Alfonso Heras, Avery Andrus, Javier Baquera, Graciela Ghiradi, Allen Gown
{"title":"Development and Validation of Antibodies Against Sars Cov-2 by Immunohistochemistry to Assess the Pathogenesis of COVID-19 and Its Role in Cytokine Storm Syndrome and Coagulopathy","authors":"Alfonso Heras, Avery Andrus, Javier Baquera, Graciela Ghiradi, Allen Gown","doi":"10.61440/jcrcs.2023.v1.01","DOIUrl":"https://doi.org/10.61440/jcrcs.2023.v1.01","url":null,"abstract":"Introduction: Understand how the SARS-Cov-2 virus uses the ACE2, TMPRSS2, and CD147 receptors to infect human cells. Research and better understand “Cytokine Storm Syndrome” and coagulopathy induced by COVID-19 infection. Objectives: To determine the expression, by means of immunohistochemistry (IHC) in FFPE tissues to evaluate the general pathological events caused by the virus. Materials and Methods: Antibodies from Bio SB Inc were used to analyze post-mortem material from SARS-CoV-2 positive patients by immunohistochemistry. Results: The findings confirmed the presence of viral particles, Cytokine Storm Syndrome inflammation effects, and indicators of coagulopathy. Conclusion: We consider that this study has enough material to provide clinicians and researchers with a detailed picture of the pathogenesis of SARSCoV-2.","PeriodicalId":472378,"journal":{"name":"Journal of Clinical Research and Case Studies","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135950612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}