利用贝塔射线发射的放射引导手术:现状与展望

IF 2.3 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Riccardo Mirabelli, Silvio Morganti, Anita Florit, Valerio Lanni, Francesco Collamati
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引用次数: 0

摘要

手术是治疗局部或局部晚期实体瘤的主要方法。然而,应用较宽的安全边缘会给患者带来明显的副作用和功能限制。相反,切除组织的手术可能会留下残余肿瘤,导致局部癌症复发或远处转移。为解决这些问题,术中放射引导(如β放射引导手术(RGS))可用于检测微小癌组织并选择性切除恶性区域。本文全面综述了基于贝塔辐射的 RGS,重点介绍了贝塔辐射不同于伽马辐射的物理原理,后者已在核医学中得到普遍应用。虽然贝塔 RGS 早在几十年前就已提出,但可能由于新开发的正电子发射计算机放射示踪剂的广泛使用,它最近越来越受欢迎。目前正在研究各种方法来评估贝塔 RGS 的有效性,包括同时使用贝塔+和贝塔-发射放射性药物。贝塔 RGS 具有独特的特点,使其成为标准程序的一种有前途的补充技术。许多体内外试验都取得了令人鼓舞的结果。不过,要证明这些前景看好的技术的真正临床价值,还需要进行临床试验。根据作者的说法,所介绍的参考文献代表了在β RGS发展过程中最具影响力的作品。这些论文是从Scopus中以 "放射引导手术 "和 "β发射器 "为关键词进行的搜索中筛选出来的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Radio-guided surgery with beta emission: status and perspectives

Surgery is a key treatment for localized or locally advanced solid tumors. However, the application of wide safety margins can result in significant side effects and functional limitations for the patient. On the contrary, tissue-sparing surgery may leave residual tumor, which can lead to local recurrent cancer or distant metastases. To address these problems, intraoperative radio-guidance, such as beta radio-guided surgery (RGS), could be used to detect small cancerous tissue and selectively resect malignant areas. This paper provides a comprehensive review of RGS based on beta emission, focusing on the physical principles that differentiate beta radiation from gamma radiation, which is already commonly used in nuclear medicine. Although beta RGS was proposed several decades ago, its popularity has recently increased, possibly due to the widespread use of newly developed PET radiotracers. Various approaches are currently being investigated to assess the effectiveness of beta RGS, including the use of both beta+ and beta− emitting radiopharmaceuticals. Beta RGS has unique characteristics that make it a promising complementary technique to standard procedures. Encouraging results have been obtained in numerous ex vivo and in vivo tests. However, clinical trials are needed to demonstrate the real clinical value of these promising technologies. The references presented represent the most impactful works in the development of beta RGS, according to the authors. Papers were selected from a Scopus search with keywords “radio-guided surgery” and “beta emitter”.

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来源期刊
Clinical and Translational Imaging
Clinical and Translational Imaging Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
3.60
自引率
4.80%
发文量
55
期刊介绍: Clinical and Translational Imaging is an international journal that publishes timely, up-to-date summaries on clinical practice and translational research and clinical applications of approved and experimental radiopharmaceuticals for diagnostic and therapeutic purposes. Coverage includes such topics as advanced preclinical evidence in the fields of physics, dosimetry, radiation biology and radiopharmacy with relevance to applications in human subjects. The journal benefits a readership of nuclear medicine practitioners and allied professionals involved in molecular imaging and therapy.
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