Nina Vidic Krhlikar, Matija Tomsic, Polona Jaki Mekjavic, Pia Klobucar, Janez Bregar, Katarina Surlan Popovic, Natasa Valentincic
{"title":"Janus kinase inhibitors and their use in non-infectious orbital inflammatory disorders: new treatment possibilities? A case series.","authors":"Nina Vidic Krhlikar, Matija Tomsic, Polona Jaki Mekjavic, Pia Klobucar, Janez Bregar, Katarina Surlan Popovic, Natasa Valentincic","doi":"10.1080/01676830.2024.2430356","DOIUrl":"https://doi.org/10.1080/01676830.2024.2430356","url":null,"abstract":"<p><p>We present a patient with isolated autoimmune anterior scleritis and a patient with nonspecific orbital inflammation (NSOI). Both patients were treated with systemic corticosteroids during multiple recurrences, with the addition of various disease-modifying antirheumatic drugs (DMARDs), including biologics, in the case of scleritis, resulting in complications and local adverse events. Both patients were subsequently effectively managed using Janus kinase inhibitors (JAK-i), specifically baricitinib and tofacitinib without relapses of inflammation during the follow-up of more than one year. Only a slight transient increase in liver enzymes was reported in a patient with scleritis and no serious side effects.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lavanya Maddi, Anannya Abhyankar Joshi, Mohammad Javed Ali
{"title":"Lacrimal sac diverticulitis.","authors":"Lavanya Maddi, Anannya Abhyankar Joshi, Mohammad Javed Ali","doi":"10.1080/01676830.2024.2439613","DOIUrl":"https://doi.org/10.1080/01676830.2024.2439613","url":null,"abstract":"","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1"},"PeriodicalIF":0.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Periorbital golden threads.","authors":"Kimberly M Papp, Andrew Ting, Kelsey A Roelofs","doi":"10.1080/01676830.2024.2439329","DOIUrl":"https://doi.org/10.1080/01676830.2024.2439329","url":null,"abstract":"","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1"},"PeriodicalIF":0.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anthony C Oganov, Nishanth S Iyengar, Nga Yan Siu, Patrick A Sibony
{"title":"Venous air embolism of the superior ophthalmic vein and cavernous sinus.","authors":"Anthony C Oganov, Nishanth S Iyengar, Nga Yan Siu, Patrick A Sibony","doi":"10.1080/01676830.2024.2439327","DOIUrl":"https://doi.org/10.1080/01676830.2024.2439327","url":null,"abstract":"","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1"},"PeriodicalIF":0.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
James O Robbins, Kourtney H Houser, Christopher R Dermarkarian
{"title":"Primary treatment of advanced ocular surface and adnexal squamous cell carcinoma with intravenous cemiplimab.","authors":"James O Robbins, Kourtney H Houser, Christopher R Dermarkarian","doi":"10.1080/01676830.2024.2439333","DOIUrl":"https://doi.org/10.1080/01676830.2024.2439333","url":null,"abstract":"","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1"},"PeriodicalIF":0.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niloufar Bineshfar, Leo Meller, Benjamin I Meyer, Wendy W Lee
{"title":"Impact of phenylephrine-induced Hering's response on Müller's muscle-conjunctival resection outcomes.","authors":"Niloufar Bineshfar, Leo Meller, Benjamin I Meyer, Wendy W Lee","doi":"10.1080/01676830.2024.2435928","DOIUrl":"https://doi.org/10.1080/01676830.2024.2435928","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of preoperative phenylephrine (PE)-induced Hering's response on postoperative outcomes in patients undergoing unilateral Müller's muscle-conjunctival resection (MMCR) for blepharoptosis correction.</p><p><strong>Methods: </strong>Sixty-five consecutive patients (65 eyes) undergoing unilateral MMCR between January 2016 and December 2023 were included in this retrospective single-surgeon study. The main outcome measure was the margin-reflex distance 1 (MRD1) at postoperative month 1 visit. Logistic regression analysis was conducted to identify factors influencing postoperative Hering's response.</p><p><strong>Results: </strong>A preoperative post-PE Hering's response was observed in 40.0% of patients. At 1 week and 1 month postoperatively, Hering's response was recorded in 20.0% and 21.5% of cases, respectively. Regression analysis revealed a significant correlation between preoperative post-PE Hering's and post-MMCR Hering's response at postoperative month 1 visit (crude odds ratio (OR): 8.80, <i>p</i> = .003; adjusted OR: 30.43, <i>p</i> = .002).</p><p><strong>Conclusion: </strong>Preoperative post-PE Hering's response is a significant predictor of postoperative Hering's response in unilateral MMCR.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arjun Watane, Brittany M Perzia, Madison E Weiss, Andrea A Tooley, Emily Li, Larissa A Habib, Phillip A Tenzel, Michelle M Maeng
{"title":"ChatGPT and frequently asked patient questions for upper eyelid blepharoplasty surgery.","authors":"Arjun Watane, Brittany M Perzia, Madison E Weiss, Andrea A Tooley, Emily Li, Larissa A Habib, Phillip A Tenzel, Michelle M Maeng","doi":"10.1080/01676830.2024.2435930","DOIUrl":"https://doi.org/10.1080/01676830.2024.2435930","url":null,"abstract":"<p><strong>Purpose: </strong>Online health information seekers may access information produced by artificial intelligence language models such as ChatGPT (OpenAI). The medical field may pose a significant challenge for incorporating these applications given the training and experience needed to master clinical reasoning. The objective was to evaluate the performance of ChatGPT responses compared to human oculofacial plastic surgeon (OPS) responses to FAQs about an upper eyelid blepharoplasty procedure.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted. Three OPS trained by the American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) and three ChatGPT instances each answered 6 frequently asked questions (FAQs) about an upper eyelid blepharoplasty procedure. Two blinded ASOPRS-trained OPS evaluated each response for their accuracy, comprehensiveness, and personal answer similarity based on a Likert scale (1=strongly disagree; 5=strongly agree).</p><p><strong>Results: </strong>ChatGPT achieved a mean Likert scale score of 3.8 (SD 0.9) in accuracy, 3.6 (SD 1.1) in comprehensiveness, and 3.2 (SD 1.1) in personal answer similarity. In comparison, OPS achieved a mean score of 3.6 (SD 1.2) in accuracy (<i>p</i> = .72), 3.0 (SD 1.1) in comprehensiveness (<i>p</i> = .03), and 2.9 (SD 1.1) in personal answer similarity (<i>p</i> = .66).</p><p><strong>Conclusions: </strong>ChatGPT was non-inferior to OPS in answering upper eyelid blepharoplasty FAQs. Compared to OPS, ChatGPT achieved better comprehensiveness ratings and non-inferior accuracy and personal answer similarity ratings. This study poses the potential for ChatGPT to serve as an adjunct to OPS for patient education but not a replacement. However, safeguards to protect patients from possible harm must be implemented.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1-4"},"PeriodicalIF":0.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Grace Lee, Julie Nellis, Chau M Pham, Randy H Kardon, Erin M Shriver
{"title":"Trigeminal nerve blocks attenuate afferent input to the puff-induced blink reflex in chronic orbital pain assessed by high-speed video.","authors":"Grace Lee, Julie Nellis, Chau M Pham, Randy H Kardon, Erin M Shriver","doi":"10.1080/01676830.2024.2435951","DOIUrl":"https://doi.org/10.1080/01676830.2024.2435951","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the trigeminal blink reflex in chronic orbital pain and its modification by orbital anesthetic injections using a novel blink reflexometer.</p><p><strong>Methods: </strong>The EyeStat (Generation 3, Blinktbi, Inc. Charleston, SC) is a device that triggers and analyzes the carbon dioxide puff-evoked trigeminal blink response. In this prospective study, CO<sub>2</sub> puffs were delivered to each eye of 6 patients with unilateral, chronic orbital pain at baseline and 30 minutes after unilateral orbital anesthetic injections consisting of lidocaine and bupivacaine. Ten healthy subjects underwent the testing once without injections. Main outcome measures were comparison of the average of the right and left eyelid responses to stimuli given to the right or left eye (to assess afferent response in the right vs left eye) and comparison of the right eyelid to left eyelid responses to both the right and left stimuli (to assess efferent response in the right vs left eye).</p><p><strong>Results: </strong>In 10 healthy patients, direct blink response of the stimulated eyelid exceeded the consensual response of the opposite eyelid (latency <i>p</i> = .001, excursion <i>p</i> = .04, time to close <i>p</i> = .03). Among the 6 pain patients, eyelid kinematics for afferent trigeminal input were similar between the affected eye and the fellow eye. However, after injection, the afferent latency of the affected eye was significantly prolonged relative to the unaffected eye (<i>p</i> = .006). Efferent blink responses were similar between the two eyelids at all time points.</p><p><strong>Conclusion: </strong>Peribulbar anesthetic injections modulate mechanical afferent input to the trigeminal blink reflex.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1-9"},"PeriodicalIF":0.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacob Schmid, Khizar Rana, Craig James, Gary Davis, Dinesh Selva
{"title":"A novel case of recurrent cylindroma of the orbit.","authors":"Jacob Schmid, Khizar Rana, Craig James, Gary Davis, Dinesh Selva","doi":"10.1080/01676830.2023.2282517","DOIUrl":"10.1080/01676830.2023.2282517","url":null,"abstract":"<p><p>Cylindroma is a rare benign tumour of eccrine origin that has not been previously reported within the orbit. We report a case of a recurrent orbital cylindroma following incomplete excision. A 75-year-old female presented with a recurrent left inferomedial orbital mass. Seven years prior a mass of the same location was excised and on histology at the time resembled a cylindroma. The patient had a history of lung adenocarcinoma. Magnetic resonance imaging (MRI) found the recurrent mass to be a well-circumscribed lesion anterior to the inferior oblique. The mass was subsequently excised. Histological analysis found a well-circumscribed neoplasm with a characteristic jigsaw pattern of nested cells, consistent with cylindroma. This case demonstrates the possibility for cylindromas to occur within the orbit and their ability to reoccur if incompletely excised.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"758-761"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Constanza Barrancos, Montserrat Medina Díaz, Juan Salvador Martinez-San-Millán, Gema Rebolleda, Marco Sales-Sanz
{"title":"Bilateral optic nerve sheath meningocele.","authors":"Constanza Barrancos, Montserrat Medina Díaz, Juan Salvador Martinez-San-Millán, Gema Rebolleda, Marco Sales-Sanz","doi":"10.1080/01676830.2021.1975774","DOIUrl":"10.1080/01676830.2021.1975774","url":null,"abstract":"","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"807"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39485948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}