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Tofacitinib: A paradigm shift in rheumatoid arthritis management 托法替尼类风湿关节炎治疗模式的转变
IP International Journal of Orthopaedic Rheumatology Pub Date : 2024-07-15 DOI: 10.18231/j.ijor.2024.002
Janakapriya Ashok, Ashok Ramanujam
{"title":"Tofacitinib: A paradigm shift in rheumatoid arthritis management","authors":"Janakapriya Ashok, Ashok Ramanujam","doi":"10.18231/j.ijor.2024.002","DOIUrl":"https://doi.org/10.18231/j.ijor.2024.002","url":null,"abstract":"Tofacitinib, a Janus kinase (JAK) inhibitor, represents a significant advancement in the treatment of rheumatoid arthritis (RA), a chronic inflammatory disorder. This manuscript provides an in-depth review of the efficacy, safety, and clinical application of tofacitinib in RA management. Through a comprehensive analysis of clinical trials, real-world studies, and comparative assessments with other RA therapies, we aim to elucidate the role of tofacitinib in improving patient outcomes. The review highlights the mechanisms of action, clinical efficacy, safety profile, and practical considerations for incorporating tofacitinib into RA treatment regimens.","PeriodicalId":483250,"journal":{"name":"IP International Journal of Orthopaedic Rheumatology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant cell tumour of tendon sheath (GCTTS) – 2 Most common tumour of hand after ganglion cyst 腱鞘巨细胞瘤（GCTTS）--继神经节囊肿之后手部最常见的肿瘤之二
IP International Journal of Orthopaedic Rheumatology Pub Date : 2024-02-15 DOI: 10.18231/j.ijor.2023.019
Naman Kandpal, Ozair Khan, Tahir Husain, V.A Senthil Kumar, B. S. Murthy, Amit Dhond
{"title":"Giant cell tumour of tendon sheath (GCTTS) – 2 Most common tumour of hand after ganglion cyst","authors":"Naman Kandpal, Ozair Khan, Tahir Husain, V.A Senthil Kumar, B. S. Murthy, Amit Dhond","doi":"10.18231/j.ijor.2023.019","DOIUrl":"https://doi.org/10.18231/j.ijor.2023.019","url":null,"abstract":"Probably one of the most common benign neoplasm in the human hand, the Giant Cell Tumour of Tendon Sheath (GCTTS) has been studied by many authors over the years as a popular tumour. There have been studies on the etilogical factors, however, limited attention has been given to etiology, prognostic factors, and recurrence rate. Because there are several factors that predispose to recurrence, it is imperative that medical practitioners ensure complete excision of the tumour, including removal of residual satellite nodules. This study is a focus on 0.5cm swelling over dorsal part of the interphalangeal joint of middle finger of the right hand of a 55-year old female that was initially unilobulated, which eventually increased to 3cm and was bilobed over 6 months. With meticulous dissection and the use of magnification loupe to obtain a low recurrence rate, thereby emphasising the key role of surgery as the first prognostic factor of GCTTS.","PeriodicalId":483250,"journal":{"name":"IP International Journal of Orthopaedic Rheumatology","volume":"27 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139776125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of bone mineral density in medical faculties and students of Tezpur medical college and hospital 泰兹普尔医学院和医院医学生骨矿物质密度研究
IP International Journal of Orthopaedic Rheumatology Pub Date : 2024-02-15 DOI: 10.18231/j.ijor.2023.017
Washim Akram, Chinmoy Das, Firoz Pegu, Ahmed Saifuddin
{"title":"Study of bone mineral density in medical faculties and students of Tezpur medical college and hospital","authors":"Washim Akram, Chinmoy Das, Firoz Pegu, Ahmed Saifuddin","doi":"10.18231/j.ijor.2023.017","DOIUrl":"https://doi.org/10.18231/j.ijor.2023.017","url":null,"abstract":"To examine the prevalence of low bone mineral density among the faculties and students of Tezpur medical college and hospital Hospital based cross-sectional study. Study will be conducted in the department of orthopaedics, Tezpur medical college and hospital for a period of 1 year. All faculties and students above 18 years attending outpatient department of orthopaedics were included in the study. Mean T-score among health staffs is -1.4. Maximum people in health staff groups are osteopenic with T-score of -1 to -2.5 comprising of 42%. Mean T-score among students is -1.2 with majority students is normal with T-score comprising of 52%. 45 patients had severe established osteoporosis. It was found that most individual in osteoporotic group had age group above 45 years.Ultrasonography can predict hip fractures and vertebral fractures. People with low bone mass and fragility fractures have osteoporosis and should be treated.","PeriodicalId":483250,"journal":{"name":"IP International Journal of Orthopaedic Rheumatology","volume":"45 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139775790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of bone mineral density in medical faculties and students of Tezpur medical college and hospital 泰兹普尔医学院和医院医学生骨矿物质密度研究
IP International Journal of Orthopaedic Rheumatology Pub Date : 2024-02-15 DOI: 10.18231/j.ijor.2023.017
Washim Akram, Chinmoy Das, Firoz Pegu, Ahmed Saifuddin
{"title":"Study of bone mineral density in medical faculties and students of Tezpur medical college and hospital","authors":"Washim Akram, Chinmoy Das, Firoz Pegu, Ahmed Saifuddin","doi":"10.18231/j.ijor.2023.017","DOIUrl":"https://doi.org/10.18231/j.ijor.2023.017","url":null,"abstract":"To examine the prevalence of low bone mineral density among the faculties and students of Tezpur medical college and hospital Hospital based cross-sectional study. Study will be conducted in the department of orthopaedics, Tezpur medical college and hospital for a period of 1 year. All faculties and students above 18 years attending outpatient department of orthopaedics were included in the study. Mean T-score among health staffs is -1.4. Maximum people in health staff groups are osteopenic with T-score of -1 to -2.5 comprising of 42%. Mean T-score among students is -1.2 with majority students is normal with T-score comprising of 52%. 45 patients had severe established osteoporosis. It was found that most individual in osteoporotic group had age group above 45 years.Ultrasonography can predict hip fractures and vertebral fractures. People with low bone mass and fragility fractures have osteoporosis and should be treated.","PeriodicalId":483250,"journal":{"name":"IP International Journal of Orthopaedic Rheumatology","volume":"789 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139835168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of combination of bone marrow aspiration concentrate (BMAC) and platelet-rich plasma (PRP) in anterior cruciate ligament reconstruction 骨髓抽吸浓缩物（BMAC）和富血小板血浆（PRP）联合应用于前十字韧带重建的效果
IP International Journal of Orthopaedic Rheumatology Pub Date : 2024-02-15 DOI: 10.18231/j.ijor.2023.022
Ashim Gupta, Surya Prakash Sharma
{"title":"Effect of combination of bone marrow aspiration concentrate (BMAC) and platelet-rich plasma (PRP) in anterior cruciate ligament reconstruction","authors":"Ashim Gupta, Surya Prakash Sharma","doi":"10.18231/j.ijor.2023.022","DOIUrl":"https://doi.org/10.18231/j.ijor.2023.022","url":null,"abstract":"","PeriodicalId":483250,"journal":{"name":"IP International Journal of Orthopaedic Rheumatology","volume":"261 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139834056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An ethno-botanical survey of medicinal plants used in the treatment of fracture and dislocation in Ogugu, Kogi State Nigeria 尼日利亚科吉州奥古古用于治疗骨折和脱臼的药用植物民族植物学调查
IP International Journal of Orthopaedic Rheumatology Pub Date : 2024-02-15 DOI: 10.18231/j.ijor.2023.016
B. A. Ali, Umar Sabdat Unoyiza, Suleiman Mohammed Salisu, Kutama Ahmad Suleiman, K. Tijani
{"title":"An ethno-botanical survey of medicinal plants used in the treatment of fracture and dislocation in Ogugu, Kogi State Nigeria","authors":"B. A. Ali, Umar Sabdat Unoyiza, Suleiman Mohammed Salisu, Kutama Ahmad Suleiman, K. Tijani","doi":"10.18231/j.ijor.2023.016","DOIUrl":"https://doi.org/10.18231/j.ijor.2023.016","url":null,"abstract":"The documented information on traditional medicinal plants in Ogugu communities of Kogi State is vague and limited to its species and thus very little research has been done on these medicinal plants. An Ethno-botanical study was conducted to take inventory of the species by the inhabitants of various communities in Ogugu, Olamaboro Local Government area of Kogi State in bone fracture treatment and dislocation. The study was carried out between May through September 2019. Ethnomedicinal knowledge was gathered from 20 traditional bone setters in 10 communities using questionnaires. The plants most referenced from the questionnaire were collected and identified using various standard methods and procedures. 80% of the respondents were male while 20% were female. 40% were in the range of 31-41 years of age and only 10% were in the age range of 20-30 years. About 45% has no formal education while only 5% had a university degree. TBS with most year of experience (21-25 years) are only 5% while the profession is dominated by those of moderate time of practice (11-15 years) with 40% representative. A total of 49 medicinal plant species distributed in 27 families and genera were documented. Family Euphorbiaceae was found to be mostly used for fracture treatment. The most frequent used plant parts were the leaves (49.5%). The method of preparation of the herbal remedies were generally best in the form of poultice administered in the form of paste to give the best result in fracture and bone setting treatment.","PeriodicalId":483250,"journal":{"name":"IP International Journal of Orthopaedic Rheumatology","volume":"111 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139776779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of osteoarthritis knee with bone marrow aspirate concentrate injection 骨髓抽吸物浓缩物注射治疗膝关节骨关节炎
IP International Journal of Orthopaedic Rheumatology Pub Date : 2024-02-15 DOI: 10.18231/j.ijor.2023.013
Somesh Saha, Chinmoy Das, P. Das, Navonil Gupta
{"title":"Treatment of osteoarthritis knee with bone marrow aspirate concentrate injection","authors":"Somesh Saha, Chinmoy Das, P. Das, Navonil Gupta","doi":"10.18231/j.ijor.2023.013","DOIUrl":"https://doi.org/10.18231/j.ijor.2023.013","url":null,"abstract":"To assess the clinical effectiveness and safety of bone marrow aspirate concentrate (BMAC) injections given intraarticularly as a potential treatment for knee osteoarthritis (OA). Data from 60 patients with knee osteoarthritis treated with BMAC injection at a single centre between December 2021 and December 2022 were retrospectively examined. We only included patients with idiopathic osteoarthritis. Post-traumatic osteoarthritis, prior knee surgery, ageless then 50 years or over 85 years, an active infection, uncontrolled diabetes mellitus, rheumatological or another systemic condition, cancer, or immunosuppressive medication use were all exclusion factors. A single-spin manual approach was used to aspirate and concentrate bone marrow from the iliac crest. The Numeric pain scale (NPS) and Oxford knee score (OKS) were used to evaluate patients both before and after the treatment. A 12-month follow-up period was used. The statistical analysis comprised a total of 60 patients. With a mean age of 67 years (range 50-85), there were 42 females and 18 males. At the end of the follow-up period, the mean NPS reduced from 8.12 to 4.31 (p< 0.001) and the mean OKS rise from 22.30 to 34.74 (p <0.001). There were no problems. A single BMAC intra-articular injection is a dependable and safe technique that improves the clinical condition of knee OA.","PeriodicalId":483250,"journal":{"name":"IP International Journal of Orthopaedic Rheumatology","volume":"137 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139836199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distraction assisted management of post burn contracture of hand 烧伤后手部挛缩的牵引辅助治疗
IP International Journal of Orthopaedic Rheumatology Pub Date : 2024-02-15 DOI: 10.18231/j.ijor.2023.020
Ravi Kumar Chittoria, Amrutha J S
{"title":"Distraction assisted management of post burn contracture of hand","authors":"Ravi Kumar Chittoria, Amrutha J S","doi":"10.18231/j.ijor.2023.020","DOIUrl":"https://doi.org/10.18231/j.ijor.2023.020","url":null,"abstract":"Burns are one of the injuries that causes significant morbidity and reduced quality of life.Despite making up only 3% of the body's surface area, hands are involved in more than 80% of serious burs. Scarring, joint contractures and stiffness are devastating in the upper extremity due to its dependence. In this article, we have used Distraction assisted management is one of the methods for the management of finger webspace contracture release. In this case, we will be using a JESS distractor in the management of web space contracture in the upper extremity.","PeriodicalId":483250,"journal":{"name":"IP International Journal of Orthopaedic Rheumatology","volume":"11 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139776111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging role of orthobiologics for the management of knee osteoarthritis 骨生物制品在膝关节骨性关节炎治疗中的新作用
IP International Journal of Orthopaedic Rheumatology Pub Date : 2024-02-15 DOI: 10.18231/j.ijor.2023.012
Ashim Gupta, Karun Jain
{"title":"Emerging role of orthobiologics for the management of knee osteoarthritis","authors":"Ashim Gupta, Karun Jain","doi":"10.18231/j.ijor.2023.012","DOIUrl":"https://doi.org/10.18231/j.ijor.2023.012","url":null,"abstract":"","PeriodicalId":483250,"journal":{"name":"IP International Journal of Orthopaedic Rheumatology","volume":"254 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139834963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distraction assisted management of post burn contracture of hand 烧伤后手部挛缩的牵引辅助治疗
IP International Journal of Orthopaedic Rheumatology Pub Date : 2024-02-15 DOI: 10.18231/j.ijor.2023.020
Ravi Kumar Chittoria, Amrutha J S
{"title":"Distraction assisted management of post burn contracture of hand","authors":"Ravi Kumar Chittoria, Amrutha J S","doi":"10.18231/j.ijor.2023.020","DOIUrl":"https://doi.org/10.18231/j.ijor.2023.020","url":null,"abstract":"Burns are one of the injuries that causes significant morbidity and reduced quality of life.Despite making up only 3% of the body's surface area, hands are involved in more than 80% of serious burs. Scarring, joint contractures and stiffness are devastating in the upper extremity due to its dependence. In this article, we have used Distraction assisted management is one of the methods for the management of finger webspace contracture release. In this case, we will be using a JESS distractor in the management of web space contracture in the upper extremity.","PeriodicalId":483250,"journal":{"name":"IP International Journal of Orthopaedic Rheumatology","volume":"172 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139835886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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