Vestnik medicinskogo instituta "REAVIZ": reabilitaciâ, vrač i zdorovʹe最新文献

{"title":"Effectiveness of simultaneous surgical treatment of patients with tuberculosis of multiple localizations: respiratory organs and lumbar spine","authors":"V. A. Khomenko, T. Sh. Guseynov, R. V. Tarasov, G. V. Chitorelidze, G. A. Asoyan, А. S. Khozikov, M. A. Bagirov","doi":"10.20340/vmi-rvz.2023.4.clin.7","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.clin.7","url":null,"abstract":"Objective: to show the effectiveness of simultaneous surgical treatment of patients with tuberculosis of multiple localizations: tuberculosis of the lungs and the lumbar spine.Materials and Methods. Simultaneous surgical treatment was performed in 24 patients. Evaluation of the effectiveness of treatment was carried out according to the signs of the early and later (after 12 months) postoperative period. Operational material for detection microbiologically and morphologically to determine its causative agent, drug sensitivity and inflammation activity.Results: the effectiveness of simultaneous surgical treatment was 87.3 %. The number of complications in the early postoperative period was 8.4 % (n = 2), in the late 4.2 % (n = 1). According to the results of the examination of the surgical material, tuberculosis was confirmed in 20 patients (83.3 %), both in the bone structure and in the lung tissue. In 4 (16.7 %) patients, nonspecific inflammation of the bone structure was noted.Conclusion: Simultaneous surgical treatment of tuberculosis of the lungs and lumbar spine is a highly effective method of treating tuberculosis of multiple localizations. It is possible to recommend the use of simultaneous surgical treatment for simultaneous sanitization of foci of infection, both in the lung tissue and in the spine.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"365 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136025570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimeglumin chlorin E6 as a photo-sensitizer in photodynamic therapy in non-oncological diseases","authors":"D. Yu. Semenov, V. K. Shubin, E. F. Stranadko, R. N. Komarov, M. V. Ryabov, Yu. K. Bogomazov, V. A. Morokhotov, A. N. Shcherbyuk, S. V. Morozov, Yu. I. Zakharov, E. V. Bondarenko, N. V. Karpov, P. B. Flegontov","doi":"10.20340/vmi-rvz.2023.4.clin.5","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.clin.5","url":null,"abstract":"This review demonstrates the possibilities of photodynamic therapy in treatment of non-tumor pathologies using dimeglumine chlorin E6 as a photosensitizer. Initially, the method was invented for the treatment of cancer and demonstrated its effectiveness and safety. In present photodynamic therapy successfully used in the treatment of the bronchus, skin, stomach, cervix, larynx cancer. In addition to the treatment of different localization tumors, various studies demonstrated other positive effects of photodynamic therapy: antimicrobial, antimycotic, autoimmune, reparative. In the presented review, dimeglumine chlorin E6, which is a derivative of chlorin e6, acts as a photosensitizer. It demonstrates safety, high selectivity of accumulation in tissues, and is characterized by a short period of excretion from the body. Using of dimeglumine chlorin E6 cans significantly reduce the number of side effects associated with long-term skin phototoxicity.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136025571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors for postoperative complications in assessing the results of surgical treatment of patients with perforated ulcer","authors":"M. М. Magomedov, M. D. Omarov, M. A. Magomedov","doi":"10.20340/vmi-rvz.2023.4.clin.4","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.clin.4","url":null,"abstract":"Emergency operations for perforated gastroduodenal ulcers are associated with a high incidence of postoperative complications. A number of studies have examined the impact of perioperative risk factors and comorbidities on postoperative morbidity after abdominal surgery, but only a few have looked at their role in perforated peptic ulcer disease. Aim. To determine possible associations between postoperative complications, comorbidity and perioperative risk factors for perforated gastroduodenal ulcer. Materials and methods . This study includes the anamnesis of 142 patients who underwent surgery for perforated gastroduodenal ulcer (PGD). In 74 cases (52.1 %), minimally invasive suturing operations were performed, in 68 cases, laparotomy suturing (47.9 %), in three cases, gastric resection was performed (2.3 %). Comparative studies between groups have not been conducted. Clinical data regarding patient characteristics, surgical techniques, and complications were collected retrospectively. Results. Postoperative complications associated with operations for perforated gastroduodenal ulcers amounted to 26.8 %, or 38 cases. A univariate analysis showed that prolonged open surgical time in female patients≥60 years of age, as well as a high American Society of Anesthesiologists (ASA) score, and the presence of preoperative shock were significant perioperative risk factors for postoperative complications. Significant comorbid risk factors included hypertension, diabetes mellitus, and lung disease. Multivariate analysis showed that long operation times, open surgery, high ASA scores, and preoperative shock were independent risk factors for postoperative complications in perforated gastroduodenal ulcer. Conclusions. High ASA, preoperative shock, open surgery, and long operative times of more than 148 minutes are high risk factors for morbidity. However, there is no association between postoperative complications and comorbidity in patients with perforated ulcers.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136025572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of hemodynamic parameters during chronic and acute episodic introduction of ethanol to animals in model experiments","authors":"S. I. Pavlenko, D. S. Gromova, O. A. Vedyasova, A. I. Budaev, A. A. Inyushkin","doi":"10.20340/vmi-rvz.2023.4.phys.1","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.phys.1","url":null,"abstract":"Diseases of the cardiovascular system continue to occupy the first place in the world among all causes of death in the population. One of the leading medical and social factors in the growth of the number of cardiovascular pathologies is alcohol consumption. The purpose of this work : to study the effect of chronic and acute episodic administration of ethanol on the features of hemodynamic parameters in rats. Materials and methods . The study was carried out on non-linear mature male rats. The group that underwent acute administration of ethanol every five days (days 1,6, 11, 16, 21) was intraperitoneally injected with a 20 % ethanol solution (5 g/kg).The group subjected to chronic alcoholization was offered 10 % ethanol solution as the only source of liquid for 21 days. Every five days in both groups, hemodynamic parameters such as systolic (SBP) and diastolic (DBP) blood pressure, heart rate (HR) were recorded. Results. With acute use of ethanol, already 30 minutes after administration, changes in hemodynamic parameters were found in the form of a decrease in SBP and DBP by an average of 43 %.60 minutes after the administration of ethanol, there was an increase in SBP and DBP by an average of 11 % relative to the initial data, which at the initial stage of alcohol consumption may be associated with a compensatory reaction of the cardiosystem in response to alcohol poisoning. Under conditions of chronic ethanol use, there was a decrease in the level of SBP, DBP and heart rate by an average of 16 % on the first day of the study, followed by their recovery to the initial values on the 21 st day of the study, which may be a sign of the development of a compensatory reaction of the body and indicate the beginning of the formation of alcoholic dependencies. Conclusions. Acute and chronic administration of ethanol has a significant, but at the same time multidirectional effect on hemodynamic parameters, which can serve as a trigger for the development of various cardiopathologies.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136072749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary artery transplantation operations (review)","authors":"A. M. Morozov, A. N. Sergeev, E. M. Askerov, V. A. Kadykov, T. S. Alieva, E. A. Fisyuk","doi":"10.20340/vmi-rvz.2023.4.clin.3","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.clin.3","url":null,"abstract":"Relevance. Coronary artery transplantation operations are an effective method for the treatment of developmental anomalies and pathologies of the coronary arteries, which lead to a cascade of negative consequences. Pathologically altered coronary arteries cannot fully function normally and this condition leads to myocardial ischemia. Ischemic heart disease (CHD) is a chronic inflammatory disease that quickly leads to functional disorders in the body. CHD is mainly caused by atherosclerosis of the arteries and is the leading cause of death in most developed countries. The purpose of study. To study the operational possibilities of coronary artery transplantation. Materials and methods . In the course of this study, a review of foreign literature on the problem of surgical interventions on the coronary arteries was carried out, in addition, data from randomized controlled trials and controlled clinical trials were analyzed, which reported on various approaches to the treatment of pathologies of the heart vessels. Results. Coronary artery bypass grafting is most often performed in coronary heart disease caused by a sharp narrowing or occlusion of the lumen of the coronary artery. Coronary artery bypass grafting (CABG) is a major surgical operation, which consists in restoring blood circulation bypassing the stenotic area of the coronary artery using venous or arterial bypasses (grafts). At the same time, blood flow to the ischemic myocardium is restored, which leads to the restoration of the function and viability of the heart muscle. Coronary artery bypass grafting, as mentioned above, is a frequently performed surgical intervention, with almost 400,000 CABG surgeries performed annually, which proves its effectiveness in the treatment of coronary artery disease. Conclusion. This study proves the importance of coronary artery transplantation in the treatment of pathologies and anomalies of the arteries of the heart. There are several types of surgical interventions, and therefore it is necessary to approach each individual case individually and find the optimal solution. An important role in preventing postoperative complications and sudden cardiac arrest is played by careful preoperative diagnostics, including coronary angiography, echocardiography, computed tomography, and other methods. With careful preoperative diagnosis, a well-chosen operation strategy and postoperative prevention, it is possible to avoid repeated cardiac revascularization and achieve complete recovery of the patient with no complications for decades.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136072750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The possibilities of machine learning in determining the variants of the course of viral pneumonia associated with COVID-19 based on computed tomography data","authors":"I. M. Skorobogach, L. T. Khamidova, R. S. Muslimov, N. V. Rybalko, S. S. Petrikov","doi":"10.20340/vmi-rvz.2023.4.covid.1","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.covid.1","url":null,"abstract":"Introduction. In acute COVID-19 respiratory infection caused by SARS-CoV-2 coronavirus (2019-nCov), lung damage has a different course, which has not been studied so far. The purpose of the study. To study the variants of the course of COVID-19 viral pneumonia (VP) based on the analysis of the dynamics of lung damage, quantified by computed tomography. Material and methods . Quantitative analysis of computed tomography (CT) data of the chest of 144 patients with VP was performed using the 3D Slicer software application. Cluster and comparative nonparametric analyses of the severity of lung damage (CT1, CT2, СТЗ, CT4) and the total volume of affected lungs (%) obtained during primary and two repeated CT studies (pCT, 1dCT and 2dCT) in the program \"Statistica 12\" were carried out. Results. With a stable course, the total volume of the affected lungs is constant, within one degree of severity: CT1 - in 23.6 %, CT2 - in 14.6 %, CT3 - in 5.6 %, CT4 - in 8.3 %. With a progressive course, the volume of lung damage gradually increases from minimum to maximum CT1-CT2-CT3 in 3.5 %, or increases to the maximum level on the second CT, remaining stable on the third study (CT2-CT3-CT3) - in 4.2 %. With a regredient course, the volume of lung damage varies from the maximum at the primary examination (pCT) to the minimum at the third (2dCT): gradually from CT4 through CT3 to CT2 in 4.2 %, or by one degree of severity CT3-CT2-CT2 in 9.7 %, CT3-CT3-CT2 in 9.0 %. With a progressive-regredient course, the volume of lung damage first reaches a maximum on 1dCT, a minimum on 2dCT - CT2-CT3-CT2 - in 17.4 %. An intragroup comparison of three repeated, dependent indicators of the total volume of the affected lungs and an intergroup comparison on pCT, 1dCT and 2dCT showed a dynamic statistically significant difference between them for variants of the course of VP (p < 0.05). Conclusions. Cluster analysis of the total volume of affected lungs on a series of three CT studies in dynamics allowed us to identify 5 variants of the course of COVID-19 - stable - light, stable-severe, progressive, regredient, progressive-regredient.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136072752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of systemic inflammatory response with structural and functional changes in the myocardium in patients with pulmonary tuberculosis","authors":"D. V. Kolchin, V. I. Ruzov, L. N. Savonenkova, V. A. Razin","doi":"10.20340/vmi-rvz.2023.4.clin.2","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.clin.2","url":null,"abstract":"Abstract. Taking into account the conflicting data on the effect of the systemic inflammatory response on the structural and functional changes in the myocardium in clinical forms of tuberculosis, we conducted an echocardiographic study and an assessment of pro- and anti-inflammatory cytokines in the blood serum. The purpose : to study the relationship of structural and functional changes in the myocardium with markers of systemic inflammation IL-6, IL-10, VEGF-A in patients with various forms of pulmonary tuberculosis. Materials and methods . The study included 77 patients with a confirmed diagnosis of pulmonary tuberculosis, who are on inpatient treatment in a tuberculosis dispensary. During the study, patients were randomized into 3 groups, cavernous form of pulmonary tuberculosis, (n = 15). The mean age of the patients was 44.2 ± 5.3 years and had no statistically significant differences between the groups. The control group consisted of 10 healthy individuals. The mean age of the control group was 42.4 ± 2.3 years. The concentration of IL-6, IL-10 and VEGF-A in blood serum was assessed by ELISA and В-mode echocardiography. The results obtained. The severity of systemic inflammation was associated with the clinical form of pulmonary tuberculosis: the maximum value of IL-6 was observed in the infiltrative form, and the minimum, but significantly higher value compared to the control group, in the fibrous-cavernous form of pulmonary tuberculosis (25, 7 ± 16.5 vs 10.3 ± 4.24). High levels of interleukin IL-6 were accompanied by higher levels of VEGF in blood serum, regardless of the form of pulmonary tuberculosis, while the highest concentration of both was observed in patients with infiltrative form of tuberculosis . A significant increase in the structural and functional values of the myocardium of the right and left parts of the heart was established both in relation to the control group and in comparison with the group of patients with an infiltrative form of pulmonary tuberculosis, despite lower levels of VEGF-A (391.43 ± 241.0 vs 274.50 ± 158.30). Conclusions. Pulmonary tuberculosis is accompanied by varying severity of systemic inflammation associated with the clinical form of the disease. Structural and functional changes in the myocardium of the right and left parts of the heart in pulmonary tuberculosis are associated with the clinical form of pulmonary tuberculosis. The most pronounced changes are observed in the fibrous-cavernous form, the minimum - in the infiltrative form. There is no direct relationship between the severity of the systemic inflammatory response and structural and functional changes in the heart.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136072751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of cognitive impairment in patients with ONMC on the background of coronary artery bypass grafting","authors":"N. V. Komissarova, D. A. Valetdinov, R. R. Adilov, A. V. Perevozchikova","doi":"10.20340/vmi-rvz.2023.4.clin.6","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.clin.6","url":null,"abstract":"Relevance . Coronary artery bypass grafting (CABG) is one of the main methods of surgical treatment of coronary heart disease and is performed in order to restore perfusion and improve the functional state of the myocardium. According to the literature, CABG has a high percentage of neurological complications. About 80 % of patients in the postoperative period have mild or moderate brain damage, which is manifested primarily by cognitive decline. One of these complications is an acute violation of cerebral circulation (ONMC). Study aim . To compare patients with ONMC after CABG and patients with ONMC, which were based on other reasons for the leading impaired cognitive functions and to assess cognitive impairment. Material and methods . The severity of cognitive impairment in patients with a history of CABG was studied using the MoCA test scale, comparing the results obtained with the data of stroke patients without CABG. Results. Significantly more often patients (ONMC with CABG) tests on visual-constructive skills, on the skills of \"Delayed reproduction\" performed worse. Memory\". Conclusion. In patients with ONMC with CABG in the anamnesis, visual disturbances were observed 2 times more often. Based on the data obtained, it can be concluded that CABG surgery significantly affects the degree of impairment of visual-constructive skills and delayed reproduction (memory) in ONMC, which is the basis for further, more in-depth study of this problem.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136193373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of cavity formation in nontuberculosis mycobacteriosis of the lungs","authors":"R. B. Amansakhedov, N. N. Makar'yants, A. Yu. Borisova, U. V. Belova, L. N. Lepekha, N. L. Karpina","doi":"10.20340/vmi-rvz.2023.5.case.4","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.5.case.4","url":null,"abstract":"The results of a long – term observation from practice are presented, which showed the gradual formation of the destruction cavity in a patient with limited focal and peribronchial fibrosis of the lung tissue. Patient H., 54 years old for more than twenty years, was observed by a pulmonologist at the place of residence with a diagnosis of chronic bronchitis with frequent annual exacerbations. She was admitted to the clinic of the FSBSI \"CRIT\" with complaints of pronounced weakness, fatigue, shortness of breath, prolonged subfebrile temperature mainly at night, cough with difficult-to-separate mucus of a mucous nature. A retrospective analysis of computed tomography of the chest revealed a consistent transformation of local focal peribronchial compaction in the middle lobe of the right lung into a limited area of bronchiectasia and the formation of a small cystic cavity with widespread zones of bilateral pneumonic infiltration. This observation shows the practical significance of CT research in understanding the mechanisms of formation of bronchiectatic cystic cavity in non-tuberculosis mycobacteriosis of the lungs.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135369631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the A82G mutation in the MMP-12 gene and C634G mutation in the VEGF-A gene on the course of lower limb varicose veins and the risk of disease recurrence","authors":"G. V. Yarovenko, S. E. Katorkin, Y. M. Komleva, P. V. Osadchaya","doi":"10.20340/vmi-rvz.2023.5.clin.3","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.5.clin.3","url":null,"abstract":"Aim : creation of a method for predicting the development of varicose veins of the lower extremities and its recurrence. Object and methods . 2 independent studies of patients with C2-C6 varicose veins of the lower extremities (CEAP-classifier) were conducted. In the first, with ultrasound diagnosis of the main veins of the lower extremities and genomic analysis of blood samples, 75 participants (men 20, women 55), mean age 43.7 ± 5.9 years. All patients were randomized into two groups: group I (n = 17) – with recurrent varicose veins; Group II (n = 58) – applied with varicose veins for the first time. The 2nd study involved 44 (men 10, women 34), mean age 55.5 ± 2.7 years. Similarly, patients were divided into groups – I (5) and II (39 people). All patients of the first stage of the study underwent real-time PCR with allele-specific primers to determine the A82G mutation in the MMP-12 gene (matrix metalloproteinase-12) and the second stage C634G in the VEGF-A gene (endothelial fibroblast growth factor – A). Results of the study . In patients of both groups I and II, having the MMP-12 gene in the heterozygous variant, dilatation of the tibial and popliteal veins was present (6.4 ± 0.3 mm and 10.7 ± 0.24 mm, respectively) with the presence reflux and slowing down the evacuation of blood from the deep venous system. In patients of group I, the MMP-12 gene was found in 80 % of cases, as A/A (homozygous) and A/G (heterozygous variation), while in group II only in 33.3 % of cases. Pearson's goodness-of-fit criterion χ2 = 10.4 (the critical value of the criterion is 6.63), p < 0.01. The frequency of recurrence of varicose veins and mutation of the MMP-12 gene according to the Spearman test was 1.0 with the number of degrees of freedom 23, p < 0.05. In the 2nd study, a correlation was found between groups I and II of patients with the C/C genotype (Pearson's coefficient χ2 = 0.79, p < 0.11) and a correlation in the duration of the disease between groups of patients with the C/C genotype (homozygous variation) and C /G (heterozygous variation) – Pearson correlation coefficient χ2 = 0.92 (p < 0.01). Conclusion . The revealed relationship between the MMP-12 gene polymorphism and the frequency of varicose vein recurrence is a predictor of the development of structural changes in the vein wall, and a mutation in the VEGF-A gene occurs with a long history of the disease.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135183032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}