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Modulation of Subcellular Redox Homeostasis with Trialkylphosphines. 用三烷基膦调节亚细胞氧化还原稳态
IF 1.2 1区 文学
Modern Language Journal Pub Date : 2022-04-27 DOI: 10.2533/chimia.2022.308
Jade Nguyen
{"title":"Modulation of Subcellular Redox Homeostasis with Trialkylphosphines.","authors":"Jade Nguyen","doi":"10.2533/chimia.2022.308","DOIUrl":"10.2533/chimia.2022.308","url":null,"abstract":"<p><p>Redox homeostasis is essential for cell function and its disruption is associated with multiple pathologies. Redox balance is largely regulated by the relative concentrations of reduced (GSH) and oxidized (GSSG) glutathione. In eukaryotic cells, this ratio is different in each cell compartment. There is a lack of chemical probes able to modulate GSH/GSSG in order to study the impact of redox stress in an organelle specific manner. Here, we highlight the importance of trialkylphosphines to induce reductive stress and how it can be targeted to a specific organelle. Our probe is selectively activated by endogenous nitroreductases, and releases tributylphosphine to trigger redox stress in mitochondria. Mechanistic studies revealed that the induced stress activates a cellular response orchestrated by transcription factor ATF4, which upregulates genes involved in glutathione catabolism.</p>","PeriodicalId":48249,"journal":{"name":"Modern Language Journal","volume":"58 1","pages":"308-311"},"PeriodicalIF":1.2,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90510934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
At the Intersection of SLA and Sociolinguistics: The Predictive Power of Social Networks During Study Abroad 二语习得与社会语言学的交汇点：留学期间社会网络的预测力
IF 4.9 1区 文学
Modern Language Journal Pub Date : 2022-03-29 DOI: 10.1111/modl.12763
Kristen M. KENNEDY TERRY
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引用次数: 2
Bridging the Gap Between Willingness to Communicate and Learner Talk 弥合沟通意愿和学习者谈话之间的差距
IF 4.9 1区 文学
Modern Language Journal Pub Date : 2022-03-27 DOI: 10.1111/modl.12764
N. Ducker
{"title":"Bridging the Gap Between Willingness to Communicate and Learner Talk","authors":"N. Ducker","doi":"10.1111/modl.12764","DOIUrl":"https://doi.org/10.1111/modl.12764","url":null,"abstract":"","PeriodicalId":48249,"journal":{"name":"Modern Language Journal","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41957277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Noun‐Phrase Complexity Measures in Chinese and Their Relationship to L2 Chinese Writing Quality: A Comparison with Topic–Comment‐Unit‐Based Measures 汉语名词-短语复杂性测度及其与二语写作质量的关系:与主题-评论-单位测度的比较
IF 4.9 1区 文学
Modern Language Journal Pub Date : 2022-03-22 DOI: 10.1111/modl.12766
Xiaofei Lu, Jifeng Wu
{"title":"Noun‐Phrase Complexity Measures in Chinese and Their Relationship to L2 Chinese Writing Quality: A Comparison with Topic–Comment‐Unit‐Based Measures","authors":"Xiaofei Lu, Jifeng Wu","doi":"10.1111/modl.12766","DOIUrl":"https://doi.org/10.1111/modl.12766","url":null,"abstract":"","PeriodicalId":48249,"journal":{"name":"Modern Language Journal","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48123129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
The Relationship Between Lexical Coverage and Type of Reading Comprehension in Beginning L2 Spanish Learners 初级二语学习者词汇覆盖与阅读理解类型的关系
IF 4.9 1区 文学
Modern Language Journal Pub Date : 2022-02-24 DOI: 10.1111/modl.12761
Eric Herman, Michael J. Leeser
{"title":"The Relationship Between Lexical Coverage and Type of Reading Comprehension in Beginning L2 Spanish Learners","authors":"Eric Herman, Michael J. Leeser","doi":"10.1111/modl.12761","DOIUrl":"https://doi.org/10.1111/modl.12761","url":null,"abstract":"","PeriodicalId":48249,"journal":{"name":"Modern Language Journal","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45002170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
“I Look Mexican, So They Assume I Speak Spanish”: Latinx Teacher Candidates’ Experiences With Raciolinguistic Policing “我看起来像墨西哥人，所以他们以为我说西班牙语”:拉丁裔教师候选人的种族语言警察经历
IF 4.9 1区 文学
Modern Language Journal Pub Date : 2022-02-23 DOI: 10.1111/modl.12762
Christian Fallas-Escobar, Kathryn I. Henderson, Kristen M Lindahl
{"title":"“I Look Mexican, So They Assume I Speak Spanish”: Latinx Teacher Candidates’ Experiences With Raciolinguistic Policing","authors":"Christian Fallas-Escobar, Kathryn I. Henderson, Kristen M Lindahl","doi":"10.1111/modl.12762","DOIUrl":"https://doi.org/10.1111/modl.12762","url":null,"abstract":"","PeriodicalId":48249,"journal":{"name":"Modern Language Journal","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43596178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Retention and Attrition in Early‐Career Foreign Language Teachers in Austria and the United Kingdom 奥地利和英国早期职业外语教师的留存和流失
IF 4.9 1区 文学
Modern Language Journal Pub Date : 2022-02-23 DOI: 10.1111/modl.12765
Giulia Sulis, Sonja Babic, Astrid Mairitsch, Sarah Mercer, Jun-xi Jin, Jim King
{"title":"Retention and Attrition in Early‐Career Foreign Language Teachers in Austria and the United Kingdom","authors":"Giulia Sulis, Sonja Babic, Astrid Mairitsch, Sarah Mercer, Jun-xi Jin, Jim King","doi":"10.1111/modl.12765","DOIUrl":"https://doi.org/10.1111/modl.12765","url":null,"abstract":"","PeriodicalId":48249,"journal":{"name":"Modern Language Journal","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41774273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Implementation of an Uncontrolled, Real‐World Task: Vocabulary Learning Opportunities and Students’ Perceptions 一项不受控制的真实世界任务的实施：词汇学习机会和学生的感知
IF 4.9 1区 文学
Modern Language Journal Pub Date : 2022-01-03 DOI: 10.1111/modl.12742
Youjin Kim, Sanghee Kang, Meredith D'Arienzo
{"title":"Implementation of an Uncontrolled, Real‐World Task: Vocabulary Learning Opportunities and Students’ Perceptions","authors":"Youjin Kim, Sanghee Kang, Meredith D'Arienzo","doi":"10.1111/modl.12742","DOIUrl":"https://doi.org/10.1111/modl.12742","url":null,"abstract":"","PeriodicalId":48249,"journal":{"name":"Modern Language Journal","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49525630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visualizing Emergent Turn Construction: Seeing Writing While Speaking 视觉化突发转折结构：边看边说
IF 4.9 1区 文学
Modern Language Journal Pub Date : 2022-01-01 DOI: 10.1111/modl.12748
T. Greer, Zachary Nanbu
{"title":"Visualizing Emergent Turn Construction: Seeing Writing While Speaking","authors":"T. Greer, Zachary Nanbu","doi":"10.1111/modl.12748","DOIUrl":"https://doi.org/10.1111/modl.12748","url":null,"abstract":"","PeriodicalId":48249,"journal":{"name":"Modern Language Journal","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48674807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Functional Diversification and Progressive Routinization of a Multiword Expression in and for Social Interaction: A Longitudinal L2 Study 社会互动中多词表达的功能多样化和渐进式常规化:一项纵向二语研究
IF 4.9 1区 文学
Modern Language Journal Pub Date : 2022-01-01 DOI: 10.1111/modl.12758
Simona Pekarek Doehler, Klara Skogmyr Marian
{"title":"Functional Diversification and Progressive Routinization of a Multiword Expression in and for Social Interaction: A Longitudinal L2 Study","authors":"Simona Pekarek Doehler, Klara Skogmyr Marian","doi":"10.1111/modl.12758","DOIUrl":"https://doi.org/10.1111/modl.12758","url":null,"abstract":"","PeriodicalId":48249,"journal":{"name":"Modern Language Journal","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48858776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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