Development and Validation of Antibodies Against Sars Cov-2 by Immunohistochemistry to Assess the Pathogenesis of COVID-19 and Its Role in Cytokine Storm Syndrome and Coagulopathy

Abstract

Introduction: Understand how the SARS-Cov-2 virus uses the ACE2, TMPRSS2, and CD147 receptors to infect human cells. Research and better understand “Cytokine Storm Syndrome” and coagulopathy induced by COVID-19 infection. Objectives: To determine the expression, by means of immunohistochemistry (IHC) in FFPE tissues to evaluate the general pathological events caused by the virus. Materials and Methods: Antibodies from Bio SB Inc were used to analyze post-mortem material from SARS-CoV-2 positive patients by immunohistochemistry. Results: The findings confirmed the presence of viral particles, Cytokine Storm Syndrome inflammation effects, and indicators of coagulopathy. Conclusion: We consider that this study has enough material to provide clinicians and researchers with a detailed picture of the pathogenesis of SARSCoV-2.