Maria Tsiaka, Elena Dieti, Rena I. Kosti, Odysseas Androutsos
{"title":"Acceptability and Short-Term Outcomes of a 4-Day Temperament-Based Treatment With Supports (TBT-S) Intervention for Anorexia Nervosa in Greece","authors":"Maria Tsiaka, Elena Dieti, Rena I. Kosti, Odysseas Androutsos","doi":"10.1002/erv.70140","DOIUrl":"10.1002/erv.70140","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Temperament-Based Treatment with Supports (TBT-S) is an intensive treatment for patients with eating disorders (EDs) integrating neurobiological insights and family dimensions with the involvement of supports. Previous studies report high acceptability among both patients and their supports, and improvements in clinical outcomes and family functioning. The present study investigated acceptability and short-term outcomes of TBT-S intervention as adjunctive to ongoing, specialised treatment for anorexia nervosa (AN) in late adolescent and young adult patients and their supports.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Thirty-two patients (mean age = 21.44, SD = 4.72), 29 mothers, and 22 fathers participated in eight TBT-S interventions in Greece. ED symptomatology, patients' and supports' psychological distress, and supports' emotional and behavioural responses were assessed immediately before and after participation in TBT-S intervention. Also, acceptability of TBT-S intervention was assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>TBT-S intervention was found to be highly acceptable among patients and their supports. Patients reported significant reductions in ED restraint symptomatology and depression. Mothers displayed significant reductions in depression, stress, criticism, and accommodating and enabling behaviours. Conversely, fathers displayed significant increases in depression and anxiety.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>TBT-S intervention demonstrated high acceptability among patients and supports, and was associated with several short-term outcomes as adjunctive to ongoing treatment for AN.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":"34 6","pages":"1547-1561"},"PeriodicalIF":3.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148296805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renee D. Rienecke, Alan Duffy, Philip S. Mehler, Dan V. Blalock
{"title":"Family Functioning Among Adolescent Males With Restrictive Eating Disorders: A Comparison to Matched Adolescent Females","authors":"Renee D. Rienecke, Alan Duffy, Philip S. Mehler, Dan V. Blalock","doi":"10.1002/erv.70147","DOIUrl":"10.1002/erv.70147","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Knowledge of family functioning (FF) for those with eating disorders (EDs) is driven by research with females, resulting in an overly gendered perception of FF. The current study: (1) descriptively examined FF among male adolescents with EDs, (2) compared FF among males with anorexia nervosa-restricting subtype (AN-R), AN-binge/purge subtype (AN-BP), and avoidant/restrictive food intake disorder (ARFID), and (3) compared FF between males and females with these EDs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Participants were 175 males and 175 females who completed the Family Assessment Device (FAD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Males scored above the clinical cutoffs on most FAD subscales. No differences in FF were found among males across ED diagnoses. Significant differences were found between males and females with AN-R on four FAD subscales (affective involvement [OR = 4.70], affective responsiveness [OR = 2.52], communication [OR = 2.78], and general functioning [OR = 2.22]), with males reporting worse FF (all <i>p</i>s < 0.03). Differences between males and females with AN-BP or ARFID were not large enough to meet statistical significance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study increases understanding of FF in EDs from a more diverse standpoint. Male adolescents with EDs experience poor FF. Qualitative studies could clarify possible reasons behind poor FF for adolescent males with EDs and help to identify specific targets for treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":"34 6","pages":"1597-1607"},"PeriodicalIF":3.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148388261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding Weight Change in Cognitive Behavioural Therapy for Adults With Eating Disorders: A Systematic Review and Meta-Analysis.","authors":"Jessica Ellingham, Glenn Waller","doi":"10.1002/erv.70177","DOIUrl":"https://doi.org/10.1002/erv.70177","url":null,"abstract":"<p><strong>Objective: </strong>To examine body mass index (BMI) change during and following cognitive behavioural therapy for eating disorders (CBT-ED), separately for underweight and non-underweight participants.</p><p><strong>Method: </strong>Random-effects meta-analyses synthesised 55 studies. Pre-to post-treatment and follow-up BMI changes were analysed by baseline weight status. Treatment setting was examined among underweight participants.</p><p><strong>Results: </strong>BMI increased substantially in underweight participants (g = 1.15, 95% CI [0.43, 1.88], k = 26) and slightly in non-underweight participants (g = 0.38, 95% CI [0.10, 0.65], k = 43) from pre-to post-treatment. Heterogeneity was very high (I<sup>2</sup> = 98.90% and 96.05%, respectively). Among underweight participants, effects were positive in inpatient (g = 1.53) and community settings (g = 0.84), with no significant between-setting difference (p = 0.168). At follow-up, BMI remained higher than baseline in underweight participants (g = 0.91, 95% CI [0.39, 1.43]) but not in non-underweight participants (g = 0.11, 95% CI [-0.11, 0.33]).</p><p><strong>Conclusions: </strong>BMI change following CBT-ED differs by baseline weight status and should be interpreted in relation to treatment goals. However, the conclusions should be considered cautiously, given the low quality of the research, and future studies should be more attentive research quality.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nuria Blay Borch, Patricia Sanazario González, Rut Vila Del Pozo, Juan David Duque-Yemail, Laura Gisbert-Gustemps, Imanol Setién-Ramos, María Martínez-Ramírez, Josep Antoni Ramos-Quiroga, Jorge Lugo-Marín
{"title":"Prevalence of Medical and Psychiatric Comorbidities in Paediatric ARFID: A Meta-Analysis.","authors":"Nuria Blay Borch, Patricia Sanazario González, Rut Vila Del Pozo, Juan David Duque-Yemail, Laura Gisbert-Gustemps, Imanol Setién-Ramos, María Martínez-Ramírez, Josep Antoni Ramos-Quiroga, Jorge Lugo-Marín","doi":"10.1002/erv.70172","DOIUrl":"https://doi.org/10.1002/erv.70172","url":null,"abstract":"<p><strong>Background: </strong>Avoidant/Restrictive Food Intake Disorder (ARFID) is increasingly recognized as a complex paediatric feeding and eating disorder associated with significant medical and psychiatric burden.</p><p><strong>Methods: </strong>This systematic review and meta-analysis followed PRISMA guidelines and was prospectively registered in PROSPERO (CRD420251241490). PsycINFO, PubMed, Scopus, and Web of Science were searched. Observational and clinical studies reporting medical and/or psychiatric comorbidities in paediatric ARFID samples were included. Random-effects models generated pooled prevalence estimates; heterogeneity, publication bias, and evidence certainty were evaluated using I<sup>2</sup>, Egger's test, and GRADE, respectively.</p><p><strong>Results: </strong>Eighty-four studies met inclusion criteria. Gastrointestinal disorders (30%; 95% CI: 21%-42%) and nutritional deficiencies (32%; 95% CI: 23%-42%) were the most prevalent medical comorbidities. Food allergies were present in 15% (95% CI: 9%-23%). Among psychiatric conditions, anxiety disorders were most common (44%; 95% CI: 39%-49%), followed by depression (18%; 95% CI: 15%-21%), autism spectrum disorder (19%; 95% CI: 15%-24%), attention-deficit/hyperactivity disorder (15%; 95% CI: 13%-18%), and obsessive-compulsive disorder (11%; 95% CI: 9%-13%). Heterogeneity was high across outcomes (I<sup>2</sup> ≥ 75%). Publication bias was detected for anxiety, depression, and nutritional deficiencies. Overall certainty of evidence ranged from very low to low.</p><p><strong>Conclusions: </strong>Paediatric ARFID is associated with substantial medical and psychiatric comorbidity, particularly anxiety and neurodevelopmental conditions. Findings support comprehensive, multidisciplinary assessment and developmentally informed interventions. Further high-quality, population-based studies are needed to reduce heterogeneity and strengthen evidence certainty.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giammarco Cascino, Laura Di Lodovico, Rossella Ceres, Rosa Cerra, Stefania Landi, Antonella Boccia, Alessio Maria Monteleone, Philip Gorwood, Palmiero Monteleone
{"title":"Higher Craving and Pleasure in Response to Exercise-Related Cues in Patients With Anorexia Nervosa and Exercise Dependence.","authors":"Giammarco Cascino, Laura Di Lodovico, Rossella Ceres, Rosa Cerra, Stefania Landi, Antonella Boccia, Alessio Maria Monteleone, Philip Gorwood, Palmiero Monteleone","doi":"10.1002/erv.70174","DOIUrl":"https://doi.org/10.1002/erv.70174","url":null,"abstract":"<p><strong>Background: </strong>Physical activity is common in patients with anorexia nervosa (AN), who often reported symptoms consistent with exercise dependence. Craving, the subjective urge to engage in a specific behaviour, is an important mechanism in the development of addiction and could be triggered by cues from the environment. Aim of the present study was to investigate craving in people with AN with respect to the presence of exercise dependence in response to video cues of physical activity and sedentary behaviours, comparing them to a sample of healthy women.</p><p><strong>Methods: </strong>A total of 57 women with AN and 20 healthy women completed the Exercise Dependence Scale-Revised (EDS-R). According to EDS-R, 21 women with AN were classified as non-dependent asymptomatic (NDA), 21 as non-dependent symptomatic (NDS) and 15 as dependent (D). All healthy women were NDA. All participants were exposed to video cues depicting subjects engaging in exercise and sedentary activities, and filled in the Crave Experience Questionnaire at three timepoints: at baseline, after exposure to sedentary activity videos, and after exposure to exercise activity videos.</p><p><strong>Results: </strong>Patients with AN displayed higher craving after exposure to physical exercise videos. D participants reported higher intensity and intrusiveness of craving for exercise, compared to all other groups. Finally, we found an association between pleasure evoked by physical activity cues and the craving triggered by these videotapes.</p><p><strong>Conclusions: </strong>Our study suggests that craving is an existing dimension of exercise dependence in AN, supporting the positive reinforcement provided by exercise, and to take into account as a relapse factor.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Zanola, Louis Fabrice Tshimanga, Valentina Meregalli, Angela Favaro, Manfredo Atzori, Enrico Collantoni
{"title":"Psychopathological and Temperamental Stratification of Eating Disorders With Clustering: From Diagnosis to Phenotypic Diversity.","authors":"Andrea Zanola, Louis Fabrice Tshimanga, Valentina Meregalli, Angela Favaro, Manfredo Atzori, Enrico Collantoni","doi":"10.1002/erv.70171","DOIUrl":"https://doi.org/10.1002/erv.70171","url":null,"abstract":"<p><strong>Objective: </strong>Eating disorders are highly heterogeneous, challenging diagnostic classification and treatment personalisation. This study aimed to identify data-driven phenotypes of anorexia nervosa and bulimia nervosa and examine their relationship with DSM-5 diagnoses and short-term treatment outcomes.</p><p><strong>Methods: </strong>We analysed 809 female patients with anorexia nervosa (restricting or binge-purge subtype) or bulimia nervosa treated in a specialist eating disorders unit. Baseline clinical, sociodemographic, eating-disorder-specific, and general psychopathology variables were assessed. Nineteen variables entered a Repeated Spectral Clustering pipeline, while body mass index and related measures were reserved for external validation. Associations with DSM-5 diagnoses and remission at discharge were examined.</p><p><strong>Results: </strong>A four-cluster solution best fit the data. Two clusters largely corresponded to restricting-type anorexia nervosa and bulimia nervosa, respectively. Two additional diagnostically mixed clusters were characterised by either greater psychopathological severity and trauma exposure or by older age, longer illness duration, and more marked malnutrition. Cluster membership was associated with remission at the end of treatment, though the effect was weak and no pairwise contrast survived correction. Descriptively, full remission was most frequent in the bulimia-like cluster.</p><p><strong>Conclusions: </strong>Computational phenotyping captured clinically meaningful heterogeneity beyond DSM-5 categories including two diagnostically mixed subgroups not identified by categorical diagnosis. Cluster membership at intake was weakly associated with end-of-treatment remission, and the resulting subgroups may provide candidate strata for precision psychiatry approaches in eating disorders.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rafael Moreton Alves da Rocha, Andrea Phillipou, Erica Neill, Stephanie Miles
{"title":"Critically Revisiting the Psychometric Properties of the EDE-Q and Its Short Forms: Is It Time to Move On?","authors":"Rafael Moreton Alves da Rocha, Andrea Phillipou, Erica Neill, Stephanie Miles","doi":"10.1002/erv.70169","DOIUrl":"https://doi.org/10.1002/erv.70169","url":null,"abstract":"<p><strong>Background: </strong>The Eating Disorder Examination Questionnaire (EDE-Q) remains the most widely used self-report measure of eating disorder symptoms, despite concerns regarding its factorial instability, construct redundancy, and local item dependence. Numerous brief versions have been proposed to address these limitations. Yet, whether these revisions represent true psychometric advances remains questionable.</p><p><strong>Methods: </strong>In the present study, we critically examined the psychometric properties of the full EDE-Q and its short forms in a sample of 772 Australian women. Dimensionality was examined using bootstrap Exploratory Graph Analysis (EGA), followed by Confirmatory Factor Analysis. Factor redundancy was assessed through correlations between factors, HTMT2, and differential associations with an external criterion. Item-level analyses evaluated the functioning of putative doublets, and receiver operating characteristic analyses examined classification accuracy and overlap across scale versions.</p><p><strong>Results: </strong>EGA yielded more parsimonious structures than the originally proposed models, often collapsing highly overlapping factors. Analyses of factor redundancy indicated limited discriminant validity between several factors. Item-level analyses indicated that putative doublets had highly similar associations with the external criterion and comparable discriminative performance. Finally, global scores were highly correlated across versions and demonstrated similar moderate classification accuracy, although versions based exclusively on shape/weight concern performed worse.</p><p><strong>Conclusions: </strong>Although brief forms reduced length, they did not meaningfully resolve the core structural weaknesses of the EDE-Q. These findings suggest that these modifications of the EDE-Q may perpetuate, rather than solve, its psychometric limitations. We therefore emphasise the need for the development of new measures and offer recommendations grounded in contemporary psychometric best practices.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ziyu Ivan Zhao, Inge E Guerrero, Sarrah I Ali, Holly K Spinner, Alejandra Medina Fernandez, Harmony F Vides-Varini, Sophie R Abber, Naomi G Hill, Pamela K Keel
{"title":"A Comparison of Bulimia Nervosa and Its OSFED Variant on Trait and Behavioural Indicators of Reward Constructs.","authors":"Ziyu Ivan Zhao, Inge E Guerrero, Sarrah I Ali, Holly K Spinner, Alejandra Medina Fernandez, Harmony F Vides-Varini, Sophie R Abber, Naomi G Hill, Pamela K Keel","doi":"10.1002/erv.70170","DOIUrl":"10.1002/erv.70170","url":null,"abstract":"<p><strong>Introduction: </strong>Although individuals with bulimia nervosa (BN) demonstrate elevated reward sensitivity and reward valuation-effort (RV-e) compared to controls, whether BN differs from its other specified feeding or eating disorder variant (OSFED-BN), remains unclear. Further, whether differences best reflect categorical distinctions or correlations with symptom severity is unknown. This study examined whether trait and behavioural reward indicators differentiate BN, OSFED-BN, and controls, predict diagnostic status, and correlate with bulimic symptom severity.</p><p><strong>Methods: </strong>Participants were 349 women (153 BN, 118 OSFED-BN, 78 controls). Group comparisons, multinomial logistic regression, and correlational analyses were conducted on the Sensitivity to Punishment/Sensitivity to Reward-Reward subscale (SPSRQ-Reward), Behavioural Activation System-Drive (BAS-Drive) scale, and progressive ratio tasks assessing RV-e for food and game rewards.</p><p><strong>Results: </strong>BN and OSFED-BN demonstrated higher SPSRQ-Reward scores than controls but did not differ from each other. OSFED-BN, but not BN, showed higher food and game RV-e compared to controls. SPSRQ-Reward predicted higher odds of BN or OSFED-BN versus controls, whereas BAS-Drive predicted lower odds. SPSRQ-Reward was positively associated with bulimic symptom frequencies. Food RV-e was inversely associated with purging frequency.</p><p><strong>Discussion: </strong>Findings supported the role of reward-related processes in contributing to both dimensional and categorical differences between BN, OSFED-BN, and controls.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew W Bergen, Carolina Makowski, Michael Garvin, Gulcan Cil, Angeline Krueger, Karlee McGlone, Irene Litvan, Heather Hower, Walter H Kaye
{"title":"Eating Disorders and Parkinson's Disease-2: Genetic Epidemiology and Shared Genomics.","authors":"Andrew W Bergen, Carolina Makowski, Michael Garvin, Gulcan Cil, Angeline Krueger, Karlee McGlone, Irene Litvan, Heather Hower, Walter H Kaye","doi":"10.1002/erv.70158","DOIUrl":"10.1002/erv.70158","url":null,"abstract":"<p><strong>Objective: </strong>Individuals with anorexia nervosa (AN) share premorbid traits with Parkinson's Disease (PD) (e.g., anxiety) and exhibit a two-fold relative risk of a reported family history of PD. Published estimates of intra- and inter-disorder genetic architecture were extracted and compared prior to conducting novel analyses to provide evidence for cross-disorder genetic risk.</p><p><strong>Methods: </strong>National register or meta-analytic familial, twin, and common variant genome-wide studies were searched; estimates and findings were extracted and compared. Novel cross-disorder conditional and conjunctional false discovery rate analyses were performed.</p><p><strong>Results: </strong>Sibling relative risks and additive genetic estimates of the two disorders were similar. AN had greater common variant heritability than PD whether measured via infinitesimal model (linkage disequilibrium score regression, LDSC) or causal mixture model (MiXeR). AN had greater polygenicity than PD (mean (SD) 2.50E-03 (1.64E-04) versus 2.72E-4 (1.47E-05), p < 0.001), but lower discoverability than PD (4.20E-05 (2.69E-06) versus 1.40E-04 (6.95E-06), p < 0.001). Global genetic correlation was significant (e.g., bivariate LDSC r<sub>g</sub> = 0.10, p = 0.0033). Novel analyses identified cross-disorder enrichment, and cross-disorder risk at chr3p21.31.</p><p><strong>Conclusions: </strong>Cross-disorder AN and PD research identified shared risk variants at chr3p21.31, genes and mechanisms (e.g., conditioning, fear, and reward) linked to a shared endophenotype.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13564348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Wilson, Hilary Grimmer, Renata A Mendes, Natalie J Loxton, Renee Calligeros, James Scott, Courtney Tyson, Melanie Dalton, Rachel Reavley, Kyle Cumner, Riccardo Dalle Grave
{"title":"Exploring Comorbid Psychopathology as Predictors of Outcome and Drop-Out From Enhanced Cognitive Behaviour Therapy for Adolescents With Anorexia Nervosa and Atypical Anorexia Nervosa.","authors":"Daniel Wilson, Hilary Grimmer, Renata A Mendes, Natalie J Loxton, Renee Calligeros, James Scott, Courtney Tyson, Melanie Dalton, Rachel Reavley, Kyle Cumner, Riccardo Dalle Grave","doi":"10.1002/erv.70168","DOIUrl":"10.1002/erv.70168","url":null,"abstract":"<p><strong>Background: </strong>Enhanced Cognitive Behaviour Therapy (CBT-E) has demonstrated effectiveness in adolescents with anorexia nervosa (AN) and atypical anorexia nervosa (AAN); however, there is limited knowledge about factors that influence treatment outcome. The current study aimed to identify whether comorbid psychopathology predicted treatment response or drop-out in CBT-E for adolescents with AN and AAN in a real-world setting.</p><p><strong>Method: </strong>A prospective cohort of 62 young people with AN or AAN engaging in CBT-E (female = 96.8%, M age = 15.31 years, SD = 1.32, range 12-17) at a public community outpatient service was evaluated. Measures included body mass index (BMI) centile and measures of eating disorder (ED) and comorbid psychopathology, which were assessed pre- and post-CBT-E.</p><p><strong>Results: </strong>Results showed that higher baseline anxiety symptoms predicted drop-out from treatment, and higher baseline BMI predicted higher end-of-treatment BMI.</p><p><strong>Discussion: </strong>Findings highlight the potential role of anxiety, ED psychopathology, and BMI in predicting the outcome of CBT-E for adolescents with AN and AAN. Future studies should examine whether tailoring CBT-E to individual physical and psychological profiles may help optimise its effectiveness in routine clinical care.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}