Vestnik medicinskogo instituta "REAVIZ": reabilitaciâ, vrač i zdorovʹe最新文献

{"title":"Clinical observations of surgical treatment of patients with Pair syndrome","authors":"I. V. Makarov, V. E. Zaitsev, D. A. Korolev, I. A. Tyumin, A. B. Petrov, E. A. Panarin, A. A. Kudashova","doi":"10.20340/vmi-rvz.2023.4.case.2","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.case.2","url":null,"abstract":"The article provides a brief overview of the frequency and prevalence of Pair syndrome, the causes of its development, the clinical picture and diagnosis of this form of splanchnoptosis, the tactics of surgical treatment depending on the stage of the disease. There are 2 clinical cases of successful surgical treatment of chronic constipation in patients with Pair syndrome. At the same time, in the classical picture of the disease, left-sided hemicolectomy with a thick-colonic anastomosis \"end to end\" was performed, in a patient with concomitant diverticular disease - an extended hemicolectomy. All patients are discharged with recovery, all have an independent regular stool every 1-3 days","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"145 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134913772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects of treatment of progressive forms of multiple sclerosis by transplantation of stem cells (review)","authors":"T. V. Sorokovikova, A. M. Morozov, A. N. Kryukova, S. A. Naumova, M. A. Belyak","doi":"10.20340/vmi-rvz.2023.4.tx.3","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.tx.3","url":null,"abstract":"Relevance. Multiple sclerosis is a global medical and social problem of our time. This is due to a decrease in the number of able-bodied population due to the onset of the disease in 20-40 years, steady progression, the appearance of persistent neurological symptoms and disability. Therapy with drugs that change the course of multiple sclerosis is not always effective for progressive forms of the disease. There are a large number of clinical trials of modern medicines and techniques that affect the main links of pathogenesis, aimed at combating further progression and reducing the existing neurological deficit. One of the promising and potentially effective methods is stem cell transplantation. The purpose of study. To analyze foreign publications on the use of stem cells for the treatment of multiple sclerosis: to assess the possibility, safety and prospects of using stem cell transplantation in patients with progressive multiple sclerosis resistant to standard therapy. Materials and methods . In the course of this study, foreign scientific articles were searched in the databases \"Elibrary\", \"PubMed\", \"Cochrane Library\". The analysis and generalization of data on the main etiopathogenetic mechanisms of multiple sclerosis development and methods of influencing them, on alternative methods of treating multiple sclerosis, properties of different types of stem cells, methods of transplantation, results of open clinical trials of stem cell transplantation in patients with multiple sclerosis. Results. Stem cell therapy can be used as an alternative method of treating progressive forms of multiple sclerosis. Several types of stem cells with individual properties and advantages were considered for clinical use. Autologous hematopoietic, mesenchymal, neuronal, embryonic and induced pluripotent stem cells are distinguished. Mesenchymal and hematopoietic stem cells have demonstrated the greatest therapeutic potential in clinical trials. The safety and good tolerability of transplantation of these cell types have been proven, but the effectiveness remains controversial. Clinical improvements were more often observed in patients of younger age, with a disease duration of less than 10, inefficiency in no more than two previous methods of treatment modifying the disease, and having a lower baseline EDSS score. Conclusion. Stem cell transplantation is indeed a promising method and can revolutionize the treatment strategy for neurodegenerative diseases. Clinically proven safety and efficacy make it possible to change the approach to therapy in relation to the progressive course of multiple sclerosis, to conduct large multicenter clinical trials to include the method in the treatment standards. The opportunity to stop the progression and prolong the relapse-free period makes it possible in the near future to eliminate the need to take drugs that change the course of multiple sclerosis, reduce their side effects on the body and return patients to their former live","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"215 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134913769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the state of th vascular endothelium in various forms of coronary heart disease","authors":"F. A. Shukurov, M. S. Tabarov, Z. M. Toshtemirova, M. Kh. Khodzhaeva","doi":"10.20340/vmi-rvz.2023.4.clin.12","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.clin.12","url":null,"abstract":"Purpose of the study : to investigate changes in markers of endothelial dysfunction and hemostasis system in patients with different forms of CHD on the background of treatment and before it. Materials and methods of the study. In order to fulfill the set tasks, 60 patients with different forms of CHD: stenocardia and myocardial infarction (according to the classification of the Canadian Association of Cardiology (L. Cam-peau, 1976)), 60 patients with different forms of CHD were examined during the study. Campeau, 1976), VNOC (2004), recommendations of the European Society of Cardiology (2007)), aged from 50 to 75 years (mean age 62.6 ± 3.5 and 65.1 ± 3.6 years, respectively) and 20 practically healthy individuals (without signs of CHD), comparable in age (mean age 62.7 ± 3.7 years), who constituted the control group. For comparative analysis of the results before and after treatment the subjects were divided into three groups: Group I - control group, respondents without CHD; Group II - patients with stable angina II and III functional classes (FC); Group III - patients with postinfarction cardiosclerosis, i.e. those who had undergone Ml. Results and their discussion Several risk factors were identified in the majority of hospitalized patients. CHD of II and III FC was more often registered in women (60%); men who had undergone myocardial infarction accounted for 63.3%, the indices were statistically insignificant (p >0.05). The main cardiovascular risk factors (obesity, arterial hypertension, body mass index and total cholesterol) were significantly higher (in % ratio) in patients of groups ll-lll compared to group I (p<0.001), but the cholesterol content and body mass index were on average higher in group II (4.5 ± 1.0 and 33.0 ± 1.3, respectively) than in group III (4.2 ±1.1 and 30.6 ± 2.6, respectively). As for the duration of the disease, group III patients were characterized by a longer history and a higher frequency of heart failure, i.e. patients in this group had a more severe clinical status (p > 0.05). It should be noted that of the total number of patients (n = 80), rural residents accounted for 46.25% and city dwellers for 53.75%. Conclusions The presence of a higher degree of endothelial dysfunction is observed in patients who underwent myocardial infarction, in contrast to the stable form of angina pectoris without myocardial infarction in the anamnesis. The progression and deterioration of vascular endothelium is mostly associated with the presence of hyperhomocysteinemia, and the most pronounced changes in endothelial function are determined in patients with a combination of cardiovascular risk factors. In different forms of CHD the increased content of DEK and homocysteine in blood serum, increasing in parallel with the severity of clinical course, their level correlates with the degree of endothelial dysfunction. A direct correlation between hemostasis markers (von-Willebrand factor, fibrinogen and platelets) and DEK was revea","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135786095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flistory and prospects of development of methods of osteosynthesis and osteosynthesis of the humerus diaphysis","authors":"K. I. Khorak, P. G. Kogan, A. R. Lyakh, D. V. Stafeev","doi":"10.20340/vmi-rvz.2023.4.clin.8","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.clin.8","url":null,"abstract":"Relevance. About 800 thousand people die every year as a result of injuries and their consequences, in the Russian Federation the frequency of injuries is 12 %. Fractures of the humerus diaphysis account for 1-5 % of the total number of traumatic injuries of the skeleton, at the same time, there is no tendency to reduce injuries in modern society, therefore, the number of surgical interventions aimed at restoring the integrity of the bone does not decrease. Among the reasons for the unsatisfactory results of osteosynthesis, iatrogenic ones are distinguished: inconsistency from a biomechanical point of view, the choice of an unsuitable metal structure, insufficiently correct comparison of the ends of bone fragments and neglect of contraindications to the use of submerged structures with increased contamination of the wound with open fractures. Non-infectious complications of primary osteosynthesis include false joints, improperly fused fractures, untenable osteosynthesis, as well as fractures and migrations of implanted metal structures. The described complications are the basis for repeated (revision) surgery, or rheosteosynthesis. The purpose of this study is to analyze the historical aspects of the development of osteosynthesis and rheosteosynthesis methods, as well as to determine the prospects for their further development. Materials and methods . In the process of writing the article, the analysis of data from literary sources published in the period from 2016 to 2023 was carried out. Results. Speaking about the choice of osteosynthesis technique, it should be noted that no recommended and maximally described techniques will be able to fully cover the variety of situations that arise during osteosynthesis operations, therefore, first of all, a positive outcome depends on the experience of the surgeon and his ability to make situational decisions. Each of the methods used has both advantages and disadvantages, and which treatment tactics the surgeon would not prefer - there is always a risk of complications and, as a result, an unsatisfactory result. In such cases, patients undergo revision operations of osteosynthesis (rheosteosynthesis), minimizing or completely eliminating bone defects. The complexity of correcting the consequences of injuries of the humerus diaphysis is due to the variety of conditions leading to the development of various kinds of bone defects or false joints, as well as in a limited number of techniques that can fully repair the damage in a short time. Taking into account the rather long periods of consolidation of fragments, rehabilitation of patients with this type of pathology implies the use of devices capable of providing stable fixation and the possibility of early restoration of upper limb functions for fastening bone fragments. As a rule, revision surgical interventions include excision of scars from the interfragmental area or corticotomy, removal of deformation (if present), rimming of the medullary cavity and","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135786094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computerized stabilometry in assessing the results of puncture vertebroplasty in patients with vertebral osteoporosis","authors":"I. E. Poverennova, D. R. Ikromova, Yu. S. Komarova, E. V. Khivintseva, S. A. Anan'eva","doi":"10.20340/vmi-rvz.2023.4.clin.13","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.clin.13","url":null,"abstract":"Osteoporosis is often referred to as a \"silent epidemic\" because the decrease in bone mass is often asymptomatic until a fracture occurs. One of the most severe manifestations of the disease is osteoporosis of vertebral bodies, the fracture of which leads to disability. In spinal osteoporosis, the main cause of pathologic compression fractures is a fall due to impaired balance. The dynamics of balance dysfunction after surgical treatment of vertebral body compression fractures remains insufficiently studied. We performed a stabilometric study in 103 patients with osteoporosis of the spine complicated by compression fracture at the thoracic and lumbar levels in the age range from 44 to 79 years. All patients underwent puncture vertebroplasty. It was demonstrated that patients with osteoporosis of the spine still have pronounced changes in the stabilogram parameters despite their positive dynamics. The most significant changes were noted in the energy expenditure index, 60% power spectrum level in the sagittal plane and dispersion of the deviation of the center of pressure in the horizontal plane. The persisting pronounced changes in stabilometric indices in the distant postoperative period make it necessary to perform rehabilitation to restore balance and gait.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135786093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenetic therapy of multiple sclerosis","authors":"N. V. Komissarova, M. A. Urban, D. M. Gaysina, A. R. Gimazdinova, Ya. M. Perevozchikova","doi":"10.20340/vmi-rvz.2023.4.clin.9","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.clin.9","url":null,"abstract":"Relevance. Multiple sclerosis is accompanied by rapid progression of the disease, the development of early disability and a violation of the patient's quality of life. In recent years, advances in understanding the etiology and pathogenesis of this disease have led to the expansion of therapeutic approaches, it has become possible to influence the course of the disease. Objective - to study the effectiveness of the use of drugs that change the course of multiple sclerosis in patients registered at the center of multiple sclerosis of the Udmurt Republic. Materials and methods . The statistical analysis was performed on 45 patients of the neurological department of the \"First Republican Clinical Hospital\" of the Ministry of Health of the Udmurt Republic, diagnosed with multiple sclerosis, using immunomodulatory or immunosuppressive therapy. Results. At the beginning of the study, the group of patients using immunomodulatory therapy included 31 patients (68.89 %), the group of immunosuppressors -14 patients (31.11 %). The average time from the onset of the disease to the start of therapy was 1.64 ± 5.71 months. 42 patients (93.33 %) out of 45 included in the study started therapy with an immunomodulator. The average time from the start of therapy to inclusion in the study was 113.00 ± 47.52 months in the immunomodulatory therapy group. 11 patients (78.57 %) out of 14 taking immunosuppressive therapy at the start of the study switched to it after previous immunomodulatory therapy. 3 patients (6.67 %) out of 45 included in the study started treatment with immunosuppressive therapy. In the immunosuppressive therapy group, the duration of treatment was 62.57 ± 74.52 months. Progression of the disease from the moment of initiation of therapy to inclusion in the study was observed in 19 patients - 42.22 %. An increase in the EDSS index was recorded by an average of 1.82 ± 0.31 points. Improvement of clinical condition was observed in 6 patients - 13.33 %. A decrease in the EDSS index was recorded by an average of 0.91 ± 0.22 points. The difference in the EDSS index in the groups of immunomodulators and immunosuppressors is insignificant. There was no dependence of the patient's clinical condition on the number and activity of foci of demyelination. Conclusions. The objective clinical condition of the patient has no significant difference in the groups of immunomodulatory and immunosuppressive therapy, which suggests that the correct selection of a particular drug by the attending physician and its constant use by the patient is important in order to reduce the risks of complications, slow down the progression of the disease and preserve the quality of life of the patient.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135786096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacoepidemiological analysis of therapy for chronic heart failure","authors":"D. D. Monakhova, V. A. Shchegoleva, T. I. Spiridonova","doi":"10.20340/vmi-rvz.2023.4.clin.10","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.clin.10","url":null,"abstract":"The aim of the study was to examine the schemes proposed in the clinical guidelines and to compare them with inpatient treatment methods. Materials and method , the case histories of 40 patients of cardiology department of Saratov medical preventive institution were analyzed. Men and women, aged from 50 to 80 years, with functional class (FC) II to IV, with reduced left ventricular ejection fraction (< 40 %) and with such diseases in anamnesis as arterial hypertension, coronary heart disease, atherosclerosis, diabetes mellitus were in the inclusion group. The exclusion group included patients with noncardiac diseases, pediatric patients, patients under 50 and over 80 years old, patients with I class, preserved and intermediate LV ejection fraction (> 40 %). The results of immunochromatographic analysis of NT-proBNP marker were studied, the identity of prescribed drugs to a certain group and their frequency of use, as well as the similarity of prescribed regimen to clinical guidelines were determined. Results. NT-proBNP level over 125 pg/ml was revealed in 21 out of 40 patients, arterial hypertension, atherosclerosis, ischemic heart disease were in the anamnesis testifying to high probability of CHF. Perindopril (80 %) and fosinopril (20 %) were the main angiotensin-converting enzyme inhibitors (ACEIs). Spironolactone (a К + -saving diuretic), thorasemide, furosemide (a loop diuretic) and indapamide (a thiazide-like diuretic) were used as diuretics. Among blockers, metoprolol (20 %), nebivolol (30 %), bisoprolol (50 %) were prescribed. Patients suffering from CHF and with a history of atherosclerosis were prescribed statins (rosuvastatin, atorvastatin) in addition to the main groups of drugs in all cases. Warfarin (9.5 %) and rivaroxaban (23.8 %) were present in 7 of 21 cases (33 %). In addition, 17 patients (81 %) were prescribed acetylsalicylic acid as an antiaggregant. Those with a history of diabetes mellitus (19 %) received metformin for glycaemic control, as an adjunctive therapy to the main combinations of drugs. Conclusions. The inpatient regimen used to treat patients with CHF is more in line with the clinical guidelines.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135786097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunotherapy for hepatocellular carcinoma in liver transplant patients (Literature review)","authors":"I. A. Dzhanyan, M. S. Novruzbekov, O. D. Olisov, D. I. Yudin, V. S. Rudakov, E. Yu. Antonova, I. V. Savchenko, I. V. Pogrebnyakov, V. V. Breder, M. Yu. Pitkevich","doi":"10.20340/vmi-rvz.2023.4.tx.4","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.tx.4","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the third cause of cancer-related mortality worldwide, accounting for more than 800,000 deaths annually. Surgical removal of the neoplasm remains the most effective treatment option. Partial liver resection is an adequate solution for patients without cirrhosis or with well-compensated cirrhosis, orthotopic liver transplantation is necessary in patients with early stage HCC on the background of cirrhosis. Tumor recurrence remains a major limitation of long-term survival of patients after liver transplantation. Posttransplant immunosuppression reduces the body's antitumor defense, which is provided by natural immunity. This contributes to the development and progression of the tumor process. Purpose of the study: to analyze domestic and foreign publications that present treatment options for HCC recurrence after liver transplantation. Literature sources were searched in PubMed, Scopus, Web of Science, MEDLINE, eLibrary databases. The search was conducted in Russian and English by keywords: hepatocellular carcinoma, tyrosine kinase inhibitors, immune checkpoint inhibitors, therapy of HCC relapse, orthotopic liver transplantation, RETREAT index, regorafenib, nivolumab. The authors presented a review of the data on the use of tyrosine kinase inhibitors and immune checkpoint inhibitors to prevent HCC recurrence. The results of the analysis of literature sources showed that the issue of post-transplant immunosuppression is relevant. The large number of studies and clinical case reviews leaves hope that an effective way of immunosuppression for recurrent HCC patients after liver transplantation will soon be found.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135886769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of severe arterial limb ischemia in patients with multifocal atherosclerosis and chd infusion of 0.01 % nitroglycerin solution","authors":"A. N. Shcherbyuk, V. L. Lemenev, B. I. Yaremin, V. M. Manuylov, Ya. E. Nemstsveridze, R. I. Stepanova, L. R. Derbina","doi":"10.20340/vmi-rvz.2023.4.clin.1","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.clin.1","url":null,"abstract":"Occlusive lesions of the main arteries of the extremities are a common and severe disease that leads to disability and has a high rate of death [1]. Many different drugs are known for the treatment of this pathology, however, despite the large number of pharmacological drugs and conservative treatment methods, surgical methods of treatment are the most effective in terms of saving the limb [3, 4]. However, methods of conservative therapy continue to be the most important component of the treatment of arterial limb ischemia, which requires the development of more effective methods. As a result of the use of intravenous administration of a 0.01 % solution of nitroglycerin for the treatment of arterial ischemia of the extremities in patients with coronary artery disease, it was possible to obtain good immediate results in an average of 57.3 % of cases.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135886770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the aqueous extract of reddish hellebore on the emotional state of the offspring of rats","authors":"S. N. Klychkova, O. N. Pavlova, O. N. Gulenko, O. V. Gerasimova, A. V. Kolesnikov, V. V. Maslyakov","doi":"10.20340/vmi-rvz.2023.4.phys.2","DOIUrl":"https://doi.org/10.20340/vmi-rvz.2023.4.phys.2","url":null,"abstract":"Anxiety is a natural survival mechanism that helps to cope with potentially dangerous situations. It is accompanied by changes in the functioning of the nervous and endocrine systems, which affect the behavior of living beings. It is possible to establish the level of anxiety and the severity of depression thanks to various behavioral methods, with the help of which it is possible to fix indicators, establish their duration, and then compare data on the emotional state of animals from the control and experimental groups. The purpose of the study: to identify the features of the emotional state of the offspring of rats that received an aqueous plant extract of reddish hellebore. Conclusions: aquatic plant extract of reddish hellebore has a modeling effect that reduces the level of anxiety and depression.","PeriodicalId":481396,"journal":{"name":"Vestnik medicinskogo instituta \"REAVIZ\": reabilitaciâ, vrač i zdorovʹe","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135886768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}