Osmangazi tıp dergisi最新文献

{"title":"Factors Affecting Peroperative Bleeding Amount and Need for Blood Transfusion in Retropubic Radical Prostatectomy Operation","authors":"Osman GERCEK, Veli Mert YAZAR, Murat Cengizhan ATİK, Kutay TOPAL","doi":"10.20515/otd.1349147","DOIUrl":"https://doi.org/10.20515/otd.1349147","url":null,"abstract":"İntraoperatif kan kaybı radikal prostatektominin önemli komplikasyonlarından biridir. Perioperatif uygun risk sınıflamasının yapılması intraoperatif kan transfüzyonu ihtimalini azaltabilir. Biz bu çalışmada kanamaya neden olabilecek risk faktörlerini ortaya koymayı amaçladık. Çalışmamıza konvansiyonel transrektal ultrasonografi biyopsi (TRUS-Bx) ile prostat kanseri tanısı konulan ve retropubik radikal prostatektomi (RP) operasyonu gerçekleştirilen 180 hasta dahil edildi. Operasyonda gerçekleşen ortalama kan kaybı ile hastanın klinik ve patolojik bulgularının ilişkisi incelendi. Kanama miktarına etki edebilecek ve operasyon öncesi kanama miktarını öngörebilecek faktörler ortaya konulmaya çalışıldı. Kanama miktarı fazla olan hastalarda TRUS-Bx ile RP arasında geçen süre istatistiksel anlamlı olarak daha uzundu (p=0.005). Peroperatif kanama düzeyi ile TRUS-Bx ve RP ISUP skorlarının karşılaştırıldığında, kanama miktarı yüksek olan (>845 cc) hastalarda hem TRUS-Bx hem de RP ISUP değerleri istatistiksel olarak anlamlı daha yüksek izlendi (sırasıyla; p=0,024, p<0,001). TRUS-Bx ISUP skorunda 1 birimlik artış, peroperatif kanama miktarında 100.04 cc artışla ilişkili bulunmuştur. Lojistik regresyon analizinde peroperatif kanama miktarı için en önemli prediktör RP ISUP derecesiydi (p=0,003). Yüksek evre hastalarda operasyon sırasında kanama daha çok olmaktadır. ISUP derecesi ve biyopsi tümör yüzdesi yüksek olan hastalarda daha dikkatli bir diseksiyon, peroperatif kanama miktarını azaltabilir. Intraoperatif kanama miktarı fazla olan hastalarda kanser evresinin biyopsi patolojisine göre daha yüksek olabileceği unutulmamalıdır.","PeriodicalId":485255,"journal":{"name":"Osmangazi tıp dergisi","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136099461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fournier Gangreni’nde Vakum Yardımlı Kapama (Vak)’nın Yara İyileşmesi ve Greft Uyumu Üzerine Etkisi","authors":"Burhan BAYLAN","doi":"10.20515/otd.1350645","DOIUrl":"https://doi.org/10.20515/otd.1350645","url":null,"abstract":"Giriş: Fournier Gangreni (FG), perineal, perianal veya genital bölgeleri etkileyen agresif bir nekrotizan fasiit olarak tanımlanmıştır. FG’de nekrotik dokuların erken dönemde agresif ve tam cerrahi debridmanı yapılmalıdır. FG'nin tedavisinde VAK ve konvansiyonel pansumanu karşılaştırarak, başlangıç cerrahisi ile greftleme arasında geçen süre ve greftleme sonrası sekonder debritman gereksinimi açısından incelemeyi amaçladık. Materyal-Metod: 2015- 2023 yılları arasında Üroloji Kliniği’mizce FG tanısı konularak cerrahi tedavi uygulanan ve greft ile doku kapama yapılmış 48 hastanın verileri retrospektif incelendi. Hastaların klinik, patofizyolojik özellikleri, predispozan faktörler, VAK veya konvansiyonel pansuman kullanımı, greft kaybı sayıları, hastanede kalış süreleri kaydedildi. VAK ve konvansiyel pansuman yapılan gruplar karşılaştırılmalı değerlendirildi. Bulgular: Fournier Gangreni tanısı ile takip ve tedavi edilen toplam 48 hastanın 25’inde (%52) postoperatif dönemde VAK pansuman kullanılırken, 23’ünde (%48) konvansiyonel pansuman kullanılmıştı. Ortalama hastanede yatış süreleri, VAK grubunda 28 gün , konvansiyonel grupta 48 gün olarak tespit edilmiş ve VAK grubunda anlamlı olarak daha kısa saptandı. (p = 0.008). VAK grubunda 2 hastada , konvansiyonel pansuman yapılan hasta grubunda 6 hastada greft ile kapama sonrası sekonder debritman gerekli olduğu tespit edildi.Greft kaybı oranları VAK pansuman yapılan grupta, konvansiyonel pansuman yapılan gruba göre istatistiksel anlamlı daha azdı. Sonuç: FG ‘de VAK tedavisi yara iyileştirmesini hızlandırmakta, hastanede kalış süresini kısaltmakta ve greft ile doku kapama sonrası ikincil cerrahi girişim oranlarını azaltmaktadır","PeriodicalId":485255,"journal":{"name":"Osmangazi tıp dergisi","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136375338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Büro Çalışanlarının Ergonomik Çalışma Koşulları ve Stres Algılarının Değerlendirilmesi: Bir Üniversite Örneği","authors":"Feyza Nehir ÖZNUR MUZ, Ali KILINÇ, Mine TEPETAŞ, Alaettin ÜNSAL, Didem ARSLANTAŞ","doi":"10.20515/otd.1314951","DOIUrl":"https://doi.org/10.20515/otd.1314951","url":null,"abstract":"The necessity of organizing the working conditions of a workplace in a way that is suitable for employees and that they can easily do their jobs brings ergonomics to the forefront in terms of occupational health and safety. It is aimed to determine the perception of ergonomic working conditions and the stress levels of a university’s office workers. This cross-sectional study was conducted among 530 office workers of a university. The Ergonomic Working Conditions Scale (EWCS) was used to determine the perception of ergonomic working conditions, and the Perceived Stress Scale (PSS), was used to determine stress perception levels. Mann-Whitney U, Kruskal-Wallis tests, Spearman correlation and Multiple linear regression analyses were used. Participants ages ranged between 19-60 years with a mean of 37.2±8.9 years. The participants' scores on the EWCS ranged between 36-130, with a mean score of 83.6±14.2 points. It was found that there was a weak negative correlation between the scores obtained from the EWCS and the scores obtained from PSS (r= -0.167, p=0.001). As a result of multiple linear regression analysis, it was found that age, gender, working time and ergonomic arrangement of working conditions by the employee were associated with the scores obtained from the EWCS (F=4318, p<0.001). It was found that the perceptions of university office workers about the ergonomic conditions of the working environment were at a moderate level. As the level of perception of the employees about ergonomic conditions increased, the level of perceived stress decreased.","PeriodicalId":485255,"journal":{"name":"Osmangazi tıp dergisi","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136378631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatrik Kutanöz Leishmania Olgularının Değerlendirilmesi","authors":"Yalçın KARA, Mahmut Can KIZIL, Merve İŞERİ NEPESOV, Hilal KAYA ERDOĞAN, Ömer KILIÇ, Nihal DOĞAN, Ener Çağrı DİNLEYİCİ","doi":"10.20515/otd.1321525","DOIUrl":"https://doi.org/10.20515/otd.1321525","url":null,"abstract":"Cutaneous Leishmaniasis (CL) is a disease caused by leishmania-type protozoans, which is transmitted by the bite of infected female phlebotomine sandflies and is characterized by ulcerated nodular lesions. Twenty-one pediatric cutaneous leishmania cases followed by pediatric infectious diseases and dermatology were included in the study. The demographic and clinical characteristics of the patients, the local or systemic treatments, and side effects were analyzed retrospectively. 14 (66%) of the patients were female and 7 (34%) were male. The mean age of the cases was 6.4 years. Fifteen of the patients were refugees (seven of the patients were from Iraq, and eight of them were from Syria). Ten of the patients ( 47%) had lesions only on the face, 6 (28%) were both on the face and hand, 4 (20%) were on the lower extremities. Seven patients (34%) had a single lesion, fourteen had multiple lesions and seven had more than four lesions. Amastigote was observed in the microbiological examination of skin scraping samples of 13 patients. Intralesional therapy was given to 15 patients, systemic treatment was given to 6 patients, and 2 patients refused systemic treatment. Five patient was given meglumine antimoniate, one patient was given amphotericin B. In one patient, side effects such as facial swelling, rash, and edema developed after amphotericin b, and the treatment was changed to meglumine antimoniate. Leishmaniasis is a chronic disease caused by flagellate protozoa of the genus Leishmania. especially in endemic countries. CL has become a relatively common condition all over the world due to international travel, migration, and refugees. Cutaneous Leishmania should be considered when there are chronic, painless skin lesions outside of endemic areas.","PeriodicalId":485255,"journal":{"name":"Osmangazi tıp dergisi","volume":"225 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135208221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Ear Surgery : 7 Years of Single Center Experience","authors":"Ercan KAYA, Armağan İNCESU, Mehmet Özgür PINARBAŞLI, Furkan KAYA","doi":"10.20515/otd.1235587","DOIUrl":"https://doi.org/10.20515/otd.1235587","url":null,"abstract":"Bu çalışmanın amacı, kliniğimizin endoskopik kulak cerrahisi deneyimlerini paylaşmak ve sonrasında daha detaylı çalışmalar için kılavuz oluşturmaktır. Araştırmada retrospektif olarak kliniğimizde 2015-2022 yılları arasında; endoskopik veya mikroskopla kombine olarak opere olan bireylerin verileri, hastane veri tabanından toplanmıştır. Araştırmaya kliniğimizde endoskopik veya mikroskopla kombine yaklaşımla kulak operasyonu olmuş 70 hastanın verileri dahil edilmiştir. Temelde yapılan cerrahinin niteliğine göre hastalar dört gruba ayrılmıştır. Tip-1 timpanoplasti olan gruptaki 26 vaka ortalama 16,3 ay takip edilmiştir. Eksplorasyon ve işitme rekonstrüksiyonu yapılan gruptaki 9 vakanın takip ortalama süresi 13,4 aydır. Kolesteatom nedeniyle opere edilen 18 kişilik vaka grubu ise ortalama 17,7 ay takip edilmiştir. Stapedetomi yapılan 17 kişilik vaka grubu ise ortalama 14,9 ay takip edilmiş olup hava ve kemik yolu arasındaki gapte ortalama 16,7 desibellik kazanç sağlanmıştır. Endoskopinin KBB pratiğinde giderek yaygınlaşması ve otoloji alanındaki kullanımı düşünüldüğünde, orta kulağa sınırlı patolojilerde geleneksel mikroskobik yaklaşıma göre avantajlarının ileri çalışmalarla desteklemesi gerektiği kanaatindeyiz.","PeriodicalId":485255,"journal":{"name":"Osmangazi tıp dergisi","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135208482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of acute respiratory viral infections of children with cancer before the COVID-19 pandemic","authors":"Ersin TÖRET, Uğur TOKDEMİR, Zeynep Canan ÖZDEMİR, Berra Nur AKSAKAL, Ömer KILIÇ, Tercan US, Gül DURMAZ, Ozcan BOR","doi":"10.20515/otd.1315573","DOIUrl":"https://doi.org/10.20515/otd.1315573","url":null,"abstract":"Children with cancer became a major high-risk group during the COVID-19 pandemic. It has become difficult for patients to reach practical and safe care and treatment all over the world. The late diagnosis of many childhood cancers was driven by limited access to healthcare due to the pandemic and fears of COVID-19 that prevented parents from making an early medical assessment of their child's symptoms. Acute respiratory diseases are an important cause of morbidity and mortality in children with cancer, regardless of the COVID-19 pandemic and were seen less frequently in the pandemic during the lockdown and distant education period in comparison to the time before the pandemic in children with cancer. Acute respiratory viral infections frequently cause febrile neutropenia attacks in children under five years of age. A three year retrospective cross-sectional study was performed in a tertiary care university hospital. Children with cancer who presented to the Department of Pediatric Hematology and Oncology with the diagnosis of acute respiratory viral infection were included in the study if they had available results of multiplex polymerase chain reaction (PCR) of nasopharyngeal aspirate samples. The qualitative detection of 18 respiratory viruses and four bacterias were detected by the real-time multiplex polymerase chain reaction. Sixty-six patients with 93 acute respiratory viral infection were included in this study. Seventy of 93 (75%) samples were positive for at least one pathogen. The most common three viruses were HRV, Influenza H1N1, and Influenza H1N3, respectively. Other than COVID-19, the risk of severe acute respiratory viral infections are always important in children with cancer and during the pandemic, hygiene measures and social restrictions caused a reduction in the number of acute respiratory viral infection. This study is critical because it shows the distribution of agents in children with cancer who had acute viral upper respiratory tract infections in the near term before the pandemic.","PeriodicalId":485255,"journal":{"name":"Osmangazi tıp dergisi","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135785244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Karbamazepin Kullanan Hastalarda Serum Lipid Düzeylerinin Değerlendirilmesi","authors":"Sinem GÜRCÜ, Ali UNCU, Gülgün UNCU","doi":"10.20515/otd.1346515","DOIUrl":"https://doi.org/10.20515/otd.1346515","url":null,"abstract":"Epilepsy is a neurological disease that requires long-term drug therapy. Carbamazepine (CBZ) is a drug that is effective in partial seizures, including complex partial seizures, and tonic-clonic seizures. It was aimed to evaluate the effect on serum lipid profile in patients who used CBZ. Medical biochemistry laboratory data between January and December 2021 were analyzed retrospectively. Patients (n=59) who used monotherapy and at least 2 years of CBZ were included in the study. Patients under 18 years of age were not included. In the control group, 34 healthy people with normal blood parameters, who applied to outpatient clinics for different reasons at the same age, and did not have a disease that would affect the lipid profile, were selected. The mean age of the patients was 36 ±8 years. LDL-cholesterol levels were found to be higher in patients treated with carbamazepine compared to the control group (p<0.05). There was no significant difference in serum triglyceride (TG), and HDL-cholesterol levels in the patient and control groups (p>0.05). There was no gender difference in the effect of carbamazepine on LDL-cholesterol (p>0.05). High serum LDL-cholesterol levels cause atherosclerosis and coronary artery disease. The lipid profile of carbamazepine, which is used regularly at the therapeutic level, changes. Due to the association of high LDL-cholesterol levels with atherosclerosis, it is important to monitor lipid levels in patients using CBZ, especially considering the long duration of use of this pharmacotherapy.","PeriodicalId":485255,"journal":{"name":"Osmangazi tıp dergisi","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135785096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluatıon of Copeptın, Mıd-Regıonal Proadrenomedullın and N-Termınal Pro-Brain Natrıuretıc Peptıt Levels in Anemıc Preterm Babıes: a Prospectıve Clınıcal Study","authors":"Tuğba BARSAN KAYA, Ozge AYDEMİR, Özge SÜRMELİ ONAY, Ayşe Neslihan TEKİN","doi":"10.20515/otd.1316497","DOIUrl":"https://doi.org/10.20515/otd.1316497","url":null,"abstract":"Yoğun bakım ihtiyacı olan prematüre yenidoğanlar en sık transfüzyon yapılan hasta grupları arasındadır. Literatürde transfüzyon kararını vermekte kullanılan kriterler ve bu kriterlerin sonuçlarını inceleyen çalışmalar olsa da transfüzyon endikasyonları konusunda net bir fikir birliği yoktur. Bu çalışmanın amacı anemik bebeklerde transfüzyon ihtiyacını belirlemede kalp debisindeki değişikliklere duyarlı olan NT-proBNP, copeptin ve MR-proADM düzeylerinin kullanılabilirliğini değerlendirmektir. Yenidoğan yoğun bakım ünitesinde izlenmekte olan ve eritrosit transfüzyonu ihtiyacı olan 24 preterm bebek Transfüzyon grubu ve yenidoğan yoğun bakım ünitesinde izlenen, hematokrit (Hct)>%25 olan ve transfüzyon endikasyonu olabilecek klinik bulgusu olmayan 23 preterm bebek Kontrol Grubuna olarak çalışmaya dahil edildi. Transfüzyon grubunda transfüzyon öncesi ve sonrası copeptin, NT-ProBNP ve MR-proADM düzeyleri arasında fark saptanmadı (p değeri sırasıyla 0,44, 0,64, 0,41). Transfüzyon grubunun transfüzyon öncesi copeptin, NT-proBNP, ve MR-proADM düzeyleri kontrol grubunun düzeyleri ile kıyaslandığında anlamlı fark saptanmadı (sırasıyla p=0,85, 0,75, 0,88). Hemoglobin düzeyi 8 mg/dl altında olan hastalarda copeptin, NT-ProBNP ve MR-proADM düzeyleri Hb düzeyi >8mg/dl iken transfüzyon yapılanlar ve kontrol grubuna göre sayısal olarak yaklaşık 2 kat yüksek bulunmasına rağmen gruplar arasındaki fark istatistiksel olarak anlamlı değildi (p değeri sırasıyla 0,15, 0,47, 0,57). Çalışma grubunun semptomatik, asemptomatik alt gruplarının kontrol grubu ile birlikte olan analizinde copeptin, NT-ProBNP ve MR-proADM düzeyleri açısından fark saptanmadı (p değeri sırasıyla 0,81, 0,99, 0,93). Serolojik belirteçler pek çok durumda yol göstericidir ancak çalışmamızda yer alan Copeptin, NT-proBNP ve MD-proADM’in anemide, transfüzyon kararı vermede kullanışlı olmadığı kanaatine varılmıştır.","PeriodicalId":485255,"journal":{"name":"Osmangazi tıp dergisi","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136025451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor-related EDTA dependent pseudothrombocytopenia after allogeneic stem cell transplantation. Can it be real?","authors":"Hava ÜSKÜDAR TEKE, Eren GUNDUZ","doi":"10.20515/otd.1326098","DOIUrl":"https://doi.org/10.20515/otd.1326098","url":null,"abstract":"Hematopoietic stem cell transplantation (HSCT) may take place in the form of an autologous or allogeneic transplant depending on the indication for transplantation. Because of the myeloablative conditioning regimens preceding HSCT, deep thrombocytopenia is experienced by most of the stem cell recipients in whom replenishment of leukocytes and platelets is expected within the first month following the transplantation. Prolonged thrombocytopenia, on the other hand, usually develops as a delayed complication of allogeneic stem cell transplantation (allo-SCT) and is associated to the source of stem cells, quantity of the infused CD34+ cells, graft-versus-host-disease (GVHD), insufficient engraftment, relapse of the malignancy, microangiopathy, alloimmunisation, medications, or viral infections. In an attempt to explain pathogenesis leading to post-HSCT thrombocytopenia, two main theories have been proposed. First one is the peripheral destruction caused by anti-platelet antibodies, splenic sequestration, or other factors. The latter blames insufficient platelet generation due to impaired thrombopoiesis. Nevertheless, most of the clinical conditions arise with overlapping of both mechanisms.Here we present a pseudothrombocytopenia case induced by donor-related ethylene-diamine-tetra-acetic acid (EDTA) as an unanticipated cause of thrombocytopenia to which most recipients of allo-SCT are prone to.","PeriodicalId":485255,"journal":{"name":"Osmangazi tıp dergisi","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical Cytology Findings in Renal Transplant Patients and Comparison of These Findings with Normal Population","authors":"Alev OK ATILGAN, Merih TEPEOĞLU, Asuman Nihan HABERAL REYHAN, Esra KUŞCU, Handan ÖZDEMİR, Mehmet HABERAL","doi":"10.20515/otd.1300851","DOIUrl":"https://doi.org/10.20515/otd.1300851","url":null,"abstract":"Long-term immunosuppressive therapy increases the likelihood of renal transplant patients developing cervical cancer. We aimed to analyze the results of cervical cytology in renal transplant patients, compare these findings to those of the normal population, and determine the risk factors linked to the development of squamous intraepithelial lesions. Our analysis involved a retrospective study of hospital records from January 2000 to April 2018, encompassing 140 female renal transplant patients. A control group of 280 women with normal health status was selected and matched based on age and the cervical cytology procedure. The cervical cytology findings of the patients were re-evaluated using the Bethesda 2014 criteria. Of the total of 420 patients, 37 patients had epithelial cell abnormalities; including 32 (86.5%) patients in the renal transplant group and 5 (13.5%) control group (p ≤ 0.001). Sixty-two patients had infections; including 44 (71%) patients in the renal transplant group and 18 (29%) control group (p ≤ 0.001). We revealed that the development of squamous intraepithelial lesions was associated with factors such as having an immunologic disease as the primary renal disease, undergoing re-transplantation, and the presence of acute rejection (p ≤ 0.05). Cervical cytology screening plays a crucial role in detecting preinvasive lesions. The incidence of epithelial cell abnormalities is significantly higher in renal transplant patients compared to the normal population. Regular cervical cytology follow-up is vital for the early detection and prevention of cervical cancer progression in transplant recipients.","PeriodicalId":485255,"journal":{"name":"Osmangazi tıp dergisi","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136025880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}