{"title":"Editorial: Renal denervation for kidney-related pain syndromes: a clue in search of proofs.","authors":"Flavio L Ribichini","doi":"10.1016/j.carrev.2025.08.002","DOIUrl":"https://doi.org/10.1016/j.carrev.2025.08.002","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michał Piotrowski, Julia Izabela Karpierz, Radosław Litwinowicz, Bogusław Kapelak, Krzysztof Bartuś
{"title":"Seven years of follow-up of first-in-human percutaneous epicardial-only left atrial appendage closure using Sierra device.","authors":"Michał Piotrowski, Julia Izabela Karpierz, Radosław Litwinowicz, Bogusław Kapelak, Krzysztof Bartuś","doi":"10.1016/j.carrev.2025.08.001","DOIUrl":"https://doi.org/10.1016/j.carrev.2025.08.001","url":null,"abstract":"<p><strong>Background: </strong>It is estimated that at least one third of the population will suffer from atrial fibrillation in their lifetime. In order to prevent strokes and thromboembolism, anticoagulation treatment should be administered. In addition, exclusion of the left atrial appendage should be considered in certain cases to prevent fatal ischemic complications. In patients at high risk of intervention, the devices available to close the left atrial appendage are not suitable. In addition, their use is limited by the anatomy of the left atrial appendage, which may not be suitable for any of the available exclusion devices. The aim of this study is to present the long-term results of the Sierra Aegis Left Atrial Appendage Ligation System - a new, exclusively epicardial system for closure of the left atrial appendage - for the first time in a human study.</p><p><strong>Methods: </strong>This was a prospective, first-in-human study investigating the efficacy and safety of the Sierra Aegis Left Atrial Appendage Ligation System for epicardial closure of the left atrial appendage. 7 patients (mean age: 57.3 ± 10.6 years, 71.4 % male) who underwent left atrial appendage exclusion with the Sierra system were followed for up to 7 years.</p><p><strong>Results: </strong>No strokes, leaks, or other complications were observed in the study group during the 7-year follow-up period.</p><p><strong>Conclusions: </strong>This 7-year follow-up of the first-in-human study of the Sierra Aegis Ligation System for left atrial appendage closure shows very good long-term results in terms of the efficacy and safety of this device when used in humans.</p>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Yang, Grace C Bloomfield, Brian C Case, Lowell F Satler, Ron Waksman, Itsik Ben-Dor
{"title":"Procedural characteristics of coronary angiography in patients with anomalous aortic origin of a coronary artery.","authors":"Michael Yang, Grace C Bloomfield, Brian C Case, Lowell F Satler, Ron Waksman, Itsik Ben-Dor","doi":"10.1016/j.carrev.2024.09.007","DOIUrl":"10.1016/j.carrev.2024.09.007","url":null,"abstract":"<p><strong>Background: </strong>Anomalous coronary arteries (ACA) are seen in 1-5 % of patients undergoing coronary angiography, and their presence may increase procedural difficulty. We aimed to compare procedural outcomes of coronary angiography in ACA patients by anatomy and prior knowledge of the ACA.</p><p><strong>Methods: </strong>This was a single-center review of ACA patients undergoing coronary angiography between October 2013 and February 2022. Primary endpoints were contrast volume, fluoroscopy dose, time, and dose-area product (DAP). Comparisons were made between groups based on ACA anatomy and based on prior knowledge of the ACA.</p><p><strong>Results: </strong>We found 176 diagnostic coronary angiograms among ACA patients. Anomalies of the right coronary artery (RCA) comprised 77 %, followed by left circumflex (LCX) at 16 % and left main or left anterior descending (LMCA/LAD) at 7 %. There was significantly more contrast use among patients with RCA (mean 110.5 mL) or LMCA/LAD (115.6 mL) anomalies than LCX (76.2 mL; p = 0.01). There was no difference in fluoroscopy dose, time, or DAP. Prior knowledge of the anomaly was recorded in 61 (35 %) cases. Contrast volume (mean difference 27.1 mL, 95 % confidence interval: 12.5-41.8) and all fluoroscopy measures decreased if the ACA was previously known to the operators.</p><p><strong>Conclusion: </strong>Different types of ACAs are associated with increased contrast use but not fluoroscopy exposure. Prior knowledge of ACA is associated with decreased contrast use and fluoroscopy exposure. Thorough review of prior catheterizations and knowledge of catheter selection is important for reducing contrast use and fluoroscopy exposure in patients with ACA.</p>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":"7-11"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taha Mansoor, Maninder Randhawa, Mahmoud Ismayl, Austin Brubaker, Santhosh K G Koshy
{"title":"Outcomes of percutaneous coronary intervention for myocardial infarction in adults with congenital heart disease.","authors":"Taha Mansoor, Maninder Randhawa, Mahmoud Ismayl, Austin Brubaker, Santhosh K G Koshy","doi":"10.1016/j.carrev.2025.03.014","DOIUrl":"10.1016/j.carrev.2025.03.014","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":"107-111"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luke P Dawson, Christopher C Y Wong, Daniel K Amponsah, William F Fearon
{"title":"FFR-guided complete or culprit-only revascularization in ST-elevation myocardial infarction: A systematic review and Meta-analysis.","authors":"Luke P Dawson, Christopher C Y Wong, Daniel K Amponsah, William F Fearon","doi":"10.1016/j.carrev.2025.03.008","DOIUrl":"10.1016/j.carrev.2025.03.008","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":"105-106"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aparna Iyer, Shim Roh, Haris Muhammad, Amer Hammad, Vicky Kumar, Dipal Patel, Jason Sayanlar
{"title":"Renal denervation for resistant hypertension: A review of current literature.","authors":"Aparna Iyer, Shim Roh, Haris Muhammad, Amer Hammad, Vicky Kumar, Dipal Patel, Jason Sayanlar","doi":"10.1016/j.carrev.2025.05.014","DOIUrl":"10.1016/j.carrev.2025.05.014","url":null,"abstract":"<p><p>Resistant hypertension is defined by persistently elevated blood pressure (BP) despite being treated with three or more antihypertensive medications including a diuretic, leading to an increased risk of cardiovascular events and mortality. It presents a substantial global health challenge, impacting about 10 % of individuals with hypertension. Renal denervation (RDN) has come up as a promising interventional strategy to address this condition by modulating the renal sympathetic nervous system. This review article explores the mechanisms underlying RDN, its historical evolution, recent procedural advancements, clinical evidence supporting its efficacy, and the existing guidelines guiding its application. Recent advances in RDN research and potential future implications are also discussed, highlighting its role in achieving improved BP control and reducing cardiovascular risks in patients with resistant hypertension.</p>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":"122-127"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Islam Shatla, Kevin Kennedy, John Thomas Saxon, Adnan K Chhatriwalla, Anthony Magalski, Kyle Lehenbauer, Islam Abdelkarim, Kenneth Christopher Huber, Chetan P Huded
{"title":"Intracardiac vs. transesophageal echocardiography guided transcatheter closure of patent foramen ovale and atrial septal defects.","authors":"Islam Shatla, Kevin Kennedy, John Thomas Saxon, Adnan K Chhatriwalla, Anthony Magalski, Kyle Lehenbauer, Islam Abdelkarim, Kenneth Christopher Huber, Chetan P Huded","doi":"10.1016/j.carrev.2024.09.016","DOIUrl":"10.1016/j.carrev.2024.09.016","url":null,"abstract":"<p><p>Transcatheter closure of atrial septal defects (ASD) and patent foramen ovale (PFO) can be performed with transesophageal echocardiography (TEE) or intracardiac echocardiography (ICE) guidance, but data comparing both modalities in contemporary practice is lacking. Using ICD-10 codes, patients who underwent transcatheter ASD/PFO closure between 2016 and 2020 using ICE or TEE in the Nationwide Readmissions Database (NRD) were identified. Propensity-score matching was performed to compare in-hospital adverse events, length of stay (LOS), cost, and 30-day non-elective readmissions. A total of 964 patients underwent ASD/PFO closure with ICE (38.3 %, n = 369) or TEE (61.7 %, n = 595) between 2016 and 2020. Propensity score matching yielded 327 patients in each group, which were well balanced. Median (IQR) age was 59.0 (46.0, 72.0) years and 54.7 % were female. No difference was observed in the rate of in-hospital major adverse events between groups. ICE guidance was associated with a lower median cost (ICE $20,140.1 (14,622.3, 25,027.0) vs TEE $20,740.4 (14,137.5, 33,045.3), p < 0.04). In conclusion, ICE guided ASD/PFO closure was associated with lower hospitalization cost without increasing in-hospital adverse events when compared with TEE guidance.</p>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":"61-65"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Timothy G Scully, Louise Roberts, Diem Dinh, Angela Brennan, David Clark, Andrew Ajani, Christopher M Reid, Ernesto Oqueli, Chin Hiew, Dion Stub, Jaya Chandrasekhar, Melanie Freeman
{"title":"Trends in utilization and clinical outcomes with and without the use of distal filter wire embolic protection devices.","authors":"Timothy G Scully, Louise Roberts, Diem Dinh, Angela Brennan, David Clark, Andrew Ajani, Christopher M Reid, Ernesto Oqueli, Chin Hiew, Dion Stub, Jaya Chandrasekhar, Melanie Freeman","doi":"10.1016/j.carrev.2024.10.008","DOIUrl":"10.1016/j.carrev.2024.10.008","url":null,"abstract":"<p><strong>Background: </strong>Embolic protection devices were developed to reduce the risk of common complications encountered during percutaneous coronary intervention (PCI) of saphenous vein grafts, however, in the setting of contemporary multi-modality medical management, their overall efficacy has been called into question. This study aimed to assess the evolving utilization and clinical outcomes associated with distal filter wire embolic protection devices in saphenous vein PCI.</p><p><strong>Methods: </strong>Consecutive patients undergoing PCI to a saphenous vein graft in a registry were included. Peri-procedural and long-term outcomes including 12-month mortality and 30-day MACCE rates were compared between PCI using a distal filter wire embolic protection device and unprotected PCI.</p><p><strong>Results: </strong>From 2005 to 2020, a total of 753 patients underwent PCI to a saphenous vein graft with 256 using a distal filter wire embolic protection device. At one year, the use of a distal filter wire embolic protection devices was not associated with a decrease in mortality (4.7 % vs 5.4 %, p = 0.19) and there was no difference in 30-day MACCE rates between protected and unprotected saphenous vein PCI (3.1 % vs 5.8 %, p = 0.10).</p><p><strong>Conclusion: </strong>In this 12-month analysis of saphenous vein graft PCI, there was no evidence that distal filter wire embolic protection devices improved short term post procedural or long-term mortality outcomes.</p>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":"97-101"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jamal Christopher Perry, Oluwasegun Matthew Akinti, Chukwuka Eneh, Henry Osarumme Aiwuyo, Charles Poluyi, Ukenenye Emmanuel, Esther Doudu, Henry Alberto Becerra, Mustafa Bilal Ozbay, Kibwey Roderick Peterkin, Rosy Thachil, Abdullah Khan
{"title":"Racial and ethnic disparities in clinical outcomes among patients with takotsubo syndrome; A nation-wide analysis.","authors":"Jamal Christopher Perry, Oluwasegun Matthew Akinti, Chukwuka Eneh, Henry Osarumme Aiwuyo, Charles Poluyi, Ukenenye Emmanuel, Esther Doudu, Henry Alberto Becerra, Mustafa Bilal Ozbay, Kibwey Roderick Peterkin, Rosy Thachil, Abdullah Khan","doi":"10.1016/j.carrev.2024.09.013","DOIUrl":"10.1016/j.carrev.2024.09.013","url":null,"abstract":"<p><strong>Background: </strong>Takotsubo syndrome (TTS), a stress-induced transient left ventricular dysfunction, remains poorly understood, with an estimated incidence of 1-2 % among acute coronary syndrome cases. This study investigates racial and ethnic disparities in hospital outcomes and clinical characteristics of TTS.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using the National Inpatient Sample data from 2016 to 2020, identifying TTS cases through validated ICD-10 codes. Statistical analysis was performed using Stata 18, with logistic regression models adjusting for confounders to identify disparities in outcomes.</p><p><strong>Results: </strong>The study included 32,785 TTS hospitalizations; the majority were White (80.5 %), followed by Black (6.7 %) and Hispanic (5.8 %) patients. Minority groups, mainly Black and Hispanic patients, were younger (average age 63) and predominantly from lower-income brackets, while Asians had the highest income bracket. Length of stay (5.1 days) and Total cost ($22,707.60) were highest among Native Americans. Notable findings include Black patients showing the highest rate of stroke (4.8 %, OR 2.1, 95 % CI 1.2 to 3.4, p = 0.003). The rate of cardiogenic shock was highest among Asians (11 %, OR 2, 95 % CI 1.5 to 2.5, p < 0.001). Mortality rates were elevated in Black (2 %, OR 1.5, 95 % CI 1.3 to 1.7 p < 0.001) and Asian populations (1.8 %, OR 1.97, 95 % CI 1.5 to 2.5, p < 0.001).</p><p><strong>Conclusion: </strong>Significant racial and ethnic disparities exist in TTS outcomes, with minority groups having more in-hospital outcomes. These findings highlight the urgent need for targeted interventions and further research to reduce healthcare inequities in TTS management.</p>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":"83-88"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kalyan R Chitturi, Gregg W Stone, Roxana Mehran, Pieter C Smits, Douglas E Drachman, Dominick J Angiolillo, Grant W Reed, Usman Baber, C Michael Gibson, Ron Waksman
{"title":"Cardiovascular Research Technologies 2025: Beyond the Guidelines: DAPT selection and duration before and after PCI.","authors":"Kalyan R Chitturi, Gregg W Stone, Roxana Mehran, Pieter C Smits, Douglas E Drachman, Dominick J Angiolillo, Grant W Reed, Usman Baber, C Michael Gibson, Ron Waksman","doi":"10.1016/j.carrev.2025.06.035","DOIUrl":"10.1016/j.carrev.2025.06.035","url":null,"abstract":"<p><p>Dual antiplatelet therapy (DAPT) remains a cornerstone of secondary prevention in patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS). The balance between ischemic protection and bleeding risk has driven refinements in therapy duration. In 2025, the American College of Cardiology (ACC), American Heart Association (AHA), American College of Emergency Physicians (ACEP), National Association of EMS Physicians (NAEMSP), and the Society of Cardiovascular Angiography and Interventions (SCAI) released joint guidelines on the management of patients with ACS, with a particular emphasis on DAPT duration. Considering these recently updated guidelines, the 2025 Cardiovascular Research Technologies (CRT) conference convened a session with leading interventional cardiology experts, entitled \"Beyond the Guidelines - DAPT Selection and Duration Before and After PCI\" to discuss implementation strategies for DAPT based on unique clinical scenarios and the new guideline recommendations. This article synthesizes the current guideline-directed recommendations and expert discussion to provide an evidence-based perspective on beyond the guidelines topics such as optimal DAPT duration, individualized de-escalation strategies, and evolving treatment paradigms for special populations.</p>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}