Research in Autism Spectrum Disorders最新文献

{"title":"Effects of alpha rhythm-guided repetitive transcranial magnetic stimulation on sleep and quality of life outcomes in autistic children: A chart review","authors":"Uchenna Ezedinma, Evan Jones, Scott Burgess, Gary Campbell, Shauna Fjaagesund, Alexandra P. Metse, Terri Downer, Florin Oprescu","doi":"10.1016/j.reia.2026.202823","DOIUrl":"https://doi.org/10.1016/j.reia.2026.202823","url":null,"abstract":"There is growing, albeit limited, evidence regarding the effects of alpha rhythm-guided repetitive transcranial magnetic stimulation (α-rTMS) on sleep and quality of life outcomes in autistic children within a clinical setting. Clinical charts, including the Children Sleep Habit Questionnaire (CSHQ) and the Paediatric Quality of Life Inventory 4.0 (PedsQLTM 4.0), were collected from participants before and after they completed nine sessions of α-rTMS. The pre-post data were analysed using paired Student t- tests. Data from the clinical charts of 36 participants (24 males and 12 females) aged between 3 and 17 years (mean (SD): 7.6 (3.5) years) were analysed. Among the participants, eight (22 %) and twenty-eight (78 %) were diagnosed with autism levels 2 and 3, respectively. The mean pre-post CSHQ analysis revealed significant improvements in the total CSHQ score (p = 0.035) and in specific subdomains: sleep duration (p = 0.035), night waking (p = 0.050), and daytime sleepiness (p = 0.026). Additionally, the mean post-total PedsQLTM 4.0 score showed significant improvement (p = 0.005), including in the emotional (p < 0.001), social (p = 0.018), and school (p = 0.019) subdomains. This study contributes to the growing evidence on the positive effects of α-rTMS on sleep difficulties and the quality of life of autistic children. Nonetheless, the findings should be interpreted cautiously until larger numbers of participants are studied within a robust study design. • Sleep difficulties co-occurring in autistic children are prevalent and significant. • Alpha rhythm-guided repetitive transcranial magnetic stimulation (α-rTMS) may be an alternative therapeutic option. • Autistic children who received α-rTMS showed improvements in sleep difficulties and quality of life. • Further robust study on α-rTMS for its translation into clinical practice is warranted.","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"131 1","pages":"202823-202823"},"PeriodicalIF":0.0,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining health behaviour profiles among children with autism and ADHD using latent profile analysis","authors":"Matthew Bourke, Martin O’Flaherty, Kathryn Fortnum, George Thomas, Jacqueline L. Walker","doi":"10.1016/j.reia.2025.202751","DOIUrl":"https://doi.org/10.1016/j.reia.2025.202751","url":null,"abstract":"Children diagnosed with autism and ADHD are at heightened risk for poor physical and mental health outcomes, potentially linked to suboptimal engagement in health-promoting behaviours. While multiple health promoting behaviours often co-occur, limited research has explored how combinations of physical activity, screen time, diet, and sleep cluster among children with ADHD and/or autism. This study employed latent profile analysis to identify distinct health behaviour profiles in a community sample of 982 Australian children aged 7–12 years with parent-reported diagnoses of autism, ADHD, or both. Parents completed validated questionnaires assessing children’s physical activity, sedentary screen time, diet quality, total sleep time, and sleep disturbances. Five latent profiles were identified, ranging from generally healthy to highly unhealthy behaviour patterns. Children with co-occurring autism and ADHD or a sole diagnosis of autism were significantly more likely to be represented in the least healthy profiles—marked by low physical activity, high screen time, poor diet quality, and greater sleep disturbances—compared to those with a sole diagnosis of ADHD. Findings highlight the need for targeted, multi-component interventions to support healthier lifestyles, especially among children with autism or co-occurring autism and ADHD. Tailored strategies may help mitigate long-term health risks in this vulnerable population by addressing the unique barriers they face in adopting and sustaining healthy behaviours. • Children with both autism and ADHD showed least healthy behaviours. • ADHD-only group most likely to engage in healthiest behaviours. • Profiles varied by activity, screen time, sleep, and diet. • Results support tailored, multi-behaviour health interventions.","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"130 1","pages":"202751-202751"},"PeriodicalIF":0.0,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental function in the dental management of pediatric patients with autistic spectrum disorder: A systematic review","authors":"Myriam Angélica De la Garza-Ramos, Guillermo Cano‐Verdugo, Angie Nathaly Verdugo-Rojas, Norma Cruz Fierro","doi":"10.1016/j.reia.2025.202558","DOIUrl":"https://doi.org/10.1016/j.reia.2025.202558","url":null,"abstract":"","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"123 1","pages":"202558-202558"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brief report: Social relationships among autistic young adults with varying cognitive abilities","authors":"Dena Gohari,&nbsp;Jamie Park,&nbsp;Hillary Schiltz,&nbsp;Catherine Lord","doi":"10.1016/j.rasd.2024.102524","DOIUrl":"10.1016/j.rasd.2024.102524","url":null,"abstract":"<div><h3>Background</h3><div>Autism is characterized by social difficulties, yet many autistic people value and desire social relationships. Given the limited research on autism in adulthood, particularly among those with lower cognitive ability, this study aimed 1) to compare self- vs informant-report of social relationships (acquaintances, friendships, and interpersonal difficulties) and 2) to compare social relationships, between more cognitively able (MCA) and less cognitively able (LCA) autistic young adults.</div></div><div><h3>Method</h3><div>Participants included 101 autistic young adults (M_<em>age</em>=25.90; SD=1.41; 82.0 % male; 79.8 % White) and their informants. Participants were interviewed, and the Interpersonal Difficulties and Social Relationships sections of the Social and Emotional Functioning Interview (SEF) were analyzed. Participants were classified as MCA (IQ≥70) or LCA (IQ&lt;70).</div></div><div><h3>Results</h3><div>For the MCA sample, informant and self-report SEF scores were all positively correlated and did not have significantly different median values. Weaker and non-significant associations emerged for social contexts outside of the home (e.g., at work) and more abstract concepts (e.g., quality of relationships). Although cognitive ability impacted the extreme SEF scores (e.g., having self-initiated reciprocal friendships), many social difficulties were shared by LCA and MCA young adults, according to informant reports.</div></div><div><h3>Conclusions</h3><div>This study is one of few on social relationships and autism to focus on adulthood and include LCA young adults. Results indicate that informant-report provides useful information on more concrete aspects of social relationships in this population. Many autistic young adults, and LCA young adults in particular, may benefit from additional social supports, yet it is also essential to collaboratively consider what types of social experiences and relationships are desired and feasible for each person. More research and intervention tailored to LCA autistic young adults are needed.</div></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"119 ","pages":"Article 102524"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the general psychopathology factor in autistic youth","authors":"Hannah Muriel Robb Burrows ,&nbsp;Brianne Derby ,&nbsp;Laura de la Roche ,&nbsp;Melissa Susko ,&nbsp;Rob Nicolson ,&nbsp;Stelios Georgiades ,&nbsp;Jessica Jones ,&nbsp;Evdokia Anagnostou ,&nbsp;Elizabeth Kelley","doi":"10.1016/j.rasd.2024.102519","DOIUrl":"10.1016/j.rasd.2024.102519","url":null,"abstract":"<div><h3>Background</h3><div>Autistic youth are at higher risk of presenting with co-occurring internalizing (I) (i.e., anxiety and depression) and externalizing (E) (i.e., aggression and impulsivity) disorders (Bauminger et al., 2010). The <em>Child Behavior Checklist for ages 6–18</em> (CBCL/6-18; Achenbach &amp; Rescorla, 2001) is a measure of I-E disorders and symptoms in autistic and neurotypical youth, providing norm-referenced subscales as factors for each form of psychopathology. The general psychopathology or “<em>p</em>” factor may provide a better measure of co-occurring disorders in autism as it has not been evaluated in this population contextually to date. The <em>p</em> factor proposes that psychopathological disorders come from the same etiological factor, implying that we can measure all I-E disorders as indicators of <em>p</em>.</div></div><div><h3>Method</h3><div>Using archival data from the <em>Province of Ontario Neurodevelopmental Disorders</em> (POND) <em>Network</em>, (<em>N</em> = 782) autistic youths’ raw scores from the CBCL/6-18 were analyzed using two confirmatory factor analyses (CFAs): an I-E CFA and a <em>p</em> factor CFA. An exploratory factor analysis (EFA) was also conducted to determine the best-fitting factor structure.</div></div><div><h3>Results</h3><div>A chi-square difference test compared each CFA to find the best model fit. Results reported each model as individually significant, however, based on recommendations from Hoyle and Panter (1995), neither model had an acceptable fit.</div></div><div><h3>Conclusions</h3><div>Given that neither the <em>p</em> factor nor the internalizing/externalizing factor models had appropriate fit, it is recommended that future research investigate whether the CBCL/6–18 is the most appropriate measure for assessing co-occurring symptoms in autistic youth. The results of the EFA also suggest that the CBCL may not be the most appropriate measure for autistic youth.</div></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"119 ","pages":"Article 102519"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Child sleep onset latency mediates parental depression and noncompliance in autistic children","authors":"Melanie A. Stearns ,&nbsp;Braden Hayse ,&nbsp;Neetu Nair ,&nbsp;Micah Mazurek ,&nbsp;Ashley F. Curtis ,&nbsp;David Beversdorf ,&nbsp;Kristin Sohl ,&nbsp;Julie Muckerman ,&nbsp;Christina S. McCrae","doi":"10.1016/j.rasd.2024.102518","DOIUrl":"10.1016/j.rasd.2024.102518","url":null,"abstract":"<div><h3>Background</h3><div>Parents diagnosed with depression often report that their children have difficulty following rules and falling asleep. Parents with depression are less likely to be consistent or enforce bedtimes, resulting in the child having fewer bedtime rules and getting less sleep. Over time this may mean the child develops poor sleep habits and difficulty falling asleep. Although these relationships have yet to be studied in children diagnosed with Autism Spectrum Disorder (ASD), it is an important area given that approximately 80 % of autistic children have sleep difficulties.</div></div><div><h3>Methods</h3><div>The current study examined whether parent-reported child sleep onset latency (SOL) mediated the relationship between parental depression and child noncompliance. The sample (<em>N</em>=34) consisted of parents (82 % female) reporting on their children aged 6–12 (<em>M</em>=8.63, <em>SD</em> = 2.00; 76.5 % male). All children were diagnosed with ASD and had parent-reported sleep complaints. Measures included the Child Sleep Health Questionnaire (CSHQ), the Pediatric Symptom Checklist (PSC), and a question asking if the parent had been diagnosed with depression (yes/no).</div></div><div><h3>Results</h3><div>Greater parent-reported child SOL significantly mediated the relation between increased parental depression and greater noncompliance.</div></div><div><h3>Conclusions</h3><div>These results suggest that difficulty falling asleep may help to explain why children of parents who have depression are noncompliant.</div></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"119 ","pages":"Article 102518"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fit club: Outcomes from 35-minute daily exercise program for autistic adolescents","authors":"Claudia L. Hilton ,&nbsp;Diane M. Collins ,&nbsp;Julie Jones ,&nbsp;Joanne Flanagan ,&nbsp;Cora Carillo ,&nbsp;Karen Ratcliff","doi":"10.1016/j.rasd.2024.102504","DOIUrl":"10.1016/j.rasd.2024.102504","url":null,"abstract":"<div><h3>Background</h3><div>Autistic children and adolescents have academic performance challenges and are often reluctant to participate in physical activities. Executive function (EF) abilities generally remain stable or worsen as autistic children get older and obesity and lack of physical fitness are frequent concerns experienced by these individuals. Finding ways to address these concerns has the potential to improve outcomes in autistic youth.</div></div><div><h3>Method</h3><div>We conducted a 12-month, repeated-measures study to examine the effectiveness of a mandatory 35-minute daily school physical activity intervention involving low to moderate exertion for autistic adolescents (n = 29). Changes in fitness, EF, social responsiveness, and restrictive and repetitive behaviors were examined.</div></div><div><h3>Results</h3><div>Significant improvements were seen in fitness, EF areas (specifically cognitive flexibility and planning/organizing), restrictive and repetitive behaviors and social responsiveness.</div></div><div><h3>Conclusion</h3><div>Findings suggest that participation in a mandatory daily 35-minute physical activity program with low to moderate exertion is feasible and may contribute to improved EF, fitness, restricted and repetitive behavior, and social responsiveness in autistic adolescents.</div></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"119 ","pages":"Article 102504"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An evaluation of the collateral child and parent outcomes of telehealth-delivered behavioral sleep intervention for Autistic children","authors":"Monique Clarke ,&nbsp;Laurie McLay ,&nbsp;Karyn France ,&nbsp;Neville Blampied","doi":"10.1016/j.rasd.2024.102514","DOIUrl":"10.1016/j.rasd.2024.102514","url":null,"abstract":"<div><h3>Purpose</h3><div>This research follows two studies that examined the efficacy and acceptability of a stepped-care model of behavioral sleep intervention (BSI) delivered to parents of Autistic children via telehealth (Clarke et al., 2024a, 2024b). The current study investigated the collateral benefits of these interventions on Autistic children’s internalizing and externalizing behaviors, health-related quality of life, and parent ratings of relationship quality, depression, anxiety, stress, and personal sleep quality.</div></div><div><h3>Methods and Results</h3><div>Data were available for 17 Autistic children (aged 3–17 years) and 22 parent participants (16 mothers, six fathers) who had received a telehealth-delivered behavioral sleep intervention (TDBSI). Parents completed a range of psychometric assessments at baseline and within six weeks of completing the program. Alongside reduced sleep problem severity (SPS), significant improvements, as indexed by non-negligible Cohen’s <em>d</em> values whose 95 % confidence intervals did not cross zero, were observed in children’s emotional and behavioral difficulties and health-related quality of life. Parents also reported that improvement in their child’s sleep positively influenced their own sleep quality and emotional well-being. There were no significant changes in parental relationship quality post-intervention, probably a ceiling effect.</div></div><div><h3>Conclusion</h3><div>TDBSIs have the potential to generate collateral benefits for Autistic children and their families. This finding is consistent with the limited existent research, suggesting that improved sleep may enhance child and parent well-being. Future research should focus on understanding the mechanisms underlying collateral change, including variations in effects among children and parents, and the durability across different telehealth modalities (i.e., self-directed versus therapist-guided) and follow-up intervals.</div></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"119 ","pages":"Article 102514"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates of age at first alcohol use among a US-based sample of autistic underage youth","authors":"Calliope Holingue ,&nbsp;Laura Graham Holmes ,&nbsp;Julia Cusano ,&nbsp;Emily F. Rothman","doi":"10.1016/j.rasd.2024.102520","DOIUrl":"10.1016/j.rasd.2024.102520","url":null,"abstract":"<div><h3>Background</h3><div>Recent research has identified risk factors for hazardous alcohol use among autistic individuals, but correlates of age at first alcohol use are unclear.</div></div><div><h3>Methods</h3><div>This study analyzed 49 U.S.-based autistic youth (ages 16–20) who had ever consumed alcohol. Participants were categorized as being less than 16 years old (n=28) or 16 years or older (n=21) at first alcohol use. The analysis aimed to descriptively compare youth with younger versus older age at first alcohol use.</div></div><div><h3>Results</h3><div>Younger age at first alcohol use was associated with hazardous alcohol use, higher levels of anxiety, and lower masking of autistic traits</div></div><div><h3>Conclusions</h3><div>These findings demonstrate that autistic youth are at risk for underage alcohol use. More research is needed on alcohol and substance use in this population to develop tailored prevention and intervention programs.</div></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"119 ","pages":"Article 102520"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which emerging autism features at 12 months of age are associated with later parent-child interaction?","authors":"Chengcheng Ke ,&nbsp;Lesley-Anne Carter ,&nbsp;Jonathan Green ,&nbsp;Andrew J.O. Whitehouse ,&nbsp;Kristelle Hudry ,&nbsp;Josephine Barbaro ,&nbsp;Cheryl Dissanayake ,&nbsp;Murray Maybery ,&nbsp;Slonims Vicky ,&nbsp;Leonie Segal ,&nbsp;Kandice Varcin ,&nbsp;Ming Wai Wan","doi":"10.1016/j.rasd.2024.102525","DOIUrl":"10.1016/j.rasd.2024.102525","url":null,"abstract":"<div><h3>Background</h3><div>Parent-child interactions (PCI) in infants with an elevated likelihood (EL) of autism start to diverge from other infants toward the end of the first year. This divergence is often attributed to emerging features of autism impacting infant social interactions in ways that become increasingly amplified. The aim was to identify which, if any, 12-month autism features were associated with later PCI qualities.</div></div><div><h3>Method</h3><div>Twelve-month-old infants (N = 103) with early autism features (3+ on the Social Attention and Communication Surveillance-Revised tool) were assessed on the Autism Observation Scale for Infants (AOSI) at 12 and 18 months, and on free play PCI using the Manchester Assessment of Caregiver-Infant Interaction at 18 months.</div></div><div><h3>Results</h3><div>AOSI autism features at 12-months were associated with 18-month PCI qualities, independent of 18-month autism features. Specifically, infants with emerging features in social attention areas later showed less attentiveness to parents and lower dyadic mutuality. By contrast, infants with emerging sensorimotor atypicality/delay later showed increased attentiveness to parents and lower negative affect, their parents were more sensitively responsive, and their interactions were more mutual. Emotional regulation scores had no significant association with later PCI.</div></div><div><h3>Conclusions</h3><div>The findings support the notion that PCI changes in EL infants are rooted in the transactional impact of early emerging autism-related features, which may have differential effects on PCI. Pending replication in a larger sample using a detailed measure of early autism features, the findings suggest that early autism features may amplify or elicit interactions.</div></div>","PeriodicalId":48255,"journal":{"name":"Research in Autism Spectrum Disorders","volume":"119 ","pages":"Article 102525"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142722056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}