Clinical and Translational Imaging最新文献

{"title":"The role of 68Ga-Pentixafor PET in Primary Aldosteronism: a systematic review and meta-analysis","authors":"Min Wang, Jiayu Zhang, Bin Wu, Chunyin Zhang","doi":"10.1007/s40336-023-00610-3","DOIUrl":"https://doi.org/10.1007/s40336-023-00610-3","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objective</h3><p>The objective of this research is to conduct a thorough evaluation, both quantitatively and qualitatively, of the effectiveness of ⁶⁸Ga-Pentixafor PET within the Primary Aldosteronism framework.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We systematically searched the PubMed and Embase databases for relevant studies concerning the use of ⁶⁸Ga-Pentixafor PET in Primary Aldosteronism, spanning from the inception of these databases up to September 1, 2023. We assessed the quality of the chosen literature employing the QUADAS-2 diagnostic test evaluation tool. Following this, we conducted comprehensive analyses, both quantitatively and qualitatively, on relevant outcome measures extracted from the selected literature.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>This study incorporated 7 articles encompassing a total of 474 patients. Among these articles, seven studies assessed the accuracy of ⁶⁸Ga-Pentixafor PET in distinguishing between different subtypes of Primary Aldosteronism, namely aldosterone-producing adenoma and non-aldosterone-producing adenoma. Of these, four studies presented complete 2 × 2 contingency tables for visual analysis, and three studies provided complete 2 × 2 contingency tables for semi-quantitative analysis. In addition, six studies reported the correlation between ⁶⁸Ga-Pentixafor PET findings and the clinical characteristics of patients. Furthermore, five studies explored the relationship between ⁶⁸Ga-Pentixafor PET outcomes and the clinical prognosis of patients. Five studies also investigated the correlation between ⁶⁸Ga-Pentixafor PET results and immunohistochemistry, whereas four studies assessed the link between ⁶⁸Ga-Pentixafor PET and nodule size.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>⁶⁸Ga-Pentixafor PET displays substantial promise in enhancing the diagnosis of Primary Aldosteronism subtypes and precisely localizing aldosterone-producing adenoma. Furthermore, ⁶⁸Ga-Pentixafor PET imaging exhibits significant correlations with the clinical characteristics, clinical prognosis, immunohistochemistry, and nodule size in Primary Aldosteronism patients.</p>","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":"26 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139501588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radio-guided surgery with beta emission: status and perspectives","authors":"Riccardo Mirabelli, Silvio Morganti, Anita Florit, Valerio Lanni, Francesco Collamati","doi":"10.1007/s40336-023-00606-z","DOIUrl":"https://doi.org/10.1007/s40336-023-00606-z","url":null,"abstract":"<p>Surgery is a key treatment for localized or locally advanced solid tumors. However, the application of wide safety margins can result in significant side effects and functional limitations for the patient. On the contrary, tissue-sparing surgery may leave residual tumor, which can lead to local recurrent cancer or distant metastases. To address these problems, intraoperative radio-guidance, such as beta radio-guided surgery (RGS), could be used to detect small cancerous tissue and selectively resect malignant areas. This paper provides a comprehensive review of RGS based on beta emission, focusing on the physical principles that differentiate beta radiation from gamma radiation, which is already commonly used in nuclear medicine. Although beta RGS was proposed several decades ago, its popularity has recently increased, possibly due to the widespread use of newly developed PET radiotracers. Various approaches are currently being investigated to assess the effectiveness of beta RGS, including the use of both beta+ and beta− emitting radiopharmaceuticals. Beta RGS has unique characteristics that make it a promising complementary technique to standard procedures. Encouraging results have been obtained in numerous ex vivo and in vivo tests. However, clinical trials are needed to demonstrate the real clinical value of these promising technologies. The references presented represent the most impactful works in the development of beta RGS, according to the authors. Papers were selected from a Scopus search with keywords “radio-guided surgery” and “beta emitter”.</p>","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":"52 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139103511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between computed tomography and magnetic resonance imaging in detecting multiple myeloma lesions in the skull: A systematic review","authors":"Thaiza Goncalves Rocha, Carla Barros de Oliveira, Roberto José Pessoa de Magalhães Filho, Angelo Maiolino, Marcela Baraúna Magno, Davi da Silva Barbirato, Eduardo Murad Villoria, Lucianne Cople Maia, Sandra Regina Torres, Maria Augusta Visconti","doi":"10.1007/s40336-023-00605-0","DOIUrl":"https://doi.org/10.1007/s40336-023-00605-0","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objective</h3><p>Review, qualify and synthesize the evidence that compared computed tomography (CT) images with magnetic resonance imaging (MRI) in detecting multiple myeloma (MM) lesions in the skull, through a systematic review.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Searches were performed in six databases and the grey literature, up to August 2023, without restriction by date or publication language. Observational studies comparing CT images and MRI of the skull of patients previously diagnosed with MM were included. Data were extracted by two reviewers in a standardized and independent manner. The methodological quality assessment was performed using the QUADAS-2 tool and the evidence certainty assessment using the GRADE tool.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Of the 911 identified references, 11 were included, and they all used either positron emission computed tomography (PET/CT) and/or low-dose computed tomography (LDCT) to compare to MRI. In 6 of 7 studies, MRI demonstrated a greater capacity to detect MM lesions than PET/CT images. When compared with LDCT images, MRI showed lower detection capacity in 4 studies. Six of the 11 included articles had a low risk of bias. However, as observational data evidence, the assessed certainty of the evidence was considered very low.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>PET/CT and MRI images presented limitations in detecting MM lesions in the skull compared to LDCT images. The evidence suggested that the greatest detection capability could be achieved by employing whole-body MRI complemented by LDCT images of the skull. Future studies are needed to confirm this result.</p>","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":"62 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138547776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary study of a novel FAP-targeted ligand 68Ga-DOTA-FL in colon cancer imaging using small-animal PET/CT","authors":"Zhan Xu, Yimeng Shi, Hongyan Yin, Jing Lv","doi":"10.1007/s40336-023-00603-2","DOIUrl":"https://doi.org/10.1007/s40336-023-00603-2","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>This study explored the feasibility of ⁶⁸gallium (Ga)-labeled novel fibroblast activation protein (FAP)-targeted ligand for tumor imaging through small-animal PET/CT (positron emission computed tomography/computed tomography).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>The FAP-ligand (FL) was created by adding the chelating group dodecane tetraacetic acid (DOTA) and labeling with ⁶⁸Ga. The MC38 cell line was used to establish a C57BL/6 mice colon cancer model. The radioactivity distribution of labeled ⁶⁸Ga-DOTA-FL across various organs of the mouse model was examined ex-vivo. In addition, ⁶⁸Ga-DOTA-FL tumor-targeted imaging in vivo was performed using small-animal PET/CT. Finally, western blotting and immunofluorescence imaging of MC38 cells and xenotransplant tumor tissues were conducted.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The radiolabeling rate and radiochemical purity of ⁶⁸Ga-DOTA-FL were above 95%. Both western blotting and immunofluorescence imaging revealed FAP expression in the tumor tissues, but not in the MC38 cells. Small-animal PET/CT imaging indicated that the tumor imaging was clearest at 30 min after ⁶⁸Ga-DOTA-FL treatment. Examination of the radioactivity distribution in vitro revealed that at 30 min after the ⁶⁸Ga-DOTA-FL treatment, the target/non-target ratio for tumor and muscle tissue was 4.0 ± 0.3 (<i>n</i> = 3).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>⁶⁸Ga-DOTA-FL can be used for the specific tumor imaging in mouse models, which might provide a novel alternative for FAP-targeted tumor imaging.</p>","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":"63 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138539079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pet-radiomics in lymphoma and multiple myeloma: update of current literature","authors":"Luca Filippi, Cristina Ferrari, Susanna Nuvoli, Francesco Bianconi, Davide Donner, Andrea Marongiu, Paolo Mammucci, Viola Vultaggio, Franca Chierichetti, Giuseppe Rubini, Angela Spanu, Orazio Schillaci, Barbara Palumbo, Laura Evangelista","doi":"10.1007/s40336-023-00604-1","DOIUrl":"https://doi.org/10.1007/s40336-023-00604-1","url":null,"abstract":"","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136347051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing factors of lung shunt fraction in transarterial radioembolization treatment","authors":"Bilal Kovan, Caner Civan, Emine Goknur Isik, Duygu Has Simsek, Zeynep Gozde Ozkan, Fikret Buyukkaya, Yasemin Sanli, Bayram Demir, Serkan Kuyumcu","doi":"10.1007/s40336-023-00602-3","DOIUrl":"https://doi.org/10.1007/s40336-023-00602-3","url":null,"abstract":"","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":"47 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135012339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Patient Communication in Radiology and Nuclear Medicine: Striking a Balance for Optimal Care","authors":"Arosh S. Perera Molligoda Arachchige, Niccolò Stomeo","doi":"10.1007/s40336-023-00600-5","DOIUrl":"https://doi.org/10.1007/s40336-023-00600-5","url":null,"abstract":"","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134975094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET receptor imaging in breast cancer","authors":"Ismet Sarikaya","doi":"10.1007/s40336-023-00601-4","DOIUrl":"https://doi.org/10.1007/s40336-023-00601-4","url":null,"abstract":"","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":"155 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135436217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodality imaging for diagnosis, risk stratification, and treatment monitoring of cardiac sarcoidosis","authors":"Kathleen A. Young, Tristan Raoult, Lucia Leccisotti, Bernhard L. Gerber, Panithaya Chareonthaitawee, Olivier Gheysens","doi":"10.1007/s40336-023-00595-z","DOIUrl":"https://doi.org/10.1007/s40336-023-00595-z","url":null,"abstract":"","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134960620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetry in Lu-177-DOTATATE peptide receptor radionuclide therapy: a systematic review","authors":"Amit Nautiyal, Sofia Michopoulou, Matt Guy","doi":"10.1007/s40336-023-00589-x","DOIUrl":"https://doi.org/10.1007/s40336-023-00589-x","url":null,"abstract":"","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136308253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}