Saudi Dental Journal最新文献

{"title":"Impact of using single-file reciprocating system on the quality of root canal treatment treated by undergraduate students","authors":"","doi":"10.1016/j.sdentj.2024.08.011","DOIUrl":"10.1016/j.sdentj.2024.08.011","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to evaluate the use of a single-file reciprocating system on the technical quality of root canal filling and treatment by radiographic assessment of cases treated by undergraduate dental students.</div></div><div><h3>Materials and methods</h3><div>This was a retrospective cross-sectional clinical study of endodontically treatments conducted by fourth-year undergraduate students during the academic year 2021–2022. Root canal preparation was performed using the WaveOne Gold system with matching single-cone gutta-percha. The collected data included sex, tooth position, number of canals, and treatment time (first or second semester). The quality of the root canal filling was assessed based on the root canal filling length, density, and taper. The presence of ledges, apical transportation, perforation, and instrument separation were recorded. Data were analyzed using SPSS version 28. Chi-square tests were used, and the statistical significance level was set at P &lt; 0.05.</div></div><div><h3>Results</h3><div>A total of 601 teeth were included. The length of the root canal filling was adequate in 93.51 % of the teeth, underfilled in 2.82 %, and overfilled in 3.66 %. The density and taper were adequate in 96.5 % and 98.16 % of the teeth, respectively. There were no significant differences among the parameters of length, taper, density, or procedural errors relative to the arch type. However, there was a significant difference between the anterior and premolar teeth in terms of taper, density, and overall quality of the root canal filling. The overall quality of root canal treatment was acceptable in 527 teeth (87.68 %), with no significant difference between teeth (P = 0.256).</div></div><div><h3>Conclusion</h3><div>The quality of root canal treatment performed by undergraduate students using a single-file reciprocating system is good or acceptable.</div></div>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical fluoride varnish application shifts dysbiotic dental plaque microbiome towards eubiosis in children with dental caries","authors":"","doi":"10.1016/j.sdentj.2024.07.010","DOIUrl":"10.1016/j.sdentj.2024.07.010","url":null,"abstract":"<div><h3>Objective</h3><div>This study used high-throughput amplicon sequencing to examine the impact of long-term continuous fluoride treatment on the dental plaque microbiota of children aged 8 to 9 with mixed dentition.</div></div><div><h3>Design</h3><div>The study population consisted of twenty 8–9-year-old children with dental caries. Topical application of fluoride-varnish was weekly administered for one month to all subjects. Clinical indicators and anthropological data, such as the caries index (DMFT and dmft), were documented for every participant at baseline. A baseline assessment and a month after the fluoride varnish treatment were conducted for the salivary pH level and the Patient-Hygiene-Performance (PHP) index. Following application of the fluoride varnish, plaque samples were obtained both one month later and before (baseline) and were then used for 16S rRNA gene-based Next Generation Sequencing.</div></div><div><h3>Results</h3><div>The results showed significant differences in the community composition structure (p &lt; 0.01). Notable caries-associated pathogens in the dental plaque microbiome were depleted whilst health associated phylum Proteobacteria was increased in the abundance following fluoride-varnish application. In children with mixed dentition, this study found that after one month of fluoride-varnish treatment, there was a significant decrease in the prevalence of the dominant pathogenic genera, <em>Fusobacterium, Porphyromonas, Capnocytophaga, Neisseria</em>, and <em>Leptrotrichia</em>, along with an increase in certain genera related to healthy oral condition, mostly from the phylum Proteobacteria, such as <em>Areinmonas</em>, <em>Pseudoxanthomonas</em>, and <em>Luteimonas</em>.</div></div><div><h3>Conclusions</h3><div>Fluoride-varnish application may shift the community level microecology from dysbiosis to eubiosis. Moreover, application of fluoride-varnish with weekly intervals for one month reduced the caries-causing bacteria while enriching the rise of unique, ubiquitous genera primarily belonging to the Proteobacteria, which may plaque a defensive role against progression of caries. Furthermore, a rising pH level towards neutrality (pH 7) indicated a healthier oral environment following the application of fluoride varnish.</div></div>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141838376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the impact of autotransplantation on the long-term stability and patient satisfaction of impacted canines? A Systematic Review","authors":"","doi":"10.1016/j.sdentj.2024.08.006","DOIUrl":"10.1016/j.sdentj.2024.08.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Autotransplantation is a surgical technique in which a tooth is repositioned after extraction. It is commonly used for impacted canines, which affect about 2% of the population and are more prevalent in females. These canines may remain embedded due to their late eruption. Treatment options include orthodontic appliances or autotransplantation, especially when canines are positioned too high or angled more than 45 degrees from the occlusal plane.</div></div><div><h3>Aim</h3><div>To review the literature regarding the effects of autotransplantation on patient satisfaction, aesthetic outcomes, and the long-term stability of autotransplantation.</div></div><div><h3>Materials and Methods</h3><div>This Systematic Review, registered with PROSPERO (CRD4202341), followed the PICO framework. Extensive searches were conducted in the Cochrane Library, PubMed, ScienceDirect, Scopus, VHL Regional Portal, and Web of Science, covering literature up to April 1, 2023.</div></div><div><h3>Results</h3><div>The review analyzed 11 studies involving the autotransplantation of 395 canine teeth, including two mandibular canines. Findings indicate higher success rates in younger patients, with a higher prevalence of transplantation in females (1<!--> <!-->6<!--> <!-->4) than males (1<!--> <!-->0<!--> <!-->5). The survival rate of transplanted canines was up to 67.9 % after 21 years, with some surviving up to 27.8 years. Success factors included young age, female gender, minimal extraoral time, proper root canal treatment, and effective post-operative care. Negative factors included ankylosis, root resorption, root fractures, infections, and periodontal issues. Complications included tooth darkening and the need for crowning. Patient satisfaction was rarely reported, with only three studies mentioning it and none addressing quality-of-life directly.</div></div><div><h3>Conclusion</h3><div>Canine autotransplantation is viable for selected patients when other treatments are insufficient. Despite various influencing factors, consensus guidelines for procedural decisions still need to be improved, and reports on patient satisfaction and quality-of-life impacts should be more frequent.</div></div>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of bulk-fill versus conventional resin-based composite in class II restorations: A dental student perspective","authors":"","doi":"10.1016/j.sdentj.2024.08.004","DOIUrl":"10.1016/j.sdentj.2024.08.004","url":null,"abstract":"<div><h3>Purpose/objectives</h3><div>The aim of the study was to evaluate the effect of two distinct light-polymerization protocols, used by dental students, on the placement time and polymerization efficiency of bulk-fill (BF) and conventional (CRC) resin-based composites (RBCs).</div></div><div><h3>Methods</h3><div>Thirty dental students participated in this study. Each student was asked to complete four Class II RBC restorations using two different types of RBCs (BF and CRC) paired with two distinct light-polymerization protocols: one using 1200 mW/cm² irradiance (P1200) and one using 800 mW/cm² irradiance (P800). Manufacturer instructions for curing times relative to these irradiance levels were adhered to. The restorations were retrieved, sectioned and Vickers microhardness (VMH) was measured at specific reading points. The placement time was recorded for each procedure. Multivariate analysis of variance and Bonferroni post hoc test were used for data analysis.</div></div><div><h3>Results</h3><div>Bulk-fill RBCs were associated with significantly shortened placement times (<em>P</em> &lt; 0.001). VMH values of CRC-P800 were significantly higher compared to all other groups (<em>P</em> &lt; 0.02). Across all groups tested, the VMH values at the deepest reading points exceeded those at the occlusal surfaces by over 80 %.</div></div><div><h3>Conclusions</h3><div>The use of<!--> <!-->BF RBCs with a P1200 light-polymerization protocol reduced students’ procedural times while maintaining effective polymerization of the restorations.</div></div>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different pulp capping agents and their effect on pulp inflammatory response: A narrative review","authors":"","doi":"10.1016/j.sdentj.2024.07.014","DOIUrl":"10.1016/j.sdentj.2024.07.014","url":null,"abstract":"<div><div>Several factors can directly damage dental pulp. Pulp healing requires controlled inflammation, which can be directed through specialized medical materials to eliminate infection and promote pulp repair. This review aimed to categorise these materials and identify their histological and molecular effects on pulp tissue or isolated cells in culture. In addition, we sought to identify which of these materials could trigger a favourable inflammatory pathway that could direct the pulpal response toward healing and regeneration. A single database (PubMed) was used, and the search strategy was based on MeSH terms. The search was conducted for articles published in English between January 2010 and December 2023, including those with histological and molecular findings. Only 33 articles met our inclusion criteria. Several conventional pulp capping agents have been shown to induce pulp healing and repair through dentine bridge formation. These materials show varying degrees of inflammation, ranging from moderate to mild, which may diminish over time. Other experimentally developed materials were also studied, either alone or in combination with conventional products; these materials demonstrated promising potential to reduce inflammation and superficial necrosis associated with conventional products. However, they still do not meet all the criteria for ideal pulp-capping materials and need further development for commercialisation. Several inflammatory pathways were also addressed in this review, along with favourable tissue responses to induce pulp regeneration. The immunomodulatory role of M2 phenotype macrophages is currently the most accepted, though the lack of standardised experimental procedures across studies hinder precise decision-making.</div></div>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical profile of Brazilian patients with temporomandibular joint disorder and orofacial pain: A 20-year retrospective study","authors":"","doi":"10.1016/j.sdentj.2024.08.003","DOIUrl":"10.1016/j.sdentj.2024.08.003","url":null,"abstract":"<div><h3>Objective</h3><div>Temporomandibular joint disorder (TMD) comprises several musculoskeletal conditions in the orofacial region, with chronic pain and/or dysfunction involving the temporomandibular joint (TMJ) and masticatory muscles. This study assessed the clinical characteristics of patients with TMD treated at a public tertiary care facility in Brazil.</div></div><div><h3>Methods</h3><div>In this retrospective study, we assessed data from adult patients attending the Center for Occlusion, TMD, and Orofacial Pain at a Brazilian school of dentistry, from 2000 to 2020. Data from eligible charts were collected: demographic variables, clinical complaints, location of pain, pain intensity (10-point VAS), duration of treatment, and therapeutic procedures. Data were analyzed using descriptive and inferential statistics at the 0.05 significance level.</div></div><div><h3>Results</h3><div>The sample consisted of 2324 patients (79.4 % females) with a median age of 38 years and median duration of treatment of 35 days. Major clinical complaints were craniofacial pain (including in the TMJ region) (82.9 %), self-reported bruxism (clenching/grinding) (44.6 %), and clicking/crepitation (39.1 %). Craniofacial pain was associated with female gender and age of 39 years and older, but not with bruxism. The most frequent procedures were counseling (96.5 %), exercises (47.5 %), occlusal splints (18.5 %), and physiotherapy (13.8 %). Reduction in pain intensity was moderately associated with multiple (3 or more) therapies and longer duration of treatment.</div></div><div><h3>Conclusion</h3><div>It can be concluded that the patients presented a diversity of clinical characteristics requiring individualized treatment. A multimodal, interdisciplinary therapeutic approach, including counseling, appears to benefit most patients with TMD-related pain.</div></div>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retreatability of calcium silicate-based sealers based on micro-computed tomographic evaluation − A systematic review","authors":"","doi":"10.1016/j.sdentj.2024.09.011","DOIUrl":"10.1016/j.sdentj.2024.09.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Endodontic retreatment procedures with calcium silicate-based sealers (CSS) have been receiving greater credibility in clinically challenging situations. The objective of this systematic review was to analyze the published <em>in vitro</em> studies for the retrievability of CSS in comparison to resin-based sealers evaluated using micro-computed tomography (micro-CT) in terms of the volume of the residual root canal filling materials, time taken, efficacy of the solvent, and different systems used during the retreatment procedure.</div></div><div><h3>Methods</h3><div>The study protocol was registered in the International Prospective Register of Systematic Reviews and conducted in adherence to PRISMA 2020 checklist. Accordingly, an electronic literature search was done to identify studies published in English language, within the time frame from January 2004 to June 2024. The search was conducted through popular databases including PubMed (Medline – National Library of Medicine), Scopus (Science Direct), EMBASE and Google Scholar following the inclusion and exclusion criteria answering the research question in focus.</div></div><div><h3>Results</h3><div>After thorough scrutiny, 15 studies qualified for the systematic review. Following retreatment, in all of the studies pre-treatment working length was achieved, with both the types of endodontic sealers. However, none of the micro-CT studies reported complete removal of endodontic filling material from the root canals. Irrespective of the sealer type used, within each root canal, apical third had the greatest amount of remaining filling material, followed by the middle and coronal thirds.</div></div><div><h3>Conclusions</h3><div>Retreatment of canals obturated with bioceramic sealers is feasible in most cases using traditional instruments and techniques. Active irrigation and supplemental mechanical removal, which employs lasers, XP-Finisher, and ultrasonics, adds advantage to maximize material removal.</div></div>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the shaping ability of different rotary file systems in severely and abruptly curved root canals using cone beam computed tomography","authors":"","doi":"10.1016/j.sdentj.2024.07.016","DOIUrl":"10.1016/j.sdentj.2024.07.016","url":null,"abstract":"<div><h3>Background</h3><div>When selecting an instrument for canal preparation, it is important to consider several parameters that influence the shaping efficiency, including instrument design, metallurgy, and operating motion. This study aimed to evaluate the shaping ability of the ProTaper Next (PTN), WaveOne Gold (WOG), and XP-endo Rise Shaper (XPRS) rotary systems in severely and abruptly curved root canals using cone beam computed tomography (CBCT) and ImageJ software.</div></div><div><h3>Materials and Methods</h3><div>Forty-eight mesial root canals of the mandibular first molars were assigned equally to three groups: PTN, WOG, and XPRS. Using ImageJ software, CBCT images were acquired pre- and post-instrumentation to assess dentin removal, remaining dentin thickness (RDT), canal transportation, and centering ratio at the coronal, middle, and apical levels. Statistical analyses were conducted on all numerical data.</div></div><div><h3>Results</h3><div>All rotary systems removed significantly more distocoronal dentin in the danger zone (DZ), than the mesiocoronal area. PTN removed significantly more dentin and caused less RDT than XPRS (p &lt; 0.05). However, there were no significant differences between PTN-WOG and WOG-XPRS. In the DZ, the highest percentage of specimens with an RDT &lt; 0.5 mm was observed when using PTN (50%), followed by WOG (31.3%), and XPRS (6.3%). Compared with PTN and WOG, XPRS demonstrated less coronal transportation. Among all rotary systems, there was no significant difference in apical transportation or centering ratio.</div></div><div><h3>Conclusions</h3><div>Based on our observations, all rotary instruments exhibited a tendency to remove dentin in the DZ, but to different degrees. XPRS demonstrated better results in terms of coronal transportation and dentin thickness in the DZ. Comparable centering abilities and minimal apical transportation were demonstrated using all rotary instruments.</div></div>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulpotomy in primary teeth: Biodentine™ versus calcium hydroxide. A systematic review and meta-analysis","authors":"","doi":"10.1016/j.sdentj.2024.08.007","DOIUrl":"10.1016/j.sdentj.2024.08.007","url":null,"abstract":"<div><h3>Introduction</h3><div>Pulpotomy is the total amputation of coronal pulp tissue and subsequent placement of a pulpotomy agent over the root canal orifices, followed by a coronal seal. The most suitable pulpotomy agent for successful treatment outcomes remains controversial.</div></div><div><h3>Objectives</h3><div>To evaluate and compare the clinical and radiographic success of calcium hydroxide (CH) and Biodentine (BD) in primary tooth pulpotomy at 6 and 12 months.</div></div><div><h3>Materials and methods</h3><div>An automatised search of the PubMed-Medline, Web of Science, and SCOPUS electronic databases was performed to identify scientific articles on primary tooth pulpotomies with either calcium hydroxide (CH) or Biodentine (BD) as a pulpotomy agent, published until January 2024. The software used for meta-analysis was R 4.3.1 (R Core Team, 2023).</div></div><div><h3>Results</h3><div>Of the 594 potentially eligible articles, 14 met the inclusion criteria: seven articles on CH pulpotomy and seven articles on BD pulpotomy with 6- and 12-months of follow-up. The meta-analysis concluded a mean clinical success rate of 91.8 % at 6 months and 79.0 % at 12 months for the CH group, and 99.2 % at 6 months and 98.8 % at 12 months for the BD group. In terms of the mean radiographic success, the CH group achieved 74.2 % at 6 months and 63.7 % at 12 months, whereas the BD group achieved 99.4 % at 6 months and 98.4 % at 12 months. In comparison, the meta-analysis concluded a marginally significant difference in clinical success in favour of the BD group at 6 months (p = 0.091). At 12 months, clinical success was significant in the BD group (p = 0.023). Regarding radiographic success, a significant difference in favour of the BD group was observed at 6 (p = 0.008) and 12 months (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>BD showed significantly higher clinical and radiographic success than CH in pulpotomy.</div></div>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of hyaluronic acid coating on polyether ether ketone dental implant surface: An in vitro analysis","authors":"","doi":"10.1016/j.sdentj.2024.07.012","DOIUrl":"10.1016/j.sdentj.2024.07.012","url":null,"abstract":"<div><h3>Objective</h3><div>Polyether ether ketone (PEEK), a biocompatible polymer, is being explored as an alternative to metallic alloys for dental implants due to its aesthetic and mechanical properties. This study aimed to enhance the surface biofunctionality through evaluating human MG-63 osteoblastic cell survival, proliferation, differentiation, and mineralization.</div></div><div><h3>Method</h3><div>Following the sandblasting and plasma treatment of the 3D-printed PEEK discs, a layer of hyaluronic acid (Hya) was coated onto the PEEK surface. Osteoblast cells were seeded onto the discs. The groups consisted of Hya-coated PEEK, uncoated PEEK, and a control group. Cell viability, proliferation, differentiation, and mineralization potential were examined after seven and twenty-one days of cell seeding using the MTT test, DAPI staining technique, alkaline phosphatase activity (ALP), and alizarin red staining.</div></div><div><h3>Results</h3><div>Hya-coated PEEK increased cell viability (1.48 ± 0.13, 1.49 ± 0.09) compared to the uncoated group (1.19 ± 0.06, 1.26 ± 0.07) and control group (0.98 ± 0.04, 1.00 ± 0.07) after 7 and 21 days. Proliferation rates of coated group (60.50 ± 3.08) were greater than the uncoated (50.33 ± 2.58) and control group (38.33 ± 4.88) at 21 days, respectively. Additionally, the ALP activity on Hya-coated PEEK disks (5.55 ± 0.65, 7.54 ± 0.64) was notably higher than that of the uncoated group (1.08 ± 0.49, 2.59 ± 0.68), and control group (0.16 ± 0.09, 0.34 ± 0.18) at both time periods. Alizarin red staining in the Hya-coated PEEK group (1.81 ± 0.23, 1.97 ± 0.20) was significantly greater in comparison with uncoated group (1.12 ± 0.17, 1.14 ± 0.19) and control group (0.99 ± 0.10, 0.98 ± 0.05) at both time intervals.</div></div><div><h3>Conclusion</h3><div>Hya’s surface coating has enhanced the biofunctional properties of PEEK implant material, as demonstrated by improved cell survival, proliferation, differentiation, and mineralization potential.</div></div>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}