Journal of Pathology and Translational Medicine最新文献_第6页

Significance of KM55 immunohistochemical staining in the diagnosis and prognosis of IgA nephropathy. KM55免疫组化染色在IgA肾病诊断及预后中的意义。

IF 3

Journal of Pathology and Translational Medicine Pub Date : 2026-01-01 Epub Date: 2026-01-14 DOI: 10.4132/jptm.2025.09.17

Hoe In Jeong, Beom Jin Lim, Minsun Jung

{"title":"Significance of KM55 immunohistochemical staining in the diagnosis and prognosis of IgA nephropathy.","authors":"Hoe In Jeong, Beom Jin Lim, Minsun Jung","doi":"10.4132/jptm.2025.09.17","DOIUrl":"10.4132/jptm.2025.09.17","url":null,"abstract":"Background: Galactose-deficient IgA1 (Gd-IgA1) plays a crucial role in IgA nephropathy (IgAN). The monoclonal antibody KM55 has emerged as a simplified method for detecting Gd-IgA1; however, the clinicopathological significance of immunohistochemistry for Gd-IgA1 remains underexplored. This study evaluated the prognostic and clinicopathological significance of KM55 immunohistochemistry in IgAN.Methods: A total of 114 native kidney biopsies showing at least mild mesangial IgA positivity on immunofluorescence were retrospectively analyzed. Patients were categorized as having IgAN or non-IgAN diseases. The KM55 immunohistochemical staining was graded as 0, 1+, 2+, 3, or 4+. Data on Oxford classification, laboratory parameters, and renal outcomes were collected.Results: The IgAN group showed significantly higher KM55 scores than the non-IgAN group (median: 3 vs. 1; p < .001). IgAN cases were further stratified into KM55-high (≥3+, n = 38) and -low groups (≤2+, n = 37). The KM55-high group had significantly higher diastolic blood pressure, blood urea nitrogen, creatinine, urine protein/creatinine ratio, and Oxford mesangial hypercellularity scores, along with lower estimated glomerular filtration rate (eGFR) and serum albumin. Cox analysis revealed significantly poorer outcomes in the KM55-high group for chronic kidney disease stage 4 (p = .015), end-stage renal disease (p = .024), and 75% eGFR decline (p = .016).Conclusions: Mesangial Gd-IgA1 deposition graded by KM55 immunohistochemistry may be a useful adjunct for IgAN diagnosis and a potential prognostic biomarker.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"60 1","pages":"69-82"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing pathology through sixty volumes: reflections and future directions. 通过六十卷推进病理学：反思和未来的方向。

IF 3

Journal of Pathology and Translational Medicine Pub Date : 2026-01-01 Epub Date: 2026-01-14 DOI: 10.4132/jptm.2025.12.08

Chan Kwon Jung, So Yeon Park, Soon Won Hong

引用次数: 0

Solitary fibrous tumor: an updated review. 孤立性纤维性肿瘤：最新综述。

IF 3

Journal of Pathology and Translational Medicine Pub Date : 2026-01-01 Epub Date: 2025-12-29 DOI: 10.4132/jptm.2025.10.08

Joon Hyuk Choi

引用次数: 0

PSMA expression in hepatic colorectal cancer metastasis. PSMA在肝结直肠癌转移中的表达。

IF 3

Journal of Pathology and Translational Medicine Pub Date : 2026-01-01 Epub Date: 2026-01-14 DOI: 10.4132/jptm.2025.10.20

Eundong Park, Michel Kmeid, Xin Wang, Haiyan Qiu, Clifton G Fulmer, Marcello P Toscano, Nusret Bekir Subasi, Maciej Gracz, Hwajeong Lee

{"title":"PSMA expression in hepatic colorectal cancer metastasis.","authors":"Eundong Park, Michel Kmeid, Xin Wang, Haiyan Qiu, Clifton G Fulmer, Marcello P Toscano, Nusret Bekir Subasi, Maciej Gracz, Hwajeong Lee","doi":"10.4132/jptm.2025.10.20","DOIUrl":"10.4132/jptm.2025.10.20","url":null,"abstract":"Background: Prostate-specific membrane antigen (PSMA) is expressed in the neovasculature of various malignancies, such as colorectal cancer (CRC) and hepatocellular carcinoma (HCC). However, PSMA expression in hepatic CRC metastasis has not been studied in detail.Methods: The PSMA expression in primary CRC and corresponding hepatic metastasis was evaluated by immunohistochemistry in a metastatic CRC cohort (n = 56), which was divided into subgroups according to treatment history and timing of metastasis. Demographic and histological characteristics of primary CRC were collected and their relationships with PSMA expression were examined. Additionally, the PSMA expression in resected HCC (n = 76) was compared with that of hepatic CRC metastasis.Results: In primary CRC, PSMA level showed a positive association with tumor size. Lower PSMA expression in hepatic metastasis was associated with higher primary CRC grade, advanced pTNM stage at the time of CRC resection, presence of tumor deposit, and unresectability of metastatic lesion. PSMA expression in primary CRC correlated with that in hepatic metastasis only in concurrent and untreated metastasis subgroup. PSMA expression in primary CRC and hepatic metastasis, regardless of treatment history and timing of metastasis, was not significantly different from that of HCC.Conclusions: Several adverse pathological features of primary CRC were associated with a lower PSMA expression in hepatic metastasis. PSMA expression in hepatic metastasis correlated with that of primary CRC only in concurrent and untreated subgroup. Primary HCC and hepatic CRC metastasis show comparable levels of PSMA expression.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"60 1","pages":"107-123"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frozen section histopathology and preanalytical factors affecting nucleic acid integrity in biobanked fresh-frozen human cancer tissues. 冷冻切片组织病理学和影响生物库新鲜冷冻人癌组织核酸完整性的分析前因素。

IF 3

Journal of Pathology and Translational Medicine Pub Date : 2025-11-01 Epub Date: 2025-09-12 DOI: 10.4132/jptm.2025.07.22

Soungeun Kim, Jaewon Kang, Boyeon Kim, Yoonjin Kwak, Hye Seung Lee

{"title":"Frozen section histopathology and preanalytical factors affecting nucleic acid integrity in biobanked fresh-frozen human cancer tissues.","authors":"Soungeun Kim, Jaewon Kang, Boyeon Kim, Yoonjin Kwak, Hye Seung Lee","doi":"10.4132/jptm.2025.07.22","DOIUrl":"10.4132/jptm.2025.07.22","url":null,"abstract":"Background: In this study, we evaluated the effects of storage duration and ischemic time on nucleic acid quality of fresh-frozen tissue (FFT) from colon adenocarcinoma (COAD), hepatocellular carcinoma (HCC), and renal cell carcinoma (RCC) collected at the Cancer Tissue Bank of Seoul National University Hospital.Methods: A total of 102 FFT samples were analyzed to compare DNA integrity number (DIN) and RNA integrity number (RIN) according to storage duration and ischemic time. Additionally, the effects of histopathologic features-such as tumor cell proportion, inflammatory cell infiltration, and stromal fibrosis-on nucleic acid quality were evaluated.Results: DIN and RIN remained stable overall even though the storage duration increased, with no statistically significant differences observed. In particular, there was almost no decrease in RNA quality in HCC and RCC samples, but in COAD samples, RIN tended to decrease slightly as the storage duration increased. No significant difference was confirmed between ischemic time and nucleic acid quality, but in COAD tissue, RNA quality variability tended to increase as the ischemic time increased. Furthermore, RIN increased as the tumor cell proportion increased, whereas inflammatory cell infiltration and extracellular mucin pool were identified as independent negative predictors of RIN.Conclusions: This study confirmed that nucleic acid integrity can be maintained even during long-term storage of FFT and demonstrated that histologic features are closely related to RNA quality. This study would contribute to the establishment of quality assessment and management standards for biobank FFT samples.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":" ","pages":"398-407"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12634257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrum of thyroiditis types: clinical, cytomorphological, and radiological findings. 甲状腺炎类型谱：临床、细胞形态学和放射学表现。

IF 3

Journal of Pathology and Translational Medicine Pub Date : 2025-11-01 Epub Date: 2025-11-06 DOI: 10.4132/jptm.2025.08.13

Anam Singh, Indrajeet Kundu

{"title":"Spectrum of thyroiditis types: clinical, cytomorphological, and radiological findings.","authors":"Anam Singh, Indrajeet Kundu","doi":"10.4132/jptm.2025.08.13","DOIUrl":"10.4132/jptm.2025.08.13","url":null,"abstract":"Background: Thyroiditis encompasses a range of inflammatory conditions affecting the thyroid gland. Lymphocytic thyroiditis (LT) is a common form of thyroiditis, with acute suppuration of the thyroid, while tuberculous thyroiditis is relatively rare. Fine-needle aspiration cytology (FNAC) remains a safe and cost-effective tool for diagnosing thyroid-related diseases, especially when paired with ultrasound (US) and clinical examination.Methods: This is a cross-sectional study including 21 cases. The cases were reported as thyroiditis on US and FNAC, and the findings were correlated with patient clinical history, symptoms during presentation, and serological profiles.Results: The cases of thyroiditis encompassed the more common forms, LT and subacute granulomatous thyroiditis (SAT), as well as relatively rare forms like tuberculous thyroiditis and thyroid abscess. Cases of follicular neoplasms (FN) arising in the context of LT also are included in this study. The case of tuberculous thyroiditis presented as a bulky thyroid gland that appeared heterogeneous on US with extensive necrosis on FNAC. The cases of thyroid abscess and SAT presented with painful neck swellings, with granulomas in the latter cases. US features of LT showed an array of appearances ranging from pseudonodular to an atrophic thyroid gland. All cases of FN showed a lymphocytic background.Conclusions: Thyroiditis is a commonly encountered condition that needs to be sub-categorized accurately into acute, subacute, and chronic types for appropriate clinical management, as they can sometimes show overlapping features. Though rare, acute suppurative and tuberculous thyroiditis are often encountered and warrant immediate care and treatment.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"59 6","pages":"421-433"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12634268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic challenge in Burkitt lymphoma of the mandible initially misdiagnosed as osteomyelitis: a case report. 下颌骨伯基特淋巴瘤最初误诊为骨髓炎的诊断挑战：1例报告。

IF 3

Journal of Pathology and Translational Medicine Pub Date : 2025-11-01 Epub Date: 2025-11-14 DOI: 10.4132/jptm.2025.09.18

Jiwon Do, Jin-Young Choi

{"title":"Diagnostic challenge in Burkitt lymphoma of the mandible initially misdiagnosed as osteomyelitis: a case report.","authors":"Jiwon Do, Jin-Young Choi","doi":"10.4132/jptm.2025.09.18","DOIUrl":"10.4132/jptm.2025.09.18","url":null,"abstract":"Burkitt lymphoma (BL) is a highly aggressive B-cell neoplasm that rarely involves the mandible in elderly without apparent immunodeficiency. We report a case of a 72-year-old male who presented with persistent mandibular pain following extraction of tooth #46. Initial imaging findings were consistent with incipient osteomyelitis, and the patient was treated with antibiotics. Despite treatment, pain persisted, and follow-up imaging revealed swelling and diffusion restriction in the lateral pterygoid muscle without evidence of a distinct mass. Biopsy revealed BL confirmed by immunohistochemistry: CD10+, BCL6+, c-MYC+, Ki-67 >95%, and negative for BCL2, MUM-1, and Epstein-Barr virus. Although c-MYC immunopositivity was demonstrated, fluorescence in situ hybridization for MYC rearrangement could not be performed due to limited tissue, representing a diagnostic limitation. Notably, the patient had no trismus despite deep muscle involvement, but complained of facial paresthesia and showed remote swelling in the scapular area during hospitalization. Systemic staging with imaging, cerebrospinal fluid cytology, and imaging revealed disseminated nodal and extranodal involvement including the central nervous system, corresponding to stage IV disease by Lugano classification. This case highlights the diagnostic challenge of distinguishing lymphoma from osteomyelitis and underscores the importance of considering malignancy in cases of refractory mandibular inflammation with atypical features.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"59 6","pages":"460-466"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12634243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of undifferentiated carcinoma of the salivary gland: clinicopathological and immunohistochemical analyses in comparison with lymphoepithelial carcinoma. 涎腺未分化癌的特征：与淋巴上皮癌比较的临床病理和免疫组织化学分析。

IF 3

Journal of Pathology and Translational Medicine Pub Date : 2025-11-01 Epub Date: 2025-09-08 DOI: 10.4132/jptm.2025.07.07

Sangjoon Choi, Gyuheon Choi, Hee Jin Lee, Joon Seon Song, Yoon Se Lee, Seung-Ho Choi, Kyung-Ja Cho

{"title":"Characterization of undifferentiated carcinoma of the salivary gland: clinicopathological and immunohistochemical analyses in comparison with lymphoepithelial carcinoma.","authors":"Sangjoon Choi, Gyuheon Choi, Hee Jin Lee, Joon Seon Song, Yoon Se Lee, Seung-Ho Choi, Kyung-Ja Cho","doi":"10.4132/jptm.2025.07.07","DOIUrl":"10.4132/jptm.2025.07.07","url":null,"abstract":"Background: This study aimed to reclassify a subset of poorly differentiated salivary gland carcinoma that do not conform to any entities of the current World Health Organization (WHO) classification into the category of undifferentiated carcinoma (UDC) because they lack specific histologic differentiation or immunophenotype.Methods: Cases of salivary gland carcinomas from Asan Medical Center (2002-2020) that did not fit any existing WHO classification criteria and were diagnosed as poorly differentiated carcinoma, high-grade carcinoma, or UDC, were retrospectively reviewed. Immunohistochemical (IHC) staining for p40, neuroendocrine markers, androgen receptor (AR), and gross cystic disease fluid protein 15 (GCDFP-15) and Epstein-Barr virus (EBV) in situ hybridization (ISH) were performed. Clinical data were collected from the electronic medical records.Results: Six salivary gland carcinomas did not align with any specific entities and lacked distinct differentiation. Two of six cases displayed lymphoepithelial carcinoma (LEC)-like morphology but were negative or showed negligible immunoreactivity for p40 and EBV ISH, distinguishing them from LEC of the salivary gland. Two cases showed strong AR positivity, suggesting a potential overlap with salivary duct carcinoma (SDC) but lacked classic SDC morphologies and GCDFP-15 expression. No cases expressed neuroendocrine markers.Conclusions: This study proposes reclassifying these poorly differentiated or high-grade salivary gland carcinomas as UDC based on their indeterminate differentiation and IHC profiles. This may lead to a clearer diagnostic category and enhance our understanding of these high-grade tumors.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":" ","pages":"361-370"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12634251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast schwannoma: review of entity and differential diagnosis. 乳腺神经鞘瘤：实体与鉴别诊断综述。

IF 3

Journal of Pathology and Translational Medicine Pub Date : 2025-11-01 Epub Date: 2025-11-03 DOI: 10.4132/jptm.2025.08.12

Sandra Ixchel Sanchez, Ashley Cimino-Mathews

引用次数: 0

Modified plasma-thrombin method using patient-derived plasma for cell block preparation in endobronchial ultrasound-guided transbronchial fine-needle aspiration. 改良血浆凝血酶法在超声引导下经支气管细针穿刺支气管内细胞阻滞制备中的应用。

IF 3

Journal of Pathology and Translational Medicine Pub Date : 2025-11-01 Epub Date: 2025-11-11 DOI: 10.4132/jptm.2025.08.20

Xizhe Zhang, Chunli Tang, Yingying Gu, Zeyun Lin, Shiqi Tang, Anzi Tan, Mengshi Li, Zhucheng Chen, Yuying Chen, Shi-Yue Li, Juhong Jiang

{"title":"Modified plasma-thrombin method using patient-derived plasma for cell block preparation in endobronchial ultrasound-guided transbronchial fine-needle aspiration.","authors":"Xizhe Zhang, Chunli Tang, Yingying Gu, Zeyun Lin, Shiqi Tang, Anzi Tan, Mengshi Li, Zhucheng Chen, Yuying Chen, Shi-Yue Li, Juhong Jiang","doi":"10.4132/jptm.2025.08.20","DOIUrl":"10.4132/jptm.2025.08.20","url":null,"abstract":"Background: The plasma-thrombin method, which uses expired blood bank plasma as an ancillary component, has been widely used in cell block (CB) preparation. However, the application of expired blood bank plasma raises concerns about nucleic acid contamination. This study investigated the feasibility of using patient-derived plasma as a substitute for blood bank plasma in the modified plasma-thrombin (MPT) method for CB preparation in endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) samples.Methods: A prospective study was conducted to compare the adequacy of CB preparation between a previously used self-clotting (SC) method and the MPT method. The EBUS-TBNA specimens from each targeted lesion were divided into paired samples: one processed using the SC method and the other using the MPT method, substituting the blood bank plasma with patient-derived plasma.Results: A total of 82 paired EBUS-TBNA samples from 59 patients were analyzed. The diagnostic yield of the SC method and the MPT method was 86.6% and 97.6%, respectively. Among patients diagnosed with non-small cell lung cancer, the adequacy rate for molecular testing was 79.2% with the SC method and 91.7% with the MPT method.Conclusions: The MPT method significantly improved the cellular yield of EBUS-TBNA-derived CBs. Using patient-derived fresh plasma rather than expired blood bank plasma avoids a known contamination risk. The additional step modestly prolongs the procedure and introduces minimal risks by vein puncture. This approach is generally considered cost-effective.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"59 6","pages":"434-443"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12634245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0