Journal of Anxiety Disorders最新文献

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What is the internal structure of intolerance of uncertainty? A network analysis approach 对不确定性的不容忍的内部结构是什么?网络分析方法
IF 4.8 2区 医学
Journal of Anxiety Disorders Pub Date : 2025-03-22 DOI: 10.1016/j.janxdis.2025.102999
Igor Marchetti , Lavinia Miriam Pedretti , Sara Iannattone , Ilaria Colpizzi , Alessandra Farina , Lisa Di Blas , Marta Ghisi , Gioia Bottesi
{"title":"What is the internal structure of intolerance of uncertainty? A network analysis approach","authors":"Igor Marchetti ,&nbsp;Lavinia Miriam Pedretti ,&nbsp;Sara Iannattone ,&nbsp;Ilaria Colpizzi ,&nbsp;Alessandra Farina ,&nbsp;Lisa Di Blas ,&nbsp;Marta Ghisi ,&nbsp;Gioia Bottesi","doi":"10.1016/j.janxdis.2025.102999","DOIUrl":"10.1016/j.janxdis.2025.102999","url":null,"abstract":"<div><h3>Background</h3><div>Intolerance of uncertainty (IU) is a well-established risk factor for anxiety disorders, as higher levels of IU increase the likelihood of future maladaptive outcomes. However, the presence of low levels of IU does not imply that maladaptive outcomes will not occur, as other risk factors can still lead to the onset of anxiety symptoms. Currently, it is unknown whether IU also serves as a necessary cause for anxiety symptoms, meaning that its absence would ensure the absence of these symptoms.</div></div><div><h3>Methods</h3><div>A sample of 186 adolescents (58.6 % boys) between 14 and 18 years of age (M = 16.58 ± 1.01) was followed for six months, with evaluations every three months. Several self-reports were administered to measure IU and general anxiety problems, derived from the Youth Self Report 11–18, and anxiety-specific symptoms, derived from the Self-Administered Psychiatric Scales for Children and Adolescents. The Necessary Condition Analysis approach was applied to determine the extent to which IU is a necessary condition for anxiety.</div></div><div><h3>Findings</h3><div>The analyses revealed that IU is a necessary condition for anxiety problems (<em>d</em> =.23 −.24), generalized anxiety disorder symptoms (<em>d</em> =.18 −.19), social anxiety disorder symptoms (<em>d</em> =.19 −.29), and school-related anxiety symptoms (<em>d</em> =.19 −.23) after three and six months. However, IU was not a statistically significant necessary condition for separation anxiety disorder symptoms. At baseline, between 29 % and 70 % of the sample exhibited the necessary levels of IU to potentially experience subclinical anxiety symptoms at subsequent follow-ups.</div></div><div><h3>Discussion</h3><div>IU is a necessary condition for the potential development of anxiety symptoms during adolescence. Recognizing necessary conditions for anxiety symptoms and mental disorders, in general, could lead to substantial progress, given its impact on enhancing our theoretical understanding and improving prevention strategies and clinical treatments.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"112 ","pages":"Article 102999"},"PeriodicalIF":4.8,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing structural models for internalizing pathology: Latent dimensions, classes, or a mix of both? 比较内化病理的结构模型:潜在维度,类别,还是两者的混合?
IF 4.8 2区 医学
Journal of Anxiety Disorders Pub Date : 2025-03-16 DOI: 10.1016/j.janxdis.2025.103006
Ana De la Rosa-Cáceres , Leon P. Wendt , Johannes Zimmermann , Carmen Díaz-Batanero
{"title":"Comparing structural models for internalizing pathology: Latent dimensions, classes, or a mix of both?","authors":"Ana De la Rosa-Cáceres ,&nbsp;Leon P. Wendt ,&nbsp;Johannes Zimmermann ,&nbsp;Carmen Díaz-Batanero","doi":"10.1016/j.janxdis.2025.103006","DOIUrl":"10.1016/j.janxdis.2025.103006","url":null,"abstract":"<div><div>In recent decades, the conceptualization of internalizing problems has changed from categorical to dimensional and hybrid approaches. However, most studies have analyzed the structure of internalizing problems at the disorder level using categorical or dimensional approaches, with only a few studies examining the structure at the symptom level, or considering a hybrid approach. This study aimed to compare categorical (latent class analysis), dimensional (confirmatory factor analysis), and hybrid models (semi-parametric factor analysis) of internalizing constructs at the symptom level regarding model fit (structural validity) and prediction (concurrent validity) in four samples: community adults (<em>n</em> = 1072; <em>n</em> = 620), students (<em>n</em> = 378), and patients (<em>n</em> = 485). All participants completed the Inventory of Depression and Anxiety Symptoms-II to assess internalizing symptoms. In two samples, participants completed additional measures to test concurrent validity regarding disability, externalizing symptoms, personality traits, impairments in personality functioning, and quality of life. Dimensional models, particularly those allowing for non-normal distributions, outperformed categorical and hybrid models in terms of structural and concurrent validity (median <sub><em>adj</em></sub><em>R</em><sup><em>2</em></sup> for dimensional models =.18–.16). Our results suggest that future studies should prefer dimensional models to better describe internalizing constructs and predict external variables. The consistent application of dimensional models of internalizing pathology would facilitate the integration of empirical findings in clinical science and enable a more valid and fine-grained assessment of individual mental health problems in clinical practice, thereby enhancing the potential to guide effective personalized interventions.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 103006"},"PeriodicalIF":4.8,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does intolerance of uncertainty predict child generalised anxiety? A longitudinal study 对不确定性的不耐受是否预示着儿童的广泛性焦虑?纵向研究
IF 4.8 2区 医学
Journal of Anxiety Disorders Pub Date : 2025-03-15 DOI: 10.1016/j.janxdis.2025.103004
Zoe J. Ryan , Holly Rayson , Jayne Morriss , Helen F. Dodd
{"title":"Does intolerance of uncertainty predict child generalised anxiety? A longitudinal study","authors":"Zoe J. Ryan ,&nbsp;Holly Rayson ,&nbsp;Jayne Morriss ,&nbsp;Helen F. Dodd","doi":"10.1016/j.janxdis.2025.103004","DOIUrl":"10.1016/j.janxdis.2025.103004","url":null,"abstract":"<div><div>Intolerance of uncertainty (IU) is the tendency to find uncertainty distressing. IU is related to anxiety in adults and youth but it is unclear whether IU plays a maintenance or causal role, particularly across childhood. Our research examined whether: (1) IU is associated with generalised anxiety in preschool-aged children; (2) IU in preschool-aged children is associated with the trajectory of generalised anxiety into middle childhood; and (3) IU is associated with the trajectory of internalising symptoms and externalising symptoms over time. Parents completed questionnaires (child anxiety, IU, internalising and externalising symptoms) about their children at three timepoints when their child was: 3–4 years old (<em>n</em> = 180); 5–7 years old (<em>n</em> = 162); and 8–10 years old (<em>n</em> = 148). Those with higher IU had higher concurrent generalised anxiety, internalising and externalising symptoms at each measurement point. Preschoolers with higher IU, relative to lower IU, had, on average, higher generalised anxiety across childhood. Unexpectedly though, children who were higher in IU as preschoolers were more likely to show a decrease in generalised anxiety over time. These findings indicate that IU is a consistent correlate of generalised anxiety, internalising and externalising symptoms, but that it may not play a causal role in the onset of generalised anxiety in children.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"112 ","pages":"Article 103004"},"PeriodicalIF":4.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emotion regulation difficulties in children and adolescents with obsessive-compulsive disorder: A multi-informant and multi-method study 儿童和青少年强迫症的情绪调节困难:一项多信息和多方法的研究
IF 4.8 2区 医学
Journal of Anxiety Disorders Pub Date : 2025-03-14 DOI: 10.1016/j.janxdis.2025.103002
Christine Lykke Thoustrup , Robert James Blair , Sofie Heidenheim Christensen , Valdemar Uhre , Linea Pretzmann , Nicoline Løcke Jepsen Korsbjerg , Camilla Uhre , Anna-Rosa Cecilie Mora-Jensen , Melanie Ritter , Nicole Nadine Lønfeldt , Emilie Damløv Thorsen , Daniel S. Quintana , Ahmad Sajadieh , Jakob Hartvig Thomsen , Kerstin Jessica Plessen , Signe Vangkilde , Anne Katrine Pagsberg , Julie Hagstrøm
{"title":"Emotion regulation difficulties in children and adolescents with obsessive-compulsive disorder: A multi-informant and multi-method study","authors":"Christine Lykke Thoustrup ,&nbsp;Robert James Blair ,&nbsp;Sofie Heidenheim Christensen ,&nbsp;Valdemar Uhre ,&nbsp;Linea Pretzmann ,&nbsp;Nicoline Løcke Jepsen Korsbjerg ,&nbsp;Camilla Uhre ,&nbsp;Anna-Rosa Cecilie Mora-Jensen ,&nbsp;Melanie Ritter ,&nbsp;Nicole Nadine Lønfeldt ,&nbsp;Emilie Damløv Thorsen ,&nbsp;Daniel S. Quintana ,&nbsp;Ahmad Sajadieh ,&nbsp;Jakob Hartvig Thomsen ,&nbsp;Kerstin Jessica Plessen ,&nbsp;Signe Vangkilde ,&nbsp;Anne Katrine Pagsberg ,&nbsp;Julie Hagstrøm","doi":"10.1016/j.janxdis.2025.103002","DOIUrl":"10.1016/j.janxdis.2025.103002","url":null,"abstract":"<div><div>Pediatric obsessive-compulsive disorder (OCD) is associated with emotion regulation (ER) difficulties. Most studies are based on self-reports, while few have examined how these difficulties are expressed across modalities, which may hold important diagnostic and therapeutic information. We applied a multi-informant and multi-method approach to examine ER difficulties in 211 children aged 8–17 years: 121 with OCD and 90 non-clinical controls. Child ER difficulties were assessed with The Difficulties in Emotion Regulation Scale (self-report and parent-report) and a Tangram frustration task with investigator-rated behavior, self-rated frustration, and heart rate variability (HRV). Children with OCD differed significantly from non-clinical controls in showing: (i) elevated child ER difficulties on self-report (partial eta squared =.068–.165) and parent-report (partial eta squared =.207–.369); (ii) more investigator-rated ER difficulties during the task (Cohen’s <em>d</em> = −.33); (iii) increased levels of self-rated frustration before and after the task (partial eta squared =.089); notably, the magnitude of this increase did not differ between children with and without OCD. Finally, (iv) all children, regardless of group, demonstrated significant HRV changes during the frustration task, with no discernible group differences in the magnitude of these changes. Results suggest the OCD-related experience of ER difficulties may not impact autonomic functioning.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 103002"},"PeriodicalIF":4.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using machine learning methods to predict the outcome of psychological therapies for post-traumatic stress disorder: A systematic review 使用机器学习方法预测创伤后应激障碍心理治疗的结果:系统回顾
IF 4.8 2区 医学
Journal of Anxiety Disorders Pub Date : 2025-03-11 DOI: 10.1016/j.janxdis.2025.103003
James Tait , Stephen Kellett , Jaime Delgadillo
{"title":"Using machine learning methods to predict the outcome of psychological therapies for post-traumatic stress disorder: A systematic review","authors":"James Tait ,&nbsp;Stephen Kellett ,&nbsp;Jaime Delgadillo","doi":"10.1016/j.janxdis.2025.103003","DOIUrl":"10.1016/j.janxdis.2025.103003","url":null,"abstract":"<div><h3>Background</h3><div>A number of treatments are available for post-traumatic stress disorder (PTSD), however, there is currently a lack of data-driven treatment selection and adaptation methods for this condition. Machine learning (ML) could potentially help to improve the prediction of treatment outcomes and enable precision mental healthcare in practice.</div></div><div><h3>Objectives</h3><div>To systematically review studies that applied ML methods to predict outcomes of psychological therapy for PTSD in adults (e.g., change in symptoms, dropout rate), and evaluate their methodological rigour.</div></div><div><h3>Methods</h3><div>This was a pre-registered systematic review (CRD42022325021), which synthesised eligible clinical prediction studies found across four research databases. Risk of bias was assessed using the PROBAST tool. Study methods and findings were narratively synthesised, and adherence to ML best practice evaluated.</div></div><div><h3>Results</h3><div>Seventeen studies met the inclusion criteria, including samples derived from experimental and observational study designs. All studies were assessed as having a high risk of bias, notably due to inadequately powered samples and a lack of sample size calculations. Training sample size ranged from <em>N</em> &lt; 36–397. The studies applied a diverse range of ML methods such as decision trees, ensembling and boosting techniques. Five studies used unsupervised ML methods, while others used supervised ML. There was an inconsistency in the reporting of hyperparameter tuning and cross-validation methods. Only one study performed external validation.</div></div><div><h3>Conclusions</h3><div>ML has the potential to advance precision psychotherapy for PTSD, but to enable this, ML methods must be applied with greater adherence to best practice guidelines.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"112 ","pages":"Article 103003"},"PeriodicalIF":4.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal dynamics of costly avoidance in anxiety disorders: Faster threat and weaker reward impact during approach-avoidance decisions in patients 焦虑症中代价高昂的回避的时间动态:患者在做出接近-回避决定时,威胁更快,奖励影响更弱
IF 4.8 2区 医学
Journal of Anxiety Disorders Pub Date : 2025-03-10 DOI: 10.1016/j.janxdis.2025.103005
Juliane M. Boschet-Lange , Valentina M. Glück , Roxana Pittig , Stefan Scherbaum , Andre Pittig
{"title":"Temporal dynamics of costly avoidance in anxiety disorders: Faster threat and weaker reward impact during approach-avoidance decisions in patients","authors":"Juliane M. Boschet-Lange ,&nbsp;Valentina M. Glück ,&nbsp;Roxana Pittig ,&nbsp;Stefan Scherbaum ,&nbsp;Andre Pittig","doi":"10.1016/j.janxdis.2025.103005","DOIUrl":"10.1016/j.janxdis.2025.103005","url":null,"abstract":"<div><div>In anxiety disorders, approach-avoidance behavior is typically biased towards excessive, maladaptive avoidance despite costs and impairments (i.e., costly avoidance). Yet, little is known about the underlying decision dynamics that may contribute to such imbalanced behavior. The current study tested for altered temporal decision dynamics in patients with anxiety disorders compared to matched healthy controls in a task where avoiding an aversive stimulus conflicted with obtaining rewards. Participants chose repeatedly between a fixed safe/low reward and a threat/high reward option with varying threat (probability of an aversive stimulus presentation) and reward information (reward magnitude). Structured computer mouse movements required for choosing between options were tracked to capture the temporal dynamics of the decision process (i.e., when and how strongly threat and reward information influenced decision preference). The current study replicated elevated costly threat avoidance in patients with anxiety disorders compared to matched controls. Importantly, time-continuous multiple regression of mouse movements revealed altered temporal dynamics: patients showed a faster (but not stronger) impact of threat and a weaker impact of competing rewards. These findings highlight that not only biases in threat processes but also competing rewards may guide excessive avoidance and could be important treatment targets in anxiety disorders. Future research may support the external validity of these findings in real-life decisions and try to identify therapeutic strategies that allow to specifically target the attenuated impact of rewards and the accelerated impact of threat in patients.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 103005"},"PeriodicalIF":4.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A randomized clinical trial investigating the clinical impact of a game-based digital therapeutic for social anxiety disorder 一项随机临床试验,调查基于游戏的数字治疗对社交焦虑症的临床影响
IF 4.8 2区 医学
Journal of Anxiety Disorders Pub Date : 2025-03-08 DOI: 10.1016/j.janxdis.2025.103000
Jennifer de Rutte , Sarah Myruski , Elizabeth Davis , Abigail Findley , Tracy A. Dennis-Tiwary
{"title":"A randomized clinical trial investigating the clinical impact of a game-based digital therapeutic for social anxiety disorder","authors":"Jennifer de Rutte ,&nbsp;Sarah Myruski ,&nbsp;Elizabeth Davis ,&nbsp;Abigail Findley ,&nbsp;Tracy A. Dennis-Tiwary","doi":"10.1016/j.janxdis.2025.103000","DOIUrl":"10.1016/j.janxdis.2025.103000","url":null,"abstract":"<div><div>The objective of this study was to determine if a novel game-based digital therapeutic intervention reduced anxiety symptom severity in adults with clinically elevated symptoms of social anxiety disorder (SAD). Participants were randomly allocated (1:1) to receive four weeks of either the active intervention, a game-based form of attention bias modification (Active ABM) for anxiety, or the sham control training (Control). Between June 2022 to June 2023, 104 participants were enrolled with 93 completing the trial per-protocol and 104 included in the final intention-to-treat analysis (54 intervention, 50 control); mean age was 38.08 (10.56) years and 79 were female. The dependent variable was reduction in SAD symptoms, measured via the Liebowitz SAD Scale (LSAS). Participants were classified as having clinically elevated SAD symptoms only, or both SAD and Generalized Anxiety Disorder (GAD) symptoms (comorbid). The Active condition induced significantly greater reductions in SAD symptoms compared to the Control condition between Baseline and Post-Treatment [Active: <em>M</em> = -29.71, <em>SD</em> = 23.68; Control: <em>M</em> = -14.59, <em>SD</em> = 21.52, <em>d</em> = .67, <em>t</em>(102) = -3.40, <em>p</em> &lt; .001] across the four-week study period. While no significant between-groups differences emerged at each timepoint individually, the Active condition induced significantly greater change over time in SAD symptoms compared to the Control condition. Use of this game-based digital ABM intervention showed benefits in the reduction of anxiety symptoms.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 103000"},"PeriodicalIF":4.8,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computationally derived parent-child interaction patterns and oxytocin in children with and without OCD 计算得出的亲子互动模式和催产素在有和没有强迫症的儿童中的作用。
IF 4.8 2区 医学
Journal of Anxiety Disorders Pub Date : 2025-03-03 DOI: 10.1016/j.janxdis.2025.102996
Anna-Rosa Cecilie Mora-Jensen , Christine Lykke Thoustrup , Eli R. Lebowitz , Julie Hagstrøm , Linea Pretzmann , Nicoline Løcke Jepsen Korsbjerg , Emilie Damløv Thorsen , Valdemar Funch Uhre , Sofie Heidenheim Christensen , Camilla Uhre , Melanie Ritter , Kerstin J. Plessen , Anne Katrine Pagsberg , Line Katrine Harder Clemmensen , Nicole Nadine Lønfeldt
{"title":"Computationally derived parent-child interaction patterns and oxytocin in children with and without OCD","authors":"Anna-Rosa Cecilie Mora-Jensen ,&nbsp;Christine Lykke Thoustrup ,&nbsp;Eli R. Lebowitz ,&nbsp;Julie Hagstrøm ,&nbsp;Linea Pretzmann ,&nbsp;Nicoline Løcke Jepsen Korsbjerg ,&nbsp;Emilie Damløv Thorsen ,&nbsp;Valdemar Funch Uhre ,&nbsp;Sofie Heidenheim Christensen ,&nbsp;Camilla Uhre ,&nbsp;Melanie Ritter ,&nbsp;Kerstin J. Plessen ,&nbsp;Anne Katrine Pagsberg ,&nbsp;Line Katrine Harder Clemmensen ,&nbsp;Nicole Nadine Lønfeldt","doi":"10.1016/j.janxdis.2025.102996","DOIUrl":"10.1016/j.janxdis.2025.102996","url":null,"abstract":"<div><h3>Background</h3><div>Parent-child interactive processes are important factors in pediatric OCD. Understanding biological mechanisms of parent-child interactive behaviors could help improve treatment of pediatric OCD. Oxytocin has been suggested as a biological mechanism in parent-child interactions. However, no studies in pediatric OCD exist. We used machine learning to discover latent patterns in parent-child interactive behaviors and explored associations with oxytocin in children with and without OCD.</div></div><div><h3>Methods</h3><div>We used parent and child salivary oxytocin levels measured with enzyme-linked immunosorbent assay (ELISA) and investigator-rated parent-child behaviors during a frustration task. Children with or without OCD and their parents – 107 mother-child and 62 father-child pairs were included. We used two machine learning techniques, principal component analysis and archetypal analysis, to generate data-driven, theory-agnostic behavioral variables, and regression to estimate their associations with oxytocin.</div></div><div><h3>Results</h3><div>Principal component and archetype analyses identified behavioral patterns describing the mother-child and father-child interactions. We found a positive association between child and mother oxytocin and the interaction patterns \"overinvolved interaction\" and \"emotional interaction\" and a negative association with \"distant interaction\". Additionally, mother oxytocin was positively associated with \"supportive interaction\" and \"varied-coping interaction\", and negatively associated with \"conflictual interaction\" and \"negative-low support interaction\". Father oxytocin was associated with “supportive interactions” only in the presence of child OCD.</div></div><div><h3>Conclusion</h3><div>Child and mother oxytocin appear related with mother-child interactive patterns. Fathers’ oxytocin was related with interaction patterns only in children with OCD. Our exploratory findings can be used to generate hypothesis for future research regarding the relationship between oxytocin and maladaptive family engagement in OCD and differences between mothers and fathers’ behaviors when the child has OCD.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 102996"},"PeriodicalIF":4.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The diagnostic utility of the PCL-5 in a traumatically injured black population PCL-5在创伤性黑人人群中的诊断价值
IF 4.8 2区 医学
Journal of Anxiety Disorders Pub Date : 2025-02-19 DOI: 10.1016/j.janxdis.2025.102988
Timothy J. Geier , Kaylen Vine , Lucas Torres , Christine L. Larson , Terri A. deRoon-Cassini
{"title":"The diagnostic utility of the PCL-5 in a traumatically injured black population","authors":"Timothy J. Geier ,&nbsp;Kaylen Vine ,&nbsp;Lucas Torres ,&nbsp;Christine L. Larson ,&nbsp;Terri A. deRoon-Cassini","doi":"10.1016/j.janxdis.2025.102988","DOIUrl":"10.1016/j.janxdis.2025.102988","url":null,"abstract":"<div><h3>Background</h3><div>Posttraumatic stress disorder (PTSD) is common after traumatic injury, negatively impacting recovery. Black Americans face elevated PTSD risk following traumatic injury, yet diagnostic accuracy of assessments in trauma center settings serving this population is unknown. The Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) exhibits strong psychometric properties but optimal cut-scores by race require examination.</div></div><div><h3>Methods</h3><div>Data were combined from three ongoing projects of injured Black American adults (N = 270). Participants completed the PCL-5 and Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) six months post-injury. Receiver operating characteristic analysis determined the PCL-5's diagnostic utility against the CAPS-5. Sensitivity, specificity, predictive values, and diagnostic efficiency were calculated across cut scores.</div></div><div><h3>Results</h3><div>Prevalence of CAPS-5 PTSD at 6-months post-injury was 34.4 %. The PCL-5 demonstrated good accuracy in detecting PTSD (AUC=.931). A PCL-5 cut-score of &gt; 33 maximized diagnostic efficiency (89.1 %), with sensitivity of 89.1 % and specificity of 87.6 %.</div></div><div><h3>Conclusions</h3><div>The PCL-5 is an accurate PTSD screening tool for injured Black Americans using an appropriate threshold. Findings have implications for improving mental health care access in trauma settings serving marginalized groups.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 102988"},"PeriodicalIF":4.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fear of positive evaluation and the bivalent fear of evaluation model of social anxiety: An Integration 社交焦虑的积极评价恐惧与二价恐惧评价模型的整合
IF 4.8 2区 医学
Journal of Anxiety Disorders Pub Date : 2025-02-10 DOI: 10.1016/j.janxdis.2025.102986
Stefan G. Hofmann
{"title":"Fear of positive evaluation and the bivalent fear of evaluation model of social anxiety: An Integration","authors":"Stefan G. Hofmann","doi":"10.1016/j.janxdis.2025.102986","DOIUrl":"10.1016/j.janxdis.2025.102986","url":null,"abstract":"<div><div>Humans have an inherent need to belong to a social group, and ostracism can lead to significant personal costs. Therefore, the fear of negative evaluation by others, along with its associated consequence of social anxiety, appears to be evolutionarily adaptive. Numerous studies have demonstrated that social anxiety, as well as its clinical manifestation, social anxiety disorder (SAD), is not only linked to an intense fear of negative evaluation but also to a fear of positive evaluation. This phenomenon has been termed the Bivalent Fear of Evaluation (BFOE) model of social anxiety. While the fear of negative evaluation can be understood from an evolutionary standpoint, the fear of positive evaluation poses a challenge for such an account. Clarifying the relationship between these two fears—positive and negative evaluation—may provide new insights into the nature of social anxiety and SAD. After summarizing and reviewing studies comprising this special issue, I will conclude that any form of evaluative feedback rising self-focused attention—whether positive, negative, or even neutral—can cause distress due to heightened sensitivity to social feedback in general. However, different mechanisms and contextual factors are implicated. In line with cognitive models of SAD, the self and self-perception are central to both social anxiety and SAD. This has significant theoretical and clinical implications.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 102986"},"PeriodicalIF":4.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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