cben.202470501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shruti Nandkishor Tanwar, Yatish R. Parauha, Yogesh There, Hendrik C. Swart, Sanjay J. Dhoble
{"title":"Plant-Based Biosynthesis of Metal and Metal Oxide Nanoparticles: An Update on Antimicrobial and Anticancer Activity","authors":"Shruti Nandkishor Tanwar, Yatish R. Parauha, Yogesh There, Hendrik C. Swart, Sanjay J. Dhoble","doi":"10.1002/cben.202400012","DOIUrl":"https://doi.org/10.1002/cben.202400012","url":null,"abstract":"<p>Nanotechnology has changed and developed all the sectors and working fields. Nanoparticles are one of the important evolutionary materials that have application in almost all the working areas such as catalysis, bioengineering, photoelectricity, antibacterial, anticancer, and medical imaging due to their unique physical and chemical properties. Traditionally used chemical and physical method of synthesis of nanoparticles have several disadvantages like using different chemicals, high cost, and most importantly they are hazardous to the environment. Counter to these disadvantages, a more eco-friendly, easy, and cost-effective green synthesis method is widely employed nowadays. Various parts of a plant are used as a fuel for reducing the metal ion salt. Plant extracts act as reducing, stabilizing, and capping agents. Besides these advantages, photosynthesized nanoparticles are nontoxic, more stable, and more uniform in size than their counterparts prepared by the traditional method. In this present review, the synthesis of various plant extract-mediated metal and metal oxide nanoparticles is discussed along with their different applications. This review provides a comprehensive overview of key findings in green synthesis of metal and metal oxide nanoparticles and attempts to determine their possible synthesis mechanism. This article also focuses on factors affecting their synthesis, characterization, potential applications, and prospects.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"11 6","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cben.202400012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MUDr. Monika Reháčková, MUDr. Miroslav Veith, Petr Stavárek, Maria Zedniková, Sandra Orvalho, Věra Pěnkavová, Natalie Jaklová, Sara Maliková, Dr. Petr Klusoň
{"title":"Chemical Engineering View on the Silicone Oil Utilization in the Treatment of Retinal Detachment","authors":"MUDr. Monika Reháčková, MUDr. Miroslav Veith, Petr Stavárek, Maria Zedniková, Sandra Orvalho, Věra Pěnkavová, Natalie Jaklová, Sara Maliková, Dr. Petr Klusoň","doi":"10.1002/cben.202400090","DOIUrl":"https://doi.org/10.1002/cben.202400090","url":null,"abstract":"<p>Retinal detachment is an acute condition in ophthalmology that needs an immediate surgical management. The treatment requires a replacement of the vitreous with a temporary substitute, usually based on a silicone oil. A certain number of patients experience adverse events during the treatment. It seems this phenomenon is related to the formation of emulsions in the affected eye. These appear macroscopically as heterogeneities resembling small droplets with a patchy occurrence in the vitreous substitute. Their existence represents a major complication that may lead to loss of vision. The heterogeneities are transported to regions of the eye in which they cause irreversible damage. The current state of knowledge describes the phenomenon and recommends certain intervention procedures. Here, specific attention is paid to the chemical engineering aspects of the utilization of silicone oils for the treatment of the retinal detachment. It is very likely that the process of tiny droplet formation leading to the development of emulsions is substantially controlled by the hydrodynamic conditions in the eye. The complexity of this statement is examined in this review text.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"11 6","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anaerobic Digestion for Textile Waste Treatment and Valorization","authors":"Naveenrajah Tharamrajah, Kaveh Shahbaz, Saeid Baroutian","doi":"10.1002/cben.202400014","DOIUrl":"https://doi.org/10.1002/cben.202400014","url":null,"abstract":"<p>Textile waste is becoming among the most polluting waste in the world, discarded mostly in landfills. Valorizing textile waste via anaerobic digestion (AD) helps conserve resources, reduce environmental impact, and foster a circular economy. Although several reviews have discussed textile waste AD, there is a lack of detailed understanding of the challenges encountered during textile waste AD. Therefore, the goal of this review is to focus on challenges encountered and possible solutions for those challenges for biogas and fertilizer conversion via AD. Potential strategies include chemical, biological, and thermal pretreatments that significantly increase the digestion process. Co-digestion of natural textile waste, cotton, and wool with carbon and nitrogen-rich substrates improves AD efficiency by twofold. Moreover, separating polyester from polycotton and textile dye removal via solvent and advanced oxidation processes significantly increases methane yield compared with untreated textile waste. This review can aid in analyzing suitable methods to optimize the biogas production of textile waste via AD.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"11 5","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cben.202400014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glycerol as a Feedstock for Chemical Synthesis","authors":"Maratul Husna, Yasemin Tabak, Meltem Yıldız","doi":"10.1002/cben.202400010","DOIUrl":"https://doi.org/10.1002/cben.202400010","url":null,"abstract":"<p>Glycerol, defined simply as a colorless, sweet syrupy liquid extracted from fatty substances through saponification, is an alcohol with three hydroxyl (OH–) groups in its structure. Glycerol has many uses in the consumer market. It is used primarily in personal care products, as an adhesive and sealing agent and many applications. Glycerol, whose name is propane-1,2,3-triol, standardized by the International Union of Pure and Applied Chemistry (IUPAC), CHO open formula CH<sub>2</sub>OH–CHOH–CH<sub>2</sub>OH. It can be said that glycerol, a by-product of biodiesel, is produced in very high quantities. Retention of the produced glycerol will lead to cost increases and environmental problems that may directly affect the development of the biodiesel market. Due to the supply of glycerol to the market in large quantities, glycerol prices have hit the bottom, and therefore, the income and profitability of biodiesel production factories from the sale of glycerol have decreased. This situation clearly shows that the excess of glycerol now poses an obstacle to developing the biodiesel market. This article aims to list the valuable chemicals into which glycerol, produced in large quantities as a biodiesel by-product, can be converted under a single heading and to detail the studies carried out on this subject.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"11 5","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cben.202400010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microwave Application in Biomass Conversion: A Review","authors":"Quanwei Liu, Mengmeng Liu, Kang Zhao, Zhen Liu","doi":"10.1002/cben.202400020","DOIUrl":"https://doi.org/10.1002/cben.202400020","url":null,"abstract":"<p>Biomass resources are abundant and have huge production capacity. Reasonably and efficiently converting biomass can not only alleviate the depletion of fossil resources but also protect the environment and promote the green and sustainable development of human society. Microwave is one of the currently highly regarded process intensification technologies. This paper reviews the research progress of microwave technology in biomass pyrolysis, biomass pretreatment, and biomass conversion, and analyzes its technical characteristics. Finally, it summarizes and prospects the application of microwave in the field of biomass conversion.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"11 5","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Toward Sustainable Production: Emerging Trends in Iron and Steel Making","authors":"Neema Adhikari, Shabina Khanam","doi":"10.1002/cben.202300055","DOIUrl":"10.1002/cben.202300055","url":null,"abstract":"<p>The iron and steel industry is a significant contributor to greenhouse gas emissions, responsible for about 7–9 % of the total emissions. This paper examines sustainable production methods in the iron and steel industry, focusing on decarbonization strategies and energy integration. It covers a wide range of alternative reductants to replace the conventional use of coal. Moreover, the paper highlights the challenges and opportunities associated with each approach. Additionally, it discusses the design modifications for coal-based sponge iron plants, aiming to reduce coal consumption and waste gas generation while ensuring economic viability. This study provides a roadmap for transitioning to environmentally friendly, technically feasible, and economically viable iron and steel manufacturing processes.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"11 5","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142204548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}