{"title":"Psychological interventions for adult posttraumatic stress disorder: A systematic review of published meta-analyses","authors":"Ahlke Kip , Linnea Ritter , Thole H. Hoppen , Davide Papola , Giovanni Ostuzzi , Corrado Barbui , Nexhmedin Morina","doi":"10.1016/j.janxdis.2025.103017","DOIUrl":"10.1016/j.janxdis.2025.103017","url":null,"abstract":"<div><h3>Objective</h3><div>A large and growing number of published meta-analyses have examined the efficacy of psychological interventions for post-traumatic stress disorder (PTSD). Conclusions drawn from these meta-analyses on treatment efficacy greatly influence clinical practice. This study aimed to provide a comprehensive review of meta-analyses of randomized controlled trials (RCTs) on psychological interventions for adult PTSD, focusing on their content, methodology, and reporting quality.</div></div><div><h3>Method</h3><div>Systematic database searches were conducted in March 2024 using MEDLINE, PsycInfo, PTSDpubs, Web of Science, and the Cochrane Database of Systematic Reviews. The quality of meta-analyses was assessed using AMSTAR 2. The systematic review was registered on PROSPERO (CRD42020151234).</div></div><div><h3>Results</h3><div>Overall, 55 meta-analyses with 93 meta-analytic comparisons at treatment endpoint and 28 comparisons at follow-up were included. Meta-analyses most consistently showed superiority of psychological interventions over control conditions. However, beneficial long-term effects exceeding one-month post-treatment were limited to trauma-focused cognitive behavior interventions (TF-CBT) and eye movement desensitization and reprocessing (EMDR). There was a substantial overlap of primary RCTs, indicating redundancy between meta-analyses. Furthermore, the quality of meta-analyses varied substantially.</div></div><div><h3>Conclusions</h3><div>There is a need to enhance the methodological and reporting quality of meta-analyses, avoid the production of redundant meta-analyses, and conduct more high-quality, large RCTs with long-term assessments.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"112 ","pages":"Article 103017"},"PeriodicalIF":4.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariel Emrich , Camille L. Garnsey, Erika K. Osherow, Crystal L. Park
{"title":"Moving towards a subjective conceptualization of betrayal: Examining associations between perceived betrayal, emotion dysregulation, and PTSD symptoms in sexual trauma survivors","authors":"Mariel Emrich , Camille L. Garnsey, Erika K. Osherow, Crystal L. Park","doi":"10.1016/j.janxdis.2025.103023","DOIUrl":"10.1016/j.janxdis.2025.103023","url":null,"abstract":"<div><h3>Background</h3><div>Sexual trauma survivors commonly experience feelings of betrayal. Betrayal has largely been studied as a static trauma characteristic that is determined by a survivor’s closeness to the perpetrator. This approach overlooks survivors’ <em>subjective feelings and experiences</em>. This study examines whether: 1) degree of perceived betrayal differs by type of survivor-perpetrator relationship, 2) perceived betrayal in the early aftermath of trauma predicts subsequent PTSD symptoms, and 3) emotion dysregulation mediates the relationship between perceived betrayal and PTSD symptoms.</div></div><div><h3>Methods</h3><div>Women (<em>N</em> = 203; ages 19–86) who experienced sexual trauma within a month of recruitment completed questionnaires on Prolific at T1 (within 30 days of trauma), T2 (4 weeks post-T1), and T3 (8 weeks post-T1). Descriptive statistics and an independent samples t-test examined differences in perceived betrayal across survivor-perpetrator relationship characteristics. Structural equation models assessed perceived betrayal at T1 predicting PTSD symptoms at T3 and the potential mediating effect of T2 emotion dysregulation.</div></div><div><h3>Results</h3><div>Although betrayal was highest among survivors who knew the perpetrator prior to the trauma (<em>M</em> = 76.8, range 0–100), average perceived betrayal was high across the sample (<em>M</em> = 70.5), and the quarter of survivors who identified the perpetrator as a stranger also reported elevated betrayal (<em>M</em> = 51.6). T1 perceived betrayal significantly predicted T3 PTSD symptoms with increases in emotion dysregulation partially mediating this effect (<em>p</em> = .01).</div></div><div><h3>Conclusions</h3><div>Findings support moving towards a subjective conceptualization of betrayal that incorporates survivors’ perceptions. Moreover, emotion dysregulation may be an important intervention target in the early aftermath of sexual trauma and warrants further empirical research.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"112 ","pages":"Article 103023"},"PeriodicalIF":4.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Parental cognitions and child anxiety: A systematic review","authors":"Jeremy K. Fox , Lauren E. Fleming","doi":"10.1016/j.janxdis.2025.103021","DOIUrl":"10.1016/j.janxdis.2025.103021","url":null,"abstract":"<div><div>Given the well-established link between maladaptive parenting behaviors (e.g., control, accommodation) and the development and maintenance of child anxiety, it is important to understand parental cognitions that may underlie these parenting behaviors. The goal of this systematic review was to examine the extent to which parental cognitions are associated with child anxiety. A systematic electronic database search of PubMed, PsycINFO, ProQuest Psychology, and EBSCO Child Development and Adolescent Studies was conducted in February 2024. In total, 31 studies met inclusion criteria from 9867 abstracts initially identified. The review revealed that a large number of studies have consistently found associations between child anxiety and two types of parental cognitions, negative beliefs about child anxiety and negative expectations of the child’s anxiety. In contrast, studies investigating parental worries about threats to their child and cognitions about parenting are more limited and have produced mixed findings and smaller effects. Future research should examine the directionality and mechanisms of relations between parental cognitions and child anxiety using longitudinal designs, as well as explore the role of cultural factors. Findings suggest that parental cognitions may be an important factor in understanding child anxiety and a potential target for prevention and early intervention.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"112 ","pages":"Article 103021"},"PeriodicalIF":4.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Using machine learning methods to predict the outcome of psychological therapies for post-traumatic stress disorder: A systematic review","authors":"James Tait , Stephen Kellett , Jaime Delgadillo","doi":"10.1016/j.janxdis.2025.103003","DOIUrl":"10.1016/j.janxdis.2025.103003","url":null,"abstract":"<div><h3>Background</h3><div>A number of treatments are available for post-traumatic stress disorder (PTSD), however, there is currently a lack of data-driven treatment selection and adaptation methods for this condition. Machine learning (ML) could potentially help to improve the prediction of treatment outcomes and enable precision mental healthcare in practice.</div></div><div><h3>Objectives</h3><div>To systematically review studies that applied ML methods to predict outcomes of psychological therapy for PTSD in adults (e.g., change in symptoms, dropout rate), and evaluate their methodological rigour.</div></div><div><h3>Methods</h3><div>This was a pre-registered systematic review (CRD42022325021), which synthesised eligible clinical prediction studies found across four research databases. Risk of bias was assessed using the PROBAST tool. Study methods and findings were narratively synthesised, and adherence to ML best practice evaluated.</div></div><div><h3>Results</h3><div>Seventeen studies met the inclusion criteria, including samples derived from experimental and observational study designs. All studies were assessed as having a high risk of bias, notably due to inadequately powered samples and a lack of sample size calculations. Training sample size ranged from <em>N</em> < 36–397. The studies applied a diverse range of ML methods such as decision trees, ensembling and boosting techniques. Five studies used unsupervised ML methods, while others used supervised ML. There was an inconsistency in the reporting of hyperparameter tuning and cross-validation methods. Only one study performed external validation.</div></div><div><h3>Conclusions</h3><div>ML has the potential to advance precision psychotherapy for PTSD, but to enable this, ML methods must be applied with greater adherence to best practice guidelines.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"112 ","pages":"Article 103003"},"PeriodicalIF":4.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"“To die, to sleep”: A systematic review and meta-analysis of the relationship between death anxiety and sleep","authors":"Rachel E. Menzies, Jessie Brown, Jye Marchant","doi":"10.1016/j.janxdis.2025.103001","DOIUrl":"10.1016/j.janxdis.2025.103001","url":null,"abstract":"<div><div>Poor sleep has long been established as both a symptom and cause of psychopathology. Similarly, death anxiety has attracted growing attention for its transdiagnostic role in mental illnesses, particularly anxiety-related disorders. However, the relationship between death anxiety and sleep has not been systematically explored. This systematic review and meta-analysis examined the relationship between sleep and death anxiety. In total, 15 studies were included in this review, representing a total sample size of 2786 participants. A review of these studies revealed that death anxiety was significantly associated with a number of sleep outcomes, particularly insomnia and poor sleep quality. Mixed results were found regarding the relationship between death anxiety and nightmare frequency. A meta-analysis of seven studies revealed a significant but small relationship between death anxiety and sleep problems (<em>r</em> = .225). Neither gender nor age emerged as a significant moderator of this relationship. These studies were generally of moderate quality, and there was limited evidence of publication bias. The current findings support the relationship between death anxiety and sleep. Further research is needed to clarify the direction of this effect, and whether targeting one in treatment may produce direct improvements in the other.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"112 ","pages":"Article 103001"},"PeriodicalIF":4.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Igor Marchetti , Lavinia Miriam Pedretti , Sara Iannattone , Ilaria Colpizzi , Alessandra Farina , Lisa Di Blas , Marta Ghisi , Gioia Bottesi
{"title":"What is the internal structure of intolerance of uncertainty? A network analysis approach","authors":"Igor Marchetti , Lavinia Miriam Pedretti , Sara Iannattone , Ilaria Colpizzi , Alessandra Farina , Lisa Di Blas , Marta Ghisi , Gioia Bottesi","doi":"10.1016/j.janxdis.2025.102999","DOIUrl":"10.1016/j.janxdis.2025.102999","url":null,"abstract":"<div><h3>Background</h3><div>Intolerance of uncertainty (IU) is a well-established risk factor for anxiety disorders, as higher levels of IU increase the likelihood of future maladaptive outcomes. However, the presence of low levels of IU does not imply that maladaptive outcomes will not occur, as other risk factors can still lead to the onset of anxiety symptoms. Currently, it is unknown whether IU also serves as a necessary cause for anxiety symptoms, meaning that its absence would ensure the absence of these symptoms.</div></div><div><h3>Methods</h3><div>A sample of 186 adolescents (58.6 % boys) between 14 and 18 years of age (M = 16.58 ± 1.01) was followed for six months, with evaluations every three months. Several self-reports were administered to measure IU and general anxiety problems, derived from the Youth Self Report 11–18, and anxiety-specific symptoms, derived from the Self-Administered Psychiatric Scales for Children and Adolescents. The Necessary Condition Analysis approach was applied to determine the extent to which IU is a necessary condition for anxiety.</div></div><div><h3>Findings</h3><div>The analyses revealed that IU is a necessary condition for anxiety problems (<em>d</em> =.23 −.24), generalized anxiety disorder symptoms (<em>d</em> =.18 −.19), social anxiety disorder symptoms (<em>d</em> =.19 −.29), and school-related anxiety symptoms (<em>d</em> =.19 −.23) after three and six months. However, IU was not a statistically significant necessary condition for separation anxiety disorder symptoms. At baseline, between 29 % and 70 % of the sample exhibited the necessary levels of IU to potentially experience subclinical anxiety symptoms at subsequent follow-ups.</div></div><div><h3>Discussion</h3><div>IU is a necessary condition for the potential development of anxiety symptoms during adolescence. Recognizing necessary conditions for anxiety symptoms and mental disorders, in general, could lead to substantial progress, given its impact on enhancing our theoretical understanding and improving prevention strategies and clinical treatments.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"112 ","pages":"Article 102999"},"PeriodicalIF":4.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer de Rutte , Sarah Myruski , Elizabeth Davis , Abigail Findley , Tracy A. Dennis-Tiwary
{"title":"A randomized clinical trial investigating the clinical impact of a game-based digital therapeutic for social anxiety disorder","authors":"Jennifer de Rutte , Sarah Myruski , Elizabeth Davis , Abigail Findley , Tracy A. Dennis-Tiwary","doi":"10.1016/j.janxdis.2025.103000","DOIUrl":"10.1016/j.janxdis.2025.103000","url":null,"abstract":"<div><div>The objective of this study was to determine if a novel game-based digital therapeutic intervention reduced anxiety symptom severity in adults with clinically elevated symptoms of social anxiety disorder (SAD). Participants were randomly allocated (1:1) to receive four weeks of either the active intervention, a game-based form of attention bias modification (Active ABM) for anxiety, or the sham control training (Control). Between June 2022 to June 2023, 104 participants were enrolled with 93 completing the trial per-protocol and 104 included in the final intention-to-treat analysis (54 intervention, 50 control); mean age was 38.08 (10.56) years and 79 were female. The dependent variable was reduction in SAD symptoms, measured via the Liebowitz SAD Scale (LSAS). Participants were classified as having clinically elevated SAD symptoms only, or both SAD and Generalized Anxiety Disorder (GAD) symptoms (comorbid). The Active condition induced significantly greater reductions in SAD symptoms compared to the Control condition between Baseline and Post-Treatment [Active: <em>M</em> = -29.71, <em>SD</em> = 23.68; Control: <em>M</em> = -14.59, <em>SD</em> = 21.52, <em>d</em> = .67, <em>t</em>(102) = -3.40, <em>p</em> < .001] across the four-week study period. While no significant between-groups differences emerged at each timepoint individually, the Active condition induced significantly greater change over time in SAD symptoms compared to the Control condition. Use of this game-based digital ABM intervention showed benefits in the reduction of anxiety symptoms.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 103000"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"And then one day you find ten years have got behind you\": Reflections on a Decade as Editor-in-Chief","authors":"Gordon J.G. Asmundson","doi":"10.1016/j.janxdis.2025.103007","DOIUrl":"10.1016/j.janxdis.2025.103007","url":null,"abstract":"","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 103007"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna-Rosa Cecilie Mora-Jensen , Christine Lykke Thoustrup , Eli R. Lebowitz , Julie Hagstrøm , Linea Pretzmann , Nicoline Løcke Jepsen Korsbjerg , Emilie Damløv Thorsen , Valdemar Funch Uhre , Sofie Heidenheim Christensen , Camilla Uhre , Melanie Ritter , Kerstin J. Plessen , Anne Katrine Pagsberg , Line Katrine Harder Clemmensen , Nicole Nadine Lønfeldt
{"title":"Computationally derived parent-child interaction patterns and oxytocin in children with and without OCD","authors":"Anna-Rosa Cecilie Mora-Jensen , Christine Lykke Thoustrup , Eli R. Lebowitz , Julie Hagstrøm , Linea Pretzmann , Nicoline Løcke Jepsen Korsbjerg , Emilie Damløv Thorsen , Valdemar Funch Uhre , Sofie Heidenheim Christensen , Camilla Uhre , Melanie Ritter , Kerstin J. Plessen , Anne Katrine Pagsberg , Line Katrine Harder Clemmensen , Nicole Nadine Lønfeldt","doi":"10.1016/j.janxdis.2025.102996","DOIUrl":"10.1016/j.janxdis.2025.102996","url":null,"abstract":"<div><h3>Background</h3><div>Parent-child interactive processes are important factors in pediatric OCD. Understanding biological mechanisms of parent-child interactive behaviors could help improve treatment of pediatric OCD. Oxytocin has been suggested as a biological mechanism in parent-child interactions. However, no studies in pediatric OCD exist. We used machine learning to discover latent patterns in parent-child interactive behaviors and explored associations with oxytocin in children with and without OCD.</div></div><div><h3>Methods</h3><div>We used parent and child salivary oxytocin levels measured with enzyme-linked immunosorbent assay (ELISA) and investigator-rated parent-child behaviors during a frustration task. Children with or without OCD and their parents – 107 mother-child and 62 father-child pairs were included. We used two machine learning techniques, principal component analysis and archetypal analysis, to generate data-driven, theory-agnostic behavioral variables, and regression to estimate their associations with oxytocin.</div></div><div><h3>Results</h3><div>Principal component and archetype analyses identified behavioral patterns describing the mother-child and father-child interactions. We found a positive association between child and mother oxytocin and the interaction patterns \"overinvolved interaction\" and \"emotional interaction\" and a negative association with \"distant interaction\". Additionally, mother oxytocin was positively associated with \"supportive interaction\" and \"varied-coping interaction\", and negatively associated with \"conflictual interaction\" and \"negative-low support interaction\". Father oxytocin was associated with “supportive interactions” only in the presence of child OCD.</div></div><div><h3>Conclusion</h3><div>Child and mother oxytocin appear related with mother-child interactive patterns. Fathers’ oxytocin was related with interaction patterns only in children with OCD. Our exploratory findings can be used to generate hypothesis for future research regarding the relationship between oxytocin and maladaptive family engagement in OCD and differences between mothers and fathers’ behaviors when the child has OCD.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 102996"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christine Lykke Thoustrup , Robert James Blair , Sofie Heidenheim Christensen , Valdemar Uhre , Linea Pretzmann , Nicoline Løcke Jepsen Korsbjerg , Camilla Uhre , Anna-Rosa Cecilie Mora-Jensen , Melanie Ritter , Nicole Nadine Lønfeldt , Emilie Damløv Thorsen , Daniel S. Quintana , Ahmad Sajadieh , Jakob Hartvig Thomsen , Kerstin Jessica Plessen , Signe Vangkilde , Anne Katrine Pagsberg , Julie Hagstrøm
{"title":"Emotion regulation difficulties in children and adolescents with obsessive-compulsive disorder: A multi-informant and multi-method study","authors":"Christine Lykke Thoustrup , Robert James Blair , Sofie Heidenheim Christensen , Valdemar Uhre , Linea Pretzmann , Nicoline Løcke Jepsen Korsbjerg , Camilla Uhre , Anna-Rosa Cecilie Mora-Jensen , Melanie Ritter , Nicole Nadine Lønfeldt , Emilie Damløv Thorsen , Daniel S. Quintana , Ahmad Sajadieh , Jakob Hartvig Thomsen , Kerstin Jessica Plessen , Signe Vangkilde , Anne Katrine Pagsberg , Julie Hagstrøm","doi":"10.1016/j.janxdis.2025.103002","DOIUrl":"10.1016/j.janxdis.2025.103002","url":null,"abstract":"<div><div>Pediatric obsessive-compulsive disorder (OCD) is associated with emotion regulation (ER) difficulties. Most studies are based on self-reports, while few have examined how these difficulties are expressed across modalities, which may hold important diagnostic and therapeutic information. We applied a multi-informant and multi-method approach to examine ER difficulties in 211 children aged 8–17 years: 121 with OCD and 90 non-clinical controls. Child ER difficulties were assessed with The Difficulties in Emotion Regulation Scale (self-report and parent-report) and a Tangram frustration task with investigator-rated behavior, self-rated frustration, and heart rate variability (HRV). Children with OCD differed significantly from non-clinical controls in showing: (i) elevated child ER difficulties on self-report (partial eta squared =.068–.165) and parent-report (partial eta squared =.207–.369); (ii) more investigator-rated ER difficulties during the task (Cohen’s <em>d</em> = −.33); (iii) increased levels of self-rated frustration before and after the task (partial eta squared =.089); notably, the magnitude of this increase did not differ between children with and without OCD. Finally, (iv) all children, regardless of group, demonstrated significant HRV changes during the frustration task, with no discernible group differences in the magnitude of these changes. Results suggest the OCD-related experience of ER difficulties may not impact autonomic functioning.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 103002"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}