Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery最新文献_第7页

Orbital necrobiotic xanthogranuloma with necrotizing scleritis and absent cutaneous manifestations. 眼眶坏死性黄疽瘤伴有坏死性巩膜炎，无皮肤表现。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2024-08-07 DOI: 10.1080/01676830.2024.2387105

Josefina Herrera, Gerard Reid, Peter McCluskey, Krishna Tumuluri

引用次数: 0

Immune checkpoint inhibitors and the orbit; two cases of reactive dacryoadenitis. 免疫检查点抑制剂与眼眶；两例反应性泪腺炎。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2024-08-07 DOI: 10.1080/01676830.2024.2385010

Matthew Fenech, Ayodeji Ajanaku, James Hsuan, Austin McCormick, Simon Shamas, Nima Ghadiri

{"title":"Immune checkpoint inhibitors and the orbit; two cases of reactive dacryoadenitis.","authors":"Matthew Fenech, Ayodeji Ajanaku, James Hsuan, Austin McCormick, Simon Shamas, Nima Ghadiri","doi":"10.1080/01676830.2024.2385010","DOIUrl":"https://doi.org/10.1080/01676830.2024.2385010","url":null,"abstract":"Immune checkpoints refer to mechanisms entrusted with the modulation of immune responses in peripheral tissues and are required for minimising collateral damage. Immune checkpoint inhibitors (ICPi) work through numerous pathways, including the anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), anti-PD-1 (programmed cell death protein 1) and the PD-L1 (protein cell death protein-ligand-1) pathways. They are proving to be an exciting therapeutic avenue in the attempt to activate anti-tumour activity. Ipilimumab is a fully human monoclonal antibody working on the anti-CTLA-4 pathway, while nivolumab and pembrolizumab are humanised monoclonal IgG4 antibodies that work on the PD-1 pathway. Despite a growing body of research pertinent to these novel therapies, early indications show that they are limited by their side effect profile. Furthermore, their efficacy appears to be greater in cancers with a high mutational burden. We present two female patients with bilateral reactive dacryoadenitis secondary to ICPi therapy, a finding that to the best of our knowledge was not previously described in the literature.","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sebaceous carcinoma masquerading as ocular mucous membrane pemphigoid. 伪装成眼部粘膜丘疹的皮脂癌。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2024-08-01 Epub Date: 2023-04-25 DOI: 10.1080/01676830.2023.2204489

Elise Timtim, Behin Barahimi, Louise A Mawn, Rachel K Sobel

引用次数: 0

The effect of traction force on eyelid blood perfusion during closure of defects. 眼睑缺损闭合过程中牵引力对眼睑血液灌注的影响

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2024-08-01 Epub Date: 2024-04-30 DOI: 10.1080/01676830.2024.2335999

Jens Nääv Ottosson, Johanna V Berggren, Kajsa Tenland, Elin Bohman, Rafi Sheikh, Malin Malmsjö, Aboma Merdasa

{"title":"The effect of traction force on eyelid blood perfusion during closure of defects.","authors":"Jens Nääv Ottosson, Johanna V Berggren, Kajsa Tenland, Elin Bohman, Rafi Sheikh, Malin Malmsjö, Aboma Merdasa","doi":"10.1080/01676830.2024.2335999","DOIUrl":"10.1080/01676830.2024.2335999","url":null,"abstract":"Purpose: In oculoplastic surgery the eyelid tissue is frequently stretched in order to repair defects after tumor surgery. However, there is a paucity of research regarding how stretching affects eyelids. The purpose of this study was to gain insight into how traction force affects eyelid stretch as well as tissue perfusion, using a laser-based in vivo monitoring technique.Method: Lower-lid pentagonal resections were performed in eight patients and a total of nine eyelids. The medial section of the eyelid was then stretched using a dynamometer up to a force of 2.3 Newtons (N), and eyelid stretching and blood perfusion were continuously measured using laser speckle contrast imaging.Results: Tissue perfusion decreased exponentially when eyelid tissue was stretched, with an initial sharp decline followed by a more gradual reduction. Perfusion approached zero at a force of approximately 2.0 N. The length of the eyelid increased with increasing force up to 1.5 N, after which there was only a very slight increase in length.Conclusions: Eyelid tissue seems to respond to traction in a non-linear fashion, where the initial force results in the greatest eyelid stretching and reduction in blood perfusion. The results provide information on the effects of a large force for direct closure of large eyelid defects. Considering how quickly perfusion approaches zero, the high success rate of eyelid reconstruction surgery is likely a testament to the extensive vascularization of the periocular region.","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraorbital lymphatic-venous malformation in an adult patient: is sirolimus the key? 一名成年患者的眶内淋巴-静脉畸形：西罗莫司是关键吗？

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2024-08-01 Epub Date: 2023-06-01 DOI: 10.1080/01676830.2023.2214938

Alejandro Ruiz Velasco Santacruz, Ismael Nieva Pascual, Pilar Cifuentes Canorea, Sissi Díaz Ramírez, Macarena Pascual González

引用次数: 0

Functional and molecular 3D mapping of angiosarcoma tumor using non-invasive laser speckle, hyperspectral, and photoacoustic imaging. 利用无创激光斑点、高光谱和光声成像技术绘制血管肉瘤肿瘤的功能和分子三维图。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2024-08-01 Epub Date: 2024-04-09 DOI: 10.1080/01676830.2024.2331718

Magne Stridh, Ulf Dahlstrand, Magdalena Naumovska, Karl Engelsberg, Bodil Gesslein, Rafi Sheikh, Aboma Merdasa, Malin Malmsjö

{"title":"Functional and molecular 3D mapping of angiosarcoma tumor using non-invasive laser speckle, hyperspectral, and photoacoustic imaging.","authors":"Magne Stridh, Ulf Dahlstrand, Magdalena Naumovska, Karl Engelsberg, Bodil Gesslein, Rafi Sheikh, Aboma Merdasa, Malin Malmsjö","doi":"10.1080/01676830.2024.2331718","DOIUrl":"10.1080/01676830.2024.2331718","url":null,"abstract":"Purpose: The gold standard for skin cancer diagnosis is surgical excisional biopsy and histopathological examination. Several non-invasive diagnostic techniques exist, although they have not yet translated into clinical use. This is a proof-of-concept study to assess the possibility of imaging an angiosarcoma in the periocular area.Methods: We use laser speckle, hyperspectral, and photoacoustic imaging to monitor blood perfusion and oxygen saturation, as well as the molecular composition of the tissue. The information obtained from each imaging modality was combined in order to yield a more comprehensive picture of the function, as well as molecular composition of a rapidly growing cutaneous angiosarcoma in the periocular area.Results: We found an increase in perfusion coupled with a reduction in oxygen saturation in the angiosarcoma. We could also extract the molecular composition of the angiosarcoma at a depth, depicting both the oxygen saturation and highlighting the presence of connective tissue via collagen.Conclusions: We demonstrate the different physiological parameters that can be obtained with the different techniques and how these can be combined to provide detailed 3D maps of the functional and molecular properties of tumors useful in preoperative assessment.","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mucous membrane grafting for cicatricial entropion repair: review of surgical techniques and outcomes. 粘膜移植修复卡他性内翻症：手术技术和效果回顾。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2024-08-01 Epub Date: 2023-05-08 DOI: 10.1080/01676830.2023.2204498

Swati Singh, Raman Malhotra, Stephanie L Watson

{"title":"Mucous membrane grafting for cicatricial entropion repair: review of surgical techniques and outcomes.","authors":"Swati Singh, Raman Malhotra, Stephanie L Watson","doi":"10.1080/01676830.2023.2204498","DOIUrl":"10.1080/01676830.2023.2204498","url":null,"abstract":"Mucous membrane graft (MMG) is used for moderate-to-severe cicatricial entropion repair either in primary or recurrent cases. We conducted a review to comprehensively summarize the various surgical techniques, outcomes, and complications of using MMG for cicatricial entropion. Though the comparison between different techniques is limited by multiple factors like small numbers of cicatricial entgropion patients, variable severity and success criteria across studies, and different underlying cicatricial entropion etiologies, the author has brought forth the nuances of the use of MMG for cicatricial entropion repair along with its outcomes and complications. MMG use in moderate-to-severe cicatricial entropion gives favourable outcomes. The shortened tarsoconjunctiva is lengthened using MMG, which is used either with terminal tarsal rotation or anterior lamellar recession (ALR) or tarsotomy alone. Non-trachomatous entropion has poor outcomes compared to trachomatous entropion. The most common source of MMG is labial or buccal mucosa and the exact size of MMG harvested is variable according to the defect, and very few prefer oversizing the graft by 10-30%. The outcomes of ALR+MMG appear similar to tarsal rotation and MMG for severe cicatricial entropion. The recurrences of trichiasis or entropion can occur for up to one year after surgery, irrespective of the technique used. Factors affecting the outcomes of cicatricial entropion repair are not well known. There is a non-uniformity in data reporting across literature; hence, future studies with details on severity of entropion, ocular surface changes, forniceal depth and ocular surface inflammation, and the degree of dry eye disease would be informative.","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9521629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous regression of a presumed orbital apex cavernous venous malformation. 假定的眶顶海绵状静脉畸形自发消退。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2024-08-01 Epub Date: 2023-05-08 DOI: 10.1080/01676830.2023.2202731

Victoria S North, Emery C Jamerson, Ann Q Tran, Michael Kazim

引用次数: 0

A minimally invasive, combined approach to the recurrent/recalcitrant sino-orbital mucocele. 复发性/再发性眶窦粘液瘤的微创联合治疗方法。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2024-08-01 DOI: 10.1080/01676830.2024.2375317

Jara Crear, Tassapol Singalavanija, Sarinee Juntipwong, Honeylen M Tiu Teo, Mark Zacharek, Hakan Demirci

{"title":"A minimally invasive, combined approach to the recurrent/recalcitrant sino-orbital mucocele.","authors":"Jara Crear, Tassapol Singalavanija, Sarinee Juntipwong, Honeylen M Tiu Teo, Mark Zacharek, Hakan Demirci","doi":"10.1080/01676830.2024.2375317","DOIUrl":"10.1080/01676830.2024.2375317","url":null,"abstract":"Purpose: To evaluate the results of a minimally invasive combined endoscopic and eyelid crease/medial suprabrow incision approach in collaboration with oculoplastic and sinus surgeons for the treatment of recurrent/recalcitrant sino-orbital mucoceles.Methods: Eighteen cases of recurrent/recalcitrant sino-orbital mucoceles, treated in collaboration with oculoplastic and sinus surgeons at the University of Michigan, were retrospectively reviewed. The recurrence of mucocele, reduction in proptosis, and complications were evaluated.Results: The mean age at the time of surgery was 49 years (range: 17-76 years). All cases had a history of previous sinus or orbital surgeries for mucoceles. Among 18 cases, eight were due to chronic sinus infections, six due to trauma, three due to Schneiderian papilloma, and one case was secondary to an inflammatory sinus disease. Thirteen cases (72%) presented with orbital or facial cellulitis, while five cases (38%) experienced periocular swelling and limited extraocular motility. Following a mean follow-up of 19 months (range: 1-76 months)), recurrence was observed in two cases (11%): one in a cystic fibrosis patient with chronic sinusitis, and the other in a case of Schneiderian papilloma. The mean pre-operative proptosis in the affected eye was 2.78 mm, with an average decrease of 2.33 mm after surgery. Complications occurred in two cases, including one case of hypoesthesia in the forehead and one case of post-operative strabismus.Conclusion: Our series of 18 cases of recurrent/recalcitrant mucoceles, with only two cases of recurrence, demonstrates that this minimally invasive approach can be successfully employed for advanced sino-orbital disease, with a low rate of adverse outcomes and aesthetically pleasing results.","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cladophialophora bantiana orbital cellulitis after penetrating injury. 穿透性损伤后的眼眶蜂窝织炎（Cladophialophora bantiana）。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2024-08-01 Epub Date: 2023-02-27 DOI: 10.1080/01676830.2023.2181976

Arian Ghanouni, Sarah A Avila, Adam G de la Garza, Duaa Sharfi, Heather Singiser, Samuel D Stampfer, George Marshall Lyon, Ahmed Babiker

引用次数: 0