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Transition Metal Catalysis Drives Innovative Activity-Based Sensing Systems. 过渡金属催化驱动创新活动传感系统。
IF 13.6 2区 化学
Trends in Chemistry Pub Date : 2025-10-02 DOI: 10.1016/j.trechm.2025.09.006
Autumn I Giger, Ramandeep Kaur, Nicholas J Dacon, Brian W Michel
{"title":"Transition Metal Catalysis Drives Innovative Activity-Based Sensing Systems.","authors":"Autumn I Giger, Ramandeep Kaur, Nicholas J Dacon, Brian W Michel","doi":"10.1016/j.trechm.2025.09.006","DOIUrl":"10.1016/j.trechm.2025.09.006","url":null,"abstract":"<p><p>Through mechanistic understanding, transition metal catalysis has evolved into a key component of organic chemists' toolbox. Improvements in ligand design continue to push the boundaries of applications beyond targeted synthesis. This forum contextualizes how mechanistic insight has influenced recent developments in transition metal-based molecular sensing.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanding Epitranscriptomics to Non-Enzymatic RNA Modifications. 扩展表转录组学到非酶修饰RNA。
IF 13.6 2区 化学
Trends in Chemistry Pub Date : 2025-09-22 DOI: 10.1016/j.trechm.2025.08.005
Kaila Nishikawa, Yael David, Anna Knörlein
{"title":"Expanding Epitranscriptomics to Non-Enzymatic RNA Modifications.","authors":"Kaila Nishikawa, Yael David, Anna Knörlein","doi":"10.1016/j.trechm.2025.08.005","DOIUrl":"https://doi.org/10.1016/j.trechm.2025.08.005","url":null,"abstract":"<p><p>Cells regulate responses to external stimuli and control cell fate through reversible modifications on proteins, DNA, and RNA typically introduced by enzymes. Next to these well-known enzymatically installed modifications, covalent modifications can also occur on these same biomolecules through spontaneous reaction with small molecules taken up from external sources or generated endogenously, e.g. byproducts of metabolic processes. These so-called non-enzymatic covalent modifications (NECMs) have been mainly studied on proteins and DNA, yet their biological role on RNA remains mostly underexplored. This review surveys identified and predicted RNA NECMs, explores their impact on RNA structure, stability, and function, and examines their potential link to diseases. Finally, we discuss regulation mechanisms of non-enzymatically modified RNAs and their potential significance on cellular dynamics.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12524911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Reaction Framework for Allyl Carboxylates. 烯丙基羧酸酯的新反应框架。
IF 13.6 2区 化学
Trends in Chemistry Pub Date : 2025-02-01 Epub Date: 2025-01-09 DOI: 10.1016/j.trechm.2024.12.004
Gaoyuan Zhao, Arman Khosravi, Sahil Sharma, Djamaladdin G Musaev, Ming-Yu Ngai
{"title":"A New Reaction Framework for Allyl Carboxylates.","authors":"Gaoyuan Zhao, Arman Khosravi, Sahil Sharma, Djamaladdin G Musaev, Ming-Yu Ngai","doi":"10.1016/j.trechm.2024.12.004","DOIUrl":"10.1016/j.trechm.2024.12.004","url":null,"abstract":"","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"7 2","pages":"99-100"},"PeriodicalIF":13.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptide Crosslinking by a Class of Plant Copper Enzymes. 一类植物铜酶的肽交联研究。
IF 14 2区 化学
Trends in Chemistry Pub Date : 2024-11-01 Epub Date: 2024-10-22 DOI: 10.1016/j.trechm.2024.09.002
M Rafiul O K Noyon, Shabnam Hematian
{"title":"Peptide Crosslinking by a Class of Plant Copper Enzymes.","authors":"M Rafiul O K Noyon, Shabnam Hematian","doi":"10.1016/j.trechm.2024.09.002","DOIUrl":"10.1016/j.trechm.2024.09.002","url":null,"abstract":"<p><p>BURP domain peptide cyclases, or BpCs (an abbreviation we recommend in this opinion), are an emerging class of copper enzymes which catalyze the oxidative macrocyclization of peptides in plants. A close examination of their novel protein fold, along with the unique dicopper active site that meticulously controls crosslinking within peptides, highlights how nature exploits intricate mechanistic strategies to achieve diverse functionalities. Here, we summarize recent discoveries regarding the sequence, structure, function, and proposed chemistry of BpCs. We also present plausible mechanistic ideas and recommend important structural considerations that could advance investigations and discussions surrounding their reactivity and underlying mechanisms.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"6 11","pages":"649-655"},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enantiospecific 1,3-hydrogen transfer of alkenes and alkynes 烯和炔的对映体 1,3-氢转移
IF 15.7 2区 化学
Trends in Chemistry Pub Date : 2024-09-12 DOI: 10.1016/j.trechm.2024.08.004
Qi Liu, Wan-Yi Xu, Cen-Cen You, Rong-Gui Zhou, Ying He
{"title":"Enantiospecific 1,3-hydrogen transfer of alkenes and alkynes","authors":"Qi Liu, Wan-Yi Xu, Cen-Cen You, Rong-Gui Zhou, Ying He","doi":"10.1016/j.trechm.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.trechm.2024.08.004","url":null,"abstract":"<p>1,3-Hydrogen (H) transfer of alkenes and alkynes has emerged as an atom-economic transformation in organic synthesis. The reaction usually takes place under mild conditions, avoids the need for external additives, and accommodates a broad range of functional groups. Although 1,3-H transfer was first realized a long time ago, only in recent times have there been more comprehensive and systematic studies on their enantiospecific transformations. This review summarizes the recent advances in enantiospecific 1,3-H transfer of alkenes and alkynes for the generation of centrally and axially chiral molecules. Examples where the enantiospecific 1,3-H transfer occurs inside a tandem reaction system are discussed. This review could inspire more studies on the development of enantiospecific 1,3-H transfer for asymmetric chemistry.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"12 1","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 15.7 2区 化学
Trends in Chemistry Pub Date : 2024-09-11 DOI: 10.1016/s2589-5974(24)00168-0
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s2589-5974(24)00168-0","DOIUrl":"https://doi.org/10.1016/s2589-5974(24)00168-0","url":null,"abstract":"No Abstract","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"2 1","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 15.7 2区 化学
Trends in Chemistry Pub Date : 2024-09-11 DOI: 10.1016/s2589-5974(24)00165-5
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s2589-5974(24)00165-5","DOIUrl":"https://doi.org/10.1016/s2589-5974(24)00165-5","url":null,"abstract":"No Abstract","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"27 1","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholesterol-mediated functionalization of liposomes for artificial cell design 胆固醇介导的脂质体功能化用于人工细胞设计
IF 15.7 2区 化学
Trends in Chemistry Pub Date : 2024-09-10 DOI: 10.1016/j.trechm.2024.08.003
Xin Qiao, Xiaoliang Wang, Xin Huang
{"title":"Cholesterol-mediated functionalization of liposomes for artificial cell design","authors":"Xin Qiao, Xiaoliang Wang, Xin Huang","doi":"10.1016/j.trechm.2024.08.003","DOIUrl":"https://doi.org/10.1016/j.trechm.2024.08.003","url":null,"abstract":"<p>To achieve functionalized liposomes and their expanding applications in assembling artificial cells and solve problems of poor stability and single structure of liposomes, recent progress in state-of-the-art liposomes has employed cholesterol as an ‘anchor’ to enrich phospholipid membranes with modifications. Cholesterol is widely used because of its capacity for robust hydrophobic interactions with phospholipids. Introducing cholesterol into liposomes renders them more similar to cells. This review summarizes the various designs and applications of cholesterol-based anchors in liposomes, including surface macromolecular modification of liposomes to achieve improved properties and functionalization, cholesterol-mediated liposome membrane fusion, and cholesterol-mediated hierarchical construction of liposomes as artificial cell models. These studies guide artificial cells to reveal the behavior of life and wider applications.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"5 1","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ChemCarnival: inspiring future STEM pioneers 化学嘉年华：激励未来的科学、技术和工程先锋
IF 15.7 2区 化学
Trends in Chemistry Pub Date : 2024-09-07 DOI: 10.1016/j.trechm.2024.08.001
Ahmad H. Akhdar, Farah B. Cheaib, Farah N. Al-Awar, Nabil M. Halabi, Areej Merhi, Bilal R. Kaafarani
{"title":"ChemCarnival: inspiring future STEM pioneers","authors":"Ahmad H. Akhdar, Farah B. Cheaib, Farah N. Al-Awar, Nabil M. Halabi, Areej Merhi, Bilal R. Kaafarani","doi":"10.1016/j.trechm.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.trechm.2024.08.001","url":null,"abstract":"<p>Contemporary pedagogical research emphasizes the necessity of outreach events to promote and foster science, technology, engineering, and mathematics (STEM) education. This is vital, both in the Middle East and North Africa (MENA) region and worldwide. Here we describe the creation of <em>ChemCarnival</em>, an annual outreach event at the American University of Beirut (AUB) to encourage STEM enthusiasm in the Lebanese community.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"8 1","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pendulum-like oscillatory adaptive catalysis 钟摆式振荡自适应催化作用
IF 15.7 2区 化学
Trends in Chemistry Pub Date : 2024-09-04 DOI: 10.1016/j.trechm.2024.08.002
Wuchao Zhao, Jianghua He, Yuetao Zhang, Eugene Y.-X. Chen
{"title":"Pendulum-like oscillatory adaptive catalysis","authors":"Wuchao Zhao, Jianghua He, Yuetao Zhang, Eugene Y.-X. Chen","doi":"10.1016/j.trechm.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.trechm.2024.08.002","url":null,"abstract":"No Abstract","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"60 1","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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