Clinics in Orthopedic Surgery最新文献

{"title":"Comparative Analysis of Minimally Invasive and Open Proximal Chevron-Akin Osteotomies in Moderate-to-Severe Hallux Valgus Deformity.","authors":"Jun Young Choi, Sun Oh Jung, Jin Soo Suh","doi":"10.4055/cios24450","DOIUrl":"10.4055/cios24450","url":null,"abstract":"<p><strong>Background: </strong>Studies comparing the minimally invasive proximal chevron and Akin osteotomies (MIPCA) technique with conventional techniques, such as the open proximal chevron metatarsal osteotomy with the Akin procedure (open PCMO-Akin procedure), are limited. This study aimed to compare and evaluate operative MIPCA and open PCMO-Akin procedure outcomes in the surgical correction of moderate-to-severe hallux valgus deformities.</p><p><strong>Methods: </strong>We conducted a retrospective comparison of clinical and radiographic outcomes between the MIPCA and open PCMO-Akin procedure in patients with a hallux valgus deformity, defined as a preoperative hallux valgus angle (HVA) of ≥ 30° and/or a first to second intermetatarsal angle of ≥ 13°. The postoperative complication rate was monitored in both groups for a minimum of 12 months. An unsatisfactory correction was defined as an HVA > 15° at final follow-up.</p><p><strong>Results: </strong>We assigned 58 and 99 patients to the MIPCA or open PCMO-Akin procedure group, respectively. At final follow-up, no significant differences were observed between the groups in terms of clinical and radiographic parameters (<i>p</i> > 0.05), with the exception of the distal metatarsal articular angle (DMAA) (<i>p</i> = 0.012). No statistically significant postoperative changes in the DMAA were observed in the MIPCA group (<i>p</i> = 0.875). Five patients (5.1%) experienced postoperative hallux varus in the open PCMO-Akin procedure group, whereas no such cases were observed in the MIPCA group. No statistically significant difference in the rate of unsatisfactory correction was observed between the groups at the final follow-up (MIPCA group, 15.5%; open PCMO-Akin procedure group, 10.1%; <i>p</i> = 0.315).</p><p><strong>Conclusions: </strong>The MIPCA technique is a viable alternative to the open PCMO-Akin procedure for correcting moderate-to-severe hallux valgus deformities. Given the potential lack of postoperative changes in the DMAA following the MIPCA technique, careful consideration is advised when applying this technique to patients with a large DMAA.</p>","PeriodicalId":47648,"journal":{"name":"Clinics in Orthopedic Surgery","volume":"17 3","pages":"514-522"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Powered Tool for the Removal of a Well-Fixed Acetabular Cup: A Comparative Experimental Study.","authors":"Jun Young Chung, Yonghan Cha, Chang-Ho Jung, Jin-Woo Kim, Jun-Il Yoo, Jung-Taek Kim, Yongho Jeon","doi":"10.4055/cios24076","DOIUrl":"10.4055/cios24076","url":null,"abstract":"<p><strong>Backgroud: </strong>The removal of a well-fixed acetabular cup is a challenging, labor-intensive, and time-consuming step during revision hip arthroplasty. Although the advent of the manual osteotome, Explant, has simplified the procedure, it is still a stressful process as it dissipates the surgeon's strength and time and risks an iatrogenic pelvic fracture. Recently, EZX, a powered tool for extraction of well-fixed acetabular cups with semicircular blade was invented. This study aimed to compare Explant and EZX in an experimental condition for their efficacy and safety.</p><p><strong>Methods: </strong>Cementless acetabular cups were press-fitted to 20 hemipelvic polyurethane models using foam adhesives. Ten cups were removed with each tool for comparison of the elapsed time, loads on the entire hemipelvis, periacetabular strain and temperature, volume of periacetabular bone removed, and diameter of the remaining acetabular rim. Strains and loads were quantitatively assessed using strain gauges and load cells for precise and reliable measurements.</p><p><strong>Results: </strong>The mean duration required to remove a well-fixed cup with EZX was 38.5 seconds (range, 25-55), whereas that with Explant was 543.7 seconds (range, 214-1,051) (<i>p</i> < 0.001). The load on the entire hemipelvis with EZX (mean, 9.1 kgf; range, 6.4-11.3) was 33% lower than that with Explant (mean, 13.6 kgf; range, 9.2-17.1) (<i>p</i> < 0.001). The periacetabular peak strains at the 3 positions with EZX were significantly lower than those with Explant (<i>p</i> < 0.001). The temperature during the removal did not differ significantly between the 2 tools. Although the mean volume of bone loss with Explant was 2.4 mL more than that with EZX (<i>p</i> < 0.001), the mean diameters of the remaining acetabular rim were not significantly different, measuring 54.1 mm with both tools.</p><p><strong>Conclusions: </strong>The present experiment revealed that a well-fixed cup could be removed using a powered tool with less strength and time and less load on the entire pelvis. Although the powered tool removed a larger volume of bone, the diameters of the remaining acetabular rims were equivalent. This tool may help surgeons remove well-fixed cups in a short time and reduce the deforming load on the bone around the cup without increasing the size of the subsequent reconstruction cup.</p>","PeriodicalId":47648,"journal":{"name":"Clinics in Orthopedic Surgery","volume":"17 3","pages":"372-380"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Enhanced Recovery after Surgery Protocol in Orthopedic Hip Surgery: A Systematic Review and Meta-Analysis.","authors":"Dong Ha Lee, Ji Wan Kim, Chul-Ho Kim","doi":"10.4055/cios24479","DOIUrl":"10.4055/cios24479","url":null,"abstract":"<p><strong>Background: </strong>The Enhanced Recovery After Surgery (ERAS) protocol has garnered global attention for optimizing perioperative care. It holds significant potential for orthopedic hip surgery, especially in elderly patients requiring rehabilitation. However, large-scale studies or meta-analyses specific to this field remain limited.</p><p><strong>Methods: </strong>A systematic search was performed using Medline (PubMed), Embase, and Cochrane Library databases for studies assessing the effects of the ERAS protocol in hip surgery up to August 13, 2024. A double-arm meta-analysis was designed to compare perioperative outcomes, including postoperative pain scores, transfusion rates, medical and surgical complications, and length of hospital stay, between ERAS and control groups.</p><p><strong>Results: </strong>Twenty-one studies were systematically reviewed, and 13 were included in the pooled analysis, comprising 1,004 patients in the ERAS group and 1,159 in the control group. Meta-analysis results demonstrated that the ERAS protocol significantly improved postoperative pain management, reduced blood transfusion requirements, decreased medical complications, and shortened hospital stays compared to standard protocols.</p><p><strong>Conclusions: </strong>This meta-analysis supports the hypothesis that the ERAS protocol enhances perioperative outcomes in orthopedic hip surgery.</p>","PeriodicalId":47648,"journal":{"name":"Clinics in Orthopedic Surgery","volume":"17 3","pages":"389-399"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adequate Tension and Clinical Results of Palmaris Longus Tendon Interpositional Graft in Closed Flexor Pollicis Longus Rupture.","authors":"Joonha Lee, Ki Hyeok Ku, Jae Hoon Lee, Jong Hun Baek","doi":"10.4055/cios24254","DOIUrl":"10.4055/cios24254","url":null,"abstract":"<p><strong>Background: </strong>Volar plate fixation for distal radial fractures is the most common cause of closed rupture of the flexor pollicis longus tendon (FPL). For treating a closed FPL rupture, transferring the fourth flexor digitorum superficialis or a tendon graft from the palmaris longus (PL) can be performed. This study reports the results of tendon grafting using the PL in closed FPL rupture and discusses the provision of optimal tendon tension.</p><p><strong>Methods: </strong>This retrospective study included 11 out of 20 patients who underwent PL tendon graft for closed FPL rupture between 2013 and 2022, with a follow-up period of more than 12 months. There were 4 men and 7 women, with an average age of 62 years. The average period from the date of rupture to surgery was 39 days. Ruptures occurred due to volar plate fixation in 7 cases, ithout a specific cause in 2 cases, and after a steroid injection for trigger thumb in 2 cases. The rupture site was in zone 2 in 4 cases and zone 5 in 7 cases. The mean follow-up period was 59 months. Optimal tension for the grafted tendon was determined by comparing the intraoperative angles of the interphalangeal (IP) and metacarpophalangeal (MCP) joints with the angles of the same joints at the final follow-up.</p><p><strong>Results: </strong>At the final follow-up, the mean IP joint motion was 61.0°, which was 81.5% of the contralateral side. The average range of motion of the MCP joint was 43.6°, which was 80.0% of the contralateral side. The pinch power was 90.8% of the contralateral side. Cases with > 70° IP joint motion were those in which the IP joint angle was > 45° during surgery. Moreover, the greater the flexion of the IP and MCP joints intraoperatively, the better the range of motion of the IP joints.</p><p><strong>Conclusions: </strong>Tendon grafting using the PL is recommended as an effective surgical method to achieve 81.5% of contralateral IP joint motion in cases of closed FPL tendon rupture. Over-tensioning of the tendon graft with IP Joint flexion more than 45° during surgery is recommended.</p>","PeriodicalId":47648,"journal":{"name":"Clinics in Orthopedic Surgery","volume":"17 3","pages":"506-513"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periprosthetic Infection after Endoprosthetic Reconstruction for Femoral Bone Metastases: Incidence and Risk Factors, a Single Center Study.","authors":"Shinn Kim, Han-Soo Kim, Yongsung Kim, Jay Hoon Park, Ilkyu Han","doi":"10.4055/cios24336","DOIUrl":"10.4055/cios24336","url":null,"abstract":"<p><strong>Background: </strong>This study aims to identify the incidence and risk factors of periprosthetic infections following endoprosthetic reconstruction of femoral metastatic bone disease (MBD). In this population with MBD, the marked impact of infection on the patient's systemic treatment highlights the importance of understanding both the incidence and associated risk factors.</p><p><strong>Methods: </strong>This retrospective cohort study included a total of 140 patients who underwent endoprosthetic reconstruction for femoral MBD at a tertiary referral hospital in South Korea between 2009 and 2019. Infection-free survival was estimated using the Kaplan-Meier method, and Cox proportional hazards model analyses were performed to evaluate the risk factors associated with periprosthetic infection.</p><p><strong>Results: </strong>The incidence of periprosthetic infection in patients who underwent endoprosthetic reconstruction for femoral MBD was 9% (12 out of 140 patients). Risk factors for periprosthetic infection were hepatocellular carcinoma (HCC) as the primary tumor (hazard ratio [HR], 6.08; 95% CI, 1.63-22.6; <i>p</i> = 0.007) and low preoperative absolute neutrophil count (HR, 6.99; 95% CI, 1.79-27.4; <i>p</i> = 0.005).</p><p><strong>Conclusions: </strong>Patients with femoral MBD had a 9% risk of developing a periprosthetic infection. Given their limited life expectancy, this translated to a substantial rate of 58.9 infections per 1,000 person-joint-years. Possible risk factors for periprosthetic infection were low preoperative absolute neutrophil count and HCC as the primary tumor. The high incidence of periprosthetic infection and its associated risk factors should be considered in patients undergoing endoprosthetic reconstruction for femoral MBD.</p>","PeriodicalId":47648,"journal":{"name":"Clinics in Orthopedic Surgery","volume":"17 3","pages":"546-554"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the Reason for the Trend Shift from Dynamic Hip Screw to Cephalomedullary Nailing for the Treatment of Intertrochanteric Fractures? A Comprehensive Retrospective Study in a Single Tertiary Referral Hospital.","authors":"Jae Hun Kim, Hong Seok Kim, Jeong Joon Yoo","doi":"10.4055/cios24425","DOIUrl":"10.4055/cios24425","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of intertrochanteric fractures is increasing with the aging population. Two surgical treatments, cephalomedullary nailing (CMN) and dynamic hip screw (DHS), have been widely utilized; however, recent trends indicate growing preference for CMN. While several studies have compared these 2 surgical methods, there has been limited comprehensive analysis with a substantial sample size from a single medical center aimed at minimizing bias.</p><p><strong>Methods: </strong>This retrospective study was conducted at a single tertiary academic hospital, analyzing data from patients who underwent surgery for intertrochanteric fractures between January 2005 and December 2021. The study focused on comparing surgery-related parameters, postoperative local complications, medical complications, and mortality between patients treated with CMN and those treated with DHS.</p><p><strong>Results: </strong>A total of 475 patients with a minimum follow-up of 3 months were enrolled. The mean (standard deviation) age of patients treated with CMN (77.0 ± 10.7 years) was older compared to those treated with DHS (73.0 ± 12.2 years; <i>p</i> < 0.001). Overall, CMN demonstrated significantly better outcomes in reducing operation time (52.7 minutes vs. 88.2 minutes, <i>p</i> < 0.001), estimated blood loss (EBL) (138.3 mL vs. 305.9 mL, <i>p</i> < 0.001), intra- and postoperative transfusion packs (0.6 vs. 0.9, <i>p</i> = 0.006), and length of hospital stay (12.0 days vs. 20.3 days, <i>p</i> < 0.001), with similar findings in the unstable subgroups. However, in stable fracture cases, CMN showed superiority only in operation time and EBL (operation time: 49.6 minutes vs. 76.5 minutes, <i>p</i> < 0.001; EBL: 103.8 mL vs. 254.8 mL, <i>p</i> < 0.001). No differences were noted in postoperative outcomes including local complications, medical complications, and mortality.</p><p><strong>Conclusions: </strong>Patients treated with CMN experienced no differences in postoperative outcomes including local and medical complications or mortality compared to DHS-treated patients. CMN reduced operation time, EBL, number of intraoperative and postoperative transfusion packs, and length of hospital stay, especially in patients with unstable intertrochanteric fractures. In conclusion, with comparable postoperative complications and mortality, CMN demonstrated superior perioperative efficiency, supporting its growing recommendation over DHS for the treatment of intertrochanteric fractures.</p>","PeriodicalId":47648,"journal":{"name":"Clinics in Orthopedic Surgery","volume":"17 3","pages":"381-388"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Incidence and Risk Factors for Periprosthetic Fracture after Total Knee Arthroplasty in South Korea from 2010 to 2020 Based on National Registry Data.","authors":"Jisu Park, Tae Woo Kim, Min Ki Kim, Jiyu Sun, Kee Jeong Bae, Moon Jong Chang, Chong Bum Chang, Seung-Baik Kang","doi":"10.4055/cios24250","DOIUrl":"10.4055/cios24250","url":null,"abstract":"<p><strong>Background: </strong>Periprosthetic fracture (PPF) is a troublesome complication as it utilizes substantial healthcare resources. Recent studies about the epidemiology of PPF after total knee arthroplasty (TKA) are still lacking, and there is limited national-level analysis focusing on the comorbid chronic conditions as risk factors of PPF. This study used national registry data from South Korea and aimed to investigate the epidemiology of PPF following TKA between 2010 and 2020 and identify which comorbidities contributed to the risk of PPF.</p><p><strong>Methods: </strong>Using Health Insurance Review and Assessment (HIRA) service data in South Korea, the incidence of PPF after TKA between 2010 and 2020 was evaluated and stratified by age and sex. Medical comorbidities were evaluated as possible risk factors for PPF using Cox regression analysis.</p><p><strong>Results: </strong>PPF occurred in 14,429 patients, accounting for 2.37% of total TKA patients. The prevalence of PPF by sex was 2.50% in women and 1.64% in men. The PPF rate was 2.82% in under 60 years, 2.25% in 60 to 69 years, 2.42% in 70 to 79 years, 2.29% in 80 to 89 years, and 2.12% in over 90 years. Among 17 analyzed comorbidities, 11 were found to be associated with PPF after TKA. Severe liver disease (hazard ratio [HR], 1.303), hemiplegia (HR, 1.244), and dementia (HR, 1.206) were the top 3 risk factors. Although osteoporosis, pulmonary disease, peptic ulcer, and diabetes showed relatively low HRs than these top 3 factors, the incidence rates were higher.</p><p><strong>Conclusions: </strong>PPF occurred in 2.37% of TKA patients in South Korea from 2010 to 2020. PPF rate was higher in women. To prevent PPF after TKA, proper patient management and education should be emphasized, particularly in patients with severe liver disease, hemiplegia, and dementia.</p>","PeriodicalId":47648,"journal":{"name":"Clinics in Orthopedic Surgery","volume":"17 3","pages":"408-416"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee Morphology and Proximal Tibial Bone Quality around the Posterior Cruciate Ligament Insertion Site Affect Injury Patterns.","authors":"Young Tak Cho, Jong Hwa Lee, Jun Hyeok Yoon, Seok Ho Hong, Joong Il Kim","doi":"10.4055/cios24440","DOIUrl":"10.4055/cios24440","url":null,"abstract":"<p><strong>Background: </strong>Several studies have investigated the morphological risk factors contributing to posterior cruciate ligament (PCL) injury. However, no study has focused on the injury patterns of intrasubstance tears or tibial avulsion fractures in relation to morphologies and regional bone quality. This study aimed to investigate the impact of the knee morphology and regional bone quality of the proximal tibia on the PCL injury pattern.</p><p><strong>Methods: </strong>This retrospective study compared the radiological features of 76 patients with PCL injuries (PI group) and 76 matched patients with normal PCL (control group). The PI group was divided into 2 subgroups: PCL avulsion fracture (PAF subgroup; n = 43) and PCL intrasubstance tear (PIT subgroup; n = 33). Measurements included the coronal notch width index, coronal tibial slope, medial and lateral posterior tibial slopes, and medial tibial depth. Three Hounsfield unit average measurements were taken from the proximal tibia around the PCL insertion site to create a summative measure of overall bone quality.</p><p><strong>Results: </strong>The medial tibial depth and coronal notch width index were significantly lower in the PI group than those in the control group (medial tibial depth: 2.04 ± 0.77 vs. 3.02 ± 1.04, <i>p</i> = 0.017; coronal notch width index: 0.21 ± 0.03 vs. 0.24 ± 0.03, <i>p</i> = 0.041). In the subgroup analysis, medial tibial depth and Hounsfield unit were significantly lower in the PAF subgroup than in the PIT subgroup (medial tibial depth: 1.74 ± 0.66 vs. 2.43 ± 0.77, <i>p</i> = 0.008, Hounsfield unit: 89.48 ± 31.73 vs. 120.15 ± 29.24, <i>p</i> = 0.004). Binary logistic regression analysis showed that medial tibial depth (odds ratio [OR], 0.161; <i>p</i> < 0.001) and Hounsfield unit (OR, 0.950; <i>p</i> < 0.001) were independent risk factors for PCL tibial avulsion fractures.</p><p><strong>Conclusions: </strong>Lower notch width index and medial tibial depth are associated with PCL injuries. Shallower medial tibial depth and lower Hounsfield unit measurements around the PCL insertion site were associated with an increased incidence of PCL avulsion fractures. These findings may assist clinicians in identifying patients at risk of distinct PCL injury patterns.</p>","PeriodicalId":47648,"journal":{"name":"Clinics in Orthopedic Surgery","volume":"17 3","pages":"400-407"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Antibody Immune Response and Immune Cells on Osteoporosis and Fractures.","authors":"Kangkang Ou, Jiarui Chen, Jichong Zhu, Weiming Tan, Cheng Wei, Guiyu Li, Yingying Qin, Chong Liu","doi":"10.4055/cios24445","DOIUrl":"10.4055/cios24445","url":null,"abstract":"<p><strong>Background: </strong>The immune system plays a critical role in the development and progression of osteoporosis and fractures. However, the causal relationships between antibody immune responses, immune cells, and these bone conditions remain unclear. This study aimed to explore these relationships using Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>We collected complete blood count data from patients with fractures and healthy individuals and analyzed their differences. Then, we conducted a 2-sample, 2-step MR analysis to investigate the causal effects of antibody immune responses on osteoporosis and fractures, using inverse-variance weighted (IVW) as the primary method. We also explored whether immune cells mediate the pathway between antibodies and osteoporosis or fractures. Finally, we analyzed the functions and expression levels of key genes involved.</p><p><strong>Results: </strong>Overall, the fracture group exhibited increased white blood cell count, absolute neutrophil count, absolute monocyte count, platelet count, and their respective proportions, while absolute lymphocyte count, absolute eosinophil count, absolute basophil count, red blood cell count, and their proportions were decreased. We identified 44 causal relationships between antibodies and osteoporosis or fractures, with 7 supported by multiple MR methods, and 5 showing odds ratios significantly deviating from 1 in the IVW analysis. Epstein-Barr virus-related antibodies had a notable impact on osteoporosis and fractures. The human leukocyte antigen (HLA) gene family, particularly HLA-DPB1, emerged as a significant risk factor. However, immune cells were not found to mediate these effects.</p><p><strong>Conclusions: </strong>This study elucidated the causal relationships between antibody immune responses, immune cells, and osteoporosis or fractures. The HLA gene family plays a crucial role in the interaction between antibodies and these bone conditions, with HLA-DPB1 identified as a key risk gene. Immune cells do not serve as mediators in this process. These findings provide valuable insights for future research.</p>","PeriodicalId":47648,"journal":{"name":"Clinics in Orthopedic Surgery","volume":"17 3","pages":"530-545"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction Loss Despite Adequate Volar Locking Plate Fixation in Distal Radius Fractures: Analysis of Characteristics and Follow-up Management.","authors":"Chi-Hoon Oh, Seungyeon Kang, Sung Woo Lee, Soo-Hong Han, Jun-Ku Lee","doi":"10.4055/cios24197","DOIUrl":"10.4055/cios24197","url":null,"abstract":"<p><strong>Background: </strong>The management of distal radius fractures (DRFs) has evolved with the introduction of volar locking plate (VLP) fixation. Nevertheless, despite the low occurrence rates, reduction loss following VLP fixation has been reported in several studies. Our objective was to determine the incidence and features of reduction loss in patients despite the appropriate application of VLP fixation for DRF.</p><p><strong>Methods: </strong>This retrospective study was conducted between March 2017 and August 2023, during which a single hand surgeon performed VLP procedures for DRFs. This study included 379 patients (382 wrists) including 3 patients who underwent bilateral surgery. We identified patients who experienced reduction loss after VLP fixation (group 1) and patients without stability problems (group 2) and compared the 2 groups.</p><p><strong>Results: </strong>The mean age of the patients was 63.5 years, with a standard deviation of 13.8. There were 90 male patients (23.6%) and 289 female patients (75.7%). We identified 14 cases of DRFs, in which reduction loss occurred even after VLP fixation during the follow-up period (group 1, 3.7%). The remaining DRFs were assigned to group 2 (n=368, 96.3%). Among the 14 patients, 7 cases of screw breakage were identified as causing the loss of fracture reduction. As the joint surface collapsed and sank down to the distal row locking screw, 4 cases presented with distal locking screws penetrating into the radiocarpal joint. There were no significant differences between the 2 groups in terms of sex, weight, fracture arm direction, and Arbeitsgemeinschaft für Osteosynthesefragen/Orthopaedic Trauma Association (AO/OTA) fracture classification. However, patients in group 1 were statistically significantly older than those in group 2 (average age, 77.5 years vs. 62 years). Among 4 patients experiencing distal screw violation of the radiocarpal joints, 3 underwent partial or complete screw removal immediately after fracture consolidation or union.</p><p><strong>Conclusions: </strong>While rare, reduction loss remains a potential complication following VLP fixation, especially in elderly patients with intra-articular DRFs. However, with diligent monitoring and timely intervention, such as implant removal if necessary, acceptable outcomes can still be attained.</p>","PeriodicalId":47648,"journal":{"name":"Clinics in Orthopedic Surgery","volume":"17 3","pages":"478-487"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}