Saudi journal of pathology and microbiology最新文献

{"title":"Hemangioendothelioma of the Forehead – A Rare Case Report","authors":"Shainaz Begum, Balina Lakshmi Nirmala, Srikanth Shastry","doi":"10.36348/sjpm.2023.v08i12.004","DOIUrl":"https://doi.org/10.36348/sjpm.2023.v08i12.004","url":null,"abstract":"Hemangioendothelioma is the term used to name those vascular neoplasms that show a borderline biological behavior, intermediate between entirely benign hemangiomas and highly malignant angiosarcomas. Although originally spindle cell hemangioendothelioma was proposed as a specific clinicopathologic variant of hemangioendothelioma, currently, it is considered as an entirely benign lesion, and thus, the name spindle cell hemangioma seems to be the most accurate for this lesion. Authentic hemangioendotheliomas involving the skin and soft tissues include Papillary intralymphatic angioendothelioma (also known as Dabska tumor), Retiform hemangioendothelioma, Kaposiform hemangioendothelioma, Epithelioid hemangioendothelioma, Pseudomyogenic hemangioendothelioma (also known as epithelioid sarcoma-like hemangioendothelioma), and Composite hemangioendothelioma. Each of these neoplasms exhibit characteristic histopathologic features.","PeriodicalId":471257,"journal":{"name":"Saudi journal of pathology and microbiology","volume":"31 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138983913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Carbapenem-Resistant Enterobacteriaceae Bloodstream Infections: An Experience from a Tertiary Care Centre in Oman","authors":"Rahma Said Al-Owaisi, Dhanya Jayaraj, Manoj N. Malviya, Amal Al-Jabri","doi":"10.36348/sjpm.2023.v08i12.002","DOIUrl":"https://doi.org/10.36348/sjpm.2023.v08i12.002","url":null,"abstract":"The emergence of Carbapenem-resistant Enterobacteriaceae (CRE)is a public health concern worldwide. It is associated with increased mortality due to limited antibiotics available to treat CRE infections. The aim of this study was to understand the epidemiology of CRE infections, associated mortality, and available treatment options. All patients with CRE isolated in blood culture were identified between December 2011 and October 2019. Risk factors and mortality associated with each risk factor at 14 and 30 days were determined.55 cases of CRE bloodstream infections were isolated, with a median age of 56 years. Eighty-four percent of patients received treatment in the ICU. All cases were caused by Klebsiella pneumonia. The rate of resistance to the tested antibiotics was as follows: meropenem 92% (50/54), imipenem 75% (40/53), etrapenam 95% (19/20), Amikacin 71% (37/52), cotrimoxazole 73% (40/53), Gentamicin 47% (25/53) and colistin 7% (3/41). Major risk factors associated were the presence of a urinary catheter (84%), central venous catheter (78%), mechanical ventilation (74%) and post-surgery (67%). Mortality at 14 days and 30 days was 41%, and 52%, respectively. Univariate analysis showed that 14 days mortality was higher in patients with central venous catheter (P=0.01). Charlson's comorbidity index was associated with an increased risk of death at 30 days (P=0.04). There was no statistically increased survival in those treated with combination therapy at 30 days (P=0.5). The mortality of CRE infections seems to be high and optimal therapy is not yet well defined. Combination therapy is not associated with increased survival in this cohort of patients.","PeriodicalId":471257,"journal":{"name":"Saudi journal of pathology and microbiology","volume":"136 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138598929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Finding of Leishmania Donovani Bodies in Bonemarrow Aspiration in a Case of Pancytopenia","authors":"Bhargavi V, Jyothi Swaroopa","doi":"10.36348/sjpm.2023.v08i12.001","DOIUrl":"https://doi.org/10.36348/sjpm.2023.v08i12.001","url":null,"abstract":"Leishmaniasis is a tropical infection transmitted to humans by the female sandfly (Phlebotomus argentipes). Leishmaniasis is widely prevalent in the Eastern states of India namely Bihar, Jharkhand, Uttar Pradesh and West Bengal having a hot and humid climate.","PeriodicalId":471257,"journal":{"name":"Saudi journal of pathology and microbiology","volume":"110 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138599807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Antimicrobial Resistance in Enterococcus Species: A Single-Center Cross-Sectional Study","authors":"Md Suzaul Alam, Md Jakaria, Rashedur Rahman","doi":"10.36348/sjpm.2023.v08i10.004","DOIUrl":"https://doi.org/10.36348/sjpm.2023.v08i10.004","url":null,"abstract":"Background: Antimicrobial resistance in Enterococcus species is a growing global concern. These bacteria, commonly found in the human gut, have resisted multiple antibiotics, making infections harder to treat. This poses a significant challenge for healthcare as it limits treatment options and highlights the urgent need for responsible antibiotic use and the development of new therapies. Aim of the study: The study aimed to determine the antimicrobial resistance pattern of Enterococcus Species at a tertiary care hospital in Bangladesh. Methods: This cross-sectional research occurred at Sample collected from deferent laboratories situated in rangpur and test/research perform, Department of Microbiology in prime institute of science and medical technology (PRISMET), Rangpur During March’ 2022 to March’ 2023. It spanned one year from [start date] to [end date]. The primary goal was to evaluate the antimicrobial susceptibility patterns of enterococci. Throughout the study, 1,450 samples were collected from various sources, including urine, blood, pus, swabs, and fluids. However, only 62 Enterococci isolates were successfully obtained. Standard microbiological protocols, such as microscopy and culture, were rigorously followed during sample processing. All clinical samples received at the Microbiology laboratory during the study were considered for inclusion. Data analysis was conducted using Microsoft Excel and presented with tables and graphs, while SPSS was employed for statistical analysis. Result: The study population primarily consisted of patients aged 36-75 (77.42%), averaging 52.01 years. Gender distribution was skewed towards males (59.68%). Enterococcus spp. They have dominated the microbial species (64.52%), with E. faecalis (14.52%) and E. faecium (11.29%) being prevalent. Urine samples were the most common (66.13%), followed by pus (11.29%) and swab (9.68%). Antibiotic susceptibility analysis showed varying results, with amoxicillin being sensitive in 87.10% of cases, while Cefixime, Ceftazidime, Ceftriaxone, and Cefotaxime exhibited over 96% resistance. Conclusion: This study highlights the rise of antimicrobial resistance (AMR) in Enterococcus species at a Bangladeshi tertiary care hospital. Once harmless, these bacteria now pose a severe risk to public health. Our research shows that E. faecalis and E. faecium have become resistant to many common antibiotics, particularly cephalosporins, urging immediate antibiotic stewardship and infection control. To combat this global health threat, we must explore novel treatments and employ a multidisciplinary approach to protect patients and healthcare systems from Enterococcus infections.","PeriodicalId":471257,"journal":{"name":"Saudi journal of pathology and microbiology","volume":"26 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135168987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Interpretation and further evaluation of Extreme Hyperferritinemia (>10,000 microg/L) with reduced % Tsat (<50%) in pediatric patients in Tertiary care Hospital","authors":"Mirza Asif Baig, Ahmed Kurdi, Suriyakala, P. C, Yasser Moshrif, Ameen Bakhsh, Ahmed Bahashwan, Mohammed M. Elgindy, Kawthar Ktea, Nabeel Almutairi, Fouad A. Alamri","doi":"10.36348/sjpm.2023.v08i10.001","DOIUrl":"https://doi.org/10.36348/sjpm.2023.v08i10.001","url":null,"abstract":"Background: Ferritin is a soluble protein which provides intracellular storage of bioavailable iron. It is found primarily in Liver, bone marrow macrophages, spleen. Ferritin is measured by ELISA, RIA and Mass spectrometry. The main aim of this study is to etiologically categorise extreme hyperferritinemia (serum ferritin > 10000 microg/L). Methodology and Results: This is 05 years retrospective study (July -2018 to June 2023), conducted in hematology section, MMCH, KSA. Out of 34 cases of extreme hyperferritinemia, viral infection was the most common cause comprising 41% of all cases. Amongst the infectious etiology, 6 cases of EBV, 3 cases of ALF of suspected viral etiology, 2 cases of PIDS with secondary infection, 1 case each of Hepatitis A virus and CMV noted. 10 cases presented as Macrophage Activating syndrome comprising 29% of total cases of which 70 were Systemic Juvenile Idiopathic arthritis and remaining 30% includes SLE and juvenile rheumatoid arthritis. Discussion: Study conducted by Dondu et al., indicate that the most common causes of hyperferritinemia are rheumatologic diseases and infections, which were identified in 59.1 and 27.3%, respectively. Present study showed infective etiology as the most common cause of extreme hyperferritinemia. Reasons for differences in results are because other studies were conducted in Adult patients and in Rheumatologic department. Conclusion: Our study formulated a systematic investigating pathway for raised serum ferritin. If the laboratory screening tests, BMA and other sophisticated tests are done in systematic way, then challenging cases can be diagnosed easily.","PeriodicalId":471257,"journal":{"name":"Saudi journal of pathology and microbiology","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136359218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studying the Prevalence of Multidrug Resistant Klebsiella pneumoniae in Kirkuk City","authors":"Fatimah Artn Hasib, Iman Tajer Abdullah, Farooq Ibrahim Mohammad","doi":"10.36348/sjpm.2023.v08i10.002","DOIUrl":"https://doi.org/10.36348/sjpm.2023.v08i10.002","url":null,"abstract":"Klebsiella pneumonia is an opportunistic pathogen causes several diseases including sepsis, pneumonia, and wound infections. There are two pathotypes of Klebsiella pneumonia: classical K. pneumoniae (cKp) and hypervirulent K. pneumonia (hvkp), which is an emerging variant of (ckp), clinically distinguished by invasive and multiple site infections. K.pneumoniae is also responsible for majority of human infections, and can infected healthy members of the community and hospitalized patients. A total 150 samples were collected from different hospitals in Kirkuk city during the period between November 2021 to June 2022. The age of patients ranged between (1– 60) years old with both sexes. These samples were highly recovered from females with a rate 66.67% compared to the males 33.33%. Thirty K. pneumonia (20%) was recovered from different clinical specimens including urine, sputum, burn and wound swabs. The current study reported that females are more likely to be infected with K. pneumoniae than man. Likewise, the most common age group infected with K.pneumoniae was between (20-40) with a rate of 63.33%. K.pneumoniae was commonly recovered from inpatients 53.33% compared with outpatients (46.67%). Antibiotic susceptibility test was conducted to all the isolates by using disc diffusion test towards 8 antimicrobial agents. Klebsiella pneumoniae isolates showed multiple resistance against 3 or more of different antibiotic groups such as gentamicin 93%, ampicillin 96% and amoxicillin –clavulanate 90%, cefotaxime 83%, ceftazidime 96%, meropenem 36%, levofloxacin 76 %and gentamicin 93 %. K. pneumoniae isolated from inpatients and from sputum samples were more resistance to various kinds of antibiotics.","PeriodicalId":471257,"journal":{"name":"Saudi journal of pathology and microbiology","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136359509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian Teratoma with Squamous Cell Carcinoma: A Rare Entity","authors":"Vishesh Dhawan, Ayushi Kediya, Anuradha Kusum, Swati Negi","doi":"10.36348/sjpm.2023.v08i09.002","DOIUrl":"https://doi.org/10.36348/sjpm.2023.v08i09.002","url":null,"abstract":"Malignant transformation in a mature cystic teratoma of the ovary is rare, occurring in only 1-2% of cases, with squamous cell carcinoma consisting of about 75% of malignant transformations. Various genomic alterations take part in this pathogenesis but due to its rare incidence, not many cases have been reported in respect to this transformation. Hence, we describe a rare case of 45-year-old female with a 7.5 cm ovarian mature teratoma with an incidental finding of squamous cell carcinoma. With this case report, we also wish to create an awareness of this entity among pathologists and physicians while dealing with dermoid cysts of large sizes in older patients.","PeriodicalId":471257,"journal":{"name":"Saudi journal of pathology and microbiology","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135427621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability of COVID-19 Vaccination by Doctors: Cross-Sectional Survey from Mohammed VI University Hospital in Marrakech","authors":"Malika Idalene, Jihane Hamdane, Noura Tassi","doi":"10.36348/sjpm.2023.v08i09.001","DOIUrl":"https://doi.org/10.36348/sjpm.2023.v08i09.001","url":null,"abstract":"Covid-19 has rapidly became a major public health crisis. Several public health and containment measures were deployed to contain this epidemy; however, a return to a normal life could only be expected after the generalization of anti-Covid 19 vaccination, allowing a global collective immunity. The success of this campaign depends essentially on the acceptance of the new Covid-19 vaccines. We conducted a descriptive and analytical observational cross-sectional study to evaluate the acceptability of Covid-19 vaccines, among resident and intern doctors at the Mohammed VI University Hospital in Marrakech, to determine the factors associated with vaccine acceptance, and the reasons for hesitation or nonacceptance of vaccination. Out of 145 participants (59.1% female, mean age 26.6 years), 89.7% received the vaccine at least partially. 49% of our population did not delay their vaccination and intended to complete it, so we considered them accepting. However, 40.7% were considered hesitant because of delayed or abandoned Covid-19 vaccination. People living alone and resident physicians in medical or biological specialties were the most likely to accept vaccination. Factors influencing refusal or hesitation included: speed of vaccine development, fear of adverse effects, lack of information on vaccine efficacy, acquisition of natural immunity following previous infection with Covid-19, lack of confidence in the pharmaceutical industry. Doctors' general attitudes towards COVID-19 vaccination, in our study, are positive, but specific concerns about the COVID-19 vaccine are widespread. Addressing barriers to vaccination in these groups will be essential to avoid exacerbating the health inequalities highlighted by this pandemic.","PeriodicalId":471257,"journal":{"name":"Saudi journal of pathology and microbiology","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135204868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}