Jacc: Cardiooncology最新文献

{"title":"Cardio-Oncology Care Delivery for All Patients With Cancer Within Academic and Community Settings","authors":"Linda A. Jacobs PhD, CRNP , Lawrence N. Shulman MD","doi":"10.1016/j.jaccao.2023.10.010","DOIUrl":"10.1016/j.jaccao.2023.10.010","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 470-472"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087323003538/pdfft?md5=7a6dc911640799cdb2d991c5d2184efb&pid=1-s2.0-S2666087323003538-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139455337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embracing the Power of the Polysocial Risk Score","authors":"Khurram Nasir MD, MPH, MSc, Zulqarnain Javed PhD, MBBS, MPH, Sadeer Al-Kindi MD","doi":"10.1016/j.jaccao.2023.10.001","DOIUrl":"10.1016/j.jaccao.2023.10.001","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 451-453"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087323002958/pdfft?md5=f83ee4b1c441fa7ebdd1022719edc96b&pid=1-s2.0-S2666087323002958-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136056430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board/Officers Page","authors":"","doi":"10.1016/S2666-0873(24)00162-5","DOIUrl":"https://doi.org/10.1016/S2666-0873(24)00162-5","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages i-iv"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324001625/pdfft?md5=7a88489b77101fdd61fb0cb5652cc665&pid=1-s2.0-S2666087324001625-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Determinants of Health in Cardio-Oncology","authors":"Foster Osei Baah MS, PhD, RN ,&nbsp;Sonal Sharda MHS ,&nbsp;Kimberly Davidow MD ,&nbsp;Sadhana Jackson MD ,&nbsp;Daphney Kernizan DO ,&nbsp;Joshua A. Jacobs PharmD ,&nbsp;Yvonne Baumer PharmD, PhD ,&nbsp;Corinna L. Schultz MD ,&nbsp;Carissa M. Baker-Smith MD, MPH ,&nbsp;Tiffany M. Powell-Wiley MD, MPH","doi":"10.1016/j.jaccao.2024.02.009","DOIUrl":"10.1016/j.jaccao.2024.02.009","url":null,"abstract":"<div><p>Addressing the need for more equitable cardio-oncology care requires attention to existing disparities in cardio-oncologic disease prevention and outcomes. This is particularly important among those affected by adverse social determinants of health (SDOH). The intricate relationship of SDOH, cancer diagnosis, and outcomes from cardiotoxicities associated with oncologic therapies is influenced by sociopolitical, economic, and cultural factors. Furthermore, mechanisms in cell signaling and epigenetic effects on gene expression link adverse SDOH to cancer and the CVD-related complications of oncologic therapies. To mitigate these disparities, a multifaceted strategy is needed that includes attention to health care access, policy, and community engagement for improved disease screening and management. Interdisciplinary teams must also promote cultural humility and competency and leverage new health technology to foster collaboration in addressing the impact of adverse SDOH in cardio-oncologic outcomes.</p></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 331-346"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324001418/pdfft?md5=aadc981182a3fc99af789a7bdaa8b968&pid=1-s2.0-S2666087324001418-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141055285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Literacy, Individual and Community Engagement, and Cardiovascular Risks and Disparities","authors":"Lauren L. Taylor MD ,&nbsp;Arthur S. Hong MD, MPH ,&nbsp;Kristine Hahm MPP ,&nbsp;Dohyeong Kim PhD ,&nbsp;Carolyn Smith-Morris PhD ,&nbsp;Vlad G. Zaha MD, PhD","doi":"10.1016/j.jaccao.2024.03.010","DOIUrl":"10.1016/j.jaccao.2024.03.010","url":null,"abstract":"<div><p>Cardiovascular and cancer outcomes intersect within the realm of cardio-oncology survivorship care, marked by disparities across ethnic, racial, social, and geographical landscapes. Although the clinical community is increasingly aware of this complex issue, effective solutions are trailing. To attain substantial public health impact, examinations of cancer types and cardiovascular risk mitigation require complementary approaches that elicit the patient’s perspective, scale it to a population level, and focus on actionable population health interventions. Adopting such a multidisciplinary approach will deepen our understanding of patient awareness, motivation, health literacy, and community resources for addressing the unique challenges of cardio-oncology. Geospatial analysis aids in identifying key communities in need within both granular and broader contexts. In this review, we delineate a pathway that navigates barriers from individual to community levels. Data gleaned from these perspectives are critical in informing interventions that empower individuals within diverse communities and improve cardio-oncology survivorship.</p></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 363-380"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324001431/pdfft?md5=05749411d0ab23aee45e3d287598ff10&pid=1-s2.0-S2666087324001431-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141056758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood Archetypes and Cardiovascular Health in Black Breast Cancer Survivors","authors":"Carola T. Sánchez-Díaz PhD ,&nbsp;Riddhi A. Babel PhD ,&nbsp;Hari S. Iyer ScD ,&nbsp;Noreen Goldman DSc ,&nbsp;Nur Zeinomar PhD ,&nbsp;Andrew G. Rundle PhD ,&nbsp;Coral O. Omene MD, PhD ,&nbsp;Karen S. Pawlish ScD ,&nbsp;Christine B. Ambrosone PhD ,&nbsp;Kitaw Demissie MD, PhD ,&nbsp;Chi-Chen Hong PhD ,&nbsp;Gina S. Lovasi PhD ,&nbsp;Elisa V. Bandera MD, PhD ,&nbsp;Bo Qin PhD","doi":"10.1016/j.jaccao.2024.04.007","DOIUrl":"https://doi.org/10.1016/j.jaccao.2024.04.007","url":null,"abstract":"<div><h3>Background</h3><p>Maintaining cardiovascular health (CVH) is critical for breast cancer (BC) survivors, particularly given the potential cardiotoxic effects of cancer treatments. Poor CVH among Black BC survivors may be influenced by various area-level social determinants of health, yet the impact of neighborhood archetypes in CVH among this population remains understudied.</p></div><div><h3>Objectives</h3><p>This study aimed to characterize the neighborhood archetypes where Black BC survivors resided at diagnosis and evaluate their associations with CVH.</p></div><div><h3>Methods</h3><p>We assessed CVH 24 months post-diagnosis in 713 participants diagnosed between 2012 and 2017 in the Women’s Circle of Health Follow-Up Study, a population-based study of Black BC survivors in New Jersey. Neighborhood archetypes, identified via latent class analysis based on 16 social and built environment features, were categorized into tertiles. Associations between neighborhood archetypes and CVH scores were estimated using polytomous logistic regression.</p></div><div><h3>Results</h3><p>CVH scores were assessed categorically (low, moderate, and optimal) and as continuous variables. On average, Black BC survivors achieved only half of the recommended score for optimal CVH. Among the 4 identified archetypes, women in the Mostly Culturally Black and Hispanic/Mixed Land Use archetype showed the lowest CVH scores. Compared to this archetype, Black BC survivors in the Culturally Diverse/Mixed Land Use archetype were nearly 3 times as likely to have optimal CVH (relative risk ratio: 2.92; 95% CI: 1.58-5.40), with a stronger association observed in younger or premenopausal women. No significant CVH differences were noted for the other 2 archetypes with fewer built environment features.</p></div><div><h3>Conclusions</h3><p>Neighborhood archetypes, integrating social and built environment factors, may represent crucial targets for promoting CVH among BC survivors.</p></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 405-418"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324001558/pdfft?md5=f72928a8f9a26cfb4ac2ab33a60567e8&pid=1-s2.0-S2666087324001558-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Social Determinants of Health and Cardiovascular Health of U.S. Adult Cancer Survivors","authors":"Danish Iltaf Satti MBBS ,&nbsp;Jeffrey Shi Kai Chan MBChB, MPH ,&nbsp;Edward Christopher Dee MD ,&nbsp;Yan Hiu Athena Lee ,&nbsp;Abraham Ka Chung Wai MBChB ,&nbsp;Sourbha S. Dani MD, MSc ,&nbsp;Salim S. Virani MD, PhD ,&nbsp;Michael D. Shapiro DO, MCR ,&nbsp;Garima Sharma MBBS ,&nbsp;Tong Liu MD, PhD ,&nbsp;Gary Tse MD, PhD","doi":"10.1016/j.jaccao.2023.07.010","DOIUrl":"10.1016/j.jaccao.2023.07.010","url":null,"abstract":"<div><h3>Background</h3><p>Relationships between the social determinants of health (SDOH) and cardiovascular health (CVH) of cancer survivors are underexplored.</p></div><div><h3>Objectives</h3><p>This study sought to investigate associations between the SDOH and CVH of adult cancer survivors.</p></div><div><h3>Methods</h3><p>Data from the U.S. National Health Interview Survey (2013-2017) were used. Participants reporting a history of cancer were included, excluding those with only nonmelanotic skin cancer, or with missing data for any domain of SDOH or CVH. SDOH was quantified with a 6-domain, 38-item score, consistent with the Centers for Disease Control and Prevention recommendations (higher score indicated worse deprivation). CVH was quantified based on the American Heart Association’s Life’s Essential 8, but due to unavailable detailed dietary data, a 7-item CVH score was used, with a higher score indicating worse CVH. Survey-specific multivariable Poisson regression was used to test associations between SDOH quartiles and CVH.</p></div><div><h3>Results</h3><p>Altogether, 8,254 subjects were analyzed, representing a population of 10,887,989 persons. Worse SDOH was associated with worse CVH (highest vs lowest quartile: risk ratio 1.30; 95% CI: 1.25-1.35; <em>P</em> &lt; 0.001), with a grossly linear relationship between SDOH and CVH scores. Subgroup analysis found significantly stronger associations in younger participants (<em>P</em>_interaction = 0.026) or women (<em>P</em>_interaction = 0.001) but without significant interactions with race (<em>P</em>_interaction = 0.051). Higher scores in all domains of SDOH were independently associated with worse CVH (all <em>P</em> &lt; 0.001). Higher SDOH scores were also independently associated with each component of the CVH score (all <em>P</em> &lt; 0.05 for highest SDOH quartile).</p></div><div><h3>Conclusions</h3><p>An unfavorable SDOH profile was independently associated with worse CVH among adult cancer survivors in the United States.</p></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 439-450"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087323002569/pdfft?md5=2119c68ae8b1a4b219ad134e2bdd5a5c&pid=1-s2.0-S2666087323002569-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136056522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Race and Socioeconomic Status Impact Diagnosis and Clinical Outcomes in Transthyretin Cardiac Amyloidosis","authors":"Bairavi Shankar MD ,&nbsp;Lisa Yanek MPH ,&nbsp;Artrish Jefferson MD ,&nbsp;Vivek Jani MS ,&nbsp;Emily Brown CGC ,&nbsp;Daniel Tsottles BS ,&nbsp;Jennifer Barranco BS ,&nbsp;Serena Zampino BS ,&nbsp;Mark Ranek PhD ,&nbsp;Kavita Sharma MD ,&nbsp;Michael Polydefkis MD ,&nbsp;Joban Vaishnav MD","doi":"10.1016/j.jaccao.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.jaccao.2024.05.001","url":null,"abstract":"<div><h3>Background</h3><p>Transthyretin amyloid cardiomyopathy (ATTR-CM) is associated with significant mortality. The Val122Ile variant, highly prevalent in Black patients, portends poorer survival compared with other ATTR-CM subtypes. Although Val122Ile is biologically more aggressive, the contribution of race and socioeconomic status (SES) to disease outcomes in patients with ATTR-CM is undefined.</p></div><div><h3>Objectives</h3><p>The aim of this study was to evaluate the impact of race and SES on clinical outcomes in patients with ATTR-CM.</p></div><div><h3>Methods</h3><p>Patients with ATTR-CM who received care at Johns Hopkins Hospital between 2006 and 2022 were included. SES was assessed using area deprivation index (ADI). Associations of race and ADI with heart failure (HF) hospitalization and/or death were measured using multivariable logistic or Cox proportional hazards models.</p></div><div><h3>Results</h3><p>Of 282 patients, 225 (80%) were men, and 129 (46%) were Black. Black vs White patients disproportionately constituted the highest ADI (most deprived) category (66% vs 28%; <em>P</em> = 0.004), and Black patients were more likely to have HF hospitalization or death over 5 years compared with White patients (log-rank <em>P</em> &lt; 0.001). Among those with ADI &gt;25, Black patients had a significantly greater hazard of HF hospitalization or death compared with White patients, independent of disease stage at diagnosis (HR: 2.77; 95% CI: 1.45-5.32; <em>P</em> = 0.002).</p></div><div><h3>Conclusions</h3><p>Black patients with low SES may be at greater risk for underdiagnosis and adverse outcomes compared with White patients. Ongoing efforts are needed to improve outcomes in this subset of patients with ATTR-CM.</p></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 454-463"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324001522/pdfft?md5=4be611fc3a6c7f3b8a2d9ca8f16d2c75&pid=1-s2.0-S2666087324001522-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Black-White Disparities in Submaximal Exercise Capacity Reductions in Breast Cancer Survivors","authors":"Kerryn W. Reding PhD, MPH, RN,&nbsp;Warren Szewczyk BA,&nbsp;Ralph B. D’Agostino Jr. PhD,&nbsp;Nathaniel S. O’Connell PhD,&nbsp;Alexi Vasbinder PhD, RN,&nbsp;Moriah P. Bellissimo PhD, RD,&nbsp;Alexander R. Lucas PhD,&nbsp;Vanessa B. Sheppard PhD,&nbsp;Arnethea L. Sutton PhD,&nbsp;Bonnie Ky MD, MSCE,&nbsp;Glenn J. Lesser MD,&nbsp;W. Gregory Hundley MD","doi":"10.1016/j.jaccao.2024.05.003","DOIUrl":"https://doi.org/10.1016/j.jaccao.2024.05.003","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 467-469"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324001546/pdfft?md5=5064c7b137ab49200b44a188209d4f30&pid=1-s2.0-S2666087324001546-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air Pollution in Cardio-Oncology and Unraveling the Environmental Nexus","authors":"Wenqiang Zhu MD, PhD ,&nbsp;Sadeer G. Al-Kindi MD ,&nbsp;Sanjay Rajagopalan MD ,&nbsp;Xiaoquan Rao MD, PhD","doi":"10.1016/j.jaccao.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.jaccao.2024.04.003","url":null,"abstract":"<div><p>Although recent advancements in cancer therapies have extended the lifespan of patients with cancer, they have also introduced new challenges, including chronic health issues such as cardiovascular disease arising from pre-existing risk factors or cancer therapies. Consequently, cardiovascular disease has become a leading cause of non–cancer-related death among cancer patients, driving the rapid evolution of the cardio-oncology field. Environmental factors, particularly air pollution, significantly contribute to deaths associated with cardiovascular disease and specific cancers, such as lung cancer. Despite these statistics, the health impact of air pollution in the context of cardio-oncology has been largely overlooked in patient care and research. Notably, the impact of air pollution varies widely across geographic areas and among individuals, leading to diverse exposure consequences. This review aims to consolidate epidemiologic and preclinical evidence linking air pollution to cardio-oncology while also exploring associated health disparities and environmental justice issues.</p></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 347-362"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324001479/pdfft?md5=c87a33775879b89ca7a0fb6ffcee9505&pid=1-s2.0-S2666087324001479-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}