Jacc: Cardiooncology最新文献

{"title":"Cardiogenic Shock From Chronic Immune Checkpoint Inhibitor Associated Myocarditis Causing Predominant Right Ventricular Failure","authors":"Harveen Sekhon MD , Pradeep S. Rajendran MD, PhD , Katherine Hampilos MS , Michael A. Raddatz MD, PhD , Cullen M. Lilley MD , Radoslav I. Zinoviev MD, MBA , Warren Tai MD , Ashley F. Stein-Merlob MD, PhD , Gregory A. Fishbein MD , Eric H. Yang MD","doi":"10.1016/j.jaccao.2026.03.005","DOIUrl":"10.1016/j.jaccao.2026.03.005","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 2","pages":"Pages 195-199"},"PeriodicalIF":12.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease Prognosis and Progression in Transthyretin Amyloidosis","authors":"Joban Vaishnav MD ,&nbsp;Dimitrios Bampatsias MD ,&nbsp;Brian C. Boursiquot MD ,&nbsp;Yevgeniy Brailovsky MD ,&nbsp;Kristin Hsu ,&nbsp;Jamie Zigterman MPH ,&nbsp;Rajshekhar Chakraborty MD ,&nbsp;Ashutosh Wechalekar MD ,&nbsp;Pablo Garcia Pavia MD, PhD ,&nbsp;Ronald Witteles MD ,&nbsp;Mazen Hanna MD ,&nbsp;Chafic Karam MD ,&nbsp;Mathew S. Maurer MD ,&nbsp;Jan M. Griffin MD","doi":"10.1016/j.jaccao.2026.02.004","DOIUrl":"10.1016/j.jaccao.2026.02.004","url":null,"abstract":"<div><div>Transthyretin amyloidosis (ATTR) is a rapidly evolving disease with a rising prevalence and improving prognosis. With an increasing number of patients diagnosed across a broad spectrum of disease stages, disease prognostication is pivotal to guiding therapeutic decisions. Similarly, with varying phenotypes identified and an expanding range of disease-modifying treatments available, the timely identification of cardiac and extracardiac disease progression remains essential. In this review, the authors highlight the current state of knowledge for disease prognosis and progression in ATTR. They focus on clinical, biomarker, functional, and imaging markers of cardiac disease progression. The authors also highlight the need for further investigation into neurologic and other noncardiac indicators of disease progression. Finally, they discuss current approaches and future directions for disease monitoring in ATTR.</div></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 2","pages":"Pages 120-136"},"PeriodicalIF":12.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PD-L1 in ICI Myocarditis","authors":"Adrian C. Chen BS ,&nbsp;Javid J. Moslehi MD","doi":"10.1016/j.jaccao.2026.03.003","DOIUrl":"10.1016/j.jaccao.2026.03.003","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 2","pages":"Pages 181-184"},"PeriodicalIF":12.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carvedilol for Prevention of Chemotherapy-Induced Cardiotoxicity","authors":"Silvia Moreira Ayub-Ferreira MD, PhD ,&nbsp;Mônica Samuel Avila MD, PhD ,&nbsp;Mauro Rogerio de Barros Wanderley Jr. MD, PhD ,&nbsp;Fatima das Dores Cruz RN, PhD ,&nbsp;Sara Michelly Gonçalves Brandão RN, PhD ,&nbsp;Vagner Oliveira Carvalho Rigaud PhD ,&nbsp;Cecilia Beatriz Bittencourt Viana Cruz MD, PhD ,&nbsp;Guilherme Veiga Guimaraes PhD ,&nbsp;Marcio Sommer Bittencourt MD, MPH, PhD ,&nbsp;Edimar Alcides Bocchi MD, PhD","doi":"10.1016/j.jaccao.2025.12.009","DOIUrl":"10.1016/j.jaccao.2025.12.009","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 2","pages":"Pages 189-191"},"PeriodicalIF":12.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147345414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Safety of T Cell Engagers","authors":"Qun Shao MD, PhD ,&nbsp;Tong Liu MD, PhD ,&nbsp;Yue Li MD, PhD ,&nbsp;Zhi-Ren Zhang MD, PhD","doi":"10.1016/j.jaccao.2026.03.004","DOIUrl":"10.1016/j.jaccao.2026.03.004","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 2","pages":"Pages 165-167"},"PeriodicalIF":12.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gamification Boosts Physical Activity in Disparate Populations of Cancer Survivors","authors":"Sanglin Zhao PhD","doi":"10.1016/j.jaccao.2025.12.010","DOIUrl":"10.1016/j.jaccao.2025.12.010","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 2","pages":"Page 206"},"PeriodicalIF":12.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S2666-0873(26)00098-0","DOIUrl":"10.1016/S2666-0873(26)00098-0","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 2","pages":"Pages I-CXIII"},"PeriodicalIF":12.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S2666-0873(26)00027-X","DOIUrl":"10.1016/S2666-0873(26)00027-X","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 1","pages":"Pages I-CIV"},"PeriodicalIF":12.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147409070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proactive Surveillance for ICI Cardiotoxicity","authors":"Artur Dziewierz MD, PhD ,&nbsp;Łukasz Wiśniowski MD, PhD","doi":"10.1016/j.jaccao.2025.09.008","DOIUrl":"10.1016/j.jaccao.2025.09.008","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 1","pages":"Page 93"},"PeriodicalIF":12.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Manifestations and Mortality Risk in Transthyretin V142I Variant Carriers","authors":"Konstantinos Sideris MD ,&nbsp;Tyler J. Nelson BS ,&nbsp;Lina Brinker MD ,&nbsp;Anthony Gao BS ,&nbsp;Catherine Tcheandjieu PhD, DVM ,&nbsp;Christos P. Kyriakopoulos MD ,&nbsp;Dan Berlowitz MD ,&nbsp;Leland Hull MD, MPH ,&nbsp;Jeffrey P. Ferraro PhD ,&nbsp;Fatai Y. Agiri BS ,&nbsp;Kathryn M. Pridgen MA ,&nbsp;Steven Roblin PhD ,&nbsp;Jacob Joseph MD ,&nbsp;Scott M. Damrauer MD ,&nbsp;Kyong-Mi Chang MD ,&nbsp;Craig C. Teerlink PhD ,&nbsp;Josef Stehlik MD, MPH ,&nbsp;Spencer Carter MD ,&nbsp;Julie A. Lynch PhD, RN, MBA","doi":"10.1016/j.jaccao.2025.12.006","DOIUrl":"10.1016/j.jaccao.2025.12.006","url":null,"abstract":"<div><h3>Background</h3><div>The most common pathogenic transthyretin variant underlying variant transthyretin amyloidosis in the United States is c.424G&gt;A, p.Val142Ile (V142I). In affected individuals, disease manifests predominantly as heart failure (HF) and cardiomyopathy (CM), with atrial fibrillation (AF) or atrial flutter (AFL), carpal tunnel syndrome (CTS), spinal stenosis (SS), and neuropathy also common.</div></div><div><h3>Objectives</h3><div>The aim of this study was to investigate the association of <em>TTR</em> V142I carrier status with these established outcomes.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted among individuals of African ancestry enrolled in the MVP (Million Veteran Program). Participants with at least 1 V142I allele were matched to control subjects on the basis of race, sex, and birth year. Outcomes included HF or CM, AF or AFL, CTS, SS, neuropathy, all-cause mortality, cardiovascular mortality, and HF-related hospitalization. Cumulative incidence and multivariable Cox proportional hazards regression models were used to compare V142I carriers with control subjects.</div></div><div><h3>Results</h3><div>The final study cohort included 2,658 V142I carriers and 13,459 matched control subjects. After multivariable adjustment, V142I carriers had significantly higher risks for HF or CM (HR: 1.20; 95% CI: 1.10-1.31), AF or AFL (HR: 1.26; 95% CI: 1.13-1.40), CTS (HR: 1.43; 95% CI: 1.30-1.57), SS (HR: 1.17; 95% CI: 1.07-1.28), and neuropathy (HR: 1.24; 95% CI: 1.13-1.36) compared with control subjects. A higher risk for HF or CM was observed among V142I carriers than matched control subjects with the following amyloidosis-related red-flag symptoms: AF or AFL (HR: 1.26; 95% CI: 1.03-1.52), CTS (HR: 1.40; 95% CI: 1.20-1.64), SS (HR: 1.26; 95% CI: 1.06-1.49), and neuropathy (HR: 1.28; 95% CI: 1.11-1.48). V142I carriers also had a significantly higher risk for all-cause mortality (HR: 1.12; 95% CI: 1.01-1.25), cardiovascular mortality (HR: 1.37; 95% CI: 1.14-1.65), and HF-related hospitalization (HR: 1.25; 95% CI: 1.07-1.45).</div></div><div><h3>Conclusions</h3><div>These findings highlight the systemic manifestations of variant transthyretin amyloidosis associated with the <em>TTR</em> V142I variant and underscore the need for increased awareness and earlier diagnostic efforts in high-risk populations.</div></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 1","pages":"Pages 31-44"},"PeriodicalIF":12.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}