{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s2589-5974(23)00174-0","DOIUrl":"https://doi.org/10.1016/s2589-5974(23)00174-0","url":null,"abstract":"","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136021774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nanomachines in living matters: the soft-robot cytochrome P450","authors":"S. Shaik, K. Dubey","doi":"10.1016/j.trechm.2023.07.002","DOIUrl":"https://doi.org/10.1016/j.trechm.2023.07.002","url":null,"abstract":"","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42330598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s2589-5974(23)00171-5","DOIUrl":"https://doi.org/10.1016/s2589-5974(23)00171-5","url":null,"abstract":"","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136021775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bioactive molecules from lignin via homogeneous and heterogeneous catalytic pathways","authors":"Mengying Liu, Zhuohua Sun, Saravanakumar Elangovan","doi":"10.1016/j.trechm.2023.08.001","DOIUrl":"https://doi.org/10.1016/j.trechm.2023.08.001","url":null,"abstract":"","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44690764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New functionality of electrode materials with highly concentrated electrolytes","authors":"Yosuke Ugata, N. Yabuuchi","doi":"10.1016/j.trechm.2023.07.003","DOIUrl":"https://doi.org/10.1016/j.trechm.2023.07.003","url":null,"abstract":"","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49079227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in ChemistryPub Date : 2023-08-01Epub Date: 2023-04-30DOI: 10.1016/j.trechm.2023.04.003
Brian Choi, A James Link
{"title":"Discovery, Function, and Engineering of Graspetides.","authors":"Brian Choi, A James Link","doi":"10.1016/j.trechm.2023.04.003","DOIUrl":"10.1016/j.trechm.2023.04.003","url":null,"abstract":"<p><p>Graspetides are a class of RiPPs (ribosomally synthesized and post-translationally modified peptides) defined by the presence of ester or amide side chain-side chain linkages resulting in peptide macrocycles. The graspetide name comes from the ATP-grasp enzymes that install the side chain-side chain linkages. This review covers the early, activity-based isolation of the first graspetides, marinostatins and microviridins, as well as the key genomics-driven experiments that established graspetide as RiPPs. The mechanism and structure of graspetide-associated ATP-grasp enzymes is discussed. Genome mining methods to discover new graspetides as well as the analytical techniques used to determine the linkages in graspetides are described. Extant knowledge on the bioactivity of graspetides as protease inhibitors is reviewed. Further chemical modifications to graspetides as well graspetide engineering studies are also described. We conclude with several suggestions about future directions of graspetide research.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"5 8","pages":"620-633"},"PeriodicalIF":14.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10104450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Celebrating Our Good ‘Four’-tune","authors":"J. Pancholi","doi":"10.1016/j.trechm.2023.07.001","DOIUrl":"https://doi.org/10.1016/j.trechm.2023.07.001","url":null,"abstract":"","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44385902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"C–N and C–S bond formation by cytochrome P450 enzymes","authors":"Richiro Ushimaru, I. Abe","doi":"10.1016/j.trechm.2023.04.008","DOIUrl":"https://doi.org/10.1016/j.trechm.2023.04.008","url":null,"abstract":"","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49335683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}