Jacc: Cardiooncology最新文献

{"title":"Refining Free Light Chain Ratio in Systemic Amyloidosis","authors":"Zhiwen Zhang MD, Quan Guo MD, Yang Gao MD, Muwei Li PhD, Cao Ma MD","doi":"10.1016/j.jaccao.2025.09.007","DOIUrl":"10.1016/j.jaccao.2025.09.007","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 1","pages":"Page 98"},"PeriodicalIF":12.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRISPR/Cas9 Screens Implicate RARA and SPNS1 in Doxorubicin Cardiotoxicity","authors":"Chris McDermott-Roe PhD ,&nbsp;Wenjian Lv PhD ,&nbsp;Yeng Shao BSN ,&nbsp;Atsushi Hoshino MD, PhD ,&nbsp;Zoltan Arany MD, PhD ,&nbsp;Kiran Musunuru MD, PhD","doi":"10.1016/j.jaccao.2026.01.003","DOIUrl":"10.1016/j.jaccao.2026.01.003","url":null,"abstract":"<div><h3>Background</h3><div>Doxorubicin (DOX) causes cardiotoxicity and heart failure in a significant fraction of patients, but the molecular etiology is poorly understood.</div></div><div><h3>Objectives</h3><div>We adopted a functional genomics-based approach to probe the genetic basis for DOX-induced cardiotoxicity in an exhaustive and agnostic manner.</div></div><div><h3>Methods</h3><div>Genome-wide and targeted CRISPR/Cas9 screens were performed in immortalized cardiomyocytes and induced pluripotent stem cell–derived cardiomyocytes to identify genetic modifiers of DOX-induced cardiotoxicity.</div></div><div><h3>Results</h3><div>Our first screen revealed that loss of the Retinoic Acid Receptor Alpha gene (<em>RARA</em>) increased DOX-induced cell death. Conversely, pharmacological activation of RARA protein with tamibarotene reduced DOX-induced toxicity. RNA-Seq analysis showed that whereas DOX broadly suppressed expression of metabolic and mitochondrial genes, tamibarotene mitigated this effect. In a second screen, we interrogated processes involved in DOX uptake, transport, and efflux. Loss of lysosome homeostasis, exemplified by SPNS lysolipid transporter 1 (<em>SPNS1</em>) deficiency, led to DOX hyperaccumulation, suppression of autophagy, increased DNA damage, and increased cell death. In contrast, ribosome loss-of-function and nutrient deprivation significantly reduced DOX accumulation and toxicity.</div></div><div><h3>Conclusions</h3><div>Our study identified numerous drug–gene interactions that illuminate mechanisms underlying DOX-induced cardiotoxicity and provide a technical framework for future functional genomics screens to nominate therapeutic targets and genetic biomarkers.</div></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 1","pages":"Pages 48-61"},"PeriodicalIF":12.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial Fibrillation After Stem Cell Transplantation","authors":"Salim S. Hayek MD ,&nbsp;Mary Riwes DO","doi":"10.1016/j.jaccao.2026.01.002","DOIUrl":"10.1016/j.jaccao.2026.01.002","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 1","pages":"Pages 28-30"},"PeriodicalIF":12.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining the Role of Epigenetic Age Acceleration in Cardiotoxicity Research","authors":"Junzhi Cao MD,&nbsp;Wenjie Han MD,&nbsp;Yuan Liu MD","doi":"10.1016/j.jaccao.2025.09.006","DOIUrl":"10.1016/j.jaccao.2025.09.006","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 1","pages":"Page 100"},"PeriodicalIF":12.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic Risk for Cardiometabolic and Cardiovascular Disease in a Multiethnic Cohort of Breast Cancer Survivors","authors":"Peter N. Fiorica BA ,&nbsp;Alexa Zimbalist MS ,&nbsp;Haiyang Sheng PhD ,&nbsp;Cecile A. Laurent MS ,&nbsp;Janise M. Roh MSW, MPH ,&nbsp;Valerie S. Lee MHS ,&nbsp;Isaac J. Ergas PhD ,&nbsp;Jennifer Delmerico MPH ,&nbsp;Qianqian Zhu PhD ,&nbsp;Richard K. Cheng MD, MSc ,&nbsp;Eileen Rillamas-Sun MPH, PhD ,&nbsp;Carlos Iribarren MD, MPH, PhD ,&nbsp;Jamal S. Rana MD, PhD ,&nbsp;Mai Nguyen-Huynh MD, MAS ,&nbsp;Dawn L. Hershman MD, MS ,&nbsp;Christine B. Ambrosone PhD ,&nbsp;Lawrence H. Kushi ScD ,&nbsp;Heather Greenlee MPH, ND, PhD ,&nbsp;Marilyn L. Kwan PhD ,&nbsp;Song Yao MD, PhD","doi":"10.1016/j.jaccao.2025.10.004","DOIUrl":"10.1016/j.jaccao.2025.10.004","url":null,"abstract":"<div><h3>Background</h3><div>Because of cancer treatment–related cardiotoxicities, women with histories of breast cancer are at increased risk for cardiovascular disease (CVD). Many polygenic scores (PGS) have been developed for predicting risk for CVD-related conditions in the general population, but their performance in breast cancer patients remains largely unexplored.</div></div><div><h3>Objectives</h3><div>The aim of this study was to examine the performance of PGS for CVD-related traits to predict incident cardiometabolic disorder (CMD) and CVD in women with histories of breast cancer.</div></div><div><h3>Methods</h3><div>In a prospective multiethnic cohort of 3,620 breast cancer survivors, 27 PGS for CVD-related traits were we computed, and their associations with 12 incident CMD and CVD events were examined. The performance of these PGS was compared relative to clinical covariates–only models and by cardiotoxic cancer treatment.</div></div><div><h3>Results</h3><div>Twenty-three significant associations were identified after Bonferroni correction between PGS and CMD or CVD events in breast cancer patients. Although the model performance of PGS and multi-PGS added to or combined with clinical models for CMD and CVD risk prediction was numerically greater, these were not statistically significant. For some outcomes, PGS performed worse among patients who received cardiotoxic cancer treatments.</div></div><div><h3>Conclusions</h3><div>Although there may be potential value of PGS in predicting the risk for CMD and CVD events in women with histories of breast cancer, current PGS performance is limited. This work highlights the need to develop de novo PGS in breast cancer patients and to include ancestrally diverse patient populations.</div></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 1","pages":"Pages 65-76"},"PeriodicalIF":12.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Exercise Capacity in Breast Cancer Compared to HFpEF","authors":"Isabela Landsteiner MD ,&nbsp;Stephen J. Foulkes PhD ,&nbsp;Joseph Campain MD ,&nbsp;Carly E. Camphausen BSc ,&nbsp;Daniel A. Zlotoff MD, PhD ,&nbsp;Gregory D. Lewis MD ,&nbsp;Mark J. Haykowsky PhD","doi":"10.1016/j.jaccao.2025.12.002","DOIUrl":"10.1016/j.jaccao.2025.12.002","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 1","pages":"Pages 80-82"},"PeriodicalIF":12.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of Exercise for Prevention of Cardiovascular Disease in Survivors of Childhood Hodgkin Lymphoma","authors":"Aron Onerup MD, PhD ,&nbsp;Qi Liu MSc ,&nbsp;Shizue Izumi PhD ,&nbsp;José Miguel Martínez-Martínez PhD ,&nbsp;Stephanie B. Dixon MD, MPH ,&nbsp;Eric J. Chow MD, MPH ,&nbsp;Melissa M. Hudson MD ,&nbsp;Claire Snyder PhD ,&nbsp;Paul C. Nathan MD, MSc ,&nbsp;Gregory T. Armstrong MD, MSCE ,&nbsp;Kirsten K. Ness PhD ,&nbsp;Yutaka Yasui PhD","doi":"10.1016/j.jaccao.2025.11.002","DOIUrl":"10.1016/j.jaccao.2025.11.002","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 1","pages":"Pages 87-89"},"PeriodicalIF":12.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Hazard Ratio","authors":"Jean Henri Maselli-Schoueri MD, PhD ,&nbsp;Samuel David Saibil MD, PhD ,&nbsp;Victor Gabriel da Silva Negrini MD ,&nbsp;Ary Serpa Neto MD, MSc, PhD ,&nbsp;Marcus Butler MD","doi":"10.1016/j.jaccao.2025.11.003","DOIUrl":"10.1016/j.jaccao.2025.11.003","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 1","pages":"Pages 90-92"},"PeriodicalIF":12.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incretin Mimetics in Cancer and Cardiovascular Disease","authors":"Darryl Leong MBBS, MPH, MBiostat, PhD ,&nbsp;Selena Gong BHSc ,&nbsp;Naveed Sattar MB, ChB, PhD ,&nbsp;Vivek Narayan MD, MSCE ,&nbsp;Natalie M. Reizine MD ,&nbsp;Hertzel Gerstein MD, MSc ,&nbsp;Jordan Vellky PhD","doi":"10.1016/j.jaccao.2025.12.003","DOIUrl":"10.1016/j.jaccao.2025.12.003","url":null,"abstract":"<div><div>Incretin mimetics (glucagon-like peptide-1 receptor agonists and dual glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptor agonists) are paradigm changing for managing obesity, diabetes, and cardiovascular risk. These phenotypes are also associated with elevated risk for numerous cancers. Limited research suggests that incretin mimetics may be associated with lower risk for developing several cancers. However, more translational and randomized clinical data are needed for confirmation. Patients with cancer were excluded from trials of incretin mimetics. Therefore, their effects on adipose tissue, muscle, cardiovascular risk factors, and outcomes in this population are unknown. Notwithstanding contraindications with a history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, translational data also promote the hypothesis that incretin mimetics could slow the growth of other cancers. Further clinical data are needed to determine which patients undergoing cancer treatment might experience benefit or harm from the anthropometric and calorie reduction effects of incretin mimetics or display cardiometabolic benefit despite the competing risk for cancer death.</div></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 1","pages":"Pages 1-16"},"PeriodicalIF":12.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major Adverse Cardiovascular Events and Cardiac Dysfunction in Patients With Acute Leukemia","authors":"Yu Kang MD, PhD ,&nbsp;Benedicte Lefebvre MD ,&nbsp;Amanda Smith MA ,&nbsp;Daniel Koropeckyj-Cox BA ,&nbsp;Priya Brahmbhatt ,&nbsp;Bonnie Ky MD, MSCE ,&nbsp;Joseph Carver MD ,&nbsp;Shannon McCurdy MD ,&nbsp;Selina Luger MD ,&nbsp;Marielle Scherrer-Crosbie MD, PhD","doi":"10.1016/j.jaccao.2025.11.004","DOIUrl":"10.1016/j.jaccao.2025.11.004","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 1","pages":"Pages 83-86"},"PeriodicalIF":12.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}