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The Borderlands of Foldability: Lessons from Simplified Proteins. 可折叠性的边界：简化蛋白质的经验教训。
IF 11.1 2区 化学
Trends in Chemistry Pub Date : 2026-05-01 Epub Date: 2026-04-16 DOI: 10.1016/j.trechm.2026.03.001
Koh Seya, Alfie-Louise R Brownless, Shina Caroline Lynn Kamerlin, Liam M Longo
{"title":"The Borderlands of Foldability: Lessons from Simplified Proteins.","authors":"Koh Seya, Alfie-Louise R Brownless, Shina Caroline Lynn Kamerlin, Liam M Longo","doi":"10.1016/j.trechm.2026.03.001","DOIUrl":"10.1016/j.trechm.2026.03.001","url":null,"abstract":"<p><p>Proteins make complex life possible, yet our understanding of their emergence remains limited. What are the information limits of protein folding, and how did the first proteins emerge? Protein simplification studies - in which contemporary folds are built from limited alphabets, symmetrized, fragmented, or shortened - have provided key insights into these questions. These studies use design constraints to address the discoverability of, and connectedness between, protein folds. By considering various environments, such as high salt concentrations or peptide-nucleic acid coacervates, the role of context in the emergence of folded domains is explored. Taken together, these studies support the early emergence of protein folds and reveal the existence of highly connected and readily traversable regions of sequence-structure space.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"8 5","pages":"362-376"},"PeriodicalIF":11.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13614685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nickel-Photochemical C-N Couplings: Moving Beyond Iridium Photocatalysts. 镍-光化学C-N耦合：超越铱光催化剂。
IF 11.1 2区 化学
Trends in Chemistry Pub Date : 2025-11-01 Epub Date: 2025-11-07 DOI: 10.1016/j.trechm.2025.08.003
Tanner J Megna, Ana Bahamonde
{"title":"Nickel-Photochemical C-N Couplings: Moving Beyond Iridium Photocatalysts.","authors":"Tanner J Megna, Ana Bahamonde","doi":"10.1016/j.trechm.2025.08.003","DOIUrl":"10.1016/j.trechm.2025.08.003","url":null,"abstract":"<p><p>Ni-photochemical C-N couplings have emerged as a powerful synthetic tool. However, limitations in catalyst stability continue to constrain applicability. This Forum highlights how the field has evolved from reliance on Ir photocatalysts toward more sustainable initiation methods and how recent ligand design are beginning to address long-standing deactivation pathways.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"7 11","pages":"637-639"},"PeriodicalIF":11.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymmetric Partial Reductions of Pyridines. 吡啶的不对称部分还原。
IF 11.1 2区 化学
Trends in Chemistry Pub Date : 2025-11-01 Epub Date: 2025-11-07 DOI: 10.1016/j.trechm.2025.09.007
Ashlyn Bohn, Benjamin M Cipriano, Peter Wipf
{"title":"Asymmetric Partial Reductions of Pyridines.","authors":"Ashlyn Bohn, Benjamin M Cipriano, Peter Wipf","doi":"10.1016/j.trechm.2025.09.007","DOIUrl":"10.1016/j.trechm.2025.09.007","url":null,"abstract":"<p><p>The asymmetric partial reduction of substituted pyridines represents a direct and versatile strategy to access chiral di- and tetrahydropyridines, which are present in many natural products and active pharmaceutical ingredients (APIs). However, this methodology remains significantly underdeveloped when compared to the numerous exhaustive asymmetric reductions of pyridines to fully saturated piperidines, and is currently still limited to the synthesis of tetrahydropyridines. In this Opinion, we highlight the benefits, challenges, and current scope of asymmetric partial pyridine reductions, emphasizing prospective future directions to address significant gaps in the current literature.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"7 11","pages":"650-658"},"PeriodicalIF":11.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12692299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming bio-derived DNA into biotechnology. 将生物衍生的DNA转化为生物技术。
IF 11.1 2区 化学
Trends in Chemistry Pub Date : 2025-10-31 DOI: 10.1016/j.trechm.2025.09.017
Wynter A Paiva, Matthew E Currier, Samuel E Ashooh, Noelle M Honan, Nathan J Oldenhuis
{"title":"Transforming bio-derived DNA into biotechnology.","authors":"Wynter A Paiva, Matthew E Currier, Samuel E Ashooh, Noelle M Honan, Nathan J Oldenhuis","doi":"10.1016/j.trechm.2025.09.017","DOIUrl":"10.1016/j.trechm.2025.09.017","url":null,"abstract":"<p><p>DNA technology is rapidly expanding, with recent advances pushing functional DNA-based materials toward larger scales. Yet producing chemically modified DNA beyond the milligram-scale remains prohibitively expensive, challenging, and relatively unexplored limiting industrial and translational use. This feature review highlights emerging strategies for sourcing, modifying, and purifying DNA at scales relevant for materials and biotechnology. We compare bio-derived DNA sources (e.g., phage, plasmid, and genomic DNA) to conventional synthetic methods and examine their trade-offs. Critically, we re-examine recent and classic literature to identify chemical and enzymatic reactions practical for modifying bio-derived nucleic acids at relevant scales. Finally, we discuss scalable purification and characterization methods to support high-throughput workflows, enabling broader use of bio-derived dsDNA in next-generation applications.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":" ","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12629255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transition Metal Catalysis Drives Innovative Activity-Based Sensing Systems. 过渡金属催化驱动创新活动传感系统。
IF 11.1 2区 化学
Trends in Chemistry Pub Date : 2025-10-02 DOI: 10.1016/j.trechm.2025.09.006
Autumn I Giger, Ramandeep Kaur, Nicholas J Dacon, Brian W Michel
{"title":"Transition Metal Catalysis Drives Innovative Activity-Based Sensing Systems.","authors":"Autumn I Giger, Ramandeep Kaur, Nicholas J Dacon, Brian W Michel","doi":"10.1016/j.trechm.2025.09.006","DOIUrl":"10.1016/j.trechm.2025.09.006","url":null,"abstract":"<p><p>Through mechanistic understanding, transition metal catalysis has evolved into a key component of organic chemists' toolbox. Improvements in ligand design continue to push the boundaries of applications beyond targeted synthesis. This forum contextualizes how mechanistic insight has influenced recent developments in transition metal-based molecular sensing.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":" ","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sigma hole donor XB and ChB catalysis in oligosaccharide synthesis. Sigma洞供体XB和ChB在低聚糖合成中的催化作用。
IF 11.1 2区 化学
Trends in Chemistry Pub Date : 2025-10-01 DOI: 10.1016/j.trechm.2025.07.001
Mukul Mahanti, M Carmen Galan
{"title":"Sigma hole donor XB and ChB catalysis in oligosaccharide synthesis.","authors":"Mukul Mahanti, M Carmen Galan","doi":"10.1016/j.trechm.2025.07.001","DOIUrl":"10.1016/j.trechm.2025.07.001","url":null,"abstract":"<p><p>Sigma hole-based noncovalent interactions (NCIs), such as halogen bonding (XB) and chalcogen bonding (ChB), offer a powerful alternative to hydrogen bonding (HB) in stereoselective catalysis. The high directionality and tunability of these catalysts have been harnessed to facilitate more efficient glycosylation processes under mild conditions. Recent advances highlight the significant yet underexplored potential of these interactions, paving the way for novel and improved catalytic strategies in carbohydrate chemistry with unique activation modes.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"7 10","pages":"571-575"},"PeriodicalIF":11.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7619583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanding Epitranscriptomics to Non-Enzymatic RNA Modifications. 扩展表转录组学到非酶修饰RNA。
IF 11.1 2区 化学
Trends in Chemistry Pub Date : 2025-09-22 DOI: 10.1016/j.trechm.2025.08.005
Kaila Nishikawa, Yael David, Anna Knörlein
{"title":"Expanding Epitranscriptomics to Non-Enzymatic RNA Modifications.","authors":"Kaila Nishikawa, Yael David, Anna Knörlein","doi":"10.1016/j.trechm.2025.08.005","DOIUrl":"10.1016/j.trechm.2025.08.005","url":null,"abstract":"<p><p>Cells regulate responses to external stimuli and control cell fate through reversible modifications on proteins, DNA, and RNA typically introduced by enzymes. Next to these well-known enzymatically installed modifications, covalent modifications can also occur on these same biomolecules through spontaneous reaction with small molecules taken up from external sources or generated endogenously, e.g. byproducts of metabolic processes. These so-called non-enzymatic covalent modifications (NECMs) have been mainly studied on proteins and DNA, yet their biological role on RNA remains mostly underexplored. This review surveys identified and predicted RNA NECMs, explores their impact on RNA structure, stability, and function, and examines their potential link to diseases. Finally, we discuss regulation mechanisms of non-enzymatically modified RNAs and their potential significance on cellular dynamics.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":" ","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12524911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Curious Case of β-Boryl Triplet States. β-硼基三重态的奇特案例。
IF 11.1 2区 化学
Trends in Chemistry Pub Date : 2025-09-01 Epub Date: 2025-09-10 DOI: 10.1016/j.trechm.2025.07.005
Jarett M Posz, Anagha Veluthanath Nair, Ryan Van Hoveln, M Kevin Brown
{"title":"The Curious Case of β-Boryl Triplet States.","authors":"Jarett M Posz, Anagha Veluthanath Nair, Ryan Van Hoveln, M Kevin Brown","doi":"10.1016/j.trechm.2025.07.005","DOIUrl":"10.1016/j.trechm.2025.07.005","url":null,"abstract":"","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"7 9","pages":"557-558"},"PeriodicalIF":11.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nickel-Mediated Aerobic Csp 2 -Nucleophile Coupling. 镍介导的好氧Csp 2 -亲核试剂偶联。
IF 11.1 2区 化学
Trends in Chemistry Pub Date : 2025-05-01 Epub Date: 2025-05-14 DOI: 10.1016/j.trechm.2025.02.004
Dipankar Das, Long P Dinh, Ryan E Smith, Dipannita Kalyani, Christo S Sevov
{"title":"Nickel-Mediated Aerobic C<i>sp</i> <sup><i>2</i></sup> -Nucleophile Coupling.","authors":"Dipankar Das, Long P Dinh, Ryan E Smith, Dipannita Kalyani, Christo S Sevov","doi":"10.1016/j.trechm.2025.02.004","DOIUrl":"10.1016/j.trechm.2025.02.004","url":null,"abstract":"","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"7 5","pages":"255-256"},"PeriodicalIF":11.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12843078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Reaction Framework for Allyl Carboxylates. 烯丙基羧酸酯的新反应框架。
IF 13.6 2区 化学
Trends in Chemistry Pub Date : 2025-02-01 Epub Date: 2025-01-09 DOI: 10.1016/j.trechm.2024.12.004
Gaoyuan Zhao, Arman Khosravi, Sahil Sharma, Djamaladdin G Musaev, Ming-Yu Ngai
{"title":"A New Reaction Framework for Allyl Carboxylates.","authors":"Gaoyuan Zhao, Arman Khosravi, Sahil Sharma, Djamaladdin G Musaev, Ming-Yu Ngai","doi":"10.1016/j.trechm.2024.12.004","DOIUrl":"10.1016/j.trechm.2024.12.004","url":null,"abstract":"","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"7 2","pages":"99-100"},"PeriodicalIF":13.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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