International Journal of Bioprinting最新文献

{"title":"Toward better drug development: Three-dimensional bioprinting in toxicological research.","authors":"Diána Szűcs,&nbsp;Zsolt Fekete,&nbsp;Melinda Guba,&nbsp;Lajos Kemény,&nbsp;Katalin Jemnitz,&nbsp;Emese Kis,&nbsp;Zoltán Veréb","doi":"10.18063/ijb.v9i2.663","DOIUrl":"https://doi.org/10.18063/ijb.v9i2.663","url":null,"abstract":"<p><p>The importance of three-dimensional (3D) models in pharmacological tests and personalized therapies is significant. These models allow us to gain insight into the cell response during drug absorption, distribution, metabolism, and elimination in an organ-like system and are suitable for toxicological testing. In personalized and regenerative medicine, the precise characterization of artificial tissues or drug metabolism processes is more than crucial to gain the safest and the most effective treatment for the patients. Using these 3D cell cultures derived directly from patient, such as spheroids, organoids, and bioprinted structures, allows for testing drugs before administration to the patient. These methods allow us to select the most appropriate drug for the patient. Moreover, they provide chance for better recovery of patients, since time is not wasted during therapy switching. These models could be used in applied and basic research as well, because their response to treatments is quite similar to that of the native tissue. Furthermore, they may replace animal models in the future because these methods are cheaper and can avoid interspecies differences. This review puts a spotlight on this dynamically evolving area and its application in toxicological testing.</p>","PeriodicalId":48522,"journal":{"name":"International Journal of Bioprinting","volume":"9 2","pages":"663"},"PeriodicalIF":8.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/72/IJB-9-2-663.PMC10090537.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9373137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and characterization of 3D-printed antibacterial hydrogel with benzyl isothiocyanate.","authors":"Yunxia Liang,&nbsp;Bimal Chitrakar,&nbsp;Zhenbin Liu,&nbsp;Xujia Ming,&nbsp;Dan Xu,&nbsp;Haizhen Mo,&nbsp;Chunyang Shi,&nbsp;Xiaolin Zhu,&nbsp;Liangbin Hu,&nbsp;Hongbo Li","doi":"10.18063/ijb.v9i2.671","DOIUrl":"https://doi.org/10.18063/ijb.v9i2.671","url":null,"abstract":"<p><p>Benzyl isothiocyanate (BITC) is an isothiocyanate of plant origin, especially the mustard family, which has good antibacterial properties. However, its applications are challenging due to its poor water solubility and chemical instability. We used food hydrocolloids, including xanthan gum, locust bean gum, konjac glucomannan, and carrageenan as three-dimensional (3D)-printing food ink base and successfully prepared 3D-printed BITC antibacterial hydrogel (BITC-XLKC-Gel). The characterization and fabrication procedure of BITC-XLKC-Gel was studied. The results show that BITC-XLKC-Gel hydrogel has better mechanical properties by low-field nuclear magnetic resonance (LF-NMR), mechanical properties, and rheometer analysis. The strain rate of BITC-XLKC-Gel hydrogel is 76.5%, which is better than that of human skin. Scanning electron microscope (SEM) analysis showed that BITC-XLKC-Gel has uniform pore size and provides a good carrier environment for BITC carriers. In addition, BITC-XLKC-Gel has good 3D-printing performance, and 3D printing can be used for customizing patterns. Finally, inhibition zone analysis showed that the BITC-XLKC-Gel added with 0.6% BITC had strong antibacterial activity against <i>Staphylococcus aureus</i> and the BITC-XLKC-Gel added with 0.4% BITC had strong antibacterial activity against <i>Escherichia coli</i>. Antibacterial wound dressing has always been considered essential in burn wound healing. In experiments that simulated burn infection, BITC-XLKC-Gel showed good antimicrobial activity against methicillin-resistant <i>S. aureus</i>. BITC-XLKC-Gel is a good 3D-printing food ink attributed to strong plasticity, high safety profile, and good antibacterial performance and has great application prospects.</p>","PeriodicalId":48522,"journal":{"name":"International Journal of Bioprinting","volume":"9 2","pages":"671"},"PeriodicalIF":8.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3d/ce/IJB-9-2-671.PMC10090813.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9373140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional printing of microfiber- reinforced hydrogel loaded with oxymatrine for treating spinal cord injury.","authors":"Shiqiang Song,&nbsp;Jing Zhou,&nbsp;Junming Wan,&nbsp;Xingchang Zhao,&nbsp;Kai Li,&nbsp;Chengliang Yang,&nbsp;Chuanchuan Zheng,&nbsp;Liqiang Wang,&nbsp;Yujin Tang,&nbsp;Chong Wang,&nbsp;Jia Liu","doi":"10.18063/ijb.692","DOIUrl":"https://doi.org/10.18063/ijb.692","url":null,"abstract":"<p><p>Spinal cord injury (SCI) causes severe neural tissue damage and motor/sensory dysfunction. Since the injured spinal cord tissue has limited self-regeneration ability, several strategies, including cell therapy, drug delivery, and tissue engineering scaffold implantation, have been employed to treat SCI. However, each of these strategies fails to obtain desirable outcomes due to their respective limitations. In comparison, advanced tissue engineering scaffolds with appropriate topographical features, favorable composition, and sustained drug delivery capability can be employed to recruit endogenous neural stem cells (NSCs), induce neuronal differentiation, and facilitate neuron maturation. This can lead to the regeneration of injured spinal cord tissue and the recovery of motor function. In this study, fiber bundle-reinforced spinal cord extracellular matrix hydrogel scaffolds loaded with oxymatrine (OMT) were produced through nearfield direct write electrospinning. The spinal cord extracellular matrix-based hydrogel was then coated with OMT. The physical/chemical properties and <i>in vitro</i> degradation behavior of the composite scaffolds were investigated. The <i>in vitro</i> cell culture results showed that composite scaffolds loaded with OMT promoted the differentiation of NSCs into neurons and inhibited differentiation into astrocytes. The <i>in vivo</i> results showed that the composite scaffolds loaded with OMT recruited NSCs from the host tissue, promoted neuronal differentiation and axon extension at the lesion site, inhibited glial scar formation at/around the lesion site, and improved the recovery of motor function in rats with SCI. To sum up, 3D-printed microfiber-reinforced spinal cord extracellular matrix hydrogel scaffolds loaded with OMT are promising biomaterials for the treatment of SCI.</p>","PeriodicalId":48522,"journal":{"name":"International Journal of Bioprinting","volume":"9 3","pages":"692"},"PeriodicalIF":8.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fe/e6/IJB-9-3-692.PMC10236342.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9578369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of a bioink composed of alginate, gelatin, and nanocellulose for meniscal tissue engineering.","authors":"Julia Anna Semba,&nbsp;Adam Aron Mieloch,&nbsp;Ewa Tomaszewska,&nbsp;Piotr Cywoniuk,&nbsp;Jakub Dalibor Rybka","doi":"10.18063/ijb.v9i1.621","DOIUrl":"https://doi.org/10.18063/ijb.v9i1.621","url":null,"abstract":"<p><p>1The necessity to preserve meniscal function prompts the research and development of novel treatment options, like three-dimensional (3D) bioprinting. However, bioinks for meniscal 3D bioprinting have not been extensively explored. Therefore, in this study, a bioink composed of alginate, gelatin, and carboxymethylated cellulose nanocrystal (CCNC) was formulated and evaluated. Firstly, bioinks with varying concentrations of the aforementioned components were subjected to rheological analysis (amplitude sweep test, temperature sweep test, and rotation). The optimal bioink formulation of 4.0% gelatin, 0.75% alginate, and 1.4% CCNC dissolved in 4.6% D-mannitol was further used for printing accuracy analysis, followed by 3D bioprinting with normal human knee articular chondrocytes (NHAC-kn). The encapsulated cells' viability was > 98%, and collagen II expression was stimulated by the bioink. The formulated bioink is printable, stable under cell culture conditions, biocompatible, and able to maintain the native phenotype of chondrocytes. Aside from meniscal tissue bioprinting, it is believed that this bioink could serve as a basis for the development of bioinks for various tissues.</p>","PeriodicalId":48522,"journal":{"name":"International Journal of Bioprinting","volume":"9 1","pages":"621"},"PeriodicalIF":8.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/cb/IJB-9-1-621.PMC9947383.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9340842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 3D bioprinted tumor model fabricated with gelatin/sodium alginate/decellularized extracellular matrix bioink.","authors":"Jie Xu,&nbsp;Shuangjia Yang,&nbsp;Ya Su,&nbsp;Xueyan Hu,&nbsp;Yue Xi,&nbsp;Yuen Yee Cheng,&nbsp;Yue Kang,&nbsp;Yi Nie,&nbsp;Bo Pan,&nbsp;Kedong Song","doi":"10.18063/ijb.v9i1.630","DOIUrl":"https://doi.org/10.18063/ijb.v9i1.630","url":null,"abstract":"<p><p>109Tissue-engineered scaffolds are more commonly used to construct three-dimensional (3D) tumor models for <i>in vitro</i> studies when compared to the conventional two-dimensional (2D) cell culture because the microenvironments provided by the 3D tumor models closely resemble the <i>in vivo</i> system and could achieve higher success rate when the scaffolds are translated for use in pre-clinical animal model. Physical properties, heterogeneity, and cell behaviors of the model could be regulated to simulate different tumors by changing the components and concentrations of materials. In this study, a novel 3D breast tumor model was fabricated by bioprinting using a bioink that consists of porcine liver-derived decellularized extracellular matrix (dECM) with different concentrations of gelatin and sodium alginate. Primary cells were removed while extracellular matrix components of porcine liver were preserved. The rheological properties of biomimetic bioinks and the physical properties of hybrid scaffolds were investigated, and we found that the addition of gelatin increased hydrophilia and viscoelasticity, while the addition of alginate increased mechanical properties and porosity. The swelling ratio, compression modulus, and porosity could reach 835.43 ± 130.61%, 9.64 ± 0.41 kPa, and 76.62 ± 4.43%, respectively. L929 cells and the mouse breast tumor cells 4T1 were subsequently inoculated to evaluate biocompatibility of the scaffolds and to form the 3D models. The results showed that all scaffolds exhibited good biocompatibility, and the average diameter of tumor spheres could reach 148.52 ± 8.02 μm on 7 d. These findings suggest that the 3D breast tumor model could serve as an effective platform for anticancer drug screening and cancer research <i>in vitro</i>.</p>","PeriodicalId":48522,"journal":{"name":"International Journal of Bioprinting","volume":"9 1","pages":"630"},"PeriodicalIF":8.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/4d/IJB-9-1-630.PMC9947382.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9356435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1Biomaterial inks for extrusion-based 3D bioprinting: Property, classification, modification, and selection.","authors":"Li Xiaorui,&nbsp;Zheng Fuyin,&nbsp;Wang Xudong,&nbsp;Geng Xuezheng,&nbsp;Zhao Shudong,&nbsp;Liu Hui,&nbsp;Dou Dandan,&nbsp;Leng Yubing,&nbsp;Wang Lizhen,&nbsp;Fan Yubo","doi":"10.18063/ijb.v9i2.649","DOIUrl":"https://doi.org/10.18063/ijb.v9i2.649","url":null,"abstract":"<p><p>Three-dimensional (3D) extrusion-based bioprinting is the most widely used bioprinting technology to fabricate bionic tissue or organ constructs by combining biomaterial ink and living cells for tissue engineering and regenerative medicine. One critical issue of this technique is the selection of suitable biomaterial ink to simulate extracellular matrix (ECM) that provides mechanical support for cells and regulates their physiological activities. Previous studies have demonstrated that it is an enormous challenge to form and maintain reproducible 3D constructs and eventually achieve the balance among biocompatibility, mechanical properties, and printability. This review highlights the properties of extrusion-based biomaterial inks and recent developments as well as details various biomaterial inks classified by their function. Key approaches related to their modification methods according to the functional requirements are also discussed, along with the selection strategies by varying extrusion paths and methods in extrusion-based bioprinting. This systematical review will assist researchers in identifying the most suitable extrusion-based biomaterial inks based on their requirements, as well as in elaborating current challenges and prospects of extrudable biomaterial inks in the field of bioprinting of in vitro tissue models.</p>","PeriodicalId":48522,"journal":{"name":"International Journal of Bioprinting","volume":"9 2","pages":"649"},"PeriodicalIF":8.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/a0/IJB-9-2-649.PMC10090818.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9490793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational simulation-based comparative analysis of standard 3D printing and conical nozzles for pneumatic and piston-driven bioprinting.","authors":"Juan Carlos Gómez-Blanco,&nbsp;J Blas Pagador,&nbsp;Victor P Galván-Chacón,&nbsp;Luisa F Sánchez-Peralta,&nbsp;Manuel Matamoros,&nbsp;Alfonso Marcos,&nbsp;Francisco M Sánchez-Margallo","doi":"10.18063/ijb.730","DOIUrl":"https://doi.org/10.18063/ijb.730","url":null,"abstract":"<p><p>Bioprinting is an application of additive manufacturing that can deliver promising results in regenerative medicine. Hydrogels, as the most used materials in bioprinting, are experimentally analyzed to assure printability and suitability for cell culture. Besides hydrogel features, the inner geometry of the microextrusion head might have an equal impact not only on printability but also on cellular viability. In this regard, standard 3D printing nozzles have been widely studied to reduce inner pressure and get faster printings using highly viscous melted polymers. Computational fluid dynamics is a useful tool capable of simulating and predicting the hydrogel behavior when the extruder inner geometry is modified. Hence, the objective of this work is to comparatively study the performance of a standard 3D printing and conical nozzles in a microextrusion bioprinting process through computational simulation. Three bioprinting parameters, namely pressure, velocity, and shear stress, were calculated using the level-set method, considering a 22G conical tip and a 0.4 mm nozzle. Additionally, two microextrusion models, pneumatic and piston-driven, were simulated using dispensing pressure (15 kPa) and volumetric flow (10 mm³/s) as input, respectively. The results showed that the standard nozzle is suitable for bioprinting procedures. Specifically, the inner geometry of the nozzle increases the flow rate, while reducing the dispensing pressure and maintaining similar shear stress compared to the conical tip commonly used in bioprinting.</p>","PeriodicalId":48522,"journal":{"name":"International Journal of Bioprinting","volume":"9 4","pages":"730"},"PeriodicalIF":8.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/a3/IJB-9-4-730.PMC10261129.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9655822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manufacturability of functionally graded porous β-Ti21S auxetic architected biomaterials produced by laser powder bed fusion: Comparison between 2D and 3D metrological characterization.","authors":"Lorena Emanuelli,&nbsp;Alireza Jam,&nbsp;Anton du Plessis,&nbsp;Carlo Lora,&nbsp;Raffaele De Biasi,&nbsp;Matteo Benedetti,&nbsp;Massimo Pellizzari","doi":"10.18063/ijb.728","DOIUrl":"https://doi.org/10.18063/ijb.728","url":null,"abstract":"<p><p>Functionally graded porous structures (FGPSs) are attracting increasing interest in the manufacture of prostheses that benefit from lower stiffness and optimized pore size for osseointegration. In this work, we explore the possibility of employing FGPSs with auxetic unit cells. Their negative Poisson's ratio was exploited to reduce the loss of connection between prosthesis and bone usually occurring in standard implant loaded under tension and therefore undergoing lateral shrinking. In addition, to further improve osseointegration and mitigate stress shielding effects, auxetic FGPSs were fabricated in this work using a novel β-Ti21S alloy characterized by a lower Young's modulus compared to traditional α + β Ti alloys. Specifically, two different auxetic FGPSs with aspect ratio equal to 1.5 and angle θ of 15° and 25° with a relative density (ρ_r) gradient of 0.34, 0.49, 0.66 and of 0.40, 0.58, 0.75 were designed and printed by laser powder bed fusion. The 2D and 3D metrological characterization of the as-manufactured structures was compared with the design. 2D metrological characterization was carried out using scanning electron microscopy analysis, while for the 3D characterization, X-ray micro-CT imaging was used. An undersizing of the pore size and strut thickness in the as-manufactured sample was observed in both auxetic FGPSs. A maximum difference in the strut thickness of -14 and -22% was obtained in the auxetic structure with θ = 15° and 25°, respectively. On the contrary, a pore undersizing of -19% and -15% was evaluated in auxetic FGPS with θ = 15° and 25°, respectively. Compression mechanical tests allowed to determine stabilized elastic modulus of around 4 GPa for both FGPSs. Homogenization method and analytical equation were used and the comparison with experimental data highlights a good agreement of around 4% and 24% for θ = 15° and 25°, respectively.</p>","PeriodicalId":48522,"journal":{"name":"International Journal of Bioprinting","volume":"9 4","pages":"728"},"PeriodicalIF":8.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/ac/IJB-9-4-728.PMC10261167.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9655824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An inkjet-printed bendable antenna for wearable electronics.","authors":"Hang Yu,&nbsp;Xingguo Zhang,&nbsp;Hao Zheng,&nbsp;Dachao Li,&nbsp;Zhihua Pu","doi":"10.18063/ijb.722","DOIUrl":"https://doi.org/10.18063/ijb.722","url":null,"abstract":"<p><p>104Flexible antennas, which can conform to the skin and transfer signals to terminals, are particularly useful for wearable electronics. Bending, which frequently occurs to flexible devices, significantly affects the performance of flexible antennas. Inkjet printing has been used as an additive manufacturing technology for fabricating flexible antenna in recent years. However, there is little research on the bending performance of inkjet printing antenna in both simulation and experiment. This paper proposes a bendable coplanar waveguide antenna with a small size of 30 × 30 × 0.05 mm³ by combining the advantages of fractal antenna and serpentine antenna, which realizes the ultra-wideband feature and avoids the problems of large dielectric layer thickness (greater than 1 mm) and large volume of traditional microstrip antenna at the same time. The structure of the antenna was optimized by simulation using the Ansys high-frequency structure simulator, and the antenna was fabricated on a flexible polyimide substrate by inkjet printing. The experimental characterization results show that the central frequency of the antenna is 2.5 GHz, the return loss is -32 dB, and the absolute bandwidth is 850 MHz, which is consistent with the simulation results. The results demonstrate that the antenna has anti-interference capability and can meet the ultra-wideband characteristics. When the traverse and longitudinal bending radius are greater than 30 mm and skin proximity greater than 1 mm, the resonance frequency offsets are mostly within 360 MHz, and return losses of the bendable antenna are within the -14 dB compared with the no bending condition. The results exhibit that the proposed inkjet-printed flexible antenna is bendable and promising for wearable applications.</p>","PeriodicalId":48522,"journal":{"name":"International Journal of Bioprinting","volume":"9 4","pages":"722"},"PeriodicalIF":8.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/54/IJB-9-4-722.PMC10261132.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9659435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional materials of 3D bioprinting for wound dressings and skin tissue engineering applications: A review.","authors":"Huan Fang,&nbsp;Jie Xu,&nbsp;Hailin Ma,&nbsp;Jiaqi Liu,&nbsp;Erpai Xing,&nbsp;Yuen Yee Cheng,&nbsp;Hong Wang,&nbsp;Yi Nie,&nbsp;Bo Pan,&nbsp;Kedong Song","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The skin plays an important role in vitamin D synthesis, humoral balance, temperature regulation, and waste excretion. Due to the complexity of the skin, fluids loss, bacterial infection, and other life-threatening secondary complications caused by skin defects often lead to the damage of skin functions. 3D bioprinting technology, as a customized and precise biomanufacturing platform, can manufacture dressings and tissue engineering scaffolds that accurately simulate tissue structure, which is more conducive to wound healing. In recent years, with the development of emerging technologies, an increasing number of 3D-bioprinted wound dressings and skin tissue engineering scaffolds with multiple functions, such as antibacterial, antiinflammatory, antioxidant, hemostatic, and antitumor properties, have significantly improved wound healing and skin treatment. In this article, we review the process of wound healing and summarize the classification of 3D bioprinting technology. Following this, we shift our focus on the functional materials for wound dressing and skin tissue engineering, and also highlight the research progress and development direction of 3D-bioprinted multifunctional wound healing materials.</p>","PeriodicalId":48522,"journal":{"name":"International Journal of Bioprinting","volume":"9 5","pages":"757"},"PeriodicalIF":8.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2f/83/IJB-9-5-757.PMC10339425.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9823681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}