Jacc: Cardiooncology最新文献

{"title":"Time to Rethink Using Cardiovascular Risk Scores for Cancer Survivors","authors":"Katrina K. Poppe PhD","doi":"10.1016/j.jaccao.2024.07.006","DOIUrl":"10.1016/j.jaccao.2024.07.006","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 4","pages":"Pages 589-591"},"PeriodicalIF":12.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324002278/pdfft?md5=ee71be796de2e752935ca8198a49de72&pid=1-s2.0-S2666087324002278-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Substructure Radiation Dose and Associations With Tachyarrhythmia and Bradyarrhythmia After Lung Cancer Radiotherapy","authors":"Katelyn M. Atkins MD, PhD ,&nbsp;Samuel C. Zhang MD ,&nbsp;Christopher Kehayias PhD ,&nbsp;Christian Guthier PhD ,&nbsp;John He BA ,&nbsp;Jordan O. Gasho BS ,&nbsp;Mina Bakhtiar MD ,&nbsp;Katrina D. Silos BA ,&nbsp;David E. Kozono MD, PhD ,&nbsp;Paul C. Zei MD ,&nbsp;Anju Nohria MD ,&nbsp;Andriana P. Nikolova MD, PhD ,&nbsp;Raymond H. Mak MD","doi":"10.1016/j.jaccao.2024.07.005","DOIUrl":"10.1016/j.jaccao.2024.07.005","url":null,"abstract":"<div><h3>Background</h3><p>Arrhythmias are common following radiotherapy for non–small cell lung cancer.</p></div><div><h3>Objectives</h3><p>The aim of this study was to analyze the association of distinct arrhythmia classes with cardiac substructure radiotherapy dose.</p></div><div><h3>Methods</h3><p>A retrospective analysis was conducted of 748 patients with locally advanced non–small cell lung cancer treated with radiotherapy. Cardiac substructure dose parameters were calculated. Receiver-operating characteristic curve analyses for predictors of Common Terminology Criteria for Adverse Events grade ≥3 atrial fibrillation (AF), atrial flutter, non-AF and non–atrial flutter supraventricular tachyarrhythmia (SVT), bradyarrhythmia, and ventricular tachyarrhythmia (VT) or asystole were calculated. Fine-Gray regression models were performed (with noncardiac death as a competing risk).</p></div><div><h3>Results</h3><p>Of 748 patients, 128 (17.1%) experienced at least 1 grade ≥3 arrhythmia, with a median time to first arrhythmia of 2.0 years (Q1-Q3: 0.9-4.2 years). The 2-year cumulative incidences of each arrhythmia group were 8.0% for AF, 2.7% for atrial flutter, 1.8% for other SVT, 1.4% for bradyarrhythmia, and 1.1% for VT or asystole. Adjusting for baseline cardiovascular risk, pulmonary vein (PV) volume receiving 5 Gy was associated with AF (subdistribution HR [sHR]: 1.04/mL; 95% CI: 1.01-1.08; <em>P</em> = 0.016), left circumflex coronary artery volume receiving 35 Gy with atrial flutter (sHR: 1.10/mL; 95% CI: 1.01-1.19; <em>P</em> = 0.028), PV volume receiving 55 Gy with SVT (sHR: 1.03 per 1%; 95% CI: 1.02-1.05; <em>P</em> &lt; 0.001), right coronary artery volume receiving 25 Gy with bradyarrhythmia (sHR: 1.14/mL; 95% CI: 1.00-1.30; <em>P</em> = 0.042), and left main coronary artery volume receiving 5 Gy with VT or asystole (sHR: 2.45/mL; 95% CI: 1.21-4.97; <em>P</em> = 0.013).</p></div><div><h3>Conclusions</h3><p>This study revealed pathophysiologically distinct arrhythmia classes associated with radiotherapy dose to discrete cardiac substructures, including PV dose with AF and SVT, left circumflex coronary artery dose with atrial flutter, right coronary artery dose with bradyarrhythmia, and left main coronary artery dose with VT or asystole, guiding potential risk mitigation approaches.</p></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 4","pages":"Pages 544-556"},"PeriodicalIF":12.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324002266/pdfft?md5=1c76e9e7009b792d3a7f1a38047cd97c&pid=1-s2.0-S2666087324002266-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board/Officers Page","authors":"","doi":"10.1016/S2666-0873(24)00229-1","DOIUrl":"10.1016/S2666-0873(24)00229-1","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 4","pages":"Pages i-iv"},"PeriodicalIF":12.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324002291/pdfft?md5=fc127db7d2f0513ec7f208f6d7167c13&pid=1-s2.0-S2666087324002291-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Neurohormonal Antagonist Withdrawal in HER2+ Breast Cancer Patients With CTRCD","authors":"Arif Albulushi MD,&nbsp;Hatem Al-Farhan MD","doi":"10.1016/j.jaccao.2024.03.013","DOIUrl":"10.1016/j.jaccao.2024.03.013","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 4","pages":"Pages 625-626"},"PeriodicalIF":12.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324002047/pdfft?md5=6f5686f5b3cf391f58933ad2d76447f6&pid=1-s2.0-S2666087324002047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding and Reducing the Social and Environmental Determinants of Health Disparities in Cardio-Oncology","authors":"Bonnie Ky MD, MSCE (Editor-in-Chief, JACC: CardioOncology)","doi":"10.1016/j.jaccao.2024.05.007","DOIUrl":"https://doi.org/10.1016/j.jaccao.2024.05.007","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 473-474"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324001595/pdfft?md5=08b82ee2af33388edaee8486efd8d9b3&pid=1-s2.0-S2666087324001595-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Determinants of Health Mediate Racial Disparities in Cardiovascular Disease in Men With Prostate Cancer","authors":"Biniyam G. Demissei MD, MSC, PhD ,&nbsp;Kyunga Ko MS ,&nbsp;Anran Huang BA ,&nbsp;Daniel J. Lee MD, MS ,&nbsp;Abigail G. Doucette MPH ,&nbsp;Amanda M. Smith BA, MA ,&nbsp;Nicholas S. Wilcox MD, MHS ,&nbsp;Jacob Reibel MD ,&nbsp;Lova Sun MD, MSCE ,&nbsp;Manuj Agarwal MD ,&nbsp;Naomi B. Haas MD ,&nbsp;Genevieve Hollis CRNP ,&nbsp;Jason E. Shpilsky MD ,&nbsp;Samuel U. Takvorian MD, MS ,&nbsp;David J. Vaughn MD ,&nbsp;Jinbo Chen PhD ,&nbsp;Rebecca A. Hubbard PhD ,&nbsp;Tiffany Powell-Wiley MD, MPH ,&nbsp;Clyde Yancy MD, MSc ,&nbsp;Vivek Narayan MD, MSCE ,&nbsp;Bonnie Ky MD, MSCE","doi":"10.1016/j.jaccao.2024.04.004","DOIUrl":"https://doi.org/10.1016/j.jaccao.2024.04.004","url":null,"abstract":"<div><h3>Background</h3><p>Cardiovascular disease (CVD) is a significant cause of morbidity and mortality in men with prostate cancer; however, data on racial disparities in CVD outcomes are limited.</p></div><div><h3>Objectives</h3><p>We quantified the disparities in CVD according to self-identified race and the role of the structural social determinants of health in mediating disparities in prostate cancer patients.</p></div><div><h3>Methods</h3><p>A retrospective cohort study of 3,543 prostate cancer patients treated with systemic androgen deprivation therapy (ADT) between 2008 and 2021 at a quaternary, multisite health care system was performed. The multivariable adjusted association between self-reported race (Black vs White) and incident major adverse cardiovascular events (MACE) after ADT initiation was evaluated using cause-specific proportional hazards. Mediation analysis determined the role of theme-specific and overall social vulnerability index (SVI) in explaining the racial disparities in CVD outcomes.</p></div><div><h3>Results</h3><p>Black race was associated with an increased hazard of MACE (HR: 1.38; 95% CI: 1.16-1.65; <em>P</em> &lt; 0.001). The association with Black race was strongest for incident heart failure (HR: 1.79; 95% CI: 1.32-2.43), cerebrovascular disease (HR: 1.98; 95% CI: 1.37-2.87), and peripheral artery disease (HR: 1.76; 95% CI: 1.26-2.45) (<em>P &lt;</em> 0.001). SVI, specifically the socioeconomic status theme, mediated 98% of the disparity in MACE risk between Black and White patients.</p></div><div><h3>Conclusions</h3><p>Black patients are significantly more likely to experience adverse CVD outcomes after systemic ADT compared with their White counterparts. These disparities are mediated by socioeconomic status and other structural determinants of health as captured by census tract SVI. Our findings motivate multilevel interventions focused on addressing socioeconomic vulnerability.</p></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 390-401"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324001480/pdfft?md5=b0f8efa70d99a66abc283d1cbfae2d03&pid=1-s2.0-S2666087324001480-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood Archetypes and Cardiovascular Health","authors":"Arnethea L. Sutton PhD, MS ,&nbsp;Nickolas Stabellini BS ,&nbsp;Avirup Guha MD, MPH","doi":"10.1016/j.jaccao.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.jaccao.2024.05.004","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 419-420"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266608732400156X/pdfft?md5=8d872cc801407607dd31954260037262&pid=1-s2.0-S266608732400156X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S2666-0873(24)00196-0","DOIUrl":"https://doi.org/10.1016/S2666-0873(24)00196-0","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages I-CXLVIII"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324001960/pdfft?md5=e2f1a3875372a1eb2b671ea94d64d661&pid=1-s2.0-S2666087324001960-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Walk Your Way Out of Cardiovascular Risk","authors":"Ashish Kumar MD ,&nbsp;Sourbha S. Dani MD, MSc ,&nbsp;Sarju Ganatra MD","doi":"10.1016/j.jaccao.2024.04.005","DOIUrl":"https://doi.org/10.1016/j.jaccao.2024.04.005","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 436-438"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324001492/pdfft?md5=108e1e9fa04cedca5ecc6a77f8c74dce&pid=1-s2.0-S2666087324001492-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Race, Genotype, and Socioeconomic Status in Transthyretin Amyloid Cardiomyopathy","authors":"Trejeeve Martyn MD, MSc ,&nbsp;Julia M. Simkowski MD ,&nbsp;Mazen Hanna MD","doi":"10.1016/j.jaccao.2024.05.006","DOIUrl":"https://doi.org/10.1016/j.jaccao.2024.05.006","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"6 3","pages":"Pages 464-466"},"PeriodicalIF":11.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666087324001583/pdfft?md5=3305344a6b6726c935136c22267ba573&pid=1-s2.0-S2666087324001583-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}