Research in Autism Spectrum Disorders最新文献

{"title":"Reliability and validity of the Polish version of Communication and Symbolic Behaviour Scales-Developmental Profile - Infant-Toddler Checklist","authors":"Mateusz Sobieski ,&nbsp;Sylwia Wrona ,&nbsp;Maria Flakus ,&nbsp;Kamila Pierchała ,&nbsp;Aleksandra Sobieska ,&nbsp;Katarzyna Podgórska ,&nbsp;Anna Wołowicz ,&nbsp;Małgorzata Sekułowicz ,&nbsp;Maria Magdalena Bujnowska-Fedak","doi":"10.1016/j.rasd.2024.102454","DOIUrl":"https://doi.org/10.1016/j.rasd.2024.102454","url":null,"abstract":"<div><h3>Background</h3><p>Early diagnosis of autism spectrum disorders allows to start a therapy tailored to the child - the earlier it happens, the better the results. This study marked a preliminary attempt to prepare culturally and linguistically adapted Polish version of the Communication and Symbolic Behavior Scales-Developmental Profile – Infant-Toddler Checklist (CSBS-DP ITC).</p></div><div><h3>Method</h3><p>The study was conducted among 1471 Polish parents of children from the general population aged 6 to 24 months, 490 of them participated in the follow-up. An additional 122 pairs of parents completed the questionnaire to determine reliability using the inter-rater method. The collected data were statistically processed to calculate the reliability and validity of the Polish version of the CSBS-DP ITC questionnaire.</p></div><div><h3>Results</h3><p>The results indicated a very good fit of the one-factor and three-factor models in confirmatory factor analysis. Both one-factor and three-factor model showed satisfactory fit in both sex subsamples. The total score of CSBS-DP ITC demonstrated satisfactory internal consistency, Cronbach's α = .92 and McDonald’s ω = .92. In test-retest all the correlation coefficients between the first and second measurements were above.70, proving a satisfactory level of stability.</p></div><div><h3>Conclusions</h3><p>The Polish version of the CSBS-DP-ITC is a reliable tool for the early screening of autism spectrum disorder, but further studies on sensitivity and specificity are essential.</p></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"117 ","pages":"Article 102454"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1750946724001296/pdfft?md5=d29964ae367fb862baf9ffdb9c1d6e6e&pid=1-s2.0-S1750946724001296-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141593275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique and enriched microbes and their potential “allies and foes” in the human gut microbiomes of ASD patients","authors":"Zhanshan (Sam) Ma ,&nbsp;Lianwei Li ,&nbsp;Hongju (Daisy) Chen","doi":"10.1016/j.rasd.2024.102440","DOIUrl":"https://doi.org/10.1016/j.rasd.2024.102440","url":null,"abstract":"<div><p>Studies with animal models and humans show that alternations in the composition and activity of the gut microbiome can contribute to the etiopathogenesis of core symptoms in the ASD (autism spectrum disorder) patients. The role has been investigated by extending classic brain-gut axis to brain-gut-microbiome (BGM) axis. Nevertheless, there is not yet a consensus regarding the compositional changes associated with ASD. Here we fill a gap by computationally detecting and compiling the lists of US (unique species) and ES (enriched species) associated with ASD from big datasets on ASD-microbiome studies. The gap is that different existing studies generated conflicting evidence regarding the ES/US status, and the existing ES/US lists often lack rigorous statistical quantifications, which is likely responsible for the inconsistencies. To fill the gap, we apply and extend a recent computational advance for virome comparison (VC) that statistical rigorously determines the US/ES status and their holistic differences between the diseased treatments and healthy controls. We further extend the VC approach by building the first-order (nearest neighbor) network (FON) of US/ES taxa to deepen our understanding of the microbes associated with ASD, including their allies and foes. We obtained the US/ES lists from 8 individual datasets separately and their pooled datasets with statistical rigor and computed their union/intersection sets to make recommendations for practical applications of US/ES catalogues. We also built the FON and revealed possibly general species occurrence patterns of US/ES in ASD patients, analyzed the extreme complexity in gut microbiome alternations associated with ASD.</p></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"117 ","pages":"Article 102440"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An examination of sleep problems and parental well-being, comparing families with and without autistic children","authors":"Arlene Mannion,&nbsp;Sally Whelan,&nbsp;Geraldine Leader","doi":"10.1016/j.rasd.2024.102462","DOIUrl":"10.1016/j.rasd.2024.102462","url":null,"abstract":"<div><h3>Background</h3><p>Sleep problems are a common comorbidity in autistic children and adolescents. Little is known about the role of sleep problems in parental well-being in the context of autism.</p></div><div><h3>Method</h3><p>The current study utilised actigraphy and questionnaire-based measures in mothers of autistic children and adolescents (n = 11), and mothers of typically developing (TD) children and adolescents (n = 11). Actigraphy is an objective, non-intrusive method for examining sleep. It involves wearing a wristwatch-like microcomputer that records motion. Measures included the Pittsburgh Sleep Quality Index, Autoimmune Disease in Family Members Questionnaire, Parenting Stress Index-Short Form, World Health Organization Quality of Life Abbreviated Version (WHOQOL-BREF), Hospital Anxiety and Depression Scale, and the Multidimensional Scale of Perceived Social Support.</p></div><div><h3>Results</h3><p>Mothers of autistic children had significantly greater difficulties with subjective sleep quality, sleep duration, sleep efficiency, and daytime dysfunction, than mothers of TD children. In mothers of autistic children, parental use of sleep medication on the PSQI was positively associated with objective sleep onset latency using actigraphy, with a large effect size. Families with an autistic child had significantly more family members with osteoarthritis and rheumatoid arthritis than did families of TD children. Families of autistic children had significantly more autistic family members than did families of TD children.</p></div><div><h3>Conclusions</h3><p>Mothers of autistic children had significantly higher levels of stress, anxiety, depression, and lower levels of quality of life and perceived social support, than parents of TD children. Sleep problems identified via actigraphy were associated with parental stress, anxiety and depression, and quality of life.</p></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"117 ","pages":"Article 102462"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint attention and maternal attention across varying dyadic interactions for autistic children","authors":"Andrew Dakopolos,&nbsp;Laudan B. Jahromi,&nbsp;Marla R. Brassard,&nbsp;Douglas Greer","doi":"10.1016/j.rasd.2024.102452","DOIUrl":"10.1016/j.rasd.2024.102452","url":null,"abstract":"<div><h3>Background</h3><p>Joint attention (JA) is an area of delay associated with autism. Individual differences in JA are shown to relate to language development. The present study examined JA initiations (IJA) and responses to JA (RJA) of autistic children in structured and unstructured contexts with their mothers to examine the relation between mother attention and JA.</p></div><div><h3>Method</h3><p>Forty-two autistic children (ages 2.5 to 5.5 years) and their mothers engaged in 15 m interactions in three social contexts (competing demands, teaching, free play). Children were categorized by language level into limited language (N = 20) and verbal (N = 21) groups based on ADOS-2 module to assess group and contextual differences. Contingency analyses assessed bi-directional temporal relations between observed child JA and mother attention in lagged intervals.</p></div><div><h3>Results</h3><p>Rate of children’s IJA and maternal attention differed depending on the context of their interaction. Child IJA and mother attention showed a bi-directional temporally contingent association such that child IJA predicted subsequent maternal attention, and maternal attention predicted subsequent child IJA. RJA was unrelated to maternal attention in contingency analyses. Post-hoc analyses indicated a language level group by receptive communication, and group by expressive communication interaction on the contingency between child IJA and subsequent mother attention such that a stronger contingency emerged for dyads wherein children had limited language.</p></div><div><h3>Conclusions</h3><p>The present study illustrates the important role that children’s social communication behaviors may have within mother-child social interactions, and how children’s verbal ability, as well as the context of the social interaction may influence bi-directional social attention.</p></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"117 ","pages":"Article 102452"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141637220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toe walking in children and adolescents with Autism Spectrum Disorder: Relationship with sensory and motor functions,language, cognition, and autism severity","authors":"Michela Camia ,&nbsp;Roberto Sacco ,&nbsp;Maria Boncoddo ,&nbsp;Fabiana Bellomo ,&nbsp;Francesca Cucinotta ,&nbsp;Arianna Ricciardello ,&nbsp;Laura Turriziani ,&nbsp;Pasquale Tomaiuolo ,&nbsp;Riccardo Cuoghi Costantini ,&nbsp;Roberto D'Amico ,&nbsp;Antonio M. Persico","doi":"10.1016/j.rasd.2024.102457","DOIUrl":"10.1016/j.rasd.2024.102457","url":null,"abstract":"<div><h3>Background</h3><p>Children and adolescents with Autism Spectrum Disorder (ASD) often present motor signs and symptoms, including toe walking (TW). The pathophysiology of TW in ASD is not fully understood. In particular, it is debated whether it may represent a persistent primitive walking pattern or the result of abnormal processing of sensory input from the lower limbs and feet. The present study is aimed at assessing the association between TW and cognitive, sensory, motor and language functions, as well as autism severity.</p></div><div><h3>Method</h3><p>We enrolled 112 children and adolescents with ASD, 61 with TW and 51 without TW. A complete psychodiagnostic assessment was performed, including ADOS-2, ADI-R, PEP-3, IQ testing or Griffiths Mental Developmental Scales, and Short Sensory Profile.</p></div><div><h3>Results</h3><p>Children and adolescents with TW have significantly lower cognitive level, greater language and motor impairment, as well as greater autism severity. Instead, no difference in severity of sensory abnormalities or in sensory profile emerges between cases with and without TW.</p></div><div><h3>Conclusions</h3><p>the present data are most compatible with a model interpreting TW as a behavioral pattern resulting from the persistence of a primitive walking pattern (i.e. lack of heel strike, prior to the acquisition of plantar walking) or possibly of archaic tonic reflexes, rather than as a consequence primarily of abnormal sensory processing. Health practitioners should monitor the gait of autistic children and plan appropriate interventions, aimed at promoting the adoption of more mature plantar walking patterns.</p></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"117 ","pages":"Article 102457"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1750946724001326/pdfft?md5=248647b2f1bfd3e3da731111e9ab688e&pid=1-s2.0-S1750946724001326-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141882469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negotiating good motherhood: Lived experiences of mothers of children with autism spectrum disorder in China","authors":"Ying Liu ,&nbsp;Jialiang Cui","doi":"10.1016/j.rasd.2024.102455","DOIUrl":"https://doi.org/10.1016/j.rasd.2024.102455","url":null,"abstract":"<div><h3>Background</h3><p>Understanding how mothers negotiate the expectations of good motherhood ideology is vital for supporting mothers of children with ASD. This paper explored how Chinese mothers of children with ASD constructed the concept of good motherhood, and how this construct was formed, resisted and negotiated in the reality of caregiving.</p></div><div><h3>Method</h3><p>In-depth interviews were conducted with 21 mothers, revealing three major themes: (1) negotiating the role expectation of a super mother; (2) negotiating the emotional expectation of a rational mother; and (3) negotiating the moral expectation of a selfless mother.</p></div><div><h3>Results</h3><p>Findings indicate that when caring for children with ASD, mothers were expected to assume multiple roles responsibilities, perform emotion work and sacrifice their own needs to become good mothers. Instead of simply conforming to the good motherhood ideology, mothers employed various strategies to reflect on and even resist these expectations. Through these efforts, mothers actively constructed their own perceptions of good mothering based on their individual experiences, contributing to diverse knowledge of motherhood.</p></div><div><h3>Conclusions</h3><p>The findings underscore the importance of future support services to acknowledge the agency of mothers of children with ASD and utilize empowering approaches to accommodate their comprehensive needs.</p></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"117 ","pages":"Article 102455"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the effects of age and sex on sensory sensitivities in middle and older aged autistic adults","authors":"Rebecca A. Charlton ,&nbsp;Goldie A. McQuaid ,&nbsp;Gregory L. Wallace","doi":"10.1016/j.rasd.2024.102460","DOIUrl":"10.1016/j.rasd.2024.102460","url":null,"abstract":"<div><h3>Purpose</h3><p>Although sensory sensitivities are common among autistic people, few studies have explored how they may be impacted by ageing. Little is known about the experiences of autistic people across adulthood or about the experiences of people assigned female-at-birth. Some results suggest that autistic people assigned female-at-birth report more sensory sensitivities, but little is known about experiences in middle-aged and older autistic people assigned female-at-birth.</p></div><div><h3>Methods</h3><p>This study explored self-reported sensory sensitivities and sensory acuity in 210 autistic people aged 42–80 years old. Associations between age and sensory sensitivities were examined using correlational and regression analyses, and t-tests explored differences based on sex-assigned-at-birth.</p></div><div><h3>Results</h3><p>No significant correlation was observed between age and sensory sensitivities, although older age was associated with poorer sensory acuity. Poorer acuity in vision and hearing was associated with more sensory sensitivities. People assigned female-at-birth reported higher scores for overall sensory sensitivities and low temperature/pain tolerance. Sex-assigned-at-birth, sensory acuity and an age-x-sensory acuity interaction term contributed significantly to a regression model explaining overall sensory sensitivity, but age did not contribute significantly.</p></div><div><h3>Conclusion</h3><p>This cross-sectional study suggests that sensory sensitivities are stable across middle-age and older adulthood. Results contrast with previous studies in young adults which have suggested reduction in sensory sensitivities with age. In keeping with studies of younger people, middle-age and older autistic adults assigned female-at-birth report higher rates of sensory sensitivities than comparably aged autistic adults assigned male-at-birth. If further studies examining individual change in sensory sensitives replicate these results, then they may contribute to understanding care needs of autistic older people.</p></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"117 ","pages":"Article 102460"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1750946724001351/pdfft?md5=b61007f3fdd65dd15795c9dfc6a90bd9&pid=1-s2.0-S1750946724001351-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141882524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationships between restrictive/repetitive behaviours, intolerance of uncertainty, and anxiety in autism: A systematic review and meta-analysis","authors":"Sydney Bird ,&nbsp;Lucy Anne Elizabeth Moid ,&nbsp;Christopher A. Jones ,&nbsp;Andrew D.R. Surtees","doi":"10.1016/j.rasd.2024.102428","DOIUrl":"https://doi.org/10.1016/j.rasd.2024.102428","url":null,"abstract":"<div><p>Autistic people are more likely to experience anxiety than their non-autistic peers. Understanding mechanisms underpinning anxiety in autism is a vital aspect of developing effective interventions. Intolerance of uncertainty (IU) and restrictive/repetitive behaviours (RRBs) are proposed to contribute to anxiety for autistic people. This paper includes the first meta-analysis to investigate the associations between all three of these variables. A systematic search identified 33 papers that measured anxiety, IU and RRBs in 8347 autistic participants. Evidence was found for positive correlations between all three variables. Analysis of average participant age demonstrated that the relationship between anxiety and IU was stronger in younger participants. No significant differences were found between the associations in studies that included participants with intellectual disabilities and those that did not. A quality assessment framework identified methodological threats to validity. Most studies had good methods of recruitment; however, many anxiety and IU measurement tools were unvalidated in autistic populations. Results suggest that IU and RRBs should be considered when designing anxiety interventions for autistic people, however, the role of RRBs in particular needs to be investigated further to prevent interventions from taking away important coping strategies due to misunderstanding of causal relationships.</p></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"117 ","pages":"Article 102428"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S175094672400103X/pdfft?md5=a113197c1e2871a2cd0318df33199d8e&pid=1-s2.0-S175094672400103X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporating self-advocacy and empowerment into small group therapy for adults on the autism spectrum: A pilot study","authors":"James A. Rankin ,&nbsp;Grace M. DiGiovanni ,&nbsp;Elizabeth S. McKeown,&nbsp;Chandni K. Shah,&nbsp;Edward S. Brodkin","doi":"10.1016/j.rasd.2024.102425","DOIUrl":"https://doi.org/10.1016/j.rasd.2024.102425","url":null,"abstract":"<div><h3>Purpose</h3><p>Few programs exist which address the needs of autistic adults. <em>Training to Understand and Navigate Emotions and Interactions</em> (TUNE In), a 17-week cognitive-behavioral treatment program, was developed to support autistic adults by addressing social anxiety and motivation, social skills and cognition, and generalization of skills. The most recent iteration of TUNE In included a 4-session self-advocacy component which provided an opportunity to apply the skills learned from earlier parts of TUNE In.</p></div><div><h3>Methods</h3><p>As part of a novel program, <em>Training to Understand and Navigate Emotions and Interactions</em> (TUNE In), participants advocated for themselves and described their experiences to an audience of health care practitioners, researchers, and therapists who work with people on the autism spectrum. Of 18 participants who completed the TUNE In program, 15 participated in a qualitative interview, using a phenomenological approach, about their understanding of and receptivity to TUNE In, as well as its usefulness and utility in their daily lives.</p></div><div><h3>Results</h3><p>The majority of participants found benefit from the self-advocacy project component, with most participants indicating they felt empowered by the experience. Participants reported enjoyment and empowerment in presenting to the audiences, as the participants could express their interests, engage others in conversation, hear other autistic perspectives, and engage in dialogues about how psychological and medical treatments should change. Participants felt they were able to apply skills learned from earlier sessions of TUNE In throughout the advocacy presentations.</p></div><div><h3>Conclusion</h3><p>This study highlights that advocacy can be incorporated into treatment without sacrificing the goals of the treatment itself. Based on participant feedback, suggestions for program refinement, implications for social skills programs, and application of advocacy and empowerment to adult group therapies are discussed.</p></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"117 ","pages":"Article 102425"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facing Your Fears in autistic youth with co-occurring psychiatric conditions: Reductions in symptoms of anxiety and depression","authors":"C.A. McMorris ,&nbsp;K. Turner ,&nbsp;K. Johnston ,&nbsp;C.A. Clark ,&nbsp;S.J. Howe ,&nbsp;M. McConnell ,&nbsp;K. McFee","doi":"10.1016/j.rasd.2024.102463","DOIUrl":"10.1016/j.rasd.2024.102463","url":null,"abstract":"<div><p>Autistic youth often experience psychiatric complexity, with up to 70 % of youth experiencing at least one mental health issue, and as many as 41 % experiencing two or more issues simultaneously, or complex psychiatric comorbidity. Adapted cognitive behaviour therapy (CBT) for anxiety is effective in reducing anxiety symptoms in autistic youth who have multiple anxiety conditions, as well as other psychiatric conditions (e.g., attention deficit hyperactivity disorder; ADHD). However, few studies have examined the secondary impact of CBT for anxiety on depressive symptoms, despite the high prevalence of depression in autistic youth. Additionally, it is unknown how psychiatric complexity may impact, or moderate, autistic youth’s response to treatment. Fifty-one autistic youth (8–13 years old) participated in an adapted CBT intervention for anxiety (Facing Your Fears). Participants were categorized into one of three groups of increasing psychiatric complexity (Anxiety only; Anxiety + ADHD; and Anxiety + other mental health conditions). Paired sample t-tests and linear mixed models highlighted that autistic youth generally benefitted from CBT for anxiety, as seen in reductions of anxiety and depressive symptoms. Caregivers of youth in all diagnostic groups reported a significant reduction in anxiety symptoms and depression at post-treatment; however, only youth in the Anxiety only group, or those with less psychiatric complexity, reported a reduction in anxiety. Autistic youth did not report any changes in depressive symptoms, regardless of psychiatric complexity. Further study is needed to determine if symptom reductions continue overtime, and whether participating in adapted CBT for anxiety is associated with reductions in other mental health symptoms.</p></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"117 ","pages":"Article 102463"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1750946724001387/pdfft?md5=0b4b431c38e617b2a06bbba1de9f18dc&pid=1-s2.0-S1750946724001387-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142041337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}