Lancet Planetary Health最新文献

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EAT–Lancet index 2.0: a dietary index measuring adherence to the Planetary Health Diet 2.0 EAT-Lancet指数2.0:衡量遵守行星健康饮食2.0的饮食指数。
IF 21.6 1区 医学
Lancet Planetary Health Pub Date : 2026-04-01 Epub Date: 2026-05-19 DOI: 10.1016/j.lanplh.2026.101469
Anna Stubbendorff , Ulrika Ericson , Elinor Hallström , Jessica Samuelsson , Yan Borné , Emily Sonestedt
{"title":"EAT–Lancet index 2.0: a dietary index measuring adherence to the Planetary Health Diet 2.0","authors":"Anna Stubbendorff , Ulrika Ericson , Elinor Hallström , Jessica Samuelsson , Yan Borné , Emily Sonestedt","doi":"10.1016/j.lanplh.2026.101469","DOIUrl":"10.1016/j.lanplh.2026.101469","url":null,"abstract":"","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"10 4","pages":"Article 101469"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Closer to the edge 更接近边缘。
IF 21.6 1区 医学
Lancet Planetary Health Pub Date : 2026-04-01 Epub Date: 2026-05-20 DOI: 10.1016/j.lanplh.2026.101480
The Lancet Planetary Health
{"title":"Closer to the edge","authors":"The Lancet Planetary Health","doi":"10.1016/j.lanplh.2026.101480","DOIUrl":"10.1016/j.lanplh.2026.101480","url":null,"abstract":"","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"10 4","pages":"Article 101480"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147983915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Planetary Health Research Digest 行星健康研究文摘。
IF 21.6 1区 医学
Lancet Planetary Health Pub Date : 2026-04-01 Epub Date: 2026-03-16 DOI: 10.1016/j.lanplh.2026.101452
Cahal McQuillan
{"title":"Planetary Health Research Digest","authors":"Cahal McQuillan","doi":"10.1016/j.lanplh.2026.101452","DOIUrl":"10.1016/j.lanplh.2026.101452","url":null,"abstract":"","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"10 4","pages":"Article 101452"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disentangling urban vulnerability to rising temperatures 解开城市对气温上升的脆弱性。
IF 21.6 1区 医学
Lancet Planetary Health Pub Date : 2026-04-01 Epub Date: 2026-04-22 DOI: 10.1016/j.lanplh.2026.101451
Hicham Achebak , Blanca Paniello-Castillo , Robbie M Parks , Kim R van Daalen
{"title":"Disentangling urban vulnerability to rising temperatures","authors":"Hicham Achebak , Blanca Paniello-Castillo , Robbie M Parks , Kim R van Daalen","doi":"10.1016/j.lanplh.2026.101451","DOIUrl":"10.1016/j.lanplh.2026.101451","url":null,"abstract":"","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"10 4","pages":"Article 101451"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiological and biological response to heat exposure in pregnancy: a systematic review and meta-analysis 妊娠期热暴露的生理和生物反应:一项系统综述和荟萃分析。
IF 21.6 1区 医学
Lancet Planetary Health Pub Date : 2026-04-01 Epub Date: 2026-05-13 DOI: 10.1016/j.lanplh.2026.101431
Ana Bonell MBChB PhD , Asma Abdul Malik Qureshi MBChB , Prof Andreas D Flouris PhD , Lydia Tsoutsoubi PhD , Prof Amanda N Sferruzzi-Perri PhD , Jai K Das MBChB PhD , Prof Jane E Hirst MBChB PhD , Leonidas G Ioannou PhD
{"title":"Physiological and biological response to heat exposure in pregnancy: a systematic review and meta-analysis","authors":"Ana Bonell MBChB PhD ,&nbsp;Asma Abdul Malik Qureshi MBChB ,&nbsp;Prof Andreas D Flouris PhD ,&nbsp;Lydia Tsoutsoubi PhD ,&nbsp;Prof Amanda N Sferruzzi-Perri PhD ,&nbsp;Jai K Das MBChB PhD ,&nbsp;Prof Jane E Hirst MBChB PhD ,&nbsp;Leonidas G Ioannou PhD","doi":"10.1016/j.lanplh.2026.101431","DOIUrl":"10.1016/j.lanplh.2026.101431","url":null,"abstract":"<div><h3>Background</h3><div>Pregnant women are vulnerable to extreme heat due to physiological adaptations that alter thermoregulation and metabolism; however, the underlying physiological mechanisms remain inconclusive. This systematic review and meta-analysis synthesises the effects of environmental heat on maternal, placental, and fetal physiology, identifying key biophysiological pathways.</div></div><div><h3>Methods</h3><div>We searched PubMed and Embase from database inception to Jan 13, 2025, for studies of pregnant women exposed to heat. Observational and experimental studies conducted in laboratory or field settings were included. Grey literature was not included. Alterations in typical physiological functions resulting from heat exposure across maternal, placental, or fetal responses were considered outcomes. AB and AAMQ screened and extracted data independently. Random-effects meta-analyses and meta-regression were applied to examine associations between heat stress exposure parameters and physiological responses. The study was registered with PROSPERO (CRD42024511153).</div></div><div><h3>Findings</h3><div>The analysis included data from 201 906 pregnant women from 27 studies. Meta-analyses of physiological changes before and after heat exposure found mean increases of 38 beats per min (bpm) in maternal heart rate (95% CI 29·3–45·8; <em>I</em><sup>2</sup> 91%; seven studies), 0·5°C in maternal core temperature (0·5–0·6; 84%; 12 studies), 1·9°C in maternal skin temperature (0·4–3·4; 99%; six studies), and 13 bpm in fetal heart rate (8·8–16·5; 78%; seven studies). On meta-regression, increased core temperature was associated with higher intensity activities and increased heat stress and inversely associated with gestational age. There were inconsistent changes in uterine and umbilical artery blood flow. However, a higher susceptibility to impaired uteroplacental blood flow was observed among pregnant women with hypertension or pre-eclampsia.</div></div><div><h3>Interpretation</h3><div>We found consistent acute physiological stress responses to heat exposure, with evidence that these responses were worse in pregnant women with pre-eclampsia. The paucity of available data highlights the need for more research to identify the underlying biological mechanisms that mediate pregnancy outcomes with high heat exposure.</div></div><div><h3>Funding</h3><div>Wellcome Trust.</div></div>","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"10 4","pages":"Article 101431"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Air quality, health, and economic effects of land use and land cover changes in southeast Asia in the 21st century: a modelling study 21世纪东南亚土地利用和土地覆盖变化的空气质量、健康和经济影响:一项模拟研究。
IF 21.6 1区 医学
Lancet Planetary Health Pub Date : 2026-04-01 Epub Date: 2026-05-25 DOI: 10.1016/j.lanplh.2026.101457
Yefu Gu PhD , Tingting Fang PhD , Yanbin Xu PhD , Xialei Duan PhD , Janice Ser Huay Lee PhD , Wenjun Zhu PhD , Yiwen Zeng PhD , Prof Steve Hung Lam Yim PhD
{"title":"Air quality, health, and economic effects of land use and land cover changes in southeast Asia in the 21st century: a modelling study","authors":"Yefu Gu PhD ,&nbsp;Tingting Fang PhD ,&nbsp;Yanbin Xu PhD ,&nbsp;Xialei Duan PhD ,&nbsp;Janice Ser Huay Lee PhD ,&nbsp;Wenjun Zhu PhD ,&nbsp;Yiwen Zeng PhD ,&nbsp;Prof Steve Hung Lam Yim PhD","doi":"10.1016/j.lanplh.2026.101457","DOIUrl":"10.1016/j.lanplh.2026.101457","url":null,"abstract":"<div><h3>Background</h3><div>Southeast Asia has had substantial land use and land cover changes (LULCCs) in recent decades, affecting air quality, human health, and economic development through biogeophysical and biogeochemical cycles. However, little research has examined the combined effects of different LULCC types and impact pathways comprehensively. We aimed to provide a holistic understanding of how LULCCs across southeast Asia in the 21st century have led to changes in air quality and the consequential effects on human health and the economy.</div></div><div><h3>Methods</h3><div>In this modelling study, we used a regional meteorology–air quality coupled model (WRF–CMAQ) to assess LULCC effects from 2001 to 2018 on the concentrations of surface PM<sub>2·5</sub> and O<sub>3</sub> through biogeophysical and biogeochemical pathways. The model was configured at a 30 × 30 km grid size throughout southeast Asia. We used a series of concentration–response models to estimate excess deaths associated with the changes in air pollution concentration caused by LULCCs. The economic implications of these health effects were quantified with age-specific value-of-statistical-life and cost-of-illness approaches.</div></div><div><h3>Findings</h3><div>LULCCs in southeast Asia were associated with 13 000 excess deaths (95% CI 11 000–14 000) in 2018 alone, resulting in US$7·79 billion losses (6·24–9·69). Forest degradation and deforestation was the primary driver, accounting for 29·7% of the burden. Furthermore, more than 60·0% of effects occurred through the biogeophysical pathway.</div></div><div><h3>Interpretation</h3><div>LULCCs in southeast Asia are degrading air quality, causing thousands of excess deaths and billions of dollars in economic losses, with forest degradation and deforestation being the primary driver. The findings emphasise the need for strategic land management to improve environmental conditions and public health, and support sustainable economic development in the area, particularly in the countries most affected, such as Indonesia, Viet Nam, and Thailand.</div></div><div><h3>Funding</h3><div>Ministry of Education Singapore and Tsao Family Foundation.</div></div>","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"10 4","pages":"Article 101457"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The burden of El Niño–Southern Oscillation-related dengue attributable to anthropogenic climate change: a multicountry modelling study 由人为气候变化引起的厄尔尼诺Niño-Southern振荡相关登革热的负担:一个多国模型研究。
IF 21.6 1区 医学
Lancet Planetary Health Pub Date : 2026-04-01 Epub Date: 2026-04-24 DOI: 10.1016/j.lanplh.2026.101454
Guoao Li MS , Peng Lu PhD , Philip Weinstein PhD , Aleš Urban PhD , Shilu Tong PhD , Niilo Ryti PhD , Francesco Sera PhD , Michelle L Bell PhD , Dominic Royé PhD , Kristie L Ebi PhD , Alistair Woodward PhD , Mengjie Geng PhD , Taiyuan Zhang MS , Wen Li PhD , Yu Yan MS , Xiaochi Zhang MS , Qiyong Liu PhD , Wei Ma PhD , Bo Lu PhD , Qi Zhao PhD
{"title":"The burden of El Niño–Southern Oscillation-related dengue attributable to anthropogenic climate change: a multicountry modelling study","authors":"Guoao Li MS ,&nbsp;Peng Lu PhD ,&nbsp;Philip Weinstein PhD ,&nbsp;Aleš Urban PhD ,&nbsp;Shilu Tong PhD ,&nbsp;Niilo Ryti PhD ,&nbsp;Francesco Sera PhD ,&nbsp;Michelle L Bell PhD ,&nbsp;Dominic Royé PhD ,&nbsp;Kristie L Ebi PhD ,&nbsp;Alistair Woodward PhD ,&nbsp;Mengjie Geng PhD ,&nbsp;Taiyuan Zhang MS ,&nbsp;Wen Li PhD ,&nbsp;Yu Yan MS ,&nbsp;Xiaochi Zhang MS ,&nbsp;Qiyong Liu PhD ,&nbsp;Wei Ma PhD ,&nbsp;Bo Lu PhD ,&nbsp;Qi Zhao PhD","doi":"10.1016/j.lanplh.2026.101454","DOIUrl":"10.1016/j.lanplh.2026.101454","url":null,"abstract":"<div><h3>Background</h3><div>Dengue is known to be associated with El Niño–Southern Oscillation (ENSO) but the size of the effect is unclear, as is the influence of anthropogenic climate change (ACC). We aimed to quantify the associations between ENSO and dengue risk in 21 countries, and to estimate the contribution of ACC to the ENSO-related dengue burden.</div></div><div><h3>Methods</h3><div>We collected monthly dengue cases and observed and simulated climate data from 21 countries including 1237 locations from 2000 to 2019. We characterised Eastern Pacific (EP) and Central Pacific (CP) ENSO exposures for each location based on the E and C indices and their respective teleconnections. Location-specific association between ENSO exposure and dengue cases was estimated using negative binomial generalised linear model combined with best linear unbiased predictions. We also estimated the ENSO-related dengue burden under scenarios with and without ACC.</div></div><div><h3>Findings</h3><div>For each standard deviation increase in EP-El Niño strength and CP-La Niña strength, the overall risk of dengue cases across locations changed by 23·70% (95% CI 21·50 to 25·94) and –9·07% (–9·91 to –8·21), respectively. During 2000 to 2019, 4·45% (95% empirical CI [eCI] 3·75 to 5·32) and –3·34% (–4·01 to –2·64) of dengue cases were attributable to EP-El Niño strength and CP-La Niña strength, respectively. ACC accounted for 48·64% (95% eCI 38·01 to 60·19) of the EP-El Niño-attributable dengue increment and 33·05% (28·66 to 38·25) of the CP-La Niña-attributable reduction. These estimates corresponded to 403 197 (95% eCI 315 109 to 498 940) and –205 641 (–238 030 to –178 329) dengue cases across 1237 locations, respectively. The associations with ENSO varied strongly across the 21 countries.</div></div><div><h3>Interpretation</h3><div>This study presents new model-based evidence of the strong associations between ENSO and dengue risk at a multicountry level, and suggests that the contribution of ACC to the effects of ENSO might differ geographically.</div></div><div><h3>Funding</h3><div>Prevention and Control of Emerging and Major Infectious Diseases National Science and Technology Major Project, the National Natural Science Foundation of China, and the Czech Ministry of Education Youth and Sport’s programme ERC CZ.</div></div>","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"10 4","pages":"Article 101454"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drought exposure and the risk of sexual, emotional, and physical violence against adolescents in Zimbabwe, Mozambique, and Lesotho: an observational study 津巴布韦、莫桑比克和莱索托的干旱暴露与青少年遭受性、情感和身体暴力的风险:一项观察性研究
IF 21.6 1区 医学
Lancet Planetary Health Pub Date : 2026-04-01 Epub Date: 2026-06-01 DOI: 10.1016/j.lanplh.2026.101448
Bothaina Eltigani MBBS MSc , Roman Hoffmann PhD , Prof Lucie Cluver PhD
{"title":"Drought exposure and the risk of sexual, emotional, and physical violence against adolescents in Zimbabwe, Mozambique, and Lesotho: an observational study","authors":"Bothaina Eltigani MBBS MSc ,&nbsp;Roman Hoffmann PhD ,&nbsp;Prof Lucie Cluver PhD","doi":"10.1016/j.lanplh.2026.101448","DOIUrl":"10.1016/j.lanplh.2026.101448","url":null,"abstract":"<div><h3>Background</h3><div>Droughts are increasing in severity and frequency, severely impacting agriculture-dependent regions, such as southern Africa. Although direct health effects are increasingly well documented, associations with violence against adolescents remain largely unexplored. This multi-country, cross-sectional study examined associations between drought and risk of intimate partner and non-partner sexual, emotional, and physical violence.</div></div><div><h3>Methods</h3><div>We combined violence victimisation and demographic data from 20 290 adolescents (aged 13–24 years) in the Violence Against Children Surveys from Zimbabwe, Mozambique, and Lesotho, between 2017 and 2019, with Standardised Precipitation and Evapotranspiration Index (SPEI) drought data for corresponding years. Multivariate logistic regression models, controlling for sociodemographic factors, assessed associations between past-year drought exposure and violence against adolescents. Interaction models explored potential moderating roles of adolescents' gender, age, and rural residence, and sensitivity analyses were used for robustness checks. Secondary analyses examined prolonged drought over the past 24 months.</div></div><div><h3>Findings</h3><div>Drought was associated with increased risk of non-partner sexual violence (odds ratio 1·46 [95% CI 1·12–1·90]), emotional violence (1·73 [1·45–2·06]), and physical violence (1·41 [1·18–1·68]), as well as intimate partner emotional violence (1·51 [1·12–2·02]) and physical violence (1·39 [1·11–1·75]). Moderation analyses showed higher risk for adolescent girls and older adolescents (aged 18–24 years) for non-partner sexual violence and non-partner and partner emotional violence, whereas older adolescents had an increased risk for partner physical violence and adolescents in rural areas had higher risk for non-partner physical violence. Prolonged drought over 24 months had positive associations with larger effect sizes than 12-month drought.</div></div><div><h3>Interpretation</h3><div>Drought exposure is associated with increased violence against adolescents in Zimbabwe, Mozambique, and Lesotho. Adolescent girls, older adolescents, and those living in rural areas are at heightened risk. Adolescent and youth-focused, gender-sensitive violence prevention strategies must be integrated into early warning systems with sustainable climate adaptation measures used in prolonged drought settings.</div></div><div><h3>Funding</h3><div>The Reuben-AfOx scholarship, University of Oxford; The Natural Environment Research Council (NERC); the European Union’s Horizon Europe Programme; and Oak Foundation, Wellspring Philanthropic Fund.</div></div>","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"10 4","pages":"Article 101448"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148103944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global environmental change and the gut–kidney–brain axis: a review and framework of vulnerability and resilience 全球环境变化和肠-肾-脑轴:脆弱性和复原力的回顾和框架。
IF 21.6 1区 医学
Lancet Planetary Health Pub Date : 2026-04-01 Epub Date: 2026-04-14 DOI: 10.1016/j.lanplh.2026.101453
Shazia Adalat BM BS , Konstantinos Giannakou PhD , Benjamin Valderrama BS , Prof Juan Guillermo Cárdenas-Aguilera MD , Giorgos K Sakkas PhD , Jonathan Overeem MSc , Gaye Hafez PhD , Dearbhla Kelly PhD , Jelena Vulevic PhD , Guohua He PhD , Silvia M Mihăilă PhD , Alessandra Tammaro PhD , Burcin Ikiz PhD , Prof John F Cryan PhD
{"title":"Global environmental change and the gut–kidney–brain axis: a review and framework of vulnerability and resilience","authors":"Shazia Adalat BM BS ,&nbsp;Konstantinos Giannakou PhD ,&nbsp;Benjamin Valderrama BS ,&nbsp;Prof Juan Guillermo Cárdenas-Aguilera MD ,&nbsp;Giorgos K Sakkas PhD ,&nbsp;Jonathan Overeem MSc ,&nbsp;Gaye Hafez PhD ,&nbsp;Dearbhla Kelly PhD ,&nbsp;Jelena Vulevic PhD ,&nbsp;Guohua He PhD ,&nbsp;Silvia M Mihăilă PhD ,&nbsp;Alessandra Tammaro PhD ,&nbsp;Burcin Ikiz PhD ,&nbsp;Prof John F Cryan PhD","doi":"10.1016/j.lanplh.2026.101453","DOIUrl":"10.1016/j.lanplh.2026.101453","url":null,"abstract":"<div><div>Climate–health research often examines organ systems in isolation, which limits our understanding of how environmental stressors shape multiorgan disease patterns. We propose an integrative framework that explores how perturbations in the gut–kidney–brain axis might contribute to differential climate and environmental vulnerability. Climatic and environmental stressors might influence intestinal and blood–brain barrier integrity alongside established haemodynamic, toxicological, endocrine, and neurovascular pathways. Experimental and mechanistic evidence indicates that some environmental exposures can alter epithelial tight junction function and promote translocation of microbial products. Such translocation can drive systemic inflammation, altered metabolic signalling, and neural dysfunction implicated in chronic kidney disease progression and neurological impairment. In the proposed framework, barrier integrity is positioned as a biologically plausible interface within a multipathway model linking the gut, kidney, and brain. The framework highlights how climate and environmental exposures interact with pre-existing physiological and social vulnerabilities, adaptive capacity, and cumulative exposure burden to shape susceptibility to adverse health outcomes across the life course. Because current evidence relies heavily on experimental models and associative data, these mechanisms require validation under real-world, multifactorial climatic and environmental conditions. We also identify crucial research priorities, including prospective studies in climate-exposed populations, biomarker validation of barrier integrity, and targeted interventions to help preserve gut–kidney–brain axis function alongside exposure-reducing efforts. If empirical evidence supports this framework, the suggested systems-based approach could inform prevention, surveillance, and equity-centred resilience strategies.</div></div>","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"10 4","pages":"Article 101453"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 2025–30 US dietary guidelines for Americans reject scientific evidence, transparency, and planetary health 2025- 2030年美国膳食指南拒绝科学证据、透明度和地球健康。
IF 21.6 1区 医学
Lancet Planetary Health Pub Date : 2026-04-01 Epub Date: 2026-04-22 DOI: 10.1016/j.lanplh.2026.101460
Gabby Headrick , Lindsey Smith Taillie , Julia A Wolfson
{"title":"The 2025–30 US dietary guidelines for Americans reject scientific evidence, transparency, and planetary health","authors":"Gabby Headrick ,&nbsp;Lindsey Smith Taillie ,&nbsp;Julia A Wolfson","doi":"10.1016/j.lanplh.2026.101460","DOIUrl":"10.1016/j.lanplh.2026.101460","url":null,"abstract":"","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"10 4","pages":"Article 101460"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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