World Journal of Orthopedics最新文献

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Platelet rich plasma and anterior cruciate ligament repair: A new frontier, or a short term adjunct. 富血小板血浆和前交叉韧带修复:一个新的前沿,或短期辅助。
IF 2
World Journal of Orthopedics Pub Date : 2025-01-18 DOI: 10.5312/wjo.v16.i1.100693
Saran Singh Gill, Giulia Cenci, Susanna Falcinelli, Fabrizio Marzano, Bruno Carriero, Nicola Filippi, Valerio Pace
{"title":"Platelet rich plasma and anterior cruciate ligament repair: A new frontier, or a short term adjunct.","authors":"Saran Singh Gill, Giulia Cenci, Susanna Falcinelli, Fabrizio Marzano, Bruno Carriero, Nicola Filippi, Valerio Pace","doi":"10.5312/wjo.v16.i1.100693","DOIUrl":"10.5312/wjo.v16.i1.100693","url":null,"abstract":"<p><p>Platelet rich plasma (PRP) is an autologous blood product rich in platelets, showing promise in reducing inflammation and accelerating healing. While extensively utilized in plastic surgery, dermatology, and osteoarthritis treatment, its application in anterior cruciate ligament (ACL) injuries is limited. This article examines PRP's potential in ACL reconstruction (ACLR), exploring its history, current usage, controversies and future directions. PRP has demonstrated significant early benefits in ligamentisation and vascularisation post-ACLR, though its long-term efficacy is inconsistent. Studies suggest that PRP may serve as both an adjunct therapy in ACLR to enhance initial healing and reduce postoperative complications, and as a non-surgical alternative for small ACL tears. Despite these promising findings, outcome variability necessitates further high-quality research to optimize PRP formulations and determine its most effective applications. The exploration of PRP as a treatment modality in ACLR offers promising but varied outcomes. PRP holds considerable promise as both an adjunct and alternative to traditional ACLR. This article underscores the need for targeted research to fully realize PRP's therapeutic potential in ACL treatment, aiming to inform future studies and clinical practices. By understanding PRP's mechanisms of efficacy and identifying the most beneficial patient populations, PRP could significantly impact orthopaedics and sports medicine, improving recovery pathways and patient outcomes.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 1","pages":"100693"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Teriparatide as a non-surgical salvage therapy for prolonged humerus fracture nonunion: A case report and literature review. 特立帕肽作为延长肱骨骨折不愈合的非手术挽救治疗:1例报告并文献复习。
IF 2
World Journal of Orthopedics Pub Date : 2025-01-18 DOI: 10.5312/wjo.v16.i1.101656
Shao-Han Guo, Chong Li, Yi-Jun Gao, Zhen Zhang, Ke Lu
{"title":"Teriparatide as a non-surgical salvage therapy for prolonged humerus fracture nonunion: A case report and literature review.","authors":"Shao-Han Guo, Chong Li, Yi-Jun Gao, Zhen Zhang, Ke Lu","doi":"10.5312/wjo.v16.i1.101656","DOIUrl":"10.5312/wjo.v16.i1.101656","url":null,"abstract":"<p><strong>Background: </strong>Fracture nonunion represents a challenging complication during fracture repair, often necessitating surgical intervention. Teriparatide, a recombinant human parathyroid hormone, has demonstrated promise in enhancing fracture healing, although its efficacy in treating established nonunion remains under investigation.</p><p><strong>Case summary: </strong>We report a case of a 27-year-old male who presented with a right humerus fracture following a traffic accident. Despite undergoing open reduction and internal fixation, the fracture resulted in a delayed union and subsequent nonunion. After 4 years of conservative management, teriparatide treatment was initiated due to persistent nonunion. Teriparatide injections were administered daily for 6 months, resulting in complete fracture healing and resolution of pain.</p><p><strong>Conclusion: </strong>Our case demonstrates the successful use of teriparatide in treating a prolonged nonunion of a humerus fracture. Teriparatide may provide a valuable therapeutic option for established bone nonunion, even in cases that have not responded to conservative treatments.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 1","pages":"101656"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the hip-spine relationship in total hip arthroplasty for childhood hip disorders sequelae. 儿童髋关节疾病后遗症全髋关节置换术中髋-脊柱关系的评估。
IF 2
World Journal of Orthopedics Pub Date : 2025-01-18 DOI: 10.5312/wjo.v16.i1.99383
Cong-Ke Shu, Hai-Song Liang, Xin-Wen Bai, Yu Deng, Qi-Long Jiang
{"title":"Assessment of the hip-spine relationship in total hip arthroplasty for childhood hip disorders sequelae.","authors":"Cong-Ke Shu, Hai-Song Liang, Xin-Wen Bai, Yu Deng, Qi-Long Jiang","doi":"10.5312/wjo.v16.i1.99383","DOIUrl":"10.5312/wjo.v16.i1.99383","url":null,"abstract":"<p><p>In this article, we comment on the article by Oommen <i>et al</i>. Oommen <i>et al</i> provided a comprehensive overview of the management of hip centre restoration in total hip arthroplasty (THA) for childhood hip disorder sequelae. Given the developmental disparity in this population, specific preoperative planning is an essential prerequisite for the success of THA procedures. In the review by Oommen <i>et al</i>, assessments of acetabular and femoral anatomic variations were fully described. However, spinal malalignment and stiffness are common in physical and radiological examinations and should be taken into careful consideration when planning surgical procedures. Poor outcomes of THA for patients with comorbid hip and spinopelvic pathologies have been widely reported, especially for hips with childhood disorder sequelae. Therefore, in this editorial, we would like to emphasize the need for a thorough hip-spine evaluation of patients with childhood hip disorder sequelae before THA.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 1","pages":"99383"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative study of a rabbit model of spinal tuberculosis using different concentrations of Mycobacterium tuberculosis. 不同浓度结核分枝杆菌对兔脊柱结核模型的比较研究。
IF 2
World Journal of Orthopedics Pub Date : 2025-01-18 DOI: 10.5312/wjo.v16.i1.101424
Yong-Jie Qiao, Xiao-Yang Song, Lv-Dan Zhang, Feng Li, Hao-Qiang Zhang, Sheng-Hu Zhou
{"title":"Comparative study of a rabbit model of spinal tuberculosis using different concentrations of <i>Mycobacterium tuberculosis</i>.","authors":"Yong-Jie Qiao, Xiao-Yang Song, Lv-Dan Zhang, Feng Li, Hao-Qiang Zhang, Sheng-Hu Zhou","doi":"10.5312/wjo.v16.i1.101424","DOIUrl":"10.5312/wjo.v16.i1.101424","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis is among the most devastating infectious diseases worldwide. Spinal tuberculosis is not easy to detect at an early stage, which without effective treatment often leads to spinal deformity and spinal cord damage which in turn cause complications such as paraplegia and quadriplegia. In this study, we established a model using three concentrations of bacteria and carried out a comprehensive evaluation of the model by imaging, general observations, and histopathological and bacteriological studies.</p><p><strong>Aim: </strong>To establish a rabbit model of spinal tuberculosis and examine the effect on the model's efficacy using different concentrations of <i>Mycobacterium tuberculosis</i> (<i>M. tuberculosis</i>) inoculum.</p><p><strong>Methods: </strong>New Zealand rabbits were randomly divided into experimental, control and blank groups. The experimental and control animals were sensitized with complete Freund's adjuvant, a hole was drilled beneath the upper endplate of the L6 vertebral body and filled with gelfoam sponge. The experimental group was divided into three subgroups (experimental 1, experimental 2, experimental 3) and infused with <i>M. tuberculosis</i> suspension at various concentrations. The control group was inoculated with saline and the blank group received no treatment. The 12-week post-operative survival rates were 100%, 80% and 30% in the experimental groups inoculated with concentrations of 10<sup>6</sup>, 10<sup>7</sup> and 10<sup>8</sup> CFU/mL bacteria, respectively.</p><p><strong>Results: </strong>The survival rate of the control and blank groups was 100%. Vertebral body destruction at 8 weeks in the three experimental groups as determined by X-ray analysis was 33.3%, 62.5% and 66.7%, and by computed tomography (CT) and 3-dimensional CT 44.4%, 75% and 100%, respectively. At 12 weeks, the figures were 44.4%, 75% and 100% by X-ray analysis and 44.4%, 100% and 100% by CT and 3-dimensional CT, respectively. All surviving rabbits of the experimental groups had vertebral destruction. The positive bacterial culture rates were 22.2%, 75% and 66.7%, respectively, in the experimental groups. After being sensitized with complete Freund's adjuvant, large differences were observed in the extent of spinal tuberculosis after inoculation of the rabbit<b>s</b> with different concentrations of H37RV standard <i>M. tuberculosis</i>.</p><p><strong>Conclusion: </strong>The experimental 1 had a low success rate at establishing an infection. The experimental 3 resulted in high mortality and complication rates. The experimental 2 was optimum for establishing a spinal tuberculosis model based on the high level of symptoms observed and the low rabbit mortality.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 1","pages":"101424"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fundamentals of intervertebral disc degeneration and related discogenic pain. 椎间盘退变的基本原理和相关的椎间盘源性疼痛。
IF 2
World Journal of Orthopedics Pub Date : 2025-01-18 DOI: 10.5312/wjo.v16.i1.102119
Bao-Gan Peng
{"title":"Fundamentals of intervertebral disc degeneration and related discogenic pain.","authors":"Bao-Gan Peng","doi":"10.5312/wjo.v16.i1.102119","DOIUrl":"10.5312/wjo.v16.i1.102119","url":null,"abstract":"<p><p>Lumbar intervertebral disc degeneration is thought to be the main cause of low back pain, although the mechanisms by which it occurs and leads to pain remain unclear. In healthy adult discs, vessels and nerves are present only in the outer layer of the annulus fibrosus and in the bony endplate. Animal models, and histological and biomechanical studies have shown that annulus tear or endplate injury is the initiating factor for painful disc degeneration. Injury to the disc triggers a local inflammatory repair response that activates nociceptors and promotes the synthesis of neuropeptides such as substance P and calcitonin gene-related peptide, by dorsal root ganglion neurons. These neuropeptides are transported to injured discs and act as pro-inflammatory molecules, promoting the production of an \"inflammatory soup\" by inducing vasodilatation and plasma extravasation as well as by promoting the release of chemical mediators from disc cells and infiltrating immune cells, causing neurogenic inflammation that leads to progressive disc degeneration and discogenic pain.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 1","pages":"102119"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Limited evidence to support demineralized bone matrix in foot and ankle surgical procedures: A systematic review. 支持脱矿骨基质在足部和踝关节外科手术中的有限证据:一项系统综述。
IF 2
World Journal of Orthopedics Pub Date : 2025-01-18 DOI: 10.5312/wjo.v16.i1.97848
Hayden Hartman, James J Butler, Megan Calton, Charles C Lin, Samantha Rettig, Jared C Tishelman, Sebastian Krebsbach, Grace W Randall, John G Kennedy
{"title":"Limited evidence to support demineralized bone matrix in foot and ankle surgical procedures: A systematic review.","authors":"Hayden Hartman, James J Butler, Megan Calton, Charles C Lin, Samantha Rettig, Jared C Tishelman, Sebastian Krebsbach, Grace W Randall, John G Kennedy","doi":"10.5312/wjo.v16.i1.97848","DOIUrl":"10.5312/wjo.v16.i1.97848","url":null,"abstract":"<p><strong>Background: </strong>Demineralized bone matrix (DBM) is a commonly utilized allogenic bone graft substitute to promote osseous union. However, little is known regarding outcomes following DBM utilization in foot and ankle surgical procedures.</p><p><strong>Aim: </strong>To evaluate the clinical and radiographic outcomes following DBM as a biological adjunct in foot and ankle surgical procedures.</p><p><strong>Methods: </strong>During May 2023, the PubMed, EMBASE and Cochrane library databases were systematically reviewed to identify clinical studies examining outcomes following DBM for the management of various foot and ankle pathologies. Data regarding study characteristics, patient demographics, subjective clinical outcomes, radiological outcomes, complications, and failure rates were extracted and analyzed. In addition, the level of evidence (LOE) and quality of evidence (QOE) for each individual study was also assessed. Thirteen studies were included in this review.</p><p><strong>Results: </strong>In total, 363 patients (397 ankles and feet) received DBM as part of their surgical procedure at a weighted mean follow-up time of 20.8 ± 9.2 months. The most common procedure performed was ankle arthrodesis in 94 patients (25.9%). Other procedures performed included hindfoot fusion, 1st metatarsophalangeal joint arthrodesis, 5th metatarsal intramedullary screw fixation, hallux valgus correction, osteochondral lesion of the talus repair and unicameral talar cyst resection. The osseous union rate in the ankle and hindfoot arthrodesis cohort, base of the 5<sup>th</sup> metatarsal cohort, and calcaneal fracture cohort was 85.6%, 100%, and 100%, respectively. The weighted mean visual analog scale in the osteochondral lesions of the talus cohort improved from a pre-operative score of 7.6 ± 0.1 to a post-operative score of 0.4 ± 0.1. The overall complication rate was 27.2%, the most common of which was non-union (8.8%). There were 43 failures (10.8%) all of which warranted a further surgical procedure.</p><p><strong>Conclusion: </strong>This current systematic review demonstrated that the utilization of DBM in foot and ankle surgical procedures led to satisfactory osseous union rates with favorable wound complication rates. Excellent outcomes were observed in patients undergoing fracture fixation augmented with DBM, with mixed evidence supporting the routine use of DBM in fusion procedures of the ankle and hindfoot. However, the low LOE together with the low QOE and significant heterogeneity between the included studies reinforces the need for randomized control trials to be conducted to identify the optimal role of DBM in the setting of foot and ankle surgical procedures.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 1","pages":"97848"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term follow-up result of short metaphyseal femoral stem in primary total hip arthroplasty: A retrospective study. 首次全髋关节置换术中短干骺端股骨干的长期随访结果:回顾性研究。
IF 2
World Journal of Orthopedics Pub Date : 2025-01-18 DOI: 10.5312/wjo.v16.i1.100173
Manoj Kumar, Ayush Sharma, Vivek P Ksheerasagar, Akash K Ghosh, Mukund Lal
{"title":"Long-term follow-up result of short metaphyseal femoral stem in primary total hip arthroplasty: A retrospective study.","authors":"Manoj Kumar, Ayush Sharma, Vivek P Ksheerasagar, Akash K Ghosh, Mukund Lal","doi":"10.5312/wjo.v16.i1.100173","DOIUrl":"10.5312/wjo.v16.i1.100173","url":null,"abstract":"<p><strong>Background: </strong>Total hip arthroplasty (THA) has increased along with an increasing demand for improved quality of life. Combined with prolonged life expectancy, the number of revision surgeries is expected to increase. Stress shielding is a significant issue with traditional femoral stems used in THA, making revision surgeries particularly challenging in younger patients. This has sparked renewed interest in studying safety and functional outcomes of short metaphyseal femoral stems, which have the potential to alleviate these challenges and simplify revision surgeries.</p><p><strong>Aim: </strong>To evaluate the long-term outcomes of short-stem THA.</p><p><strong>Methods: </strong>A total of 124 hips that underwent THA using the short femoral stem (TRILOCK<sup>®</sup> Depuy) between May 2006 and November 2008 were included in this study. Patients were followed for a period of 15 years. Outcomes were assessed in terms of pain relief, hip joint range of motion, improvement in mobility, and functional outcomes using the modified Harris Hip Score, Oxford hip score, and Western Ontario and McMaster Universities Osteoarthritis index score.</p><p><strong>Results: </strong>A total of 124 hips in 98 patients were evaluated. Significant improvements in functional outcomes were observed over the 15-year follow-up period, with no cases of subsidence, implant loosening, or complications necessitating revision surgery. The only complication reported was heterotopic ossification in 1 patient.</p><p><strong>Conclusion: </strong>Short metaphyseal stems provide better functional outcomes with early mobilization, and its long-term follow-up without subsidence, implant loosening, or proximal femoral bone loss simplifies revision surgery in younger patients.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 1","pages":"100173"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current status of nanofat in the management of knee osteoarthritis: A systematic review. 纳米脂肪在膝关节骨关节炎治疗中的现状:系统综述。
IF 2
World Journal of Orthopedics Pub Date : 2025-01-18 DOI: 10.5312/wjo.v16.i1.99690
Naveen Jeyaraman, Sandeep Shrivastava, V R Ravi, Arulkumar Nallakumarasamy, Madhan Jeyaraman
{"title":"Current status of nanofat in the management of knee osteoarthritis: A systematic review.","authors":"Naveen Jeyaraman, Sandeep Shrivastava, V R Ravi, Arulkumar Nallakumarasamy, Madhan Jeyaraman","doi":"10.5312/wjo.v16.i1.99690","DOIUrl":"10.5312/wjo.v16.i1.99690","url":null,"abstract":"<p><strong>Background: </strong>Osteoarthritis (OA) is a prevalent joint disorder requiring innovative treatment approaches.</p><p><strong>Aim: </strong>To evaluate the use of nanofat, a specialized form of adipose tissue-derived cells, in the treatment of OA, by examining its efficacy, safety profile, mechanisms of action, comparative effectiveness, and long-term outcomes.</p><p><strong>Methods: </strong>A comprehensive review of preclinical studies, clinical trials, and <i>in vitro</i> investigations was conducted. The included studies provided insights into the potential role of nanofat in OA treatment, addressing its efficacy, safety profile, mechanisms of action, comparative effectiveness, and long-term outcomes.</p><p><strong>Results: </strong>Clinical studies consistently reported the efficacy of nanofat in providing pain relief and functional improvement in patients with OA. Local adverse events were limited to the injection site, such as localized pain and inflammation, and resolved within a few days to weeks. Systemic adverse events were rare, and no significant long-term complications were observed. Mechanistically, nanofat was found to enhance chondrocyte proliferation, reduce inflammation, and promote angiogenesis, thereby contributing to its therapeutic effects.</p><p><strong>Conclusion: </strong>Nanofat therapy holds promise as a therapeutic option for managing OA, providing pain relief, functional improvement, and potential tissue regeneration. The safety profile of nanofat treatment appears favorable, but long-term data are still limited. Standardized protocols, larger randomized controlled trials, longer follow-up periods, and cost-effectiveness evaluations are warranted to establish optimal protocols, comparative effectiveness, and long-term outcomes. Despite current limitations, nanofat therapy demonstrates translational potential and should be considered in clinical practice for OA treatment, with careful patient selection and monitoring.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 1","pages":"99690"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating finite element analysis in total hip arthroplasty for childhood hip disorders: Enhancing precision and outcomes. 整合有限元分析在全髋关节置换术治疗儿童髋关节疾病:提高精度和结果。
IF 2
World Journal of Orthopedics Pub Date : 2025-01-18 DOI: 10.5312/wjo.v16.i1.98871
Muhammad Imam Ammarullah
{"title":"Integrating finite element analysis in total hip arthroplasty for childhood hip disorders: Enhancing precision and outcomes.","authors":"Muhammad Imam Ammarullah","doi":"10.5312/wjo.v16.i1.98871","DOIUrl":"10.5312/wjo.v16.i1.98871","url":null,"abstract":"<p><p>Total hip arthroplasty for adults with sequelae from childhood hip disorders poses significant challenges due to altered anatomy. The paper published by Oommen <i>et al</i> reviews the essential management strategies for these complex cases. This article explores the integration of finite element analysis (FEA) to enhance surgical precision and outcomes. FEA provides detailed biomechanical insights, aiding in preoperative planning, implant design, and surgical technique optimization. By simulating implant configurations and assessing bone quality, FEA helps in customizing implants and evaluating surgical techniques like subtrochanteric shortening osteotomy. Advanced imaging techniques, such as 3D printing, virtual reality, and augmented reality, further enhance total hip arthroplasty precision. Future research should focus on validating FEA models, developing patient-specific simulations, and promoting multidisciplinary collaboration. Integrating FEA and advanced technologies in total hip arthroplasty can improve functional outcomes, reduce complications, and enhance quality of life for patients with childhood hip disorder sequelae.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 1","pages":"98871"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of neurogenic inflammation in intervertebral disc degeneration. 神经源性炎症在椎间盘退变中的作用。
IF 2
World Journal of Orthopedics Pub Date : 2025-01-18 DOI: 10.5312/wjo.v16.i1.102120
Bao-Gan Peng, Yong-Chao Li, Liang Yang
{"title":"Role of neurogenic inflammation in intervertebral disc degeneration.","authors":"Bao-Gan Peng, Yong-Chao Li, Liang Yang","doi":"10.5312/wjo.v16.i1.102120","DOIUrl":"10.5312/wjo.v16.i1.102120","url":null,"abstract":"<p><p>In healthy intervertebral discs (IVDs), nerves and blood vessels are present only in the outer annulus fibrosus, while in degenerative IVDs, a large amount of nerve and blood vessel tissue grows inward. Evidence supports that neurogenic inflammation produced by neuropeptides such as substance P and calcitonin gene related peptide released by the nociceptive nerve fibers innervating the IVDs plays a crucial role in the process of IVD degeneration. Recently, non-neuronal cells, including IVD cells and infiltrating immune cells, have emerged as important players in neurogenic inflammation. IVD cells and infiltrating immune cells express functional receptors for neuropeptides through which they receive signals from the nervous system. In return, IVD cells and immune cells produce neuropeptides and nerve growth factor, which stimulate nerve fibers. This communication generates a positive bidirectional feedback loop that can enhance the inflammatory response of the IVD. Recently emerging transient receptor potential channels have been recognized as contributors to neurogenic inflammation in the degenerative IVDs. These findings suggest that neurogenic inflammation involves complex pathophysiological interactions between sensory nerves and multiple cell types in the degenerative IVDs. Clarifying the mechanism of neurogenic inflammation in IVD degeneration may provide in-depth understanding of the pathology of discogenic low back pain.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 1","pages":"102120"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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