Journal of Clinical Research and Case Studies最新文献

{"title":"Role of Traction-Assisted Endoscopic Submucosal Dissection (ESD) in Large Esophageal Cancers","authors":"Annie She, Luis Nasif","doi":"10.61440/jcrcs.2024.v2.22","DOIUrl":"https://doi.org/10.61440/jcrcs.2024.v2.22","url":null,"abstract":"","PeriodicalId":472378,"journal":{"name":"Journal of Clinical Research and Case Studies","volume":"39 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140357949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Endoscopic Sleeve Gastroplasty (ESG) in Non-Alcoholic Fatty Liver Disease","authors":"Annie Shergill, Luis Nasif","doi":"10.61440/jcrcs.2024.v2.30","DOIUrl":"https://doi.org/10.61440/jcrcs.2024.v2.30","url":null,"abstract":"","PeriodicalId":472378,"journal":{"name":"Journal of Clinical Research and Case Studies","volume":"22 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140360723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorectal Cancer (CRC) Screening in Indian-American Population: Recognizing Social & Cultural Barriers","authors":"Annie Shergill, Luis Nasif","doi":"10.61440/jcrcs.2024.v2.27","DOIUrl":"https://doi.org/10.61440/jcrcs.2024.v2.27","url":null,"abstract":"","PeriodicalId":472378,"journal":{"name":"Journal of Clinical Research and Case Studies","volume":"32 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140360503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Endoscopic Mucosal Resection in Large Superficial Non-Ampullary Duodenal Adenomas","authors":"Annie Shergill, Luis Nasiff","doi":"10.61440/jcrcs.2024.v2.33","DOIUrl":"https://doi.org/10.61440/jcrcs.2024.v2.33","url":null,"abstract":"","PeriodicalId":472378,"journal":{"name":"Journal of Clinical Research and Case Studies","volume":"19 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140358565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Vestibular Rehabilitation in Patients with Superior Semicircular Canal Dehiscence Syndrome","authors":"Heloisa Coutinho de Toledo, Erika Celis Aguilar","doi":"10.61440/jcrcs.2024.v2.34","DOIUrl":"https://doi.org/10.61440/jcrcs.2024.v2.34","url":null,"abstract":"Superior canal dehiscence syndrome (SCDS) described in 1998 is a disorder characterized by vertigo in response to loud sounds, pulsatile tinnitus, conductive hyperacusis, autophony and chronic disequilibrium. While resurfacing and/or plugging of the superior canal may improve autophony and reduce dizziness handicap, it can result in immediate and long-term deficits in VOR function, necessitating vestibular rehabilitation (VR) during the early post-operative recovery period. Case description: a 34- year-old man with a history of autophony, pulsatile tinnitus and audible eye movements in his right ear. He denied any vertigo or disequilibrium. Immediately after surgical plugging he presented severe vertigo and disequilibrium as well as deterioration of right hearing loss. Due to persistent instability, VR was performed for five months after surgery with improved outcomes. Our purpose is to emphasize and increase awareness in surgeons, especially in Latin America, the importance of VR immediately after surgery. Additionally, we make some comments about the surgical decisions in two patients with otosclerosis and SCDS and the importance of VR.","PeriodicalId":472378,"journal":{"name":"Journal of Clinical Research and Case Studies","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140361029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare but Sinister Case of Hodgkin Lymphoma Transforming into Large B-cell Lymphoma in HIV Infected Patient","authors":"Amrutha Jagaragallu, Sampath Kumar Madapathi, Kaluvakolanu Priyanka, Vaddera Pavan Theja","doi":"10.61440/jcrcs.2023.v1.16","DOIUrl":"https://doi.org/10.61440/jcrcs.2023.v1.16","url":null,"abstract":"A dual diagnosis of cancer and HIV places a greater psychosocial burden on the patient. From a medical perspective, it complicates treatment for both diseases. Potential drug interactions, compounded side effects, and chemotherapy’s tendency to negatively impact CD4 count or HIV viral load, can all complicate treatment. It is imperative to advocate a keen and subtle vigilance while managing such patients to enhance the overall care for the patients. Here, we report such a case in a 36-year-old man who presented with HL as first manifestation of HIV infection that later transformed into DLBCL despite successful virologic suppression with ART","PeriodicalId":472378,"journal":{"name":"Journal of Clinical Research and Case Studies","volume":"143 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fasting Plasma Glucose May Behave as a Positive in Mild But as a Negative Acute Phase Reactant in Moderate and Severe İnflammatory Disorders","authors":"Mehmet Rami Helvaci, Ummuhan Kodal Tuncsezen, Kubra Piral, Mehpare Camlibel, Abdulrazak Abyad, Lesley Pocock","doi":"10.61440/jcrcs.2023.v1.15","DOIUrl":"https://doi.org/10.61440/jcrcs.2023.v1.15","url":null,"abstract":"Background: There may be significant relationships between fasting plasma glucose (FPG) and severity of inflammations. Method: All cases with the digital clubbing were included. Results: The study included 104 cases with clubbing detected among 2.428 cases (1.044 males). So clubbing was higher in males (8.1% versus 1.3%,p<0.001). Mean age of clubbing cases was 49.2 years, and there was a male predominance (81.7%), again. Parallel to the male predominance, there were higher prevalences of smoking (69.2% versus 41.6%, p<0.001), chronic obstructive pulmonary disease (COPD) (27.8% versus 10.8%, p<0.001), and coronary heart disease (CHD) and/or peripheric artery disease (PAD) (7.6% versus 0.0%, p<0.01) in the clubbing cases. Whereas the body weight, body mass index (BMI), and FPG were lower in the clubbing cases but the differences were nonsignificant probably due to the small sample size. But diabetes mellitus (DM) (12.5% versus 21.6%, p<0.05) and systolic blood pressure (BP) (127.6 versus 136.9 mmHg, p= 0.011) were lower in the clubbing cases, significantly. Conclusion: There are significant relationships between smoking, digital clubbing, COPD, CHD, and PAD probably due to strong atherosclerotic effects of smoking. Similarly, the body weight, BMI, FPG, systolic BP, and DM are inversely related with the clubbing probably due to the severe inflammatory effects of smoking on the vascular endothelium, again. FPG may behave as a positive acute phase reactant (APR) in mild inflammatory disorders such as irritable bowel syndrome but as a negative APR in moderate and severe inflammatory disorders such as smoking, digital clubbing, and sickle cell diseases.","PeriodicalId":472378,"journal":{"name":"Journal of Clinical Research and Case Studies","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Large Uterine Fibroid in Pregnancy","authors":"Bhakti Dhamangaonkar, Padmja Maslekar, Harshal Pandve","doi":"10.61440/jcrcs.2023.v1.17","DOIUrl":"https://doi.org/10.61440/jcrcs.2023.v1.17","url":null,"abstract":"","PeriodicalId":472378,"journal":{"name":"Journal of Clinical Research and Case Studies","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Analyis of Efficacy and Toxicidad of Zoledroinic Acid in Patients with Multiple Myeloma","authors":"Agustin Aviles, Sergio Cleto","doi":"10.61440/jcrcs.2023.v1.07","DOIUrl":"https://doi.org/10.61440/jcrcs.2023.v1.07","url":null,"abstract":"Myeloma bone disease MBD) is the most common and dangerous effects in patients with multiple myeloma. Bisphosphonates (BP), are the treatment of choice. But, efficacy and adverse events has not been evaluated at longer follow-up. Thus, we review our experience in a tertiary cancer center, whose received zoledronic acid (ZO): in a large number of cases (1041) and longer follow-up: 4.2 to 21.6 years (median 13.8).Skeletal event (SE) were statistically better in patients who received ZA: 52 events: 8.96%,compared to 207 (42.6) p < 0.001 in patients whose did not received ZA, independently if the patients received autologous stem cell transplant or not. But, progression free survival and overall survival did not show any benefit. Adverse events were minimal, and jaw necrosis were not observed. Thus, we considered that ZA, remain to be the best treatment of MBD, but, we confirm that ZA did not show at longer follow-up any antitumor effect.","PeriodicalId":472378,"journal":{"name":"Journal of Clinical Research and Case Studies","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136364844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dried Fruit and Aspaghola: New Approaches in Treating Lipid Metabolism","authors":"Dried Fruit and Aspaghola: New Approaches in Treating Lipid Metabolism, Sajida Zafar, Ali Abuzar Raza, Jamil Ahmed Lakhair, Shah Murad, Abdul Fatah, Ejaz Fatima","doi":"10.61440/jcrcs.2023.v1.08","DOIUrl":"https://doi.org/10.61440/jcrcs.2023.v1.08","url":null,"abstract":"Cholesterol is carried through the bloodstream attached to two different compounds called lipoproteins: low-density lipoproteins (LDL) and high-density lipoproteins (HDL). LDL is commonly known as the “bad” cholesterol because it transports cholesterol from the liver throughout the body, and potentially allows it to be deposited in artery walls. HDL, known as the “good cholesterol,” picks up cholesterol from the blood and delivers it to cells that use it, or takes it back to the liver to be recycled or eliminated from the body. The focus has shifted to the novel risk factors as well as characteristics and stability of atherosclerotic plaque; the genetic predisposition has further broadened the pathogenetic mechanisms. This review focuses on the molecular mechanisms involved in the evolution of the atherosclerotic plaque that may pave the way for selecting optimal therapies and preventing plaque complications. Atherosclerosis is no longer a disease attributed mainly to the high lipid content of the body. New insight into the disease pathology has shown it to be a disease of much greater ramifications. Endothelial damage and reactive oxygen species (and other free radicals) have predominantly emerged as factors in virtually all pathways leading to the development of atherosclerosis due to hyperlipidemia, diabetes, hypertension or smoking. Novel risk factors such as hyperhomocysteinemia, infections and systemic lupus erythematosus have emerged. Hypolipidemic herbs can normalize lipid profile of patients suffering from primary or secondary hyperlipidemia. Psyllium husk and Ficus Carica (Anjeer) are being used successfully for treatment of both types of Hyperlipidemia. This research study was single blind placebo-controlled, and was conducted at General Hospital Lahore-Pakistan from January to June 2018. One hundred hyperlipidemic patients were enrolled for the research work. Base line lipid profile was measured in Biochemistry Lab of the hospital. Patients were divided in four groups, 25 patients in each group. Group-I was on Figs, Group-II was on Psyllium, Group-III was on combination of these two herbal medicines. After three months therapy, their lipid profile was determined and mean values with ±SEM were compared before and after treatment. When analyzed statistically and compared with placebo effects, all patients’ LDL-cholesterol was reduced significantly. HDL-cholesterol was increased in all groups of patient. We concluded from this study that when used in good amount/dose, Psyllium husk and Figs reduce LDL-cholesterol and increase HDL-cholesterol significantly.","PeriodicalId":472378,"journal":{"name":"Journal of Clinical Research and Case Studies","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136364845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}