Yale Journal of Biology and Medicine最新文献_第7页

Therapeutic Potential of Nitrogen-Doped Rutin-Bound Glucose Carbon Dots for Alzheimer's Disease. 掺氮芦丁结合葡萄糖碳点对阿尔茨海默病的治疗潜力

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-06-28 eCollection Date: 2024-06-01 DOI: 10.59249/EWOI2166

Sana Khan, Faria Hasan Jatala, Alveena Muti, Noor Afza, Aneeqa Noor, Sara Mumtaz, Saima Zafar

{"title":"Therapeutic Potential of Nitrogen-Doped Rutin-Bound Glucose Carbon Dots for Alzheimer's Disease.","authors":"Sana Khan, Faria Hasan Jatala, Alveena Muti, Noor Afza, Aneeqa Noor, Sara Mumtaz, Saima Zafar","doi":"10.59249/EWOI2166","DOIUrl":"10.59249/EWOI2166","url":null,"abstract":"The blood-brain barrier (BBB) prevents the use of many drugs for the treatment of neurological disorders. Recently, nitrogen-doped carbon dots (NCDs) have emerged as promising nanocarriers to cross BBB. The primary focus of our study was to evaluate the effectiveness of NCDs for the symptomatic treatment of Alzheimer's disease (AD). In this study, we developed and characterized NCDs bound to rutin, a flavonoid with known benefits for AD. Despite its benefits, the transportation of rutin via NCDs for AD therapy has not been explored previously. We characterized the particles using FTIR and UV-visible spectroscopy followed by atomic force microscopy. Once the design was optimized and validated, we performed in vivo testing via a hemolytic assay to optimize the dosage. Preliminary in vitro testing was performed in AlCl3-induced rat models of AD whereby a single dose of 10 mg/kg NCDs-rutin was administered intraperitoneally. Interestingly, this single dose of 10 mg/kg NCDs-rutin produced the same behavioral effects as 50 mg/kg rutin administered intraperitoneally for 1 month. Similarly, histological and biomarker profiles (SOD2 and TLR4) also presented significant protective effects of NCDs-rutin against neuronal loss, inflammation, and oxidative stress. Hence, NCDs-rutin are a promising approach for the treatment of neurological diseases.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 2","pages":"153-164"},"PeriodicalIF":2.5,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11202111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reevaluating Biota Alteration: Reframing Environmental Influences on Chronic Immune Disorders and Exploring Novel Therapeutic Opportunities. 重新评估生物群变化：重塑环境对慢性免疫疾病的影响，探索新的治疗机会。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-06-28 eCollection Date: 2024-06-01 DOI: 10.59249/VUNF1315

William Parker, Kateřina Jirků, Esha Patel, Lauren Williamson, Lauren Anderson, Jon D Laman

{"title":"Reevaluating Biota Alteration: Reframing Environmental Influences on Chronic Immune Disorders and Exploring Novel Therapeutic Opportunities.","authors":"William Parker, Kateřina Jirků, Esha Patel, Lauren Williamson, Lauren Anderson, Jon D Laman","doi":"10.59249/VUNF1315","DOIUrl":"10.59249/VUNF1315","url":null,"abstract":"Environmental mismatches are defined as changes in the environment that induce public health crises. Well known mismatches leading to chronic disease include the availability of technologies that facilitate unhealthy diets and sedentary lifestyles, both factors that adversely affect cardiovascular health. This commentary puts these mismatches in context with biota alteration, an environmental mismatch involving hygiene-related technologies necessary for avoidance of infectious disease. Implementation of hygiene-related technologies causes a loss of symbiotic helminths and protists, profoundly affecting immune function and facilitating a variety of chronic conditions, including allergic disorders, autoimmune diseases, and several inflammation-associated neuropsychiatric conditions. Unfortunately, despite an established understanding of the biology underpinning this and other environmental mismatches, public health agencies have failed to stem the resulting tide of increased chronic disease burden. Both biomedical research and clinical practice continue to focus on an ineffective and reactive pharmaceutical-based paradigm. It is argued that the healthcare of the future could take into account the biology of today, effectively and proactively dealing with environmental mismatch and the resulting chronic disease burden.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 2","pages":"253-263"},"PeriodicalIF":2.5,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11202117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the Impact of Social Support on Psychological Well-Being Among Canadian Individuals With COPD: Implications for Government Policies. 研究社会支持对加拿大慢性阻塞性肺病患者心理健康的影响：对政府政策的启示。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-06-28 eCollection Date: 2024-06-01 DOI: 10.59249/OKAB8606

Rosina E Mete

{"title":"Examining the Impact of Social Support on Psychological Well-Being Among Canadian Individuals With COPD: Implications for Government Policies.","authors":"Rosina E Mete","doi":"10.59249/OKAB8606","DOIUrl":"10.59249/OKAB8606","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a significant respiratory disease and is globally ranked as the third leading cause of death. In Canada, the direct healthcare costs associated with COPD are estimated to be $1.5 billion annually. This study utilized quantitative analyses to examine the impact of specific dimensions of social support, namely, guidance, reliable alliance, reassurance of worth, attachment, and social integration within a clinically identified population of individuals with COPD who exhibit symptoms of depression and anxiety. The study was based on the Social Provisions Theory and stress-buffering hypothesis, utilizing large-scale population data from Statistics Canada's 2012 Canadian Community Health Survey (CCHS) Mental Health component. On a national scale, individuals were more likely to report a decreased sense of belonging to a group of friends (social integration) and struggle to depend on others in stressful times (reliable alliance) while experiencing symptoms of anxiety and depression. These findings underscore the potential benefits of integrating peer support, socialization initiatives, and caregiver training into clinical programs designed for individuals with COPD.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 2","pages":"125-139"},"PeriodicalIF":2.5,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11202116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suppressor of Cytokine Signaling Proteins 3 and 5 Potentially Delineate Polarization of Th cells in Chronic Rhinosinusitis. 细胞因子信号转导抑制蛋白 3 和 5 有可能划定慢性鼻炎 Th 细胞的极化。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-06-28 eCollection Date: 2024-06-01 DOI: 10.59249/HZFN2950

Babak Ghalehbaghi, Hossein Aazami, Majid Khoshmirsafa, Alireza Mohebbi, Pegah Babaheidarian, Nesa Rashidi, Kobra Mokhtarian, Reza Ahmadi, Monireh Kamali, Majid Ponour, Ayda Sanaei, Farhad Seif, Maryam Jalessi

{"title":"Suppressor of Cytokine Signaling Proteins 3 and 5 Potentially Delineate Polarization of Th cells in Chronic Rhinosinusitis.","authors":"Babak Ghalehbaghi, Hossein Aazami, Majid Khoshmirsafa, Alireza Mohebbi, Pegah Babaheidarian, Nesa Rashidi, Kobra Mokhtarian, Reza Ahmadi, Monireh Kamali, Majid Ponour, Ayda Sanaei, Farhad Seif, Maryam Jalessi","doi":"10.59249/HZFN2950","DOIUrl":"10.59249/HZFN2950","url":null,"abstract":"Background: Chronic rhinosinusitis (CRS) is an inflammatory condition classified into chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP). Th cells manage inflammatory cells in CRS. Suppressor of Cytokine Signaling (SOCS) proteins regulate Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway in Th cells by polarizing toward Th1, Th2, and Th17 cells. This study evaluated the levels of SOCS1,3,5 in CRS patients to find associations with Th cells. Methods: In this cross-sectional study, 20 CRSwNP patients, 12 CRSsNP patients, and 12 controls participated. The infiltration of CD4+ T cells was determined using immunohistochemistry. The expression of specific transcription factors and SOCS proteins was assessed using real-time PCR. Cytokine levels were evaluated using ELISA. SOCS protein levels were investigated using western blot analysis. Results: The expression of SOCS3 increased in the CRSwNP group compared to CRSsNP and control groups (p <0.001). SOCS3 protein levels increased in the CRSwNP group compared to CRSsNP (p <0.05) and control (p <0.001) groups. Although there was a significant difference in SOCS5 expression between CRSsNP and control groups, SOCS5 protein levels were significantly different between CRSsNP and control (p <0.001) and CRSwNP (p <0.05) groups. Conclusions: Targeted therapies may be suggested for CRS by modulating SOCS3 and SOCS5 proteins that are responsible for polarization of Th cells toward Th2 or Th1 cells, respectively. JAK-STAT pathway targeting, which encompasses numerous cells, can be limited to SOCS proteins to more effectively orchestrate Th cell differentiation.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 2","pages":"165-177"},"PeriodicalIF":2.5,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11202107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer to Cataracts: The Mechanistic Impact of Aldo-Keto Reductases in Chronic Diseases. 从癌症到白内障：慢性疾病中醛酮还原酶的机理影响。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-06-28 eCollection Date: 2024-06-01 DOI: 10.59249/VTBV6559

Anirudh P Shanbhag, Purnendu Bhowmik

引用次数: 0

Causes and Effects of COVID-19 Vaccine Hesitancy Among Pregnant Women and its Association with Adverse Maternal, Placental, and Perinatal Outcomes. 孕妇不接种 COVID-19 疫苗的原因和影响及其与孕产妇、胎盘和围产期不良结果的关联。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI: 10.59249/LPOQ5146

Kristen Lee Moriarty, Roselyn O Oyenuga, Olatoyosi Olafuyi, David A Schwartz

引用次数: 0

Effect of Prenatal Care on Perinatal Outcomes of Pregnant Women with Diabetes Mellitus: A Systematic Review. 产前护理对糖尿病孕妇围产期结果的影响：系统回顾

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI: 10.59249/WPTY4075

Letícia B G da Silva, Lenita Zajdenverg, Elisa Keating, Manoela Pereira Smith Silvestre, Beatriz M B Dos Santos, Cláudia Saunders

{"title":"Effect of Prenatal Care on Perinatal Outcomes of Pregnant Women with Diabetes Mellitus: A Systematic Review.","authors":"Letícia B G da Silva, Lenita Zajdenverg, Elisa Keating, Manoela Pereira Smith Silvestre, Beatriz M B Dos Santos, Cláudia Saunders","doi":"10.59249/WPTY4075","DOIUrl":"10.59249/WPTY4075","url":null,"abstract":"Objective: to evaluate the effect of prenatal care (PC) on perinatal outcomes of pregnant women with diabetes mellitus (DM). Methods: systematic review developed according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines and conducted through the population, intervention, control, and outcomes (PICO) strategy. Clinical trials and observational studies were selected, with adult pregnant women, single-fetus pregnancy, diagnosis of DM, or gestational DM and who had received PC and/or nutritional therapy (NT). The search was carried out in PubMed, Scopus, and BIREME databases. The quality of the studies was evaluated using the tools of the National Heart, Lung and Blood Institute-National Institutes of Health (NHLBI-NIH). Results: We identified 5972 records, of which 15 (n=47 420 pregnant women) met the eligibility criteria. The most recurrent outcomes were glycemic control (14 studies; n=9096 participants), hypertensive disorders of pregnancy (2; n=39 282), prematurity (6; n=40 163), large for gestational age newborns (4; n=1556), fetal macrosomia (birth weight >4kg) (6; n=2980) and intensive care unit admission (4; n=2022). Conclusions: The findings suggest that PC interferes with the perinatal outcome, being able to reduce the risks of complications associated with this comorbidity through early intervention, especially when the NT is an integral part of this assistance.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 1","pages":"49-65"},"PeriodicalIF":2.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of Genetic and Artificial Intelligence approaches to improving Gestational Diabetes Mellitus Screening and Diagnosis in sub-Saharan Africa. 审查改进撒哈拉以南非洲妊娠糖尿病筛查和诊断的遗传和人工智能方法。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI: 10.59249/ZBSC2656

Vansh V Gadhia, Jaspreet Loyal

{"title":"Review of Genetic and Artificial Intelligence approaches to improving Gestational Diabetes Mellitus Screening and Diagnosis in sub-Saharan Africa.","authors":"Vansh V Gadhia, Jaspreet Loyal","doi":"10.59249/ZBSC2656","DOIUrl":"10.59249/ZBSC2656","url":null,"abstract":"Background: Adverse outcomes from gestational diabetes mellitus (GDM) in the mother and newborn are well established. Genetic variants may predict GDM and Artificial Intelligence (AI) can potentially assist with improved screening and early identification in lower resource settings. There is limited information on genetic variants associated with GDM in sub-Saharan Africa and the implementation of AI in GDM screening in sub-Saharan Africa is largely unknown. Methods: We reviewed the literature on what is known about genetic predictors of GDM in sub-Saharan African women. We searched PubMed and Google Scholar for single nucleotide polymorphisms (SNPs) involved in GDM predisposition in a sub-Saharan African population. We report on barriers that limit the implementation of AI that could assist with GDM screening and offer possible solutions. Results: In a Black South African cohort, the minor allele of the SNP rs4581569 existing in the PDX1 gene was significantly associated with GDM. We were not able to find any published literature on the implementation of AI to identify women at risk of GDM before second trimester of pregnancy in sub-Saharan Africa. Barriers to successful integration of AI into healthcare systems are broad but solutions exist. Conclusions: More research is needed to identify SNPs associated with GDM in sub-Saharan Africa. The implementation of AI and its applications in the field of healthcare in the sub-Saharan African region is a significant opportunity to positively impact early identification of GDM.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 1","pages":"67-72"},"PeriodicalIF":2.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

External Disruption of Ocular Development in Utero. 胎儿眼部发育的外部干扰

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI: 10.59249/RRMM8911

Hyun Sue Kim, Soshian Sarrafpour, Christopher C Teng, Ji Liu

{"title":"External Disruption of Ocular Development in Utero.","authors":"Hyun Sue Kim, Soshian Sarrafpour, Christopher C Teng, Ji Liu","doi":"10.59249/RRMM8911","DOIUrl":"10.59249/RRMM8911","url":null,"abstract":"The intricate steps of human ocular embryology are impacted by cellular and genetic signaling pathways and a myriad of external elements that can affect pregnancy, such as environmental, metabolic, hormonal factors, medications, and intrauterine infections. This review focuses on presenting some of these factors to recognize the multifactorial nature of ocular development and highlight their clinical significance. This review is based on English-language articles sourced from PubMed, Web of Science, and Google Scholar; keywords searched included \"ocular development in pregnancy,\" \"ocular embryology,\" \"maternal nutrition,\" \"ophthalmic change,\" and \"visual system development.\" While some animal models show the disruption of ocular embryology from these external factors, there are limited post-birth assessments in human studies. Much remains unknown about the precise mechanisms of how these external factors can disrupt normal ocular development in utero, and more significant research is needed to understand the pathophysiology of these disruptive effects further. Findings in this review emphasize the importance of additional research in understanding the dynamic association between factors impacting gestation and neonatal ocular development, particularly in the setting of limited resources.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 1","pages":"41-48"},"PeriodicalIF":2.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Open Conversation About Postpartum Psychosis: An Interview with Jessie Hunt: Communications Lead, Advocate, and Expert by Experience. 关于产后精神病的公开对话：采访杰西-亨特（Jessie Hunt）：沟通领导者、倡导者和经验专家。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI: 10.59249/PWXZ3821

Udita Iyengar, Jessie Hunt

引用次数: 0