{"title":"Relationships of Hypnotics with Incident Dementia and Alzheimer's Disease: A Longitudinal Study and Meta-Analysis.","authors":"J-H Hou, S-L Sun, C-C Tan, Y-M Huang, L Tan, W Xu","doi":"10.14283/jpad.2023.78","DOIUrl":"10.14283/jpad.2023.78","url":null,"abstract":"<p><strong>Background: </strong>Evidence describing the association between hypnotics use and dementia risk is conflicting. It is unknown if the controversy is related to the type or dose of hypnotics or if hypnotics affect different populations.</p><p><strong>Objectives: </strong>We sought to derive lessons learned and future projections based on evidence from longitudinal studies.</p><p><strong>Measurements: </strong>In the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort, 1,543 older adults without dementia (mean age = 73.3 years, female = 45%) were followed for four years. The association between hypnotics and the risk of Alzheimer's disease (AD) was investigated using Cox proportional hazards regressions. Next, electronic databases were searched until March 2022 to conduct the evidence synthesis of the associations of hypnotics with incident risk of dementia.</p><p><strong>Results: </strong>In the ADNI cohort, ever use of hypnotics was associated with an increased risk of AD (hazard ratio = 1.96, 95% confidence intervals = 1.23-3.11, p < 0.01). This association was significant for benzodiazepines and Z-drugs but not for melatonin. The association was stronger in long-term (more than one year) users and those with high cumulative doses. A meta-analysis of 26 longitudinal studies with 3,942,018 participants revealed a correlation between the use of hypnotics and the risk of dementia (relative risk = 1.23, 95% confidence intervals = 1.13-1.33, p < 0.001, median risk difference = 4%). It is a linear dose-response relationship, if a person takes the daily recommended dose for 100 days, their risk of developing dementia increases by 5% relative to non-users. According to subgroup analyses, neither association was significant among patients with a history of insomnia.</p><p><strong>Conclusions: </strong>Individuals who use hypnotics, especially high-dose or long-term users, are at a higher risk of dementia and AD. The main issue with conclusion credibility is heterogeneity.</p>","PeriodicalId":48280,"journal":{"name":"Third World Quarterly","volume":"41 1","pages":"117-129"},"PeriodicalIF":6.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66894362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dependency theory meets feminist economics: a research agenda","authors":"Belén Villegas Plá","doi":"10.1080/01436597.2023.2292176","DOIUrl":"https://doi.org/10.1080/01436597.2023.2292176","url":null,"abstract":"","PeriodicalId":48280,"journal":{"name":"Third World Quarterly","volume":"21 4","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of the sustainable development goals for digital development professionals: lessons for the post-2030 development goals","authors":"Franz-Ferdinand Rothe","doi":"10.1080/01436597.2023.2290125","DOIUrl":"https://doi.org/10.1080/01436597.2023.2290125","url":null,"abstract":"","PeriodicalId":48280,"journal":{"name":"Third World Quarterly","volume":"27 S1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Continuity and change in Saudi Arabia’s development and humanitarian aid","authors":"N. Sritharan, Ammar A. Malik, Asad Sami","doi":"10.1080/01436597.2023.2288852","DOIUrl":"https://doi.org/10.1080/01436597.2023.2288852","url":null,"abstract":"","PeriodicalId":48280,"journal":{"name":"Third World Quarterly","volume":"116 13","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138999478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustapha Kamal Pasha, Shahram Akbarzadeh, Morten Bøås, Matt Davies, Jing Gu, I. Kvangraven, Rirhandu Mageza-Barthel, Marianne H. Marchand, S. O. Opondo, Heloise Weber, Tiffany Willoughby-Herard
{"title":"Legacies and futures for Global South research","authors":"Mustapha Kamal Pasha, Shahram Akbarzadeh, Morten Bøås, Matt Davies, Jing Gu, I. Kvangraven, Rirhandu Mageza-Barthel, Marianne H. Marchand, S. O. Opondo, Heloise Weber, Tiffany Willoughby-Herard","doi":"10.1080/01436597.2023.2285566","DOIUrl":"https://doi.org/10.1080/01436597.2023.2285566","url":null,"abstract":"","PeriodicalId":48280,"journal":{"name":"Third World Quarterly","volume":"138 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandar Deejay, Tamas Wells, Kathryn Henne, Stefan Baechtold
{"title":"Bad adopters or bad proponents of technology? Facebook and the violence against Muslims in Myanmar","authors":"Aleksandar Deejay, Tamas Wells, Kathryn Henne, Stefan Baechtold","doi":"10.1080/01436597.2023.2285808","DOIUrl":"https://doi.org/10.1080/01436597.2023.2285808","url":null,"abstract":"","PeriodicalId":48280,"journal":{"name":"Third World Quarterly","volume":"4 12","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138586563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Forging alliances: political competition and industrial policy in democratic Brazil","authors":"R. H. de Gaspi","doi":"10.1080/01436597.2023.2283466","DOIUrl":"https://doi.org/10.1080/01436597.2023.2283466","url":null,"abstract":"","PeriodicalId":48280,"journal":{"name":"Third World Quarterly","volume":"22 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139229338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Environmental pollution, variegated violence: the fizzling bond of Delta State diaspora from their homeland","authors":"Henrietta Omo Oshokunofa","doi":"10.1080/01436597.2023.2278705","DOIUrl":"https://doi.org/10.1080/01436597.2023.2278705","url":null,"abstract":"","PeriodicalId":48280,"journal":{"name":"Third World Quarterly","volume":"8 16","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139246289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Power and networks in the shaping of the Alliance for a Green Revolution in Africa (AGRA)","authors":"Stefan Vicedom, Rachel Wynberg","doi":"10.1080/01436597.2023.2276820","DOIUrl":"https://doi.org/10.1080/01436597.2023.2276820","url":null,"abstract":"","PeriodicalId":48280,"journal":{"name":"Third World Quarterly","volume":"15 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139244433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Love in war? The strategic use of intimacy in armed conflict","authors":"Kiran Stallone","doi":"10.1080/01436597.2023.2276817","DOIUrl":"https://doi.org/10.1080/01436597.2023.2276817","url":null,"abstract":"","PeriodicalId":48280,"journal":{"name":"Third World Quarterly","volume":"45 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139245370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}